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Items: 1 to 50 of 129

1.

Neutrophils: New insights and open questions.

Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD.

Sci Immunol. 2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579. Epub 2018 Dec 7. Review.

PMID:
30530726
2.

TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation.

Oppong-Nonterah GO, Lakhdari O, Yamamura A, Hoffman HM, Prince LS.

J Innate Immun. 2019;11(1):99-108. doi: 10.1159/000494070. Epub 2018 Nov 8.

3.

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice.

Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE.

Hepatology. 2018 Sep 4. doi: 10.1002/hep.30252. [Epub ahead of print]

PMID:
30180270
4.

In silico validation of the Autoinflammatory Disease Damage Index.

Ter Haar NM, van Delft ALJ, Annink KV, van Stel H, Al-Mayouf SM, Amaryan G, Anton J, Barron KS, Benseler S, Brogan PA, Cantarini L, Cattalini M, Cochino AV, de Benedetti F, Dedeoglu F, de Jesus AA, Demirkaya E, Dolezalova P, Durrant KL, Fabio G, Gallizzi R, Goldbach-Mansky R, Hachulla E, Hentgen V, Herlin T, Hofer M, Hoffman HM, Insalaco A, Jansson AF, Kallinich T, Kone-Paut I, Kozlova A, Kuemmerle-Deschner JB, Lachmann HJ, Laxer RM, Martini A, Nielsen S, Nikishina I, Ombrello AK, Özen S, Papadopoulou-Alataki E, Quartier P, Rigante D, Russo R, Simon A, Trachana M, Uziel Y, Ravelli A, Schulert G, Gattorno M, Frenkel J.

Ann Rheum Dis. 2018 Nov;77(11):1599-1605. doi: 10.1136/annrheumdis-2018-213725. Epub 2018 Aug 4.

PMID:
30077992
5.

CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis.

Willeford A, Suetomi T, Nickle A, Hoffman HM, Miyamoto S, Heller Brown J.

JCI Insight. 2018 Jun 21;3(12). pii: 97054. doi: 10.1172/jci.insight.97054. [Epub ahead of print]

6.

JAK inhibitors in autoinflammation.

Hoffman HM, Broderick L.

J Clin Invest. 2018 Jul 2;128(7):2760-2762. doi: 10.1172/JCI121526. Epub 2018 Jun 11.

7.

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

De Benedetti F, Gattorno M, Anton J, Ben-Chetrit E, Frenkel J, Hoffman HM, Koné-Paut I, Lachmann HJ, Ozen S, Simon A, Zeft A, Calvo Penades I, Moutschen M, Quartier P, Kasapcopur O, Shcherbina A, Hofer M, Hashkes PJ, Van der Hilst J, Hara R, Bujan-Rivas S, Constantin T, Gul A, Livneh A, Brogan P, Cattalini M, Obici L, Lheritier K, Speziale A, Junge G.

N Engl J Med. 2018 May 17;378(20):1908-1919. doi: 10.1056/NEJMoa1706314.

8.

New workflow for classification of genetic variants' pathogenicity applied to hereditary recurrent fevers by the International Study Group for Systemic Autoinflammatory Diseases (INSAID).

Van Gijn ME, Ceccherini I, Shinar Y, Carbo EC, Slofstra M, Arostegui JI, Sarrabay G, Rowczenio D, Omoyımnı E, Balci-Peynircioglu B, Hoffman HM, Milhavet F, Swertz MA, Touitou I.

J Med Genet. 2018 Aug;55(8):530-537. doi: 10.1136/jmedgenet-2017-105216. Epub 2018 Mar 29.

PMID:
29599418
9.

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.

Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G.

J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.

10.

Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

Johnson JL, Ramadass M, Haimovich A, McGeough MD, Zhang J, Hoffman HM, Catz SD.

Front Cell Infect Microbiol. 2017 Dec 11;7:507. doi: 10.3389/fcimb.2017.00507. eCollection 2017.

11.

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies.

McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM.

J Clin Invest. 2017 Dec 1;127(12):4488-4497. doi: 10.1172/JCI90699. Epub 2017 Nov 13.

