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Amixicile targets anaerobic bacteria within the oral microbiome.

Gui Q, Hoffman PS, Lewis JP.

J Oral Biosci. 2019 Dec;61(4):226-235. doi: 10.1016/j.job.2019.10.004. Epub 2019 Nov 6.


The small molecule nitazoxanide selectively disrupts BAM-mediated folding of the outer membrane usher protein.

Psonis JJ, Chahales P, Henderson NS, Rigel NW, Hoffman PS, Thanassi DG.

J Biol Chem. 2019 Sep 27;294(39):14357-14369. doi: 10.1074/jbc.RA119.009616. Epub 2019 Aug 7.


Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium.

Bartelt LA, Bolick DT, Kolling GL, Stebbins E, Huston CD, Guerrant RL, Hoffman PS.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00718-18. doi: 10.1128/AAC.00718-18. Print 2018 Dec.


Antimicrobial activity of amixicile against Treponema denticola and other oral spirochetes associated with periodontal disease.

Reed LA, O'Bier NS, Oliver LD Jr, Hoffman PS, Marconi RT.

J Periodontol. 2018 Dec;89(12):1467-1474. doi: 10.1002/JPER.17-0185. Epub 2018 Sep 5.


Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.

Qu Y, Olsen JR, Yuan X, Cheng PF, Levesque MP, Brokstad KA, Hoffman PS, Oyan AM, Zhang W, Kalland KH, Ke X.

Nat Chem Biol. 2018 Jan;14(1):94-101. doi: 10.1038/nchembio.2510. Epub 2017 Oct 30.


Amixicile, a novel strategy for targeting oral anaerobic pathogens.

Hutcherson JA, Sinclair KM, Belvin BR, Gui Q, Hoffman PS, Lewis JP.

Sci Rep. 2017 Sep 5;7(1):10474. doi: 10.1038/s41598-017-09616-0.


Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion.

Cheruvanky A, Stoesser N, Sheppard AE, Crook DW, Hoffman PS, Weddle E, Carroll J, Sifri CD, Chai W, Barry K, Ramakrishnan G, Mathers AJ.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00025-17. doi: 10.1128/AAC.00025-17. Print 2017 Jun.


Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.

Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):3980-7. doi: 10.1128/AAC.00670-16. Print 2016 Jul.


Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane.

Chahales P, Hoffman PS, Thanassi DG.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2028-38. doi: 10.1128/AAC.02221-15. Print 2016 Apr.


Legionella pneumophila utilizes a single-player disulfide-bond oxidoreductase system to manage disulfide bond formation and isomerization.

Kpadeh ZZ, Day SR, Mills BW, Hoffman PS.

Mol Microbiol. 2015 Mar;95(6):1054-69. doi: 10.1111/mmi.12914. Epub 2015 Jan 30.


Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori.

Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL.

Antimicrob Agents Chemother. 2014 Aug;58(8):4703-12. doi: 10.1128/AAC.03112-14. Epub 2014 Jun 2.


Response to metronidazole and oxidative stress is mediated through homeostatic regulator HsrA (HP1043) in Helicobacter pylori.

Olekhnovich IN, Vitko S, Valliere M, Hoffman PS.

J Bacteriol. 2014 Feb;196(4):729-39. doi: 10.1128/JB.01047-13. Epub 2013 Dec 2.


Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection.

Galano JJ, Alías M, Pérez R, Velázquez-Campoy A, Hoffman PS, Sancho J.

J Med Chem. 2013 Aug 8;56(15):6248-58. doi: 10.1021/jm400786q. Epub 2013 Jul 26.


Disulfide bond oxidoreductase DsbA2 of Legionella pneumophila exhibits protein disulfide isomerase activity.

Kpadeh ZZ, Jameson-Lee M, Yeh AJ, Chertihin O, Shumilin IA, Dey R, Day SR, Hoffman PS.

J Bacteriol. 2013 Apr;195(8):1825-33. doi: 10.1128/JB.01949-12. Epub 2013 Feb 22.


Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects.

Olekhnovich IN, Vitko S, Chertihin O, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Hoffman PS.

Infect Immun. 2013 May;81(5):1439-49. doi: 10.1128/IAI.01193-12. Epub 2013 Feb 19.


Infection of nonphagocytic host cells by legionella.

Day SR, Sifri CD, Hoffman PS.

Methods Mol Biol. 2013;954:463-78. doi: 10.1007/978-1-62703-161-5_28.


Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice.

Warren CA, van Opstal EJ, Riggins MS, Li Y, Moore JH, Kolling GL, Guerrant RL, Hoffman PS.

Antimicrob Agents Chemother. 2013 Feb;57(2):689-96. doi: 10.1128/AAC.00877-12. Epub 2012 Nov 12.


Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori.

Martínez-Júlvez M, Rojas AL, Olekhnovich I, Espinosa Angarica V, Hoffman PS, Sancho J.

FEBS J. 2012 Dec;279(23):4306-17. doi: 10.1111/febs.12020. Epub 2012 Nov 7.


Germination and amplification of anthrax spores by soil-dwelling amoebas.

Dey R, Hoffman PS, Glomski IJ.

Appl Environ Microbiol. 2012 Nov;78(22):8075-81. doi: 10.1128/AEM.02034-12. Epub 2012 Sep 14.


Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.

Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS.

Antimicrob Agents Chemother. 2012 Aug;56(8):4103-11. doi: 10.1128/AAC.00360-12. Epub 2012 May 14.


Cell mediated immunity in Legionnaires' disease.

Hoffman PS, Edelstein PH.

Vaccine. 2011 Sep 2;29(38):6437-8; author reply 6439-40. doi: 10.1016/j.vaccine.2011.06.118. Epub 2011 Jul 14. No abstract available.


Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model.

Costa LB, JohnBull EA, Reeves JT, Sevilleja JE, Freire RS, Hoffman PS, Lima AA, Oriá RB, Roche JK, Guerrant RL, Warren CA.

J Parasitol. 2011 Dec;97(6):1113-20. doi: 10.1645/GE-2848.1. Epub 2011 Jun 28.


DsbA2 (27 kDa Com1-like protein) of Legionella pneumophila catalyses extracytoplasmic disulphide-bond formation in proteins including the Dot/Icm type IV secretion system.

Jameson-Lee M, Garduño RA, Hoffman PS.

Mol Microbiol. 2011 May;80(3):835-52. doi: 10.1111/j.1365-2958.2011.07615.x. Epub 2011 Mar 22.


Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity.

Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Salamoun J, Warthan M, Hoffman PS, Macdonald TL.

ChemMedChem. 2011 Feb 7;6(2):362-77. doi: 10.1002/cmdc.201000475. Epub 2010 Dec 29.


Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.

Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Hoffman PS, Macdonald TL.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3537-9. doi: 10.1016/j.bmcl.2010.04.126. Epub 2010 May 18.


Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces.

Tchouaffi-Nana F, Ballard TE, Cary CH, Macdonald TL, Sifri CD, Hoffman PS.

Antimicrob Agents Chemother. 2010 Jul;54(7):2767-74. doi: 10.1128/AAC.00901-09. Epub 2010 Apr 19.


Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae.

Shamir ER, Warthan M, Brown SP, Nataro JP, Guerrant RL, Hoffman PS.

Antimicrob Agents Chemother. 2010 Apr;54(4):1526-33. doi: 10.1128/AAC.01279-09. Epub 2010 Jan 19.


Newer antibacterial drugs for a new century.

Devasahayam G, Scheld WM, Hoffman PS.

Expert Opin Investig Drugs. 2010 Feb;19(2):215-34. doi: 10.1517/13543780903505092. Review.


Caenorhabditis is a metazoan host for Legionella.

Brassinga AK, Kinchen JM, Cupp ME, Day SR, Hoffman PS, Sifri CD.

