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Items: 1 to 50 of 88

1.

TMEM41B is a novel regulator of autophagy and lipid mobilization.

Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B.

EMBO Rep. 2018 Sep;19(9). pii: e45889. doi: 10.15252/embr.201845889. Epub 2018 Aug 20.

PMID:
30126924
2.

p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.

Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A.

Nat Med. 2018 Jul;24(7):939-946. doi: 10.1038/s41591-018-0050-6. Epub 2018 Jun 11.

PMID:
29892062
3.

TRRAP is a central regulator of human multiciliated cell formation.

Wang Z, Plasschaert LW, Aryal S, Renaud NA, Yang Z, Choo-Wing R, Pessotti AD, Kirkpatrick ND, Cochran NR, Carbone W, Maher R, Lindeman A, Russ C, Reece-Hoyes J, McAllister G, Hoffman GR, Roma G, Jaffe AB.

J Cell Biol. 2018 Jun 4;217(6):1941-1955. doi: 10.1083/jcb.201706106. Epub 2018 Mar 27.

4.

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.

Potting C, Crochemore C, Moretti F, Nigsch F, Schmidt I, Manneville C, Carbone W, Knehr J, DeJesus R, Lindeman A, Maher R, Russ C, McAllister G, Reece-Hoyes JS, Hoffman GR, Roma G, Müller M, Sailer AW, Helliwell SB.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E180-E189. doi: 10.1073/pnas.1711023115. Epub 2017 Dec 21. Erratum in: Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8579.

5.

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.

6.

Outcome of Head and Neck Cancer Patients Who Did Not Receive Curative-Intent Treatment.

Shah D, Hoffman GR.

J Oral Maxillofac Surg. 2017 Nov;75(11):2456-2464. doi: 10.1016/j.joms.2017.03.051. Epub 2017 Apr 6.

PMID:
28460212
7.

Liquor legislation, last drinks, and lockouts: the Newcastle (Australia) solution.

Hoffman GR, Palazzi K, Oteng Boateng BK, Oldmeadow C.

Int J Oral Maxillofac Surg. 2017 Jun;46(6):740-745. doi: 10.1016/j.ijom.2017.01.019. Epub 2017 Feb 21.

PMID:
28254401
8.

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.

Estoppey D, Hewett JW, Guy CT, Harrington E, Thomas JR, Schirle M, Cuttat R, Waldt A, Gerrits B, Yang Z, Schuierer S, Pan X, Xie K, Carbone W, Knehr J, Lindeman A, Russ C, Frias E, Hoffman GR, Varadarajan M, Ramadan N, Reece-Hoyes JS, Wang Q, Chen X, McAllister G, Roma G, Bouwmeester T, Hoepfner D.

Sci Rep. 2017 Feb 16;7:42728. doi: 10.1038/srep42728.

9.

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.

van Overbeek M, Capurso D, Carter MM, Thompson MS, Frias E, Russ C, Reece-Hoyes JS, Nye C, Gradia S, Vidal B, Zheng J, Hoffman GR, Fuller CK, May AP.

Mol Cell. 2016 Aug 18;63(4):633-646. doi: 10.1016/j.molcel.2016.06.037. Epub 2016 Aug 4.

10.

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.

DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, Frias E, Alford J, Reece-Hoyes JS, Lindeman A, Kelliher J, Russ C, Knehr J, Carbone W, Beibel M, Roma G, Ng A, Tallarico JA, Porter JA, Xavier RJ, Mickanin C, Murphy LO, Hoffman GR, Nyfeler B.

Elife. 2016 Jun 28;5. pii: e17290. doi: 10.7554/eLife.17290.

11.

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.

Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR.

Science. 2016 Mar 11;351(6278):1208-13. doi: 10.1126/science.aad5944. Epub 2016 Feb 11.

12.

A Medical School Elective Can Promote an Interest in and an Exposure to the Scope of Oral and Maxillofacial Surgery: Education, Exemplars, and Electives.

