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Items: 1 to 50 of 202

1.

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, LaChapelle EA, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2018 Apr 26;61(8):3753. doi: 10.1021/acs.jmedchem.8b00475. Epub 2018 Apr 6. No abstract available.

PMID:
29624389
2.

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.

Helal CJ, Arnold E, Boyden T, Chang C, Chappie TA, Fisher E, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Pandit J, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, McGinnis D, O'Connor RE, O'Donnell CJ, Ogden A, Piotrowski M, Schmidt CJ, Seymour PA, Ueno H, Vansell N, Verhoest PR, Yang EX.

J Med Chem. 2018 Feb 8;61(3):1001-1018. doi: 10.1021/acs.jmedchem.7b01466. Epub 2018 Jan 16.

PMID:
29293004
3.

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2017 Jul 13;60(13):5673-5698. doi: 10.1021/acs.jmedchem.7b00397. Epub 2017 Jun 16. Erratum in: J Med Chem. 2018 Apr 26;61(8):3753.

PMID:
28574706
4.

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.

Claffey MM, Helal CJ, Verhoest PR, Kang Z, Fors KS, Jung S, Zhong J, Bundesmann MW, Hou X, Lui S, Kleiman RJ, Vanase-Frawley M, Schmidt AW, Menniti F, Schmidt CJ, Hoffman WE, Hajos M, McDowell L, O'Connor RE, Macdougall-Murphy M, Fonseca KR, Becker SL, Nelson FR, Liras S.

J Med Chem. 2012 Nov 8;55(21):9055-68. doi: 10.1021/jm3009635. Epub 2012 Oct 12.

PMID:
23025719
5.

Plasma biochemistry values of recently wild-caught purple mouth moray eels (Gymnothorax vicinus).

Erlacher-Reid C, Hoffman WE, Priede M, Pulver R, Tuttle AD.

J Zoo Wildl Med. 2011 Dec;42(4):671-9.

PMID:
22204062
6.

Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats.

Ebersp├Ącher E, Eckel B, Engelhard K, M├╝ller K, Hoffman WE, Blobner M, Werner C.

Acta Anaesthesiol Scand. 2009 Jul;53(6):774-82. doi: 10.1111/j.1399-6576.2009.01954.x. Epub 2009 Apr 15.

PMID:
19388889
7.

Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia.

Schmidt CJ, Chapin DS, Cianfrogna J, Corman ML, Hajos M, Harms JF, Hoffman WE, Lebel LA, McCarthy SA, Nelson FR, Proulx-LaFrance C, Majchrzak MJ, Ramirez AD, Schmidt K, Seymour PA, Siuciak JA, Tingley FD 3rd, Williams RD, Verhoest PR, Menniti FS.

J Pharmacol Exp Ther. 2008 May;325(2):681-90. doi: 10.1124/jpet.107.132910. Epub 2008 Feb 20.

PMID:
18287214
8.

Age effects on brain oxygenation during hypercapnia.

Gatto R, Hoffman WE, Mueller M, Paisansathan C, Charbel F.

J Biomed Opt. 2007 Nov-Dec;12(6):062113. doi: 10.1117/1.2804705.

9.

Sevoflurane anesthesia decreases cardiac vagal activity and heart rate variability.

Paisansathan C, Lee M, Hoffman WE, Wheeler P.

Clin Auton Res. 2007 Dec;17(6):370-4. Epub 2007 Aug 31.

PMID:
17767378
10.

Autonomic activity during desflurane anesthesia in patients with brain tumors.

Paisansathan C, Hoffman WE, Lee M, Ananda RC, Wheeler P.

J Clin Monit Comput. 2007 Oct;21(5):265-9. Epub 2007 Jul 20.

PMID:
17641979
11.

Increased brain oxygenation during intubation-related stress.

Paisansathan C, Hoffman WE, Gatto RG, Baughman VL, Mueller M, Charbel FT.

Eur J Anaesthesiol. 2007 Dec;24(12):1016-20. Epub 2007 Jun 14.

PMID:
17568474
12.

Autonomic activity during dexmedetomidine or fentanyl infusion with desflurane anesthesia.

Feld J, Hoffman WE, Paisansathan C, Park H, Ananda RC.

