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Items: 23


Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis.

Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR.

Oncotarget. 2018 Feb 3;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 2.


Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate.

Fredericks GJ, Hoffmann FW, Hondal RJ, Rozovsky S, Urschitz J, Hoffmann PR.

Antioxidants (Basel). 2017 Dec 29;7(1). pii: E4. doi: 10.3390/antiox7010004.


Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.

Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR.

Cancer Med. 2018 Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6.


Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR-mediated phagocytosis.

Norton RL, Fredericks GJ, Huang Z, Fay JD, Hoffmann FW, Hoffmann PR.

J Leukoc Biol. 2017 Feb;101(2):439-448. doi: 10.1189/jlb.2A0316-156RR. Epub 2016 Sep 6.


Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Rose AH, Hoffmann FW, Hara JH, Urschitz J, Moisyadi S, Hoffmann PR, Bertino P.

Hum Vaccin Immunother. 2015;11(9):2305-11. doi: 10.1080/21645515.2015.1047567. Epub 2015 Jun 19.


Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.

Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR.

Inflamm Bowel Dis. 2015 Sep;21(9):2005-15. doi: 10.1097/MIB.0000000000000471.


Preclinical development of HIvax: Human survivin highly immunogenic vaccines.

Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P.

Hum Vaccin Immunother. 2015;11(7):1585-95. doi: 10.1080/21645515.2015.1050572.


Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.

Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83. doi: 10.1073/pnas.1417176111. Epub 2014 Nov 3.


Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses.

Bertino P, Urschitz J, Hoffmann FW, You BR, Rose AH, Park WH, Moisyadi S, Hoffmann PR.

Vaccine. 2014 Mar 26;32(15):1670-7. doi: 10.1016/j.vaccine.2014.01.063. Epub 2014 Feb 7.


Increasing dietary selenium elevates reducing capacity and ERK activation associated with accelerated progression of select mesothelioma tumors.

Rose AH, Bertino P, Hoffmann FW, Gaudino G, Carbone M, Hoffmann PR.

Am J Pathol. 2014 Apr;184(4):1041-1049. doi: 10.1016/j.ajpath.2013.12.008. Epub 2014 Feb 1.


Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR.

J Immunol. 2013 Oct 1;191(7):3778-88. doi: 10.4049/jimmunol.1300972. Epub 2013 Aug 28.


MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN.

Mol Cell. 2013 Aug 8;51(3):397-404. doi: 10.1016/j.molcel.2013.06.019. Epub 2013 Aug 1.


Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis.

Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA.

J Leukoc Biol. 2013 May;93(5):771-80. doi: 10.1189/jlb.1212647. Epub 2013 Feb 26.


Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase.

Huang Z, Hoffmann FW, Fay JD, Hashimoto AC, Chapagain ML, Kaufusi PH, Hoffmann PR.

J Biol Chem. 2012 Feb 10;287(7):4492-502. doi: 10.1074/jbc.M111.315598. Epub 2011 Dec 28.


Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages.

Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR.

J Biol Chem. 2011 Oct 7;286(40):34830-8. doi: 10.1074/jbc.M111.265520. Epub 2011 Aug 17.


Specific antioxidant selenoproteins are induced in the heart during hypertrophy.

Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR.

Arch Biochem Biophys. 2011 Aug 1;512(1):38-44. doi: 10.1016/ Epub 2011 May 20.


Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.

Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.

J Immunol. 2011 Feb 15;186(4):2127-37. doi: 10.4049/jimmunol.1002878. Epub 2011 Jan 10.


Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

Hoffmann FW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR.

J Nutr. 2010 Jun;140(6):1155-61. doi: 10.3945/jn.109.120725. Epub 2010 Apr 7.


A new approach for analyzing cellular infiltration during allergic airway inflammation.

Hoffmann PR, Gurary A, Hoffmann FW, Jourdan-Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ.

J Immunol Methods. 2007 Dec 1;328(1-2):21-33. Epub 2007 Aug 27.


A role for dietary selenium and selenoproteins in allergic airway inflammation.

Hoffmann PR, Jourdan-Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ.

J Immunol. 2007 Sep 1;179(5):3258-67.


The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.

Hoffmann PR, Höge SC, Li PA, Hoffmann FW, Hashimoto AC, Berry MJ.

Nucleic Acids Res. 2007;35(12):3963-73. Epub 2007 Jun 6.


Isolation of trans-delta-tetrahydrocannabinol from marijuana.

Hively RL, Mosher WA, Hoffmann FW.

J Am Chem Soc. 1966 Apr 20;88(8):1832-3. No abstract available.


Preparation of aliphatic fluorides.


J Am Chem Soc. 1948 Jul;70(7):2596. No abstract available.


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