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A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.

Getz RA, Kwak G, Cornell S, Mbugua S, Eberhard J, Huang SX, Abbasi Z, de Medeiros AS, Thomas R, Bukowski B, Dranchak PK, Inglese J, Hoffman CS.

Cell Signal. 2019 Aug;60:114-121. doi: 10.1016/j.cellsig.2019.04.010. Epub 2019 Apr 24.


lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter.

Senmatsu S, Asada R, Abe T, Hoffman CS, Ohta K, Hirota K.

Sci Rep. 2019 Jan 22;9(1):299. doi: 10.1038/s41598-018-36049-0.


Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.

Umeda M, Tsunekawa C, Senmatsu S, Asada R, Abe T, Ohta K, Hoffman CS, Hirota K.

Mol Cell Biol. 2018 Aug 28;38(18). pii: e00194-18. doi: 10.1128/MCB.00194-18. Print 2018 Sep 15.


Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Asada R, Umeda M, Adachi A, Senmatsu S, Abe T, Iwasaki H, Ohta K, Hoffman CS, Hirota K.

Nucleic Acids Res. 2017 Sep 19;45(16):9361-9371. doi: 10.1093/nar/gkx555.


Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.

de Medeiros AS, Wyman AR, Alaamery MA, Allain C, Ivey FD, Wang L, Le H, Morken JP, Habara A, Le C, Cui S, Lerner A, Hoffman CS.

Cell Signal. 2017 Dec;40:73-80. doi: 10.1016/j.cellsig.2017.08.011. Epub 2017 Sep 1.


Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1.

Adachi A, Senmatsu S, Asada R, Abe T, Hoffman CS, Ohta K, Hirota K.

Genes Genet Syst. 2018 May 3;92(6):267-276. doi: 10.1266/ggs.17-00018. Epub 2017 Jun 30.


Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

Xu C, Wyman AR, Alaamery MA, Argueta SA, Ivey FD, Meyers JA, Lerner A, Burdo TH, Connolly T, Hoffman CS, Chiles TC.

Int Immunopharmacol. 2016 Sep;38:223-32. doi: 10.1016/j.intimp.2016.06.004. Epub 2016 Jun 13.


A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years.

Fantes PA, Hoffman CS.

Genetics. 2016 Jun;203(2):621-9. doi: 10.1534/genetics.116.189407.


Corrigendum. An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

Hoffman CS, Wood V, Fantes PA.

Genetics. 2016 Mar;202(3):1241. doi: 10.1534/genetics.116.187088. No abstract available.


Local potentiation of stress-responsive genes by upstream noncoding transcription.

Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, Sugano S, Hoffman CS, Hirota K, Ohta K.

Nucleic Acids Res. 2016 Jun 20;44(11):5174-89. doi: 10.1093/nar/gkw142. Epub 2016 Mar 3.


An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

Hoffman CS, Wood V, Fantes PA.

Genetics. 2015 Oct;201(2):403-23. doi: 10.1534/genetics.115.181503. Review. Erratum in: Genetics. 2016 Mar;202(3):1241.


A yeast-based high-throughput screen for modulators of phosphodiesterase activity.

de Medeiros AS, Hoffman CS.

Methods Mol Biol. 2015;1294:181-90. doi: 10.1007/978-1-4939-2537-7_14.


Fission yeast-based high-throughput screens for PKA pathway inhibitors and activators.

de Medeiros AS, Kwak G, Vanderhooft J, Rivera S, Gottlieb R, Hoffman CS.

Methods Mol Biol. 2015;1263:77-91. doi: 10.1007/978-1-4939-2269-7_6.


Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor.

Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K.

Mol Cell Biol. 2015 Mar;35(5):847-55. doi: 10.1128/MCB.00924-14. Epub 2014 Dec 22.


Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Mudge DK, Yang F, Currie BM, Kim JM, Yeda K, Bashyakarla VK, Ivey FD, Hoffman CS.

Eukaryot Cell. 2014 Feb;13(2):202-8. doi: 10.1128/EC.00277-13. Epub 2013 Dec 2.


Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe.

de Medeiros AS, Magee A, Nelson K, Friedberg L, Trocka K, Hoffman CS.

Biochem Soc Trans. 2013 Dec;41(6):1692-5. doi: 10.1042/BST20130159. Review.


A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition.

Demirbas D, Wyman AR, Shimizu-Albergine M, Cakici O, Beavo JA, Hoffman CS.

PLoS One. 2013 Aug 14;8(8):e71279. doi: 10.1371/journal.pone.0071279. eCollection 2013.


Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

Tong K, Keller T, Hoffman CS, Annunziato AT.

Eukaryot Cell. 2012 Sep;11(9):1095-103. doi: 10.1128/EC.00123-12. Epub 2012 Jul 6.


Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.

Ceyhan O, Birsoy K, Hoffman CS.

Chem Biol. 2012 Jan 27;19(1):155-63. doi: 10.1016/j.chembiol.2011.12.010.


Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe.

Mudge DK, Hoffman CA, Lubinski TJ, Hoffman CS.

Curr Genet. 2012 Feb;58(1):59-64. doi: 10.1007/s00294-011-0360-4. Epub 2011 Dec 25.


A fission yeast-based platform for phosphodiesterase inhibitor HTSs and analyses of phosphodiesterase activity.

Demirbas D, Ceyhan O, Wyman AR, Hoffman CS.

Handb Exp Pharmacol. 2011;(204):135-49. doi: 10.1007/978-3-642-17969-3_5. Review.


Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.

Demirbas D, Ceyhan O, Wyman AR, Ivey FD, Allain C, Wang L, Sharuk MN, Francis SH, Hoffman CS.

Cell Signal. 2011 Mar;23(3):594-601. doi: 10.1016/j.cellsig.2010.11.013. Epub 2010 Nov 29.


The relationship between water intake and foetal growth and preterm delivery in a prospective cohort study.

Wright JM, Hoffman CS, Savitz DA.

BMC Pregnancy Childbirth. 2010 Aug 24;10:48. doi: 10.1186/1471-2393-10-48.


New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

Alaamery MA, Wyman AR, Ivey FD, Allain C, Demirbas D, Wang L, Ceyhan O, Hoffman CS.

J Biomol Screen. 2010 Apr;15(4):359-67. doi: 10.1177/1087057110362100. Epub 2010 Mar 12.


Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

Ivey FD, Taglia FX, Yang F, Lander MM, Kelly DA, Hoffman CS.

Eukaryot Cell. 2010 Apr;9(4):626-33. doi: 10.1128/EC.00010-10. Epub 2010 Feb 5.


Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Roux AE, Leroux A, Alaamery MA, Hoffman CS, Chartrand P, Ferbeyre G, Rokeach LA.

PLoS Genet. 2009 Mar;5(3):e1000408. doi: 10.1371/journal.pgen.1000408. Epub 2009 Mar 6.


Comparison of gestational age at birth based on last menstrual period and ultrasound during the first trimester.

Hoffman CS, Messer LC, Mendola P, Savitz DA, Herring AH, Hartmann KE.

Paediatr Perinat Epidemiol. 2008 Nov;22(6):587-96. doi: 10.1111/j.1365-3016.2008.00965.x.


Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.

Hirota K, Miyoshi T, Kugou K, Hoffman CS, Shibata T, Ohta K.

Nature. 2008 Nov 6;456(7218):130-4. doi: 10.1038/nature07348. Epub 2008 Sep 28.


Drinking water disinfection by-product exposure and fetal growth.

Hoffman CS, Mendola P, Savitz DA, Herring AH, Loomis D, Hartmann KE, Singer PC, Weinberg HS, Olshan AF.

Epidemiology. 2008 Sep;19(5):729-37. doi: 10.1097/EDE.0b013e3181812bd4.


Drinking water disinfection by-product exposure and duration of gestation.

Hoffman CS, Mendola P, Savitz DA, Herring AH, Loomis D, Hartmann KE, Singer PC, Weinberg HS, Olshan AF.

Epidemiology. 2008 Sep;19(5):738-46. doi: 10.1097/EDE.0b013e3181812beb.


Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Alaamery MA, Hoffman CS.

Genetics. 2008 Apr;178(4):1927-36. doi: 10.1534/genetics.107.086165.


Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.

Leem YE, Ripmaster TL, Kelly FD, Ebina H, Heincelman ME, Zhang K, Grewal SI, Hoffman CS, Levin HL.

Mol Cell. 2008 Apr 11;30(1):98-107. doi: 10.1016/j.molcel.2008.02.016.


Preparation of yeast DNA.

Hoffman CS.

Curr Protoc Mol Biol. 2001 May;Chapter 13:Unit13.11. doi: 10.1002/0471142727.mb1311s39.


Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases.

Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS.

J Biomol Screen. 2008 Jan;13(1):62-71. doi: 10.1177/1087057107312127.


Endometriosis among women exposed to polybrominated biphenyls.

Hoffman CS, Small CM, Blanck HM, Tolbert P, Rubin C, Marcus M.

Ann Epidemiol. 2007 Jul;17(7):503-10. Epub 2007 Apr 19.


Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

Benson LJ, Phillips JA, Gu Y, Parthun MR, Hoffman CS, Annunziato AT.

J Biol Chem. 2007 Jan 12;282(2):836-42. Epub 2006 Oct 19.


Cloning the Schizosaccharomyces pombe lys2+ gene and construction of new molecular genetic tools.

Hoffman RL, Hoffman CS.

Curr Genet. 2006 Jun;49(6):414-20. Epub 2006 Feb 21.


Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

Kao RS, Morreale E, Wang L, Ivey FD, Hoffman CS.

Genetics. 2006 May;173(1):49-61. Epub 2006 Feb 19.


Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

Ivey FD, Hoffman CS.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6108-13. Epub 2005 Apr 14.


Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe.

Hoffman CS.

Biochem Soc Trans. 2005 Feb;33(Pt 1):257-60. Review.


Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J, Wang L, Kelly DA, Janoo RT, Seitz J, Whitehall SK, Hoffman CS.

Eukaryot Cell. 2004 Jun;3(3):610-9.


Strategies for gene disruptions and plasmid constructions in fission yeast.

Wang L, Kao R, Ivey FD, Hoffman CS.

Methods. 2004 Jul;33(3):199-205.


Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses.

Hirota K, Hasemi T, Yamada T, Mizuno KI, Hoffman CS, Shibata T, Ohta K.

Nucleic Acids Res. 2004 Feb 3;32(2):855-62. Print 2004.


Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation.

Schadick K, Fourcade HM, Boumenot P, Seitz JJ, Morrell JL, Chang L, Gould KL, Partridge JF, Allshire RC, Kitagawa K, Hieter P, Hoffman CS.

Eukaryot Cell. 2002 Aug;1(4):558-67.

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