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Items: 1 to 50 of 88

1.

When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis.

Franchet C, Hoffmann JS.

Cancers (Basel). 2019 Dec 19;12(1). pii: E26. doi: 10.3390/cancers12010026. Review.

2.

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y.

JCI Insight. 2019 Nov 1;4(21). pii: 121951. doi: 10.1172/jci.insight.121951.

3.

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.

Lutzmann M, Bernex F, da Costa de Jesus C, Hodroj D, Marty C, Plo I, Vainchenker W, Tosolini M, Forichon L, Bret C, Queille S, Marchive C, Hoffmann JS, Méchali M.

Cell Rep. 2019 Sep 10;28(11):2851-2865.e4. doi: 10.1016/j.celrep.2019.07.095.

4.

Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.

González Besteiro MA, Calzetta NL, Loureiro SM, Habif M, Bétous R, Pillaire MJ, Maffia A, Sabbioneda S, Hoffmann JS, Gottifredi V.

EMBO J. 2019 Aug 15;38(16):e101284. doi: 10.15252/embj.2018101284. Epub 2019 Jul 11.

PMID:
31294866
5.

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.

Bianco JN, Bergoglio V, Lin YL, Pillaire MJ, Schmitz AL, Gilhodes J, Lusque A, Mazières J, Lacroix-Triki M, Roumeliotis TI, Choudhary J, Moreaux J, Hoffmann JS, Tourrière H, Pasero P.

Nat Commun. 2019 Feb 22;10(1):910. doi: 10.1038/s41467-019-08886-8.

6.

The Protective Role of Dormant Origins in Response to Replicative Stress.

Courtot L, Hoffmann JS, Bergoglio V.

Int J Mol Sci. 2018 Nov 12;19(11). pii: E3569. doi: 10.3390/ijms19113569. Review.

7.

Germline mutation p.N363K in POLE is associated with an increased risk of colorectal cancer and giant cell glioblastoma.

Vande Perre P, Siegfried A, Corsini C, Bonnet D, Toulas C, Hamzaoui N, Selves J, Chipoulet E, Hoffmann JS, Uro-Coste E, Guimbaud R.

Fam Cancer. 2019 Apr;18(2):173-178. doi: 10.1007/s10689-018-0102-6.

PMID:
30368636
8.

DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF.

Bétous R, Goullet de Rugy T, Pelegrini AL, Queille S, de Villartay JP, Hoffmann JS.

PLoS Genet. 2018 Jul 30;14(7):e1007541. doi: 10.1371/journal.pgen.1007541. eCollection 2018 Jul.

9.

DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status.

Grgurevic S, Montilla-Perez P, Bradbury A, Gilhodes J, Queille S, Pelofy S, Bancaud A, Filleron T, Ysebaert L, Récher C, Laurent G, Fournié JJ, Cazaux C, Quillet-Mary A, Hoffmann JS.

Haematologica. 2018 Jun;103(6):1038-1046. doi: 10.3324/haematol.2017.174243. Epub 2018 Mar 22.

10.

Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Oct 26;8:16171. doi: 10.1038/ncomms16171.

11.

Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance.

David L, Manenti S, Récher C, Hoffmann JS, Didier C.

Mol Cell Oncol. 2017 Sep 18;4(5):e1289293. doi: 10.1080/23723556.2017.1289293. eCollection 2017.

12.

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission.

Bournique E, Dall'Osto M, Hoffmann JS, Bergoglio V.

Mutat Res. 2018 Mar;808:62-73. doi: 10.1016/j.mrfmmm.2017.08.002. Epub 2017 Aug 14. Review.

PMID:
28843435
13.

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Jul 17;8:15983. doi: 10.1038/ncomms15983. Erratum in: Nat Commun. 2017 Oct 26;8:16171.

14.

Proper sister chromatid disjunction requires CDA and PARP-1.

Hoffmann JS, Cordelier P.

Cell Cycle. 2017 Jul 3;16(13):1239-1240. doi: 10.1080/15384101.2017.1326767. Epub 2017 Jun 9. No abstract available.

15.

Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress.

Bétous R, Renoud ML, Hoede C, Gonzalez I, Jones N, Longy M, Sensebé L, Cazaux C, Hoffmann JS.

Stem Cells Transl Med. 2017 Jan;6(1):68-76. doi: 10.5966/sctm.2015-0401. Epub 2016 Aug 2.

16.

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.

Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ.

Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048.

17.

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.

Mansilla SF, Bertolin AP, Bergoglio V, Pillaire MJ, González Besteiro MA, Luzzani C, Miriuka SG, Cazaux C, Hoffmann JS, Gottifredi V.

Elife. 2016 Oct 14;5. pii: e18020. doi: 10.7554/eLife.18020.

18.

CHK1 as a therapeutic target to bypass chemoresistance in AML.

David L, Fernandez-Vidal A, Bertoli S, Grgurevic S, Lepage B, Deshaies D, Prade N, Cartel M, Larrue C, Sarry JE, Delabesse E, Cazaux C, Didier C, Récher C, Manenti S, Hoffmann JS.