12.

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice.

Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE.

Hepatology. 2017 Sep 13. doi: 10.1002/hep.29523. [Epub ahead of print]

PMID:
28902427
13.

NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.

Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7766-E7775. doi: 10.1073/pnas.1702946114. Epub 2017 Aug 28.

14.

Group A streptococcal M protein activates the NLRP3 inflammasome.

Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V.

Nat Microbiol. 2017 Oct;2(10):1425-1434. doi: 10.1038/s41564-017-0005-6. Epub 2017 Aug 7.

15.

IL-1β is an innate immune sensor of microbial proteolysis.

LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AAB, Cooper MA, Hoffman HM, Nizet V.

Sci Immunol. 2016 Aug 19;1(2):eaah3539. doi: 10.1126/sciimmunol.aah3539. Epub 2016 Aug 19.

PMID:
28783696
16.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

17.

Clinical and Molecular Phenotypes of Low-Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges.

Kuemmerle-Deschner JB, Verma D, Endres T, Broderick L, de Jesus AA, Hofer F, Blank N, Krause K, Rietschel C, Horneff G, Aksentijevich I, Lohse P, Goldbach-Mansky R, Hoffman HM, Benseler SM.

Arthritis Rheumatol. 2017 Nov;69(11):2233-2240. doi: 10.1002/art.40208. Epub 2017 Oct 17.

18.

Intestinal fungi contribute to development of alcoholic liver disease.

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B.

J Clin Invest. 2017 Jun 30;127(7):2829-2841. doi: 10.1172/JCI90562. Epub 2017 May 22.

19.

Safety of vaccinations in patients with cryopyrin-associated periodic syndromes: a prospective registry based study.

Jaeger VK, Hoffman HM, van der Poll T, Tilson H, Seibert J, Speziale A, Junge G, Franke K, Vritzali E, Hawkins PN, Kuemmerle-Deschner J, Walker UA.

Rheumatology (Oxford). 2017 Sep 1;56(9):1484-1491. doi: 10.1093/rheumatology/kex185.

PMID:
28482054
20.

The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity.

Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L861-L872. doi: 10.1152/ajplung.00554.2016. Epub 2017 Mar 23.

21.

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH.

J Immunol. 2017 Apr 15;198(8):3017-3022. doi: 10.4049/jimmunol.1601848. Epub 2017 Mar 8.

22.

Development of the autoinflammatory disease damage index (ADDI).

Ter Haar NM, Annink KV, Al-Mayouf SM, Amaryan G, Anton J, Barron KS, Benseler SM, Brogan PA, Cantarini L, Cattalini M, Cochino AV, De Benedetti F, Dedeoglu F, De Jesus AA, Della Casa Alberighi O, Demirkaya E, Dolezalova P, Durrant KL, Fabio G, Gallizzi R, Goldbach-Mansky R, Hachulla E, Hentgen V, Herlin T, Hofer M, Hoffman HM, Insalaco A, Jansson AF, Kallinich T, Koné-Paut I, Kozlova A, Kuemmerle-Deschner JB, Lachmann HJ, Laxer RM, Martini A, Nielsen S, Nikishina I, Ombrello AK, Ozen S, Papadopoulou-Alataki E, Quartier P, Rigante D, Russo R, Simon A, Trachana M, Uziel Y, Ravelli A, Gattorno M, Frenkel J.

Ann Rheum Dis. 2017 May;76(5):821-830. doi: 10.1136/annrheumdis-2016-210092. Epub 2016 Nov 3.

23.

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137. Epub 2016 Oct 31.

24.

Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease.

Hoffman HM, Broderick L.

Arthritis Rheumatol. 2017 Feb;69(2):253-256. doi: 10.1002/art.39961. No abstract available.

25.

Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).

Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, Kone-Paut I, Goldbach-Mansky R, Lachmann H, Blank N, Hoffman HM, Weissbarth-Riedel E, Hugle B, Kallinich T, Gattorno M, Gul A, Ter Haar N, Oswald M, Dedeoglu F, Cantarini L, Benseler SM.

