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Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis.

Jones JD, Sinder BP, Paige D, Soki FN, Koh AJ, Thiele S, Shiozawa Y, Hofbauer LC, Daignault S, Roca H, McCauley LK.

Neoplasia. 2018 Dec 23;21(2):172-184. doi: 10.1016/j.neo.2018.11.003. [Epub ahead of print]


Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer.

Rachner TD, Kasimir-Bauer S, Göbel A, Erdmann K, Hoffmann O, Browne A, Wimberger P, Rauner M, Hofbauer LC, Kimmig R, Bittner AK.

Clin Cancer Res. 2018 Nov 13. doi: 10.1158/1078-0432.CCR-18-2482. [Epub ahead of print]


Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption.

Picke AK, Campbell GM, Schmidt FN, Busse B, Rauner M, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Front Cell Dev Biol. 2018 Oct 2;6:127. doi: 10.3389/fcell.2018.00127. eCollection 2018.


Denosumab effects on bone density and turnover in postmenopausal women with low bone mass with or without previous treatment.

Tsourdi E, Makras P, Rachner TD, Polyzos S, Rauner M, Mandanas S, Hofbauer LC, Anastasilakis AD.

Bone. 2018 Oct 4;120:44-49. doi: 10.1016/j.bone.2018.10.001. [Epub ahead of print]


β-Blockers and bone health.

Hofbauer LC, Henneicke H.

J Clin Invest. 2018 Nov 1;128(11):4745-4747. doi: 10.1172/JCI122992. Epub 2018 Oct 2.


Thy-1 (CD90) promotes bone formation and protects against obesity.

Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaao6806. doi: 10.1126/scitranslmed.aao6806.


Differential effects of high-fat diet and exercise training on bone and energy metabolism.

Picke AK, Sylow L, Møller LLV, Kjøbsted R, Schmidt FN, Steejn MW, Salbach-Hirsch J, Hofbauer C, Blüher M, Saalbach A, Busse B, Rauner M, Hofbauer LC.

Bone. 2018 Nov;116:120-134. doi: 10.1016/j.bone.2018.07.015. Epub 2018 Jul 20.


Apalutamide and Metastasis-free Survival in Prostate Cancer.

Rachner TD, Tsourdi E, Hofbauer LC.

N Engl J Med. 2018 Jun 28;378(26):2541-2. doi: 10.1056/NEJMc1806189. No abstract available.


Role of WNT5A receptors FZD5 and RYK in prostate cancer cells.

Thiele S, Zimmer A, Göbel A, Rachner TD, Rother S, Fuessel S, Froehner M, Wirth MP, Muders MH, Baretton GB, Jakob F, Rauner M, Hofbauer LC.

Oncotarget. 2018 Jun 5;9(43):27293-27304. doi: 10.18632/oncotarget.25551. eCollection 2018 Jun 5.


Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.

Hildebrandt S, Baschant U, Thiele S, Tuckermann J, Hofbauer LC, Rauner M.

Sci Rep. 2018 Jun 7;8(1):8711. doi: 10.1038/s41598-018-26300-z.


Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction.

Slavic S, Andrukhova O, Ford K, Handschuh S, Latic N, Reichart U, Sasgary S, Bergow C, Hofbauer LC, Kostenuik PJ, Erben RG.

J Mol Med (Berl). 2018 May 8. doi: 10.1007/s00109-018-1641-x. [Epub ahead of print]


Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.

Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC, Rauner M.

J Bone Miner Res. 2018 Sep;33(9):1698-1707. doi: 10.1002/jbmr.3463. Epub 2018 Jun 12.


Associations of myeloid hematological diseases of the elderly with osteoporosis: A longitudinal analysis of routine health care data.

Datzmann T, Trautmann F, Tesch F, Mies A, Hofbauer LC, Platzbecker U, Schmitt J.

Leuk Res. 2018 Jun;69:81-86. doi: 10.1016/j.leukres.2018.04.010. Epub 2018 Apr 21.


Denosumab: a new treatment option for glucocorticoid-induced osteoporosis.