Cell Microbiol. 2010 Mar;12(3):343-61. doi: 10.1111/j.1462-5822.2009.01398.x. Epub 2009 Oct 27.


Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.

Cremades N, Velázquez-Campoy A, Martínez-Júlvez M, Neira JL, Pérez-Dorado I, Hermoso J, Jiménez P, Lanas A, Hoffman PS, Sancho J.

ACS Chem Biol. 2009 Nov 20;4(11):928-38. doi: 10.1021/cb900166q.


Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.

Olekhnovich IN, Goodwin A, Hoffman PS.

FEBS J. 2009 Jun;276(12):3354-64. doi: 10.1111/j.1742-4658.2009.07060.x. Epub 2009 May 7.


Reciprocal expression of integration host factor and HU in the developmental cycle and infectivity of Legionella pneumophila.

Morash MG, Brassinga AK, Warthan M, Gourabathini P, Garduño RA, Goodman SD, Hoffman PS.

Appl Environ Microbiol. 2009 Apr;75(7):1826-37. doi: 10.1128/AEM.02756-08. Epub 2009 Feb 5.


An ortholog of OxyR in Legionella pneumophila is expressed postexponentially and negatively regulates the alkyl hydroperoxide reductase (ahpC2D) operon.

LeBlanc JJ, Brassinga AK, Ewann F, Davidson RJ, Hoffman PS.

J Bacteriol. 2008 May;190(10):3444-55. doi: 10.1128/JB.00141-08. Epub 2008 Mar 21.


Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.

Hoffman PS, Sisson G, Croxen MA, Welch K, Harman WD, Cremades N, Morash MG.

Antimicrob Agents Chemother. 2007 Mar;51(3):868-76. Epub 2006 Dec 11.


CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.

Petroni A, Melano RG, Saka HA, Garutti A, Mange L, Pasterán F, Rapoport M, Miranda M, Faccone D, Rossi A, Hoffman PS, Galas MF.

Antimicrob Agents Chemother. 2004 Oct;48(10):4042-6.


Expression of magA in Legionella pneumophila Philadelphia-1 is developmentally regulated and a marker of formation of mature intracellular forms.

Hiltz MF, Sisson GR, Brassinga AK, Garduno E, Garduno RA, Hoffman PS.

J Bacteriol. 2004 May;186(10):3038-45.


A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila.

Brassinga AK, Hiltz MF, Sisson GR, Morash MG, Hill N, Garduno E, Edelstein PH, Garduno RA, Hoffman PS.

J Bacteriol. 2003 Aug;185(15):4630-7.


An inducible tellurite-resistance operon in Proteus mirabilis.

Toptchieva A, Sisson G, Bryden LJ, Taylor DE, Hoffman PS.

Microbiology. 2003 May;149(Pt 5):1285-1295. doi: 10.1099/mic.0.25981-0.


Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori.

Hoffman PS, Vats N, Hutchison D, Butler J, Chisholm K, Sisson G, Raudonikiene A, Marshall JS, Veldhuyzen van Zanten SJ.

Infect Immun. 2003 May;71(5):2534-41.


The fdxA ferredoxin gene can down-regulate frxA nitroreductase gene expression and is essential in many strains of Helicobacter pylori.

Mukhopadhyay AK, Jeong JY, Dailidiene D, Hoffman PS, Berg DE.

J Bacteriol. 2003 May;185(9):2927-35.


Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.

Sisson G, Goodwin A, Raudonikiene A, Hughes NJ, Mukhopadhyay AK, Berg DE, Hoffman PS.

Antimicrob Agents Chemother. 2002 Jul;46(7):2116-23.


Treatment of intestinal parasitic infections: a review of nitazoxanide.

Gilles HM, Hoffman PS.

Trends Parasitol. 2002 Mar;18(3):95-7. No abstract available.


Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole.

Jeong JY, Mukhopadhyay AK, Akada JK, Dailidiene D, Hoffman PS, Berg DE.

J Bacteriol. 2001 Sep;183(17):5155-62.

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