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The analogous and opposing roles of double-stranded RNA-binding proteins in bacterial resistance.

Lim GH, Zhu S, Zhang K, Hoey T, Deragon JM, Kachroo A, Kachroo P.

J Exp Bot. 2019 Mar 11;70(5):1627-1638. doi: 10.1093/jxb/erz019.


COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins.

Lim GH, Hoey T, Zhu S, Clavel M, Yu K, Navarre D, Kachroo A, Deragon JM, Kachroo P.

PLoS Pathog. 2018 Mar 7;14(3):e1006894. doi: 10.1371/journal.ppat.1006894. eCollection 2018 Mar.


RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations.

Fischer MM, Yeung VP, Cattaruzza F, Hussein R, Yen WC, Murriel C, Evans JW, O'Young G, Brunner AL, Wang M, Cain J, Cancilla B, Kapoun A, Hoey T.

Sci Rep. 2017 Nov 10;7(1):15270. doi: 10.1038/s41598-017-15704-y.


WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death.

Fischer MM, Cancilla B, Yeung VP, Cattaruzza F, Chartier C, Murriel CL, Cain J, Tam R, Cheng CY, Evans JW, O'Young G, Song X, Lewicki J, Kapoun AM, Gurney A, Yen WC, Hoey T.

Sci Adv. 2017 Jun 21;3(6):e1700090. doi: 10.1126/sciadv.1700090. eCollection 2017 Jun.


Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.

Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J.

Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10.


Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates ╬▓-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.

Chartier C, Raval J, Axelrod F, Bond C, Cain J, Dee-Hoskins C, Ma S, Fischer MM, Shah J, Wei J, Ji M, Lam A, Stroud M, Yen WC, Yeung P, Cancilla B, O'Young G, Wang M, Kapoun AM, Lewicki J, Hoey T, Gurney A.

Cancer Res. 2016 Feb 1;76(3):713-23. doi: 10.1158/0008-5472.CAN-15-0561. Epub 2015 Dec 30.


Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.

Yen WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla B, Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang M, Zhang C, Kapoun AM, Lewicki J, Gurney A, Hoey T.

Clin Cancer Res. 2015 May 1;21(9):2084-95. doi: 10.1158/1078-0432.CCR-14-2808.


DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.

Minuzzo S, Agnusdei V, Pusceddu I, Pinazza M, Moserle L, Masiero M, Rossi E, Crescenzi M, Hoey T, Ponzoni M, Amadori A, Indraccolo S.

Carcinogenesis. 2015 Jan;36(1):115-21. doi: 10.1093/carcin/bgu223. Epub 2014 Oct 29.


NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells.

Past├▓ A, Serafin V, Pilotto G, Lago C, Bellio C, Trusolino L, Bertotti A, Hoey T, Plateroti M, Esposito G, Pinazza M, Agostini M, Nitti D, Amadori A, Indraccolo S.

Cancer Res. 2014 Apr 1;74(7):2106-18. doi: 10.1158/0008-5472.CAN-13-2022. Epub 2014 Feb 13.


Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.

Agnusdei V, Minuzzo S, Frasson C, Grassi A, Axelrod F, Satyal S, Gurney A, Hoey T, Seganfreddo E, Basso G, Valtorta S, Moresco RM, Amadori A, Indraccolo S.

Leukemia. 2014 Feb;28(2):278-88. doi: 10.1038/leu.2013.183. Epub 2013 Jun 18.


Canonical wnt signaling is required for pancreatic carcinogenesis.

Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M.

Cancer Res. 2013 Aug 1;73(15):4909-22. doi: 10.1158/0008-5472.CAN-12-4384. Epub 2013 Jun 12.


Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.

Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T.

Clin Cancer Res. 2012 Oct 1;18(19):5374-86. doi: 10.1158/1078-0432.CCR-12-0736. Epub 2012 Sep 5.


Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.

Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM, Lam A, Lazetic S, Ma S, Mitra S, Park IK, Pickell K, Sato A, Satyal S, Stroud M, Tran H, Yen WC, Lewicki J, Hoey T.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22. doi: 10.1073/pnas.1120068109. Epub 2012 Jul 2.


Anti-DLL4, a cancer therapeutic with multiple mechanisms of action.

Gurney A, Hoey T.

Vasc Cell. 2011 Aug 10;3:18. doi: 10.1186/2045-824X-3-18.


Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

Fischer M, Yen WC, Kapoun AM, Wang M, O'Young G, Lewicki J, Gurney A, Hoey T.

Cancer Res. 2011 Mar 1;71(5):1520-5. doi: 10.1158/0008-5472.CAN-10-2817. Epub 2010 Dec 30.


Drug resistance, epigenetics, and tumor cell heterogeneity.

Hoey T.

Sci Transl Med. 2010 Apr 21;2(28):28ps19. doi: 10.1126/scitranslmed.3001056.


DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.

Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A.

Cell Stem Cell. 2009 Aug 7;5(2):168-77. doi: 10.1016/j.stem.2009.05.019.


Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo.

van der Horst EH, Chinn L, Wang M, Velilla T, Tran H, Madrona Y, Lam A, Ji M, Hoey TC, Sato AK.

