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CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.

Pálinkás HL, Rácz GA, Gál Z, Hoffmann OI, Tihanyi G, Róna G, Gócza E, Hiripi L, Vértessy BG.

Biomolecules. 2019 Apr 4;9(4). pii: E136. doi: 10.3390/biom9040136.


Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients.

Nabieva N, Häberle L, Brucker SY, Janni W, Volz B, Loehberg CR, Hartkopf AD, Walter CB, Baake G, Fridman A, Malter W, Wuerstlein R, Harbeck N, Hoffmann O, Kuemmel S, Martin B, Thomssen C, Graf H, Wolf C, Lux MP, Bayer CM, Rauh C, Hack CC, Almstedt K, Gass P, Heindl F, Brodkorb T, Lindner C, Kolberg HC, Krabisch P, Weigel M, Steinfeld-Birg D, Kohls A, Brucker C, Schulz V, Fischer G, Pelzer V, Rack B, Beckmann MW, Fehm T, Rody A, Maass N, Hein A, Fasching PA.

Int J Cancer. 2019 Oct 15;145(8):2114-2121. doi: 10.1002/ijc.32294. Epub 2019 Apr 2.


Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer.

Benson S, Hagen S, Hoffmann O, Pasler A, Bingel U, Schedlowski M, Peters J, Elsenbruch S, Frey UH.

Pain. 2019 Jul;160(7):1562-1571. doi: 10.1097/j.pain.0000000000001546.


Cell-Free DNA Variant Sequencing Using CTC-Depleted Blood for Comprehensive Liquid Biopsy Testing in Metastatic Breast Cancer.

Keup C, Storbeck M, Hauch S, Hahn P, Sprenger-Haussels M, Tewes M, Mach P, Hoffmann O, Kimmig R, Kasimir-Bauer S.

Cancers (Basel). 2019 Feb 18;11(2). pii: E238. doi: 10.3390/cancers11020238.


Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer.

König L, Mairinger FD, Hoffmann O, Bittner AK, Schmid KW, Kimmig R, Kasimir-Bauer S, Bankfalvi A.

BMC Cancer. 2019 Feb 4;19(1):120. doi: 10.1186/s12885-019-5320-2.


Safety of apnea testing for the diagnosis of brain death: a comprehensive study on neuromonitoring data and blood gas analysis.

Salih F, Hoffmann O, Brandt SA, Masuhr F, Schreiber S, Weissinger F, Rocco A, Wolf S.

Eur J Neurol. 2019 Jun;26(6):887-892. doi: 10.1111/ene.13903. Epub 2019 Feb 3.


Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer.

Wunderle M, Pretscher J, Brucker SY, Volz B, Hartmann A, Fiessler C, Hein A, Häberle L, Jud SM, Lux MP, Janni W, Loehberg CR, Hartkopf AD, Walter CB, Baake G, Fridman A, Malter W, Wuerstlein R, Harbeck N, Hoffmann O, Kümmel S, Martin B, Thomssen C, Graf H, Wolf C, Bayer CM, Hack CC, Almstedt K, Gass P, Heindl F, Brodkorb TF, Nabieva N, Lindner C, Kolberg HC, Krabisch P, Weigel M, Steinfeld-Birg D, Kohls A, Brucker C, Schulz V, Fischer G, Pelzer V, Wallwiener D, Rack B, Fehm T, Rody A, Maass N, Beckmann MW, Fasching PA, Rauh C.

Breast Cancer Res Treat. 2019 Apr;174(2):453-461. doi: 10.1007/s10549-018-05115-6. Epub 2019 Jan 2.


Biological Compatibility Profile on Biomaterials for Bone Regeneration.

Kampleitner C, Obi J, Vassilev N, Epstein MM, Hoffmann O.

J Vis Exp. 2018 Nov 16;(141). doi: 10.3791/58077.


Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer.

Rachner TD, Kasimir-Bauer S, Göbel A, Erdmann K, Hoffmann O, Browne A, Wimberger P, Rauner M, Hofbauer LC, Kimmig R, Bittner AK.

Clin Cancer Res. 2019 Feb 15;25(4):1369-1378. doi: 10.1158/1078-0432.CCR-18-2482. Epub 2018 Nov 13.


Local and whole-body staging in patients with primary breast cancer: a comparison of one-step to two-step staging utilizing 18F-FDG-PET/MRI.