Tsourdi E, Hofbauer LC.

Lancet Diabetes Endocrinol. 2018 Jun;6(6):428-429. doi: 10.1016/S2213-8587(18)30097-4. Epub 2018 Apr 6. No abstract available.


Bone health during endocrine therapy for cancer.

Rachner TD, Coleman R, Hadji P, Hofbauer LC.

Lancet Diabetes Endocrinol. 2018 Nov;6(11):901-910. doi: 10.1016/S2213-8587(18)30047-0. Epub 2018 Mar 20. Review.


Romosozumab versus Alendronate and Fracture Risk in Women with Osteoporosis.

Tsourdi E, Rachner TD, Hofbauer LC.

N Engl J Med. 2018 Jan 11;378(2):195. doi: 10.1056/NEJMc1714810. No abstract available.


Immunoadsorption Followed by Rituximab as a Definitive Treatment for Insulin Autoimmune Syndrome (Hirata Syndrome): A Case Report.

Kroemer TM, Erler A, Tsourdi E, Gruber M, Tselmin S, Julius U, Aringer M, Hofbauer LC, Rachner TD.

Diabetes Care. 2018 Mar;41(3):e23-e24. doi: 10.2337/dc17-1974. Epub 2017 Dec 27. No abstract available.


Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway.

Balaian E, Wobus M, Weidner H, Baschant U, Stiehler M, Ehninger G, Bornhäuser M, Hofbauer LC, Rauner M, Platzbecker U.

Haematologica. 2018 Jan;103(1):61-68. doi: 10.3324/haematol.2017.172726. Epub 2017 Oct 27.


Sclerostin Blockade and Zoledronic Acid Improve Bone Mass and Strength in Male Mice With Exogenous Hyperthyroidism.

Tsourdi E, Lademann F, Ominsky MS, Rijntjes E, Köhrle J, Misof BM, Roschger P, Klaushofer K, Hofbauer LC, Rauner M.

Endocrinology. 2017 Nov 1;158(11):3765-3777. doi: 10.1210/en.2017-00247.


Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer.

Browne AJ, Kubasch ML, Göbel A, Hadji P, Chen D, Rauner M, Stölzel F, Hofbauer LC, Rachner TD.

Breast Cancer Res. 2017 Aug 9;19(1):92. doi: 10.1186/s13058-017-0885-7.


Immune Suppressive and Bone Inhibitory Effects of Prednisolone in Growing and Regenerating Zebrafish Tissues.

Geurtzen K, Vernet A, Freidin A, Rauner M, Hofbauer LC, Schneider JE, Brand M, Knopf F.

J Bone Miner Res. 2017 Dec;32(12):2476-2488. doi: 10.1002/jbmr.3231. Epub 2017 Sep 13.


Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells.

Streicher C, Heyny A, Andrukhova O, Haigl B, Slavic S, Schüler C, Kollmann K, Kantner I, Sexl V, Kleiter M, Hofbauer LC, Kostenuik PJ, Erben RG.

Sci Rep. 2017 Jul 25;7(1):6460. doi: 10.1038/s41598-017-06614-0.


Osteoporosis treatment: recent developments and ongoing challenges.

Khosla S, Hofbauer LC.

Lancet Diabetes Endocrinol. 2017 Nov;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2. Epub 2017 Jul 7. Review.


Prediction of Fractures and Major Cardiovascular Events in Men Using Serum Osteoprotegerin Levels: The Prospective STRAMBO Study.

Szulc P, Chapurlat R, Hofbauer LC.

J Bone Miner Res. 2017 Nov;32(11):2288-2296. doi: 10.1002/jbmr.3213. Epub 2017 Aug 7.


Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs.

Schulz MC, Kowald J, Estenfelder S, Jung R, Kuhlisch E, Eckelt U, Mai R, Hofbauer LC, Stroszczynski C, Stadlinger B.

Front Physiol. 2017 Jun 20;8:426. doi: 10.3389/fphys.2017.00426. eCollection 2017.


Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis.

Sinder BP, Zweifler L, Koh AJ, Michalski MN, Hofbauer LC, Aguirre JI, Roca H, McCauley LK.

J Bone Miner Res. 2017 Oct;32(10):2116-2127. doi: 10.1002/jbmr.3196. Epub 2017 Aug 31.


Adjuvant tamoxifen but not aromatase inhibitor therapy decreases serum levels of the Wnt inhibitor dickkopf-1 while not affecting sclerostin in breast cancer patients.

Göbel A, Kuhlmann JD, Link T, Wimberger P, Browne AJ, Rauner M, Hofbauer LC, Rachner TD.

Breast Cancer Res Treat. 2017 Aug;164(3):737-743. doi: 10.1007/s10549-017-4296-3. Epub 2017 May 19.


[New Osteoanabolic Therapies for Osteoporosis].

Tsourdi E, Lademann F, Hofbauer LC.

Dtsch Med Wochenschr. 2017 Apr;142(7):475-478. doi: 10.1055/s-0042-122721. Epub 2017 Apr 7. German. No abstract available.


Myelodysplastic syndromes and bone loss in mice and men.

Weidner H, Rauner M, Trautmann F, Schmitt J, Balaian E, Mies A, Helas S, Baschant U, Khandanpour C, Bornhäuser M, Hofbauer LC, Platzbecker U.

Leukemia. 2017 Apr;31(4):1003-1007. doi: 10.1038/leu.2017.7. Epub 2017 Jan 11. No abstract available.


Bone Formation and the Wnt Signaling Pathway.

Rauner M, Rachner TD, Hofbauer LC.

N Engl J Med. 2016 Nov 10;375(19):1902. doi: 10.1056/NEJMc1609768. No abstract available.


Romosozumab Treatment in Postmenopausal Women with Osteoporosis.

Cosman F, Crittenden DB, Adachi JD, Binkley N, Czerwinski E, Ferrari S, Hofbauer LC, Lau E, Lewiecki EM, Miyauchi A, Zerbini CA, Milmont CE, Chen L, Maddox J, Meisner PD, Libanati C, Grauer A.

N Engl J Med. 2016 Oct 20;375(16):1532-1543. Epub 2016 Sep 18.


Sclerostin Blockade-A Dual Mode of Action After All?

Baschant U, Henneicke H, Hofbauer LC, Rauner M.

J Bone Miner Res. 2016 Oct;31(10):1787-1790. doi: 10.1002/jbmr.2988. Epub 2016 Sep 14. No abstract available.


Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.

Rauner M, Franke K, Murray M, Singh RP, Hiram-Bab S, Platzbecker U, Gassmann M, Socolovsky M, Neumann D, Gabet Y, Chavakis T, Hofbauer LC, Wielockx B.

J Bone Miner Res. 2016 Oct;31(10):1877-1887. doi: 10.1002/jbmr.2857. Epub 2016 May 13.


Postmenopausal osteoporosis.

Eastell R, O'Neill TW, Hofbauer LC, Langdahl B, Reid IR, Gold DT, Cummings SR.

Nat Rev Dis Primers. 2016 Sep 29;2:16069. doi: 10.1038/nrdp.2016.69. Review.


Role of milk fat globule-epidermal growth factor 8 in osteoimmunology.

Sinningen K, Thiele S, Hofbauer LC, Rauner M.

Bonekey Rep. 2016 Jul 20;5:820. doi: 10.1038/bonekey.2016.52. eCollection 2016. Review.


Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors.

Baschant U, Rauner M, Balaian E, Weidner H, Roetto A, Platzbecker U, Hofbauer LC.

Haematologica. 2016 Dec;101(12):1499-1507. Epub 2016 Aug 18.


Effects of insulin therapy on porosity, non-enzymatic glycation and mechanical competence in the bone of rats with type 2 diabetes mellitus.

Campbell GM, Tiwari S, Picke AK, Hofbauer C, Rauner M, Morlock MM, Hofbauer LC, Glüer CC.