Hoffman GR, Sasidharan P.

J Oral Maxillofac Surg. 2016 Apr;74(4):665-7. doi: 10.1016/j.joms.2015.11.005. Epub 2015 Nov 17. No abstract available.

PMID:
26682521
13.

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.

Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham RT, Murphy LO, Nyfeler B.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):182-7. doi: 10.1073/pnas.1515617113. Epub 2015 Dec 17.

14.

Orbital Exenteration to Manage Infiltrative Sinonasal, Orbital Adnexal, and Cutaneous Malignancies Provides Acceptable Survival Outcomes: An Institutional Review, Literature Review, and Meta-Analysis.

Hoffman GR, Jefferson ND, Reid CB, Eisenberg RL.

J Oral Maxillofac Surg. 2016 Mar;74(3):631-43. doi: 10.1016/j.joms.2015.09.019. Epub 2015 Sep 28. Review.

PMID:
26475973
15.

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.

Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E21-9. doi: 10.1073/pnas.1417015112. Epub 2014 Dec 18.

16.

Elective neck dissection for primary oral cavity squamous cell carcinoma involving the tongue should include sublevel IIb.

Maher NG, Hoffman GR.

J Oral Maxillofac Surg. 2014 Nov;72(11):2333-43. doi: 10.1016/j.joms.2014.05.022. Epub 2014 May 29.

PMID:
25172672
17.

Intra-operative monitoring of the spinal accessory nerve: a systematic review.

McGarvey AC, Hoffman GR, Osmotherly PG, Chiarelli PE.

J Laryngol Otol. 2014 Sep;128(9):746-51. doi: 10.1017/S0022215113002934. Epub 2014 Aug 29. Review.

PMID:
25170992
18.

Pressure injury can occur in patients undergoing prolonged head and neck surgery.

Wright KM, Van Netten Y, Dorrington CA, Hoffman GR.

J Oral Maxillofac Surg. 2014 Oct;72(10):2060-5. doi: 10.1016/j.joms.2014.04.018. Epub 2014 Apr 24.

PMID:
25053571
19.

Maximizing shoulder function after accessory nerve injury and neck dissection surgery: A multicenter randomized controlled trial.

McGarvey AC, Hoffman GR, Osmotherly PG, Chiarelli PE.

Head Neck. 2015 Jul;37(7):1022-31. doi: 10.1002/hed.23712. Epub 2014 Jul 11.

PMID:
25042422
20.

Anaphylaxis: an update for dental practitioners.

Maher NG, de Looze J, Hoffman GR.

Aust Dent J. 2014 Jun;59(2):142-8; quiz 273. doi: 10.1111/adj.12161. Review.

21.

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, Wilson BG, Meyer MJ, Saenz-Vash V, Zhai H, Myer VE, Porter JA, Keen N, McLaughlin ME, Mickanin C, Roberts CW, Stegmeier F, Jagani Z.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3128-33. doi: 10.1073/pnas.1316793111. Epub 2014 Feb 11.

22.

Equine-associated maxillofacial injuries: retrospective 5-year analysis.

Islam S, Gupta B, Taylor CJ, Chow J, Hoffman GR.

Br J Oral Maxillofac Surg. 2014 Feb;52(2):124-7. doi: 10.1016/j.bjoms.2013.09.019. Epub 2013 Oct 26.

PMID:
24168759
23.

Head and neck cutaneous squamous cell carcinoma metastatic to cervical sublevel IIb lymph nodes occurred from primary sites involving the auricle and adjacent neck.

Maher NG, Hoffman GR.

J Oral Maxillofac Surg. 2014 Mar;72(3):627-32. doi: 10.1016/j.joms.2013.08.024. Epub 2013 Oct 18. Review.

PMID:
24140439
24.

Lymphoedema following treatment for head and neck cancer: impact on patients, and beliefs of health professionals.

McGarvey AC, Osmotherly PG, Hoffman GR, Chiarelli PE.