Sci Signal. 2016 Sep 13;9(445):ra90. doi: 10.1126/scisignal.aac9704.

PMID:
27625304
19.

Analysis of DNA Replication by Optical Mapping in Nanochannels.

Lacroix J, Pélofy S, Blatché C, Pillaire MJ, Huet S, Chapuis C, Hoffmann JS, Bancaud A.

Small. 2016 Nov;12(43):5963-5970. doi: 10.1002/smll.201503795. Epub 2016 Sep 14.

20.

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.

Goullet de Rugy T, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS.

Biol Open. 2016 Oct 15;5(10):1485-1492. doi: 10.1242/bio.018028.

21.

3R gene expression in chronic lymphocytic leukemia reveals insight into disease evolution.

Grgurevic S, Berquet L, Quillet-Mary A, Laurent G, Récher C, Ysebaert L, Cazaux C, Hoffmann JS.

Blood Cancer J. 2016 Jun 3;6(6):e429. doi: 10.1038/bcj.2016.39. No abstract available.

22.

Impact of the DNA polymerase Theta on the DNA replication program.

Baldacci G, Hoffmann JS, Cadoret JC.

Genom Data. 2014 Dec 5;3:90-3. doi: 10.1016/j.gdata.2014.11.014. eCollection 2015 Mar.

23.

A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.

Brandalize AP, Schüler-Faccini L, Hoffmann JS, Caleffi M, Cazaux C, Ashton-Prolla P.

BMC Cancer. 2014 Nov 19;14:850. doi: 10.1186/1471-2407-14-850.

24.

A role for DNA polymerase θ in the timing of DNA replication.

Fernandez-Vidal A, Guitton-Sert L, Cadoret JC, Drac M, Schwob E, Baldacci G, Cazaux C, Hoffmann JS.

Nat Commun. 2014 Jul 3;5:4285. doi: 10.1038/ncomms5285.

PMID:
24989122
25.

Role of DNA polymerase κ in the maintenance of genomic stability.

Pillaire MJ, Bétous R, Hoffmann JS.

Mol Cell Oncol. 2014 Jul 15;1(1):e29902. doi: 10.4161/mco.29902. eCollection 2014. Review.

26.

Pol κ in replication checkpoint.

Maiorano D, Hoffmann JS.

Cell Cycle. 2013 Dec 15;12(24):3713-4. doi: 10.4161/cc.26976. Epub 2013 Oct 28. No abstract available.

27.

The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity.

Boyer AS, Grgurevic S, Cazaux C, Hoffmann JS.

J Mol Biol. 2013 Nov 29;425(23):4767-81. doi: 10.1016/j.jmb.2013.09.022. Epub 2013 Oct 3. Review.

PMID:
24095858
28.

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS.

EMBO J. 2013 Jul 31;32(15):2172-85. doi: 10.1038/emboj.2013.148. Epub 2013 Jun 25.

29.

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.

Bergoglio V, Boyer AS, Walsh E, Naim V, Legube G, Lee MY, Rey L, Rosselli F, Cazaux C, Eckert KA, Hoffmann JS.

J Cell Biol. 2013 Apr 29;201(3):395-408. doi: 10.1083/jcb.201207066. Epub 2013 Apr 22.

30.

DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions.

Schamber-Reis BL, Nardelli S, Régis-Silva CG, Campos PC, Cerqueira PG, Lima SA, Franco GR, Macedo AM, Pena SD, Cazaux C, Hoffmann JS, Motta MC, Schenkman S, Teixeira SM, Machado CR.

Mol Biochem Parasitol. 2012 Jun;183(2):122-31. doi: 10.1016/j.molbiopara.2012.02.007. Epub 2012 Feb 24.

31.

DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.

Allera-Moreau C, Rouquette I, Lepage B, Oumouhou N, Walschaerts M, Leconte E, Schilling V, Gordien K, Brouchet L, Delisle MB, Mazieres J, Hoffmann JS, Pasero P, Cazaux C.

Oncogenesis. 2012 Oct 22;1:e30. doi: 10.1038/oncsis.2012.29.

32.

Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer.

Hoffmann JS, Cazaux C.

Semin Cancer Biol. 2010 Oct;20(5):312-9. doi: 10.1016/j.semcancer.2010.10.001. Epub 2010 Oct 8. Review.

PMID:
20934518
33.

The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway.

Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, Canitrot Y.

Carcinogenesis. 2010 Oct;31(10):1742-7. doi: 10.1093/carcin/bgq166. Epub 2010 Aug 6.

PMID:
20693240
34.

Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.

Schmitt MW, Venkatesan RN, Pillaire MJ, Hoffmann JS, Sidorova JM, Loeb LA.

J Biol Chem. 2010 Oct 15;285(42):32264-72. doi: 10.1074/jbc.M110.147017. Epub 2010 Jul 13.

35.

