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Items: 1 to 50 of 442

1.

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.

Lecca D, Bader M, Tweedie D, Hoffman AF, Jung YJ, Hsueh SC, Hoffer BJ, Becker RE, Pick CG, Lupica CR, Greig NH.

Neurobiol Dis. 2019 Jul 8;130:104528. doi: 10.1016/j.nbd.2019.104528. [Epub ahead of print]

PMID:
31295555
2.

Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease.

Lai JH, Chen KY, Chung-Che Wu J, Olson L, Brené S, Huang CZ, Chen YH, Kang SJ, Ma KH, Hoffer BJ, Hsieh TH, Chiang YH.

Brain Res. 2019 Jun 18:146301. doi: 10.1016/j.brainres.2019.146301. [Epub ahead of print] Review.

3.

(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice.

Hsueh SC, Lecca D, Greig NH, Wang JY, Selman W, Hoffer BJ, Miller JP, Chiang YH.

Cell Transplant. 2019 Jun 10:963689719854693. doi: 10.1177/0963689719854693. [Epub ahead of print]

PMID:
31177840
4.

MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.

Hartman JH, Richie CT, Gordon KL, Mello DF, Castillo P, Zhu A, Wang Y, Hoffer BJ, Sherwood DR, Meyer JN, Harvey BK.

Eur J Cell Biol. 2019 May 21. pii: S0171-9335(18)30348-0. doi: 10.1016/j.ejcb.2019.05.002. [Epub ahead of print]

PMID:
31138438
5.

Pomalidomide Reduces Ischemic Brain Injury in Rodents.

Tsai YR, Tweedie D, Navas-Enamorado I, Scerba MT, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, de Cabo R, Greig NH, Chiang YH, Chen KY.

Cell Transplant. 2019 Apr;28(4):439-450. doi: 10.1177/0963689719850078. Epub 2019 May 16.

PMID:
31094216
6.

Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors.

Chen YH, Hsieh TH, Kuo TT, Kao JH, Ma KH, Huang EY, Chou YC, Olson L, Hoffer BJ.

J Neurochem. 2019 Jul;150(1):56-73. doi: 10.1111/jnc.14702. Epub 2019 May 9.

PMID:
30933310
7.

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6'-Dithiothalidomide on Traumatic Brain Injury.

Batsaikhan B, Wang JY, Scerba MT, Tweedie D, Greig NH, Miller JP, Hoffer BJ, Lin CT, Wang JY.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E502. doi: 10.3390/ijms20030502.

8.

Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.

Bader M, Li Y, Lecca D, Rubovitch V, Tweedie D, Glotfelty E, Rachmany L, Kim HK, Choi HI, Hoffer BJ, Pick CG, Greig NH, Kim DS.

Neurobiol Dis. 2019 Apr;124:439-453. doi: 10.1016/j.nbd.2018.11.023. Epub 2018 Nov 22.

PMID:
30471415
9.

Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.

Tsai YR, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, Tweedie D, Luo W, Greig NH, Chiang YH, Chen KY.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3252. doi: 10.3390/ijms19103252.

10.

Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice.

Lai JH, Karlsson TE, Wu JC, Huang CZ, Chen YH, Kang SJ, Brodin ATS, Hoffer BJ, Olson L, Chiang YH, Chen KY.

J Neurotrauma. 2019 Apr 1;36(7):1054-1059. doi: 10.1089/neu.2018.5949. Epub 2018 Nov 17.

PMID:
30226403
11.

Author Correction: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson's disease.

Chen S, Yu SJ, Li Y, Lecca D, Glotfelty E, Kim HK, Choi HI, Hoffer BJ, Greig NH, Kim DS, Wang Y.

Sci Rep. 2018 Sep 12;8(1):13953. doi: 10.1038/s41598-018-31455-w.

12.

Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson's disease.

Chen S, Yu SJ, Li Y, Lecca D, Glotfelty E, Kim HK, Choi HI, Hoffer BJ, Greig NH, Kim DS, Wang Y.