Eur J Cancer Care (Engl). 2014 May;23(3):317-27. doi: 10.1111/ecc.12134. Epub 2013 Oct 10.

PMID:
24118385
25.

Malignant transformation of metachronous bilateral Schneiderian inverted papilloma of the lacrimal sac: management considerations and the contentious issue of orbital exenteration.

Islam S, Eisenberg RL, Hoffman GR.

Eur Arch Otorhinolaryngol. 2014 Jul;271(7):1857-60. doi: 10.1007/s00405-013-2632-8. Epub 2013 Aug 4. Review.

PMID:
23912602
26.

Early screening in patients with head and neck cancer identified high levels of pain and distress.

Maher NG, Britton B, Hoffman GR.

J Oral Maxillofac Surg. 2013 Aug;71(8):1458-64. doi: 10.1016/j.joms.2013.02.009. Epub 2013 Apr 21.

PMID:
23611602
27.

Scapular muscle exercises following neck dissection surgery for head and neck cancer: a comparative electromyographic study.

McGarvey AC, Osmotherly PG, Hoffman GR, Chiarelli PE.

Phys Ther. 2013 Jun;93(6):786-97. doi: 10.2522/ptj.20120385. Epub 2013 Feb 21.

PMID:
23431215
28.

Psychiatric outcomes in operatively compared with non-operatively managed patients with facial trauma: Is there a difference?

Islam S, Cole JL, Walton GM, Dinan TG, Hoffman GR.

J Plast Surg Hand Surg. 2012 Dec;46(6):399-403. doi: 10.3109/2000656X.2012.718715.

PMID:
23157500
29.

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J.

Mol Cell. 2013 Jan 10;49(1):172-85. doi: 10.1016/j.molcel.2012.10.003. Epub 2012 Nov 8.

30.

Microvascular reconstruction of the mouth, face and jaws. Oromandibular reconstruction - free fibula flap.

Hoffman GR, Islam S, Eisenberg RL.

Aust Dent J. 2012 Sep;57(3):379-87. doi: 10.1111/j.1834-7819.2012.01709.x. Epub 2012 Jul 24.

31.

Impact of neck dissection on scapular muscle function: a case-controlled electromyographic study.

McGarvey AC, Osmotherly PG, Hoffman GR, Chiarelli PE.

Arch Phys Med Rehabil. 2013 Jan;94(1):113-9. doi: 10.1016/j.apmr.2012.07.017. Epub 2012 Aug 1.

PMID:
22864015
32.

Facial trauma patients with a preexisting psychiatric illness: a 5-year study.

Hoffman GR, Islam S.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Nov;116(5):e368-74. doi: 10.1016/j.oooo.2012.01.043. Epub 2012 Aug 2.

PMID:
22858020
33.

Microvascular reconstruction of the mouth, jaws, and face: experience of an Australian oral and maxillofacial surgery unit.

Hoffman GR, Islam S, Eisenberg RL.

J Oral Maxillofac Surg. 2012 May;70(5):e371-7. doi: 10.1016/j.joms.2012.01.016.

PMID:
22538027
34.

Surgical management of a tumour involving both peri-mandibular spaces and skull base.

Hoffman GR, Islam S, Eisenberg RL.

ANZ J Surg. 2012 Jan-Feb;82(1-2):82-3. doi: 10.1111/j.1445-2197.2011.05946.x. No abstract available.

PMID:
22507504
35.

Local recurrence of an oral squamous cell carcinoma confined to a free flap.

Islam S, Hoffman GR.

ANZ J Surg. 2011 Dec;81(12):948-9. doi: 10.1111/j.1445-2197.2011.05920.x. No abstract available.

PMID:
22507437
36.

Does attribution of blame influence psychological outcomes in facial trauma victims?

Islam S, Cole JL, Walton GM, Dinan TG, Hoffman GR.