Bone. 2016 Oct;91:186-93. doi: 10.1016/j.bone.2016.08.003. Epub 2016 Aug 4.


Microdialysis Sampling from Wound Fluids Enables Quantitative Assessment of Cytokines, Proteins, and Metabolites Reveals Bone Defect-Specific Molecular Profiles.

Förster Y, Schmidt JR, Wissenbach DK, Pfeiffer SE, Baumann S, Hofbauer LC, von Bergen M, Kalkhof S, Rammelt S.

PLoS One. 2016 Jul 21;11(7):e0159580. doi: 10.1371/journal.pone.0159580. eCollection 2016.


WNT5A and Its Receptors in the Bone-Cancer Dialogue.

Thiele S, Rachner TD, Rauner M, Hofbauer LC.

J Bone Miner Res. 2016 Aug;31(8):1488-96. doi: 10.1002/jbmr.2899. Review.


Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes.

Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV.

Diabetes. 2016 Jul;65(7):1757-66. doi: 10.2337/db16-0063. Review.


[Diagnostics in osteology].

Jakob F, Genest F, Seefried L, Tsourdi E, Lapa C, Hofbauer LC.

Internist (Berl). 2016 Jul;57(7):631-7. doi: 10.1007/s00108-016-0081-3. Review. German.


[Bone metastases : New aspects of pathogenesis and systemic therapy].

Rachner TD, Jakob F, Hofbauer LC.

Internist (Berl). 2016 Jul;57(7):666-74. doi: 10.1007/s00108-016-0076-0. Review. German.


GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab.

Hadji P, Kyvernitakis I, Kann PH, Niedhart C, Hofbauer LC, Schwarz H, Kurth AA, Thomasius F, Schulte M, Intorcia M, Psachoulia E, Schmid T.

Osteoporos Int. 2016 Oct;27(10):2967-78. doi: 10.1007/s00198-016-3623-6. Epub 2016 May 12.


The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease.

Dotterweich J, Tower RJ, Brandl A, Müller M, Hofbauer LC, Beilhack A, Ebert R, Glüer CC, Tiwari S, Schütze N, Jakob F.

PLoS One. 2016 May 9;11(5):e0155087. doi: 10.1371/journal.pone.0155087. eCollection 2016.


Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function.

Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC.

Biomaterials. 2016 Jul;96:11-23. doi: 10.1016/j.biomaterials.2016.04.013. Epub 2016 Apr 21.


Functional Interference in the Bone Marrow Microenvironment by Disseminated Breast Cancer Cells.

Dhawan A, von Bonin M, Bray LJ, Freudenberg U, Pishali Bejestani E, Werner C, Hofbauer LC, Wobus M, Bornhäuser M.

Stem Cells. 2016 Aug;34(8):2224-35. doi: 10.1002/stem.2384. Epub 2016 May 18.


Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells.

Göbel A, Thiele S, Browne AJ, Rauner M, Zinna VM, Hofbauer LC, Rachner TD.

Cancer Lett. 2016 May 28;375(1):162-171. doi: 10.1016/j.canlet.2016.03.004. Epub 2016 Mar 8.


Alterations within the Osteo-Hematopoietic Niche in MDS and their Therapeutic Implications.

Mies A, Bulycheva E, Rogulj IM, Hofbauer LC, Platzbecker U.

Curr Pharm Des. 2016;22(16):2323-32. Review.


p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells.

Browne AJ, Göbel A, Thiele S, Hofbauer LC, Rauner M, Rachner TD.

Cell Death Dis. 2016 Feb 25;7:e2119. doi: 10.1038/cddis.2016.32.


Associations between serum 25-hydroxyvitamin D and bone turnover markers in a population based sample of German children.

Thiering E, Brüske I, Kratzsch J, Hofbauer LC, Berdel D, von Berg A, Lehmann I, Hoffmann B, Bauer CP, Koletzko S, Heinrich J.

Sci Rep. 2015 Dec 15;5:18138. doi: 10.1038/srep18138.

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