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Items: 1 to 50 of 142

1.

Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.

Joseph LC, Kokkinaki D, Valenti MC, Kim GJ, Barca E, Tomar D, Hoffman NE, Subramanyam P, Colecraft HM, Hirano M, Ratner AJ, Madesh M, Drosatos K, Morrow JP.

JCI Insight. 2017 Sep 7;2(17). pii: 94248. doi: 10.1172/jci.insight.94248. eCollection 2017 Sep 7.

2.

Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.

Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, Nieman MT, Yu J, Edelstein LC, Rowley JW, Weyrich AS, Goldfinger LE.

Blood. 2017 Aug 3;130(5):567-580. doi: 10.1182/blood-2016-11-751099. Epub 2017 May 12.

3.

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.

Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jaña F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M.

Cell Rep. 2016 May 24;15(8):1673-85. doi: 10.1016/j.celrep.2016.04.050. Epub 2016 May 12.

4.

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.

Li X, Fang P, Li Y, Kuo YM, Andrews AJ, Nanayakkara G, Johnson C, Fu H, Shan H, Du F, Hoffman NE, Yu D, Eguchi S, Madesh M, Koch WJ, Sun J, Jiang X, Wang H, Yang X.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1090-100. doi: 10.1161/ATVBAHA.115.306964. Epub 2016 Apr 28.

5.

Leptospirosis Seroprevalence Among Blue Metal Mine Workers of Tamil Nadu, India.

Parveen SM, Suganyaa B, Sathya MS, Margreat AA, Sivasankari K, Shanmughapriya S, Hoffman NE, Natarajaseenivasan K.

Am J Trop Med Hyg. 2016 Jul 6;95(1):38-42. doi: 10.4269/ajtmh.16-0095. Epub 2016 Apr 4.

6.

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.

Circ Res. 2016 Apr 15;118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.

7.

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tilley DG, Gao E, Hoffman NE, Tomar D, Madesh M, Rabinowitz J, Koch WJ, Su F, Khalili K, Cheung JY.

J Mol Cell Cardiol. 2016 Mar;92:10-20. doi: 10.1016/j.yjmcc.2016.01.015. Epub 2016 Jan 19.

8.

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair.

Li YF, Huang X, Li X, Gong R, Yin Y, Nelson J, Gao E, Zhang H, Hoffman NE, Houser SR, Madesh M, Tilley DG, Choi ET, Jiang X, Huang CX, Wang H, Yang XF.

Front Biosci (Landmark Ed). 2016 Jan 1;21:178-91.

9.

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M.

Mol Cell. 2015 Oct 1;60(1):47-62. doi: 10.1016/j.molcel.2015.08.009. Epub 2015 Sep 17.

10.

Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy.

Woitek F, Zentilin L, Hoffman NE, Powers JC, Ottiger I, Parikh S, Kulczycki AM, Hurst M, Ring N, Wang T, Shaikh F, Gross P, Singh H, Kolpakov MA, Linke A, Houser SR, Rizzo V, Sabri A, Madesh M, Giacca M, Recchia FA.

J Am Coll Cardiol. 2015 Jul 14;66(2):139-53. doi: 10.1016/j.jacc.2015.04.071.

11.

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.

Chu J, Li JG, Hoffman NE, Stough AM, Madesh M, Praticò D.

Sci Rep. 2015 Jun 16;5:11086. doi: 10.1038/srep11086.

12.

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

Shanmughapriya S, Rajan S, Hoffman NE, Zhang X, Guo S, Kolesar JE, Hines KJ, Ragheb J, Jog NR, Caricchio R, Baba Y, Zhou Y, Kaufman BA, Cheung JY, Kurosaki T, Gill DL, Madesh M.

Sci Signal. 2015 Mar 3;8(366):ra23. doi: 10.1126/scisignal.2005673.

13.

Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.

Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY.

Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9.

14.

Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway.

Chu J, Li JG, Hoffman NE, Madesh M, Praticò D.