Sci Rep. 2018 Jul 16;8(1):10722. doi: 10.1038/s41598-018-28449-z. Erratum in: Sci Rep. 2018 Sep 12;8(1):13953.

13.

Nicotine-Induced Conditional Place Preference Is Affected by Head Injury: Correlation with Dopamine Release in the Nucleus Accumbens Shell.

Chen YH, Kuo TT, Huang EY, Hoffer BJ, Kao JH, Chou YC, Chiang YH, Miller J.

Int J Neuropsychopharmacol. 2018 Oct 1;21(10):949-961. doi: 10.1093/ijnp/pyy055.

14.

Differences in Nicotine Encoding Dopamine Release between the Striatum and Shell Portion of the Nucleus Accumbens.

Chen YH, Lin BJ, Hsieh TH, Kuo TT, Miller J, Chou YC, Huang EY, Hoffer BJ.

Cell Transplant. 2019 Mar;28(3):248-261. doi: 10.1177/0963689718775382. Epub 2018 May 28.

15.

Glucose-Dependent Insulinotropic Polypeptide Mitigates 6-OHDA-Induced Behavioral Impairments in Parkinsonian Rats.

Yu YW, Hsueh SC, Lai JH, Chen YH, Kang SJ, Chen KY, Hsieh TH, Hoffer BJ, Li Y, Greig NH, Chiang YH.

Int J Mol Sci. 2018 Apr 11;19(4). pii: E1153. doi: 10.3390/ijms19041153.

16.

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam.

Chen YH, Kuo TT, Yi-Kung Huang E, Hoffer BJ, Chou YC, Chiang YH, Ma HI, Miller JP.

Oncotarget. 2018 Jan 4;9(14):11515-11527. doi: 10.18632/oncotarget.23923. eCollection 2018 Feb 20.

17.

Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell.

Chen YH, Kuo TT, Yi-Kung Huang E, Chou YC, Chiang YH, Hoffer BJ, Miller J.

Oncotarget. 2018 Jan 13;9(11):10016-10028. doi: 10.18632/oncotarget.24245. eCollection 2018 Feb 9.

18.

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson's Model.

Chen YH, Kuo TT, Kao JH, Huang EY, Hsieh TH, Chou YC, Hoffer BJ.

Sci Rep. 2018 Mar 5;8(1):3973. doi: 10.1038/s41598-018-22462-y.

19.

Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs.

Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y.

Cell Transplant. 2017 Sep;26(9):1596-1600. doi: 10.1177/0963689717721230. Review.

20.

A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway.

Kim DS, Choi HI, Wang Y, Luo Y, Hoffer BJ, Greig NH.

Cell Transplant. 2017 Sep;26(9):1560-1571. doi: 10.1177/0963689717721234. Review.

21.

Impact of Traumatic Brain Injury on Dopaminergic Transmission.

Chen YH, Huang EY, Kuo TT, Miller J, Chiang YH, Hoffer BJ.

Cell Transplant. 2017 Jul;26(7):1156-1168. doi: 10.1177/0963689717714105. Review.

22.

Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine.

Hoffer BJ, Pick CG, Hoffer ME, Becker RE, Chiang YH, Greig NH.

J Biomed Sci. 2017 Sep 9;24(1):71. doi: 10.1186/s12929-017-0377-1. Review.

23.

Mass Spectrometric Imaging of Ceramide Biomarkers Tracks Therapeutic Response in Traumatic Brain Injury.

Barbacci DC, Roux A, Muller L, Jackson SN, Post J, Baldwin K, Hoffer B, Balaban CD, Schultz JA, Gouty S, Cox BM, Woods AS.

ACS Chem Neurosci. 2017 Oct 18;8(10):2266-2274. doi: 10.1021/acschemneuro.7b00189. Epub 2017 Aug 14.

PMID:
28745861
24.

Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.

Rachmany L, Tweedie D, Rubovitch V, Li Y, Holloway HW, Kim DS, Ratliff WA, Saykally JN, Citron BA, Hoffer BJ, Greig NH, Pick CG.