J Oral Maxillofac Surg. 2012 Mar;70(3):593-8. doi: 10.1016/j.joms.2011.09.005. Epub 2011 Dec 16.

PMID:
22177817
37.

Surgical management of transitional cell carcinoma of the lacrimal sac: Is it time for a new treatment algorithm?

Islam S, Thomas A, Eisenberg RL, Hoffman GR.

J Plast Reconstr Aesthet Surg. 2012 Feb;65(2):e33-6. doi: 10.1016/j.bjps.2011.09.029. Epub 2011 Oct 8.

PMID:
21986110
38.

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J.

Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484.

39.

The prevalence of psychological distress in a sample of facial trauma victims. A comparative cross-sectional study between UK and Australia.

Islam S, Ahmed M, Walton GM, Dinan TG, Hoffman GR.

J Craniomaxillofac Surg. 2012 Jan;40(1):82-5. doi: 10.1016/j.jcms.2011.01.014. Epub 2011 Mar 4.

PMID:
21376610
40.

Development of in-cell Western assays using far-red fluorophores.

Moerke NJ, Hoffman GR.

Curr Protoc Chem Biol. 2011 Mar 1;3(1):39-52. doi: 10.1002/9780470559277.ch100153.

PMID:
23836588
41.

Physiotherapy for accessory nerve shoulder dysfunction following neck dissection surgery: a literature review.

McGarvey AC, Chiarelli PE, Osmotherly PG, Hoffman GR.

Head Neck. 2011 Feb;33(2):274-80. doi: 10.1002/hed.21366. Review.

PMID:
20222043
42.

Two rare causes of frey syndrome.

Islam S, Hoffman GR.

J Maxillofac Oral Surg. 2010 Mar;9(1):107. doi: 10.1007/s12663-010-0004-0. Epub 2010 Jun 4. No abstract available.

43.

A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique.

Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J.

Assay Drug Dev Technol. 2010 Apr;8(2):186-99. doi: 10.1089/adt.2009.0213.

44.

The association between depression and anxiety disorders following facial trauma--a comparative study.

Islam S, Ahmed M, Walton GM, Dinan TG, Hoffman GR.

Injury. 2010 Jan;41(1):92-6. doi: 10.1016/j.injury.2009.07.012.

PMID:
19691959
45.

Presence of pre-existing psychological comorbidity in a group of facially injured patients: a preliminary investigation.

Islam S, Hooi H, Hoffman GR.

J Oral Maxillofac Surg. 2009 Sep;67(9):1889-94. doi: 10.1016/j.joms.2009.04.044.

PMID:
19686926
46.

Parotid dermoid cyst: a rare entity.

Islam S, Hoffman GR.

J Laryngol Otol. 2009 Feb;123(2):e7. doi: 10.1017/S0022215109004447. Epub 2009 Jan 20.

PMID:
19152721
47.

The difficult Le Fort I osteotomy and downfracture: a review with consideration given to an atypical maxillary morphology.

Hoffman GR, Islam S.

J Plast Reconstr Aesthet Surg. 2008 Sep;61(9):1029-33. doi: 10.1016/j.bjps.2008.02.011. Epub 2008 Jun 18. Review.

PMID:
18562266
48.

Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.

DeRegis CJ, Rahl PB, Hoffman GR, Cerione RA, Collins RN.

BMC Cell Biol. 2008 Jan 22;9:3. doi: 10.1186/1471-2121-9-3.

49.

Use of peripherally inserted central catheters in the management of recalcitrant maxillofacial infection.

Islam S, Loewenthal MR, Hoffman GR.

J Oral Maxillofac Surg. 2008 Feb;66(2):330-5. doi: 10.1016/j.joms.2007.06.681.

PMID:
18201618
50.

Multidisciplinary management of a complicated orbital injury inflicted by a horse.

Islam S, Walton GM, Dean F, Hoffman GR.

Ophthalmic Plast Reconstr Surg. 2007 Nov-Dec;23(6):486-8.

PMID:
18030125

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