J Clin Anesth. 2007 Feb;19(1):30-6.

PMID:
17321924
13.

Measurement of intracerebral oxygen pressure: practicalities and pitfalls.

Hoffman WE.

Curr Opin Anaesthesiol. 1999 Oct;12(5):497-502.

PMID:
17016239
14.

Response entropy is more reactive than bispectral index during laparoscopic gastric banding.

Feld J, Hoffman WE.

J Clin Monit Comput. 2006 Aug;20(4):229-34. Epub 2006 Jul 4.

PMID:
16819583
15.
16.

Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery.

Feld JM, Hoffman WE, Stechert MM, Hoffman IW, Ananda RC.

J Clin Anesth. 2006 Feb;18(1):24-8.

PMID:
16517328
17.

Recovery from paralysis with succinylcholine increased Response entropy and EMG but not State entropy.

Baughman VL, Hoffman WE, Koenig HM, Wheeler PL, Ananda RC, Wang M.

J Clin Monit Comput. 2005 Jun;19(3):201-5.

PMID:
16244842
18.

Clip readjustment in aneurysm surgery after flow evaluation using the ultrasonic perivascular probe: case report.

Fagundes-Pereyra WJ, Hoffman WE, Misra M, Charbel FT.

Arq Neuropsiquiatr. 2005 Jun;63(2A):339-44.

19.

Response entropy increases during painful stimulation.

Wheeler P, Hoffman WE, Baughman VL, Koenig H.

J Neurosurg Anesthesiol. 2005 Apr;17(2):86-90.

PMID:
15840994
20.

Jet injector compared with oral midazolam for preoperative sedation in children.

Fine B, Castillo R, McDonald T, Paisansathan C, Zsigmond E, Hoffman WE.

Paediatr Anaesth. 2004 Sep;14(9):739-43.

PMID:
15330955
21.
22.

Loss of SSEP during sitting craniotomy.

Paisansathan C, Koenig HM, Wheeler PJ, Baughman VL, Hoffman WE.

J Neurosurg Anesthesiol. 2003 Oct;15(4):327-9.

PMID:
14508175
23.

The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats.

Engelhard K, Werner C, Hoffman WE, Matthes B, Blobner M, Kochs E.

Anesth Analg. 2003 Oct;97(4):1155-61, table of contents.

PMID:
14500174
24.

Comparison of adenosine, isoflurane, and desflurane on myocardial tissue oxygen pressure during coronary artery constriction in dogs.

Hoffman WE, Albrecht RF 2nd, Jonjev ZS.

J Cardiothorac Vasc Anesth. 2003 Aug;17(4):495-8.

PMID:
12968239
25.

Characterization and localization of alkaline phosphatase in canine seminal plasma and gonadal tissues.

Kutzler MA, Solter PF, Hoffman WE, Volkmann DH.

Theriogenology. 2003 Jul;60(2):299-306.

PMID:
12749943
26.

Non-opioid analgesia improves pain relief and decreases sedation after gastric bypass surgery.

Feld JM, Laurito CE, Beckerman M, Vincent J, Hoffman WE.

Can J Anaesth. 2003 Apr;50(4):336-41. English, French.

PMID:
12670809
27.

Glyburide decreases myocardial oxygen pressure in dogs.

Hoffman WE, Albrecht RF Jr, Jonjev ZS.

Acta Anaesthesiol Scand. 2003 Feb;47(2):221-5.

PMID:
12631053
28.
29.

Myocardial tissue oxygen during coronary artery constriction and hypotension in dogs.

Hoffman WE, Albrecht RF, Jonjev ZS.

Acta Anaesthesiol Scand. 2002 Jul;46(6):707-12.

PMID:
12059896
30.

GABA alpha6 receptors mediate midazolam-induced anxiolysis.

Hoffman WE, Balyasnikova IV, Mahay H, Danilov SM, Baughman VL.

J Clin Anesth. 2002 May;14(3):206-9.

PMID:
12031754
31.

Brain compared to heart tissue oxygen pressure during changes in arterial carbon dioxide in the dog.

Hoffman WE, Albrecht RF 2nd, Ripper R, Jonjev ZS.