Kirchner J, Grueneisen J, Martin O, Oehmigen M, Quick HH, Bittner AK, Hoffmann O, Ingenwerth M, Catalano OA, Heusch P, Buchbender C, Forsting M, Antoch G, Herrmann K, Umutlu L.

Eur J Nucl Med Mol Imaging. 2018 Dec;45(13):2328-2337. doi: 10.1007/s00259-018-4102-4. Epub 2018 Jul 28.


Glomerulosclerosis in transgenic rabbits with ubiquitous Venus protein expression.

Lipták N, Hoffmann OI, Skoda G, Gócza E, Kerekes A, Bősze Z, Hiripi L.

Acta Vet Hung. 2018 Jun;66(2):281-293. doi: 10.1556/004.2018.026.


Self-fitting shape memory polymer foam inducing bone regeneration: A rabbit femoral defect study.

Xie R, Hu J, Hoffmann O, Zhang Y, Ng F, Qin T, Guo X.

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):936-945. doi: 10.1016/j.bbagen.2018.01.013. Epub 2018 Jan 31.


[New Challenges: Diagnosis of Brain Death in Newborn, Children and Adolescents].

Masuhr F, Dame C, Gratopp A, Hoffmann O.

Klin Padiatr. 2018 Mar;230(2):88-96. doi: 10.1055/s-0043-124677. Epub 2018 Jan 17. German.


Elevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy.

König L, Kasimir-Bauer S, Bittner AK, Hoffmann O, Wagner B, Santos Manvailer LF, Kimmig R, Horn PA, Rebmann V.

Oncoimmunology. 2017 Sep 27;7(1):e1376153. doi: 10.1080/2162402X.2017.1376153. eCollection 2017.


Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer.

Kolberg HC, Lövey G, Akpolat-Basci L, Stephanou M, Fasching P, Untch M, Hoffmann O, Bulsara M, Vaidya J, Liedtke C.

Breast Care (Basel). 2017 Oct;12(5):318-323. doi: 10.1159/000479424. Epub 2017 Sep 21.


Biocompatibility and immunogenicity of elastin-like recombinamer biomaterials in mouse models.

Changi K, Bosnjak B, Gonzalez-Obeso C, Kluger R, Rodríguez-Cabello JC, Hoffmann O, Epstein MM.

J Biomed Mater Res A. 2018 Apr;106(4):924-934. doi: 10.1002/jbm.a.36290. Epub 2017 Nov 28.


Secretion of a recombinant protein without a signal peptide by the exocrine glands of transgenic rabbits.

Kerekes A, Hoffmann OI, Iski G, Lipták N, Gócza E, Kues WA, Bősze Z, Hiripi L.

PLoS One. 2017 Oct 27;12(10):e0187214. doi: 10.1371/journal.pone.0187214. eCollection 2017.


An Ultralow-Dose 1-Day Protocol With Activities Lower Than 20 MBq for the Detection of Sentinel Lymph Nodes in Breast Cancer-Experiences After 150 Cases.

Kolberg HC, Afsah S, Kuehn T, Winzer U, Akpolat-Basci L, Stephanou M, Wetzig S, Hoffmann O, Liedtke C.

Technol Cancer Res Treat. 2017 Jan 1:1533034617728862. doi: 10.1177/1533034617728862. [Epub ahead of print]


Placenta-specific gene manipulation in rabbits.

Skoda G, Hoffmann OI, Gócza E, Bodrogi L, Kerekes A, Bösze Z, Hiripi L.

J Biotechnol. 2017 Oct 10;259:86-90. doi: 10.1016/j.jbiotec.2017.07.037. Epub 2017 Aug 1.


A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid.

Tálas A, Kulcsár PI, Weinhardt N, Borsy A, Tóth E, Szebényi K, Krausz SL, Huszár K, Vida I, Sturm Á, Gordos B, Hoffmann OI, Bencsura P, Nyeste A, Ligeti Z, Fodor E, Welker E.

DNA Res. 2017 Dec 1;24(6):609-621. doi: 10.1093/dnares/dsx029.


A genomic landscape of mitochondrial DNA insertions in the pig nuclear genome provides evolutionary signatures of interspecies admixture.

Schiavo G, Hoffmann OI, Ribani A, Utzeri VJ, Ghionda MC, Bertolini F, Geraci C, Bovo S, Fontanesi L.

DNA Res. 2017 Oct 1;24(5):487-498. doi: 10.1093/dnares/dsx019.


Lateral Wall Regeneration and Membrane Repair After Attempted Sinus Augmentation Using a Non-Resorbable Membrane.

Zafiropoulos GG, Hoffmann O, John G.