J Neurochem. 2015 May;133(3):432-9. doi: 10.1111/jnc.13011. Epub 2015 Feb 13.

15.

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.

Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA.

J Biol Chem. 2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12.

16.

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M.

FASEB J. 2014 Nov;28(11):4936-49. doi: 10.1096/fj.14-256453. Epub 2014 Jul 30. Erratum in: FASEB J. 2015 Aug;29(8):3593.

17.

Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease.

Chu J, Li JG, Joshi YB, Giannopoulos PF, Hoffman NE, Madesh M, Praticò D.

Biol Psychiatry. 2015 Apr 15;77(8):720-8. doi: 10.1016/j.biopsych.2014.06.003. Epub 2014 Jun 16.

18.

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction.

Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR.

Circ Res. 2014 Aug 29;115(6):567-580. doi: 10.1161/CIRCRESAHA.115.303831. Epub 2014 Jul 21.

19.

Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors.

Brailoiu GC, Deliu E, Marcu J, Hoffman NE, Console-Bram L, Zhao P, Madesh M, Abood ME, Brailoiu E.

Biochemistry. 2014 Aug 5;53(30):4990-9. doi: 10.1021/bi500632a. Epub 2014 Jul 24.

20.

TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.

Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY.

J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3.

21.

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M.

Mol Biol Cell. 2014 Mar;25(6):936-47. doi: 10.1091/mbc.E13-08-0502. Epub 2014 Jan 15.

22.

Direct evidence of intracrine angiotensin II signaling in neurons.

Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E.

Am J Physiol Cell Physiol. 2014 Apr 15;306(8):C736-44. doi: 10.1152/ajpcell.00131.2013. Epub 2014 Jan 8.

23.

Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties.

Sharma VD, Lees J, Hoffman NE, Brailoiu E, Madesh M, Wunder SL, Ilies MA.

Mol Pharm. 2014 Feb 3;11(2):545-59. doi: 10.1021/mp4005035. Epub 2014 Jan 6.

24.

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

Hoffman NE, Chandramoorthy HC, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M.

Cell Rep. 2013 Dec 26;5(6):1576-1588. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12.

25.

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.

Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ.

Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.

26.

Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart.

Vagnozzi RJ, Gatto GJ Jr, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VL, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M, Force T.

Sci Transl Med. 2013 Oct 16;5(207):207ra141. doi: 10.1126/scitranslmed.3006479.

27.

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, Brailoiu GC, Madesh M, Cheung JY, Force T, Abood ME, Koch WJ, Tilley DG, Brailoiu E.

J Biol Chem. 2013 Aug 2;288(31):22481-92. doi: 10.1074/jbc.M113.456178. Epub 2013 Jun 27.

28.

Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms.

Duran JM, Makarewich CA, Sharp TE, Starosta T, Zhu F, Hoffman NE, Chiba Y, Madesh M, Berretta RM, Kubo H, Houser SR.

Circ Res. 2013 Aug 16;113(5):539-52. doi: 10.1161/CIRCRESAHA.113.301202. Epub 2013 Jun 25.

29.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.

30.

Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.

Kato K, Lillehoj EP, Park YS, Umehara T, Hoffman NE, Madesh M, Kim KC.

J Immunol. 2012 Feb 15;188(4):2014-22. doi: 10.4049/jimmunol.1102405. Epub 2012 Jan 16.

31.

Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease.

Vagnozzi RJ, Hoffman NE, Elrod JW, Madesh M, Force T.

Drug Discov Today Ther Strateg. 2012;9(4):e173-e182.

32.

The hospital mortality project: a tool for using administrative data for continuous clinical quality assurance.

Mukhtar SA, Hoffman NE, MacQuillan G, Semmens JB.

Health Inf Manag. 2008;37(2):9-18.

PMID:
18583717
33.

Canonical signal recognition particle components can be bypassed for posttranslational protein targeting in chloroplasts.