Sci Rep. 2017 Jun 16;7(1):3735. doi: 10.1038/s41598-017-03792-9.

25.

Dopamine release in the nucleus accumbens is altered following traumatic brain injury.

Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, Chiang YH.

Neuroscience. 2017 Apr 21;348:180-190. doi: 10.1016/j.neuroscience.2017.02.001. Epub 2017 Feb 11.

PMID:
28196657
26.

Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats.

Hao F, Yang C, Chen SS, Wang YY, Zhou W, Hao Q, Lu T, Hoffer B, Zhao LR, Duan WM, Xu QY.

Exp Neurol. 2017 May;291:120-133. doi: 10.1016/j.expneurol.2017.01.008. Epub 2017 Jan 25.

PMID:
28131727
27.

CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.

Chou SY, Ajoy R, Changou CA, Hsieh YT, Wang YK, Hoffer B.

Sci Rep. 2016 Nov 29;6:37659. doi: 10.1038/srep37659.

28.

Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.

Yang LY, Greig NH, Huang YN, Hsieh TH, Tweedie D, Yu QS, Hoffer BJ, Luo Y, Kao YC, Wang JY.

Neurobiol Dis. 2016 Dec;96:216-226. doi: 10.1016/j.nbd.2016.08.012. Epub 2016 Aug 20.

29.
30.

Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.

Wang JY, Huang YN, Chiu CC, Tweedie D, Luo W, Pick CG, Chou SY, Luo Y, Hoffer BJ, Greig NH, Wang JY.

J Neuroinflammation. 2016 Sep 12;13(1):228. No abstract available.

31.

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P, Hoffer B, Luo Y.

Brain Behav. 2016 May 25;6(8):e00491. doi: 10.1002/brb3.491. eCollection 2016 Aug.

32.

Reduced power spectra of heart rate variability are correlated with anxiety in patients with mild traumatic brain injury.

Liao KH, Sung CW, Chu SF, Chiu WT, Chiang YH, Hoffer B, Ou JC, Chen KY, Tsai SH, Lin CM, Chen GS, Li WJ, Wang JY.

Psychiatry Res. 2016 Sep 30;243:349-56. doi: 10.1016/j.psychres.2016.07.001. Epub 2016 Jul 1.

PMID:
27449003
33.

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.

Wang JY, Huang YN, Chiu CC, Tweedie D, Luo W, Pick CG, Chou SY, Luo Y, Hoffer BJ, Greig NH, Wang JY.

J Neuroinflammation. 2016 Jun 28;13(1):168. doi: 10.1186/s12974-016-0631-6. Erratum in: J Neuroinflammation. 2016;13(1):228.

34.

Editorial.

Hoffer BJ.

J Neurosci Methods. 2016 Oct 15;272:1-3. doi: 10.1016/j.jneumeth.2016.06.019. Epub 2016 Jun 23. No abstract available.

PMID:
27344236
35.

Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model.

Qi X, Davis B, Chiang YH, Filichia E, Barnett A, Greig NH, Hoffer B, Luo Y.

J Neurochem. 2016 Sep;138(5):746-57. doi: 10.1111/jnc.13706. Epub 2016 Jul 15.

36.

Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons.

Zhou X, Pace J, Filichia E, Lv T, Davis B, Hoffer B, Selman W, Luo Y.

Exp Neurol. 2016 Sep;283(Pt A):235-45. doi: 10.1016/j.expneurol.2016.06.013. Epub 2016 Jun 15.

37.

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI).

Baratz-Goldstein R, Deselms H, Heim LR, Khomski L, Hoffer BJ, Atlas D, Pick CG.

PLoS One. 2016 Jun 10;11(6):e0157064. doi: 10.1371/journal.pone.0157064. eCollection 2016.

38.

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.

Tweedie D, Fukui K, Li Y, Yu QS, Barak S, Tamargo IA, Rubovitch V, Holloway HW, Lehrmann E, Wood WH 3rd, Zhang Y, Becker KG, Perez E, Van Praag H, Luo Y, Hoffer BJ, Becker RE, Pick CG, Greig NH.

