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Items: 22


Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.

Kahn-Kirby AH, Amagata A, Maeder CI, Mei JJ, Sideris S, Kosaka Y, Hinman A, Malone SA, Bruegger JJ, Wang L, Kim V, Shrader WD, Hoff KG, Latham JC, Ashley EA, Wheeler MT, Bertini E, Carrozzo R, Martinelli D, Dionisi-Vici C, Chapman KA, Enns GM, Gahl W, Wolfe L, Saneto RP, Johnson SC, Trimmer JK, Klein MB, Holst CR.

PLoS One. 2019 Mar 28;14(3):e0214250. doi: 10.1371/journal.pone.0214250. eCollection 2019.


Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD.

PLoS One. 2018 Aug 15;13(8):e0201369. doi: 10.1371/journal.pone.0201369. eCollection 2018.


A genetically encoded and gate for cell-targeted metabolic labeling of proteins.

Mahdavi A, Segall-Shapiro TH, Kou S, Jindal GA, Hoff KG, Liu S, Chitsaz M, Ismagilov RF, Silberg JJ, Tirrell DA.

J Am Chem Soc. 2013 Feb 27;135(8):2979-82. doi: 10.1021/ja400448f. Epub 2013 Feb 18.


A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.

Zhai P, Vu MT, Hoff KG, Silberg JJ.

Biochem Biophys Res Commun. 2011 May 20;408(4):589-94. doi: 10.1016/j.bbrc.2011.04.066. Epub 2011 Apr 21.


Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing.

Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD.

Nucleic Acids Res. 2011 Apr;39(7):2981-94. doi: 10.1093/nar/gkq954. Epub 2010 Dec 11.


Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.

Culler SJ, Hoff KG, Smolke CD.

Science. 2010 Nov 26;330(6008):1251-5. doi: 10.1126/science.1192128.


Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors.

Culler SJ, Hoff KG, Voelker RB, Berglund JA, Smolke CD.

Nucleic Acids Res. 2010 Aug;38(15):5152-65. doi: 10.1093/nar/gkq248. Epub 2010 Apr 12.


In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.

Hoff KG, Culler SJ, Nguyen PQ, McGuire RM, Silberg JJ, Smolke CD.

Chem Biol. 2009 Dec 24;16(12):1299-308. doi: 10.1016/j.chembiol.2009.11.011.


Invest in postdocs.

Hoff KG.

Science. 2009 May 15;324(5929):880. doi: 10.1126/science.324_880b. No abstract available.


Fluorescence detection of a protein-bound 2Fe2S cluster.

Hoff KG, Goodlitt R, Li R, Smolke CD, Silberg JJ.

Chembiochem. 2009 Mar 2;10(4):667-70. doi: 10.1002/cbic.200800747.


Synthetic control of a fitness tradeoff in yeast nitrogen metabolism.

Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD.

J Biol Eng. 2009 Jan 2;3:1. doi: 10.1186/1754-1611-3-1.


Model-guided design of ligand-regulated RNAi for programmable control of gene expression.

Beisel CL, Bayer TS, Hoff KG, Smolke CD.

Mol Syst Biol. 2008;4:224. doi: 10.1038/msb.2008.62. Epub 2008 Oct 28.


Structural insights into intermediate steps in the Sir2 deacetylation reaction.

Hawse WF, Hoff KG, Fatkins DG, Daines A, Zubkova OV, Schramm VL, Zheng W, Wolberger C.

Structure. 2008 Sep 10;16(9):1368-77. doi: 10.1016/j.str.2008.05.015.


Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide.

Hoff KG, Avalos JL, Sens K, Wolberger C.

Structure. 2006 Aug;14(8):1231-40.


Getting a grip on O-acetyl-ADP-ribose.

Hoff KG, Wolberger C.

Nat Struct Mol Biol. 2005 Jul;12(7):560-1. No abstract available.


Regulation of the HscA ATPase reaction cycle by the co-chaperone HscB and the iron-sulfur cluster assembly protein IscU.

Silberg JJ, Tapley TL, Hoff KG, Vickery LE.

J Biol Chem. 2004 Dec 24;279(52):53924-31. Epub 2004 Oct 13.


Contributions of the LPPVK motif of the iron-sulfur template protein IscU to interactions with the Hsc66-Hsc20 chaperone system.

Hoff KG, Cupp-Vickery JR, Vickery LE.

J Biol Chem. 2003 Sep 26;278(39):37582-9. Epub 2003 Jul 17.


Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU.

Hoff KG, Ta DT, Tapley TL, Silberg JJ, Vickery LE.

J Biol Chem. 2002 Jul 26;277(30):27353-9. Epub 2002 May 6.


Transfer of sulfur from IscS to IscU during Fe/S cluster assembly.

Urbina HD, Silberg JJ, Hoff KG, Vickery LE.

J Biol Chem. 2001 Nov 30;276(48):44521-6. Epub 2001 Sep 27.


The Fe/S assembly protein IscU behaves as a substrate for the molecular chaperone Hsc66 from Escherichia coli.

Silberg JJ, Hoff KG, Tapley TL, Vickery LE.

J Biol Chem. 2001 Jan 19;276(3):1696-700. Epub 2000 Oct 26.


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