J Oral Implantol. 2017 Aug;43(4):303-306. doi: 10.1563/aaid-joi-D-17-00023. Epub 2017 Apr 19. No abstract available.


Changes of the peri-implant soft tissue thickness after grafting with a collagen matrix.

Zafiropoulos GG, Deli G, Hoffmann O, John G.

J Indian Soc Periodontol. 2016 Jul-Aug;20(4):441-445. doi: 10.4103/0972-124X.181245.


Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study.

Limmroth V, Ziemssen T, Lang M, Richter S, Wagner B, Haas J, Schmidt S, Gerbershagen K, Lassek C, Klotz L, Hoffmann O, Albert C, Schuh K, Baier-Ebert M, Wendt G, Schieb H, Hoyer S, Dechend R, Haverkamp W.

BMC Neurol. 2017 Jan 18;17(1):11. doi: 10.1186/s12883-016-0789-7.


HIV-1 Genetic Diversity Among Incident Infections in Mbeya, Tanzania.

Billings E, Sanders-Buell E, Bose M, Kijak GH, Bradfield A, Crossler J, Arroyo MA, Maboko L, Hoffmann O, Geis S, Birx DL, Kim JH, Michael NL, Robb ML, Hoelscher M, Tovanabutra S.

AIDS Res Hum Retroviruses. 2017 Apr;33(4):373-381. doi: 10.1089/AID.2016.0111. Epub 2016 Dec 19.


Monitoring of Venus transgenic cell migration during pregnancy in non-transgenic rabbits.

Lipták N, Hoffmann OI, Kerekes A, Iski G, Ernszt D, Kvell K, Hiripi L, Bősze Z.

Transgenic Res. 2017 Apr;26(2):291-299. doi: 10.1007/s11248-016-9994-9. Epub 2016 Nov 10.


Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice.

Rusch P, Hoffmann O, Stickelmann AL, Böhmer S, Gätje R, Krüger KG, Niesert S, Schmidt A, Kimmig R.

Springerplus. 2016 Jul 7;5(1):1010. doi: 10.1186/s40064-016-2703-6. eCollection 2016.


Outcome of heparin-treated patients with acute cerebral venous sinus thrombosis: influence of the temporal pattern of intracerebral haemorrhage.

Busch MA, Hoffmann O, Einhäupl KM, Masuhr F.

Eur J Neurol. 2016 Sep;23(9):1387-92. doi: 10.1111/ene.13064. Epub 2016 Jun 14.


Intracranial pressure and cerebral perfusion pressure in patients developing brain death.

Salih F, Holtkamp M, Brandt SA, Hoffmann O, Masuhr F, Schreiber S, Weissinger F, Vajkoczy P, Wolf S.

J Crit Care. 2016 Aug;34:1-6. doi: 10.1016/j.jcrc.2016.03.009. Epub 2016 Mar 16.


Different prognostic value of circulating and disseminated tumor cells in primary breast cancer: Influence of bisphosphonate intake?

Kasimir-Bauer S, Reiter K, Aktas B, Bittner AK, Weber S, Keller T, Kimmig R, Hoffmann O.

Sci Rep. 2016 May 23;6:26355. doi: 10.1038/srep26355.


Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits.

Hoffmann OI, Kerekes A, Lipták N, Hiripi L, Bodo S, Szaloki G, Klein S, Ivics Z, Kues WA, Bosze Z.

PLoS One. 2016 May 5;11(5):e0154489. doi: 10.1371/journal.pone.0154489. eCollection 2016.


Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids.

Halfter K, Hoffmann O, Ditsch N, Ahne M, Arnold F, Paepke S, Grab D, Bauerfeind I, Mayer B.

J Transl Med. 2016 May 3;14(1):112. doi: 10.1186/s12967-016-0855-3.


B3-lesions of the breast and cancer risk - an analysis of mammography screening patients.

Hoffmann O, Stamatis GA, Bittner AK, Arnold G, Schnabel R, Krüger K, Kimmig R, Heubner M.

Mol Clin Oncol. 2016 May;4(5):705-708. Epub 2016 Feb 23.


Differential roles of hypoxia and innate immunity in juvenile and adult dermatomyositis.

Preuße C, Allenbach Y, Hoffmann O, Goebel HH, Pehl D, Radke J, Doeser A, Schneider U, Alten RH, Kallinich T, Benveniste O, von Moers A, Schoser B, Schara U, Stenzel W.