J Neurosurg Anesthesiol. 2001 Oct;13(4):303-9.

PMID:
11733661
32.
33.
34.

Brain tissue PO(2), PCO(2), and pH during cerebral vasospasm.

Charbel FT, Du X, Hoffman WE, Ausman JI.

Surg Neurol. 2000 Dec;54(6):432-7; discussion 438.

PMID:
11240169
35.

Plasma naltrexone during opioid detoxification.

McDonald T, Berkowitz R, Hoffman WE.

J Addict Dis. 2000;19(4):59-64.

PMID:
11110065
36.

Comparison of brain tissue and local cerebral venous gas tensions and pH.

Edelman GJ, Hoffman WE, Rico C, Ripper R.

Neurol Res. 2000 Sep;22(6):642-4.

PMID:
11045031
37.

Cerebral oxygen reactivity in the dog.

Hoffman WE, Edelman G, Wheeler P.

Neurol Res. 2000 Sep;22(6):620-2.

PMID:
11045027
38.

Isoflurane increases brain oxygen reactivity in dogs.

Hoffman WE, Edelman G.

Anesth Analg. 2000 Sep;91(3):637-41.

PMID:
10960391
39.

Enhancement of brain tissue oxygenation during high dose isoflurane anesthesia in the dog.

Hoffman WE, Edelman G.

J Neurosurg Anesthesiol. 2000 Apr;12(2):95-8.

PMID:
10774602
40.

Hypoxic brain tissue following subarachnoid hemorrhage.

Hoffman WE, Wheeler P, Edelman G, Charbel FT, Torres NJ, Ausman JI.

Anesthesiology. 2000 Feb;92(2):442-6.

PMID:
10691231
41.

What does measurement of brain tissue pO2, pCO2 & pH add to neuromonitoring?

Charbel FT, Hoffman WE, Misra M, Nabhani T, Ausman JI.

Acta Neurochir Suppl. 1999;75:41-3.

PMID:
10635375
42.

Quantitative assessment of vessel flow integrity for aneurysm surgery. Technical note.

Charbel FT, Gonzales-Portillo G, Hoffman WE, Ostergren LA, Misra M.

J Neurosurg. 1999 Dec;91(6):1050-4.

PMID:
10584856
43.

Median EEG frequency is more sensitive to increases in sympathetic activity than bispectral index.

McDonald T, Berkowitz R, Hoffman WE.

J Neurosurg Anesthesiol. 1999 Oct;11(4):255-9.

PMID:
10527144
44.

Cerebral venous and tissue gases and arteriovenous shunting in the dog.

Edelman G, Hoffman WE.

Anesth Analg. 1999 Sep;89(3):679-83.

PMID:
10475305
45.

Heart rate variability and plasma catecholamines in patients during opioid detoxification.

McDonald T, Hoffman WE, Berkowitz R, Cunningham F, Cooke B.

J Neurosurg Anesthesiol. 1999 Jul;11(3):195-9.

PMID:
10414675
46.

Measurement of ischemia by changes in tissue oxygen, carbon dioxide, and pH.

Hoffman WE, Charbel FT, Gonzalez-Portillo G, Ausman JI.

Surg Neurol. 1999 Jun;51(6):654-8.

PMID:
10369235
47.

Increased brain tissue oxygenation during arteriovenous malformation resection.

Charbel FT, Hoffman WE, Misra M, Ausman JI.

Neurol Med Chir (Tokyo). 1998;38 Suppl:171-6.

48.

Role of a perivascular ultrasonic micro-flow probe in aneurysm surgery.

Charbel FT, Hoffman WE, Misra M, Hannigan K, Ausman JI.

Neurol Med Chir (Tokyo). 1998;38 Suppl:35-8.

49.

The effect of anticonvulsant therapy on two doses of rocuronium-induced neuromuscular blockade.

Koenig HM, Hoffman WE.

J Neurosurg Anesthesiol. 1999 Apr;11(2):86-9.

PMID:
10213434
50.

Thiopental and desflurane treatment for brain protection.

Hoffman WE, Charbel FT, Edelman G, Ausman JI.

Neurosurgery. 1998 Nov;43(5):1050-3.

PMID:
9802848

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