Ann Rheum Dis. 2017 Jun;76(6):942-947. doi: 10.1136/annrheumdis-2016-209686. Epub 2016 Oct 4. Review.

PMID:
27707729
26.

The role of the inflammasome in patients with autoinflammatory diseases.

Hoffman HM, Broderick L.

J Allergy Clin Immunol. 2016 Jul;138(1):3-14. doi: 10.1016/j.jaci.2016.05.001. Epub 2016 May 17. Review.

PMID:
27373321
27.

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.

Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS.

J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049/jimmunol.1500906. Epub 2016 Mar 7.

28.

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.

Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):886-97. doi: 10.1161/ATVBAHA.115.307072. Epub 2016 Mar 3.

29.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.

Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.

30.

Brief Report: Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes.

Walker UA, Hoffman HM, Williams R, Kuemmerle-Deschner J, Hawkins PN.

Arthritis Rheumatol. 2016 Feb;68(2):516-20. doi: 10.1002/art.39482.

31.

IL-1β is an innate immune sensor of microbial proteolysis.

LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V.

Sci Immunol. 2016 Aug;1(2). pii: eaah3539. doi: 10.1126/sciimmunol.aah3539. Epub 2016 Aug 19.

32.

The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis.

Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS.

PLoS One. 2015 Dec 14;10(12):e0144651. doi: 10.1371/journal.pone.0144651. eCollection 2015.

33.

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.

Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2605-16. doi: 10.1161/ATVBAHA.115.306475. Epub 2015 Oct 29.

34.

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.

35.

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK.

J Immunol. 2015 Jul 15;195(2):488-97. doi: 10.4049/jimmunol.1403225. Epub 2015 Jun 8.

36.

Transplantation: Outcomes of prenatal immunosuppression.

Mak RH, Hoffman HM.

Nat Rev Nephrol. 2015 Jul;11(7):390-1. doi: 10.1038/nrneph.2015.78. Epub 2015 May 19. No abstract available.

PMID:
25986424
37.

A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response.

Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V.

MBio. 2015 Mar 10;6(2):e00133. doi: 10.1128/mBio.00133-15.

38.

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A.

Cardiovasc Res. 2015 Feb 1;105(2):203-12. doi: 10.1093/cvr/cvu259. Epub 2014 Dec 18.

39.

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4.

40.

The inflammasomes and autoinflammatory syndromes.

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E.

Annu Rev Pathol. 2015;10:395-424. doi: 10.1146/annurev-pathol-012414-040431. Epub 2014 Nov 19. Review.

PMID:
25423351
41.

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.

Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15514-9. doi: 10.1073/pnas.1414859111. Epub 2014 Oct 13.

42.

Possible cold autoinflammatory syndrome.

Lieberman P, Hoffman HM.

J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):642. doi: 10.1016/j.jaip.2014.01.007. Epub 2014 Apr 18. No abstract available.

PMID:
25213069
43.

cASCading specks.

Broderick L, Hoffman HM.

Nat Immunol. 2014 Aug;15(8):698-700. doi: 10.1038/ni.2942. No abstract available.

PMID:
25045869
44.

IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.

Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS.

J Immunol. 2014 Aug 1;193(3):1184-93. doi: 10.4049/jimmunol.1302516. Epub 2014 Jun 30.

45.

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE.

J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28.

46.

The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.

Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI.

Innate Immun. 2015 Feb;21(2):203-14. doi: 10.1177/1753425914526074. Epub 2014 Mar 20.

47.

ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH.

J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.

48.

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.

Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM.

J Clin Invest. 2013 Nov;123(11):4695-705.

49.

Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry.

Tilson H, Primatesta P, Kim D, Rauer B, Hawkins PN, Hoffman HM, Kuemmerle-Deschner J, van der Poll T, Walker UA.

Orphanet J Rare Dis. 2013 Sep 10;8:139. doi: 10.1186/1750-1172-8-139.

50.

Recurrent fevers and failure to thrive in an infant.

Scott DR, Chan S, Chang J, Broderick L, Hoffman HM.

Allergy Asthma Proc. 2013 Sep-Oct;34(5):473-9. doi: 10.2500/aap.2013.34.3672.

PMID:
23998246

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