PLoS One. 2016 Jun 2;11(6):e0156493. doi: 10.1371/journal.pone.0156493. eCollection 2016.

39.

Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury.

Chen YH, Huang EY, Kuo TT, Hoffer BJ, Wu PJ, Ma HI, Tsai JJ, Chou YC, Chiang YH.

Brain Res. 2016 Jul 1;1642:581-589. doi: 10.1016/j.brainres.2016.04.013. Epub 2016 Apr 19.

PMID:
27106270
40.

Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.

Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P, Hoffer BJ, Luo Y.

Am J Psychiatry. 2016 Apr 1;173(4):429-31. doi: 10.1176/appi.ajp.2015.15121545. No abstract available.

41.

Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats.

Yu YW, Hsieh TH, Chen KY, Wu JC, Hoffer BJ, Greig NH, Li Y, Lai JH, Chang CF, Lin JW, Chen YH, Yang LY, Chiang YH.

J Neurotrauma. 2016 Nov 15;33(22):2044-2054. Epub 2016 May 9.

42.

Post-treatment with cocaine- and amphetamine-regulated transcript enhances infarct resolution, reinnervation, and angiogenesis in stroke rats - an MRI study.

Liu HS, Shen H, Luo Y, Hoffer BJ, Wang Y, Yang Y.

NMR Biomed. 2016 Mar;29(3):361-70. doi: 10.1002/nbm.3461. Epub 2016 Jan 15.

PMID:
26915794
43.

Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury.

Roux A, Muller L, Jackson SN, Post J, Baldwin K, Hoffer B, Balaban CD, Barbacci D, Schultz JA, Gouty S, Cox BM, Woods AS.

J Neurosci Methods. 2016 Oct 15;272:19-32. doi: 10.1016/j.jneumeth.2016.02.004. Epub 2016 Feb 10.

PMID:
26872743
44.

Mitochondria: A Therapeutic Target for Parkinson's Disease?

Luo Y, Hoffer A, Hoffer B, Qi X.

Int J Mol Sci. 2015 Sep 1;16(9):20704-30. doi: 10.3390/ijms160920704. Review.

45.

Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4.

Tweedie D, Rachmany L, Rubovitch V, Li Y, Holloway HW, Lehrmann E, Zhang Y, Becker KG, Perez E, Hoffer BJ, Pick CG, Greig NH.

Alzheimers Dement. 2016 Jan;12(1):34-48. doi: 10.1016/j.jalz.2015.07.489. Epub 2015 Aug 29.

46.

L-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or L-Dopa history.

Shan L, Diaz O, Zhang Y, Ladenheim B, Cadet JL, Chiang YH, Olson L, Hoffer BJ, Bäckman CM.

Brain Res. 2015 Aug 27;1618:261-9. doi: 10.1016/j.brainres.2015.06.005. Epub 2015 Jun 16.

47.

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice.

Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH, Pick CG.

J Neuroinflammation. 2015 Mar 7;12:45. doi: 10.1186/s12974-015-0237-4.

48.

Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.

Yang LY, Chu YH, Tweedie D, Yu QS, Pick CG, Hoffer BJ, Greig NH, Wang JY.

Exp Neurol. 2015 Jul;269:56-66. doi: 10.1016/j.expneurol.2015.03.015. Epub 2015 Mar 24.

49.

Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.

Filichia E, Shen H, Zhou X, Qi X, Jin K, Greig N, Hoffer B, Luo Y.

Neuroscience. 2015 Jun 4;295:1-10. doi: 10.1016/j.neuroscience.2015.03.018. Epub 2015 Mar 14.

50.

Maternally transmitted mitochondrial DNA mutations can reduce lifespan.

Ross JM, Coppotelli G, Hoffer BJ, Olson L.

Sci Rep. 2014 Oct 9;4:6569. doi: 10.1038/srep06569.

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