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

Lemée F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire MJ, Bieth A, Gentil C, Baker L, Martin AL, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roché H, Bourdon JC, Wood RD, Hoffmann JS, Cazaux C.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13390-5. doi: 10.1073/pnas.0910759107. Epub 2010 Jul 12.

36.

A 'DNA replication' signature of progression and negative outcome in colorectal cancer.

Pillaire MJ, Selves J, Gordien K, Gourraud PA, Gentil C, Danjoux M, Do C, Negre V, Bieth A, Guimbaud R, Trouche D, Pasero P, Méchali M, Hoffmann JS, Cazaux C.

Oncogene. 2010 Feb 11;29(6):876-87. doi: 10.1038/onc.2009.378. Epub 2009 Nov 9. Erratum in: Oncogene. 2010 Apr 8;29(14):2160. Gouraud, P-A [corrected to Gourraud, P-A].

PMID:
19901968
37.

Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

Terrados G, Capp JP, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsocq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L.

PLoS One. 2009 Oct 6;4(10):e7290. doi: 10.1371/journal.pone.0007290.

38.

Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.

Faumont N, Le Clorennec C, Teira P, Goormachtigh G, Coll J, Canitrot Y, Cazaux C, Hoffmann JS, Brousset P, Delsol G, Feuillard J, Meggetto F.

Cancer Res. 2009 Jun 15;69(12):5177-85. doi: 10.1158/0008-5472.CAN-08-2866. Epub 2009 Jun 2.

39.

Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Rey L, Sidorova JM, Puget N, Boudsocq F, Biard DS, Monnat RJ Jr, Cazaux C, Hoffmann JS.

Mol Cell Biol. 2009 Jun;29(12):3344-54. doi: 10.1128/MCB.00115-09. Epub 2009 Apr 20.

40.

Isolation and characterization of HC1: a novel human DNA repair gene.

Lopes DO, Falconi FC, Goes AM, Canitrot Y, Hoffmann JS, Cazaux C, Franco GR, Macedo AM, Pena SD, Machado CR.

Genet Mol Res. 2009;8(1):247-60.

PMID:
19291873
41.

The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.

Mattera L, Escaffit F, Pillaire MJ, Selves J, Tyteca S, Hoffmann JS, Gourraud PA, Chevillard-Briet M, Cazaux C, Trouche D.

Oncogene. 2009 Mar 26;28(12):1506-17. doi: 10.1038/onc.2008.499. Epub 2009 Jan 26.

PMID:
19169279
42.

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

Bétous R, Rey L, Wang G, Pillaire MJ, Puget N, Selves J, Biard DS, Shin-ya K, Vasquez KM, Cazaux C, Hoffmann JS.

Mol Carcinog. 2009 Apr;48(4):369-78. doi: 10.1002/mc.20509.

43.

Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance.

Lopes Dde O, Schamber-Reis BL, Regis-da-Silva CG, Rajão MA, Darocha WD, Macedo AM, Franco GR, Nardelli SC, Schenkman S, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

DNA Repair (Amst). 2008 Nov 1;7(11):1882-92. doi: 10.1016/j.dnarep.2008.07.018. Epub 2008 Sep 11.

PMID:
18761429
44.

Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer.

Lopes DO, Regis-da-Silva CG, Machado-Silva A, Macedo AM, Franco GR, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

Genet Mol Res. 2007 May 7;6(2):250-5.

45.

Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells.

Capp JP, Boudsocq F, Besnard AG, Lopez BS, Cazaux C, Hoffmann JS, Canitrot Y.

Nucleic Acids Res. 2007;35(11):3551-60. Epub 2007 May 5.

46.

In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery.

Golzio M, Mazzolini L, Ledoux A, Paganin A, Izard M, Hellaudais L, Bieth A, Pillaire MJ, Cazaux C, Hoffmann JS, Couderc B, Teissié J.

Gene Ther. 2007 May;14(9):752-9. Epub 2007 Mar 8.

PMID:
17344906
47.

Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint.

Pillaire MJ, Betous R, Conti C, Czaplicki J, Pasero P, Bensimon A, Cazaux C, Hoffmann JS.

Cell Cycle. 2007 Feb 15;6(4):471-7. Epub 2007 Feb 19.

PMID:
17329970
48.

Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.

Lemée F, Bavoux C, Pillaire MJ, Bieth A, Machado CR, Pena SD, Guimbaud R, Selves J, Hoffmann JS, Cazaux C.

Oncogene. 2007 May 17;26(23):3387-94. Epub 2006 Nov 13.

PMID:
17099721
49.

Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation.

Regis-da-Silva CG, Freitas JM, Passos-Silva DG, Furtado C, Augusto-Pinto L, Pereira MT, DaRocha WD, Franco GR, Macedo AM, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

Mol Biochem Parasitol. 2006 Oct;149(2):191-200. Epub 2006 Jun 21.

PMID:
16828179
50.

Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.

Canitrot Y, Laurent G, Astarie-Dequeker C, Bordier C, Cazaux C, Hoffmann JS.

Anticancer Res. 2006 Jan-Feb;26(1B):523-5.

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