Acta Neuropathol Commun. 2016 Apr 27;4(1):45. doi: 10.1186/s40478-016-0308-5.


Cyclic volatile methylsiloxanes in human blood as markers for ruptured silicone gel-filled breast implants.

Rosendahl P, Hippler J, Schmitz OJ, Hoffmann O, Rusch P.

Anal Bioanal Chem. 2016 May;408(12):3309-17. doi: 10.1007/s00216-016-9401-7. Epub 2016 Mar 11.


Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy.

Kasimir-Bauer S, Bittner AK, König L, Reiter K, Keller T, Kimmig R, Hoffmann O.

Breast Cancer Res. 2016 Feb 12;18(1):20. doi: 10.1186/s13058-016-0679-3.


The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients.

König L, Kasimir-Bauer S, Hoffmann O, Bittner AK, Wagner B, Manvailer LF, Schramm S, Bankfalvi A, Giebel B, Kimmig R, Horn PA, Rebmann V.

Hum Immunol. 2016 Sep;77(9):791-9. doi: 10.1016/j.humimm.2016.01.002. Epub 2016 Jan 12.


[Ancillary procedures in the diagnostics of brain death. Utilization, results and consequences in northeastern Germany].

Hoffmann O, Masuhr F.

Nervenarzt. 2016 Feb;87(2):169-77. doi: 10.1007/s00115-015-0044-2. German.


Positron Emission Tomography/Magnetic Resonance Imaging for Local Tumor Staging in Patients With Primary Breast Cancer: A Comparison With Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging.

Grueneisen J, Nagarajah J, Buchbender C, Hoffmann O, Schaarschmidt BM, Poeppel T, Forsting M, Quick HH, Umutlu L, Kinner S.

Invest Radiol. 2015 Aug;50(8):505-13. doi: 10.1097/RLI.0000000000000197.


Use of Observational Periods or Ancillary Tests in the Determination of Brain Death in Germany.

Hoffmann O, Masuhr F.

Eur Neurol. 2015;74(1-2):11-7. doi: 10.1159/000431089. Epub 2015 Jun 13.


Evaluation of the prognostic significance of disseminated tumor cells in the bone marrow of primary, non-metastatic breast cancer patients after a 7-year follow-up.

Hoffmann O, Schroer-Zuendorf IA, Kasimir-Bauer S, Oberhoff C, Kimmig R, Heubner M.

Arch Gynecol Obstet. 2015 Nov;292(5):1117-25. doi: 10.1007/s00404-015-3748-4. Epub 2015 May 19.


Impact of the spheroid model complexity on drug response.

Hoffmann OI, Ilmberger C, Magosch S, Joka M, Jauch KW, Mayer B.

J Biotechnol. 2015 Jul 10;205:14-23. doi: 10.1016/j.jbiotec.2015.02.029. Epub 2015 Mar 3.


Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis.

Hoffmann O, Rung O, Held J, Boettcher C, Prokop S, Stenzel W, Priller J.

Infect Immun. 2015 Jan;83(1):259-67. doi: 10.1128/IAI.02682-14. Epub 2014 Oct 27.


[Access to brain death diagnostics].

Hoffmann O, Masuhr F.

Nervenarzt. 2014 Dec;85(12):1573-81. doi: 10.1007/s00115-014-4171-y. German.


A method for fabrication of implant-supported fixed partial dentures.

Zafiropoulos GG, Hoffmann O, Deli G.

J Oral Implantol. 2014 Jun;40(3):271-9. doi: 10.1563/AAID-JOI-D-11-00048.


Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):794-809. doi: 10.1038/nprot.2014.009. Epub 2014 Mar 13.


Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):773-93. doi: 10.1038/nprot.2014.008. Epub 2014 Mar 13.


[Better efficacy of buprenorphine and methadone in opioid dependence. Requirements for abstinence from non-opioids before starting treatment paid off].

Hoffmann O, Frisell F, Ljungberg T.

Lakartidningen. 2014 Jan 29-Feb 4;111(5):147-9. Swedish. No abstract available.


Low titer lentiviral transgenesis in rodents with simian immundeficiency virus vector.

Bender B, Hoffmann OI, Negre D, Kvell K, Bősze Z, Hiripi L.

Biotechniques. 2013 Sep;55(3):137-40. doi: 10.2144/000114078.


[Safety of silicone breast implants, especially of Poly Implant Prothese (PIP) breast implants].

Hoffmann O.

MMW Fortschr Med. 2013 Feb 7;155(2):50-2. German. No abstract available.


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