Tzvetkova-Chevolleau T, Hutin C, Noël LD, Goforth R, Carde JP, Caffarri S, Sinning I, Groves M, Teulon JM, Hoffman NE, Henry R, Havaux M, Nussaume L.

Plant Cell. 2007 May;19(5):1635-48. Epub 2007 May 18.

34.

Complication rates of colonoscopy in an Australian teaching hospital environment.

Viiala CH, Zimmerman M, Cullen DJ, Hoffman NE.

Intern Med J. 2003 Aug;33(8):355-9.

PMID:
12895166
35.

Colonoscopic surveillance after surgery for colorectal cancer.

Yusoff IF, Hoffman NE, Ee HC.

ANZ J Surg. 2003 Jan-Feb;73(1-2):3-7.

PMID:
12534728
36.

Routine colonic mucosal biopsy and ileoscopy increases diagnostic yield in patients undergoing colonoscopy for diarrhea.

Yusoff IF, Ormonde DG, Hoffman NE.

J Gastroenterol Hepatol. 2002 Mar;17(3):276-80.

PMID:
11982697
37.

Colonoscopic surveillance for family history of colorectal cancer: are NHMRC guidelines being followed?

Yusoff IF, Hoffman NE, Ee HC.

Med J Aust. 2002 Feb 18;176(4):151-4.

PMID:
11913913
38.

Complete colonoscopy rarely misses cancer.

Ee HC, Semmens JB, Hoffman NE; Perth Teaching Hospitals Endoscopy Group.

Gastrointest Endosc. 2002 Feb;55(2):167-71.

PMID:
11818917
39.

The anatomical distribution of colorectal polyps at colonoscopy.

Patel K, Hoffman NE.

J Clin Gastroenterol. 2001 Sep;33(3):222-5.

PMID:
11500612
40.

Growth stage-based phenotypic analysis of Arabidopsis: a model for high throughput functional genomics in plants.

Boyes DC, Zayed AM, Ascenzi R, McCaskill AJ, Hoffman NE, Davis KR, Görlach J.

Plant Cell. 2001 Jul;13(7):1499-510.

41.

Functional analysis of the protein-interacting domains of chloroplast SRP43.

Jonas-Straube E, Hutin C, Hoffman NE, Schünemann D.

J Biol Chem. 2001 Jul 6;276(27):24654-60. Epub 2001 Apr 16.

42.

The L18 domain of light-harvesting chlorophyll proteins binds to chloroplast signal recognition particle 43.

Tu CJ, Peterson EC, Henry R, Hoffman NE.

J Biol Chem. 2000 May 5;275(18):13187-90.

43.

Arabidopsis mutants lacking the 43- and 54-kilodalton subunits of the chloroplast signal recognition particle have distinct phenotypes.

Amin P, Sy DA, Pilgrim ML, Parry DH, Nussaume L, Hoffman NE.

Plant Physiol. 1999 Sep;121(1):61-70.

45.
46.
47.
48.

Functional divergence of the plastid and cytosolic forms of the 54-kDa subunit of signal recognition particle.

Schuenemann D, Amin P, Hoffman NE.

Biochem Biophys Res Commun. 1999 Jan 8;254(1):253-8.

PMID:
9920766
49.

A chromodomain protein encoded by the arabidopsis CAO gene is a plant-specific component of the chloroplast signal recognition particle pathway that is involved in LHCP targeting.

Klimyuk VI, Persello-Cartieaux F, Havaux M, Contard-David P, Schuenemann D, Meiherhoff K, Gouet P, Jones JD, Hoffman NE, Nussaume L.

Plant Cell. 1999 Jan;11(1):87-99.

50.

A novel signal recognition particle targets light-harvesting proteins to the thylakoid membranes.

Schuenemann D, Gupta S, Persello-Cartieaux F, Klimyuk VI, Jones JD, Nussaume L, Hoffman NE.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10312-6.

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