Neoplasia. 2009 Apr;11(4):355-64.


Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.

Dylla SJ, Beviglia L, Park IK, Chartier C, Raval J, Ngan L, Pickell K, Aguilar J, Lazetic S, Smith-Berdan S, Clarke MF, Hoey T, Lewicki J, Gurney AL.

PLoS One. 2008 Jun 18;3(6):e2428. doi: 10.1371/journal.pone.0002428. Erratum in: PLoS ONE. 2008;3(8). doi: 10.1371/annotation/2aa6a20a-e63c-49b6-aeea-aae62435617f.


Expression and purification of lacZ and trpE fusion proteins.

Hoey T.

Curr Protoc Mol Biol. 2001 May;Chapter 16:Unit16.5. doi: 10.1002/0471142727.mb1605s28.


Phenotypic characterization of human colorectal cancer stem cells.

Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63. Epub 2007 Jun 4.


The prognostic role of a gene signature from tumorigenic breast-cancer cells.

Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF.

N Engl J Med. 2007 Jan 18;356(3):217-26.


Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.

van der Horst EH, Degenhardt YY, Strelow A, Slavin A, Chinn L, Orf J, Rong M, Li S, See LH, Nguyen KQ, Hoey T, Wesche H, Powers S.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15901-6. Epub 2005 Oct 24.


Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.

Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ.

Biochem J. 2005 Aug 15;390(Pt 1):125-36.


G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.

Yang M, Zhong WW, Srivastava N, Slavin A, Yang J, Hoey T, An S.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6027-32. Epub 2005 Apr 18.


Multiclass cancer classification and biomarker discovery using GA-based algorithms.

Liu JJ, Cutler G, Li W, Pan Z, Peng S, Hoey T, Chen L, Ling XB.

Bioinformatics. 2005 Jun 1;21(11):2691-7. Epub 2005 Apr 6.


Wip1-deficient mice are resistant to common cancer genes.

Harrison M, Li J, Degenhardt Y, Hoey T, Powers S.

Trends Mol Med. 2004 Aug;10(8):359-61. Review.


Identification of a novel type 1 diabetes susceptibility gene, T-bet.

Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, Kusuhara K, Takeya R, Hoey T, Sumimoto H, Hara T.

Hum Genet. 2004 Aug;115(3):177-84. Epub 2004 Jul 6.


G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.

Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, An S, Yang J.

Oncogene. 2004 Aug 19;23(37):6299-303.


A comparative analysis of HGSC and Celera human genome assemblies and gene sets.

Li S, Cutler G, Liu JJ, Hoey T, Chen L, Schultz PG, Liao J, Ling XB.

Bioinformatics. 2003 Sep 1;19(13):1597-605.


Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses.

Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH.

EMBO J. 2003 Aug 15;22(16):4237-48.


STAT4 requires the N-terminal domain for efficient phosphorylation.

Chang HC, Zhang S, Oldham I, Naeger L, Hoey T, Kaplan MH.

J Biol Chem. 2003 Aug 22;278(34):32471-7. Epub 2003 Jun 12.


Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.

Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7803-7. Epub 2003 Jun 2.


Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.

Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S.

Cancer Cell. 2003 Mar;3(3):297-302.


PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

Pei L, Peng Y, Yang Y, Ling XB, Van Eyndhoven WG, Nguyen KC, Rubin M, Hoey T, Powers S, Li J.

Cancer Res. 2002 Oct 1;62(19):5420-4.


Comparative analysis of human genome assemblies reveals genome-level differences.

Li S, Liao J, Cutler G, Hoey T, Hogenesch JB, Cooke MP, Schultz PG, Ling XB.

Genomics. 2002 Aug;80(2):138-9.


Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M.

Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, Kaplan MH.

Immunity. 2002 Jun;16(6):815-25.


Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S.

Nat Genet. 2002 Jun;31(2):133-4. Epub 2002 May 20.


Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.

Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH.

J Immunol. 2000 Dec 15;165(12):6803-8.


STATs as mediators of cytokine-induced responses.

Hoey T, Grusby MJ.

Adv Immunol. 1999;71:145-62. Review. No abstract available.


Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.

Naeger LK, McKinney J, Salvekar A, Hoey T.

J Biol Chem. 1999 Jan 22;274(4):1875-8.


The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells.

Sweetser MT, Hoey T, Sun YL, Weaver WM, Price GA, Wilson CB.

J Biol Chem. 1998 Dec 25;273(52):34775-83.


STAT structure and function in signaling.

Hoey T, Schindler U.

Curr Opin Genet Dev. 1998 Oct;8(5):582-7. Review.


The transcription factor NFAT4 is involved in the generation and survival of T cells.

Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH.

Immunity. 1998 Sep;9(3):295-304.


The transcription factor NF-ATc is essential for cardiac valve formation.

Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH.

Nature. 1998 Mar 12;392(6672):186-90.


Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.

Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH.

Immunity. 1998 Jan;8(1):125-34.


A new player in cell death.

Hoey T.

Science. 1997 Nov 28;278(5343):1578-9. No abstract available.


Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.

Kaplan MH, Sun YL, Hoey T, Grusby MJ.

Nature. 1996 Jul 11;382(6587):174-7.


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