Hoetelmans RM[au] - PubMed

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Select item 300980421.

Single- and multiple-dose pharmacokinetics and safety of pimodivir, a novel, non-nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open-label study in healthy volunteers.

Deleu S, Kakuda TN, Spittaels K, Vercauteren JJ, Hillewaert V, Lwin A, Leopold L, Hoetelmans RMW.

Br J Clin Pharmacol. 2018 Nov;84(11):2663-2672. doi: 10.1111/bcp.13733. Epub 2018 Sep 14.

PMID:: 30098042

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Select item 270603412.

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Etravirine in HIV-1-Infected, Treatment-Experienced Children and Adolescents in PIANO.

Kakuda TN, Brochot A, Green B, Nijs S, Vis P, Opsomer M, Tomaka FL, Hoetelmans RM.

J Clin Pharmacol. 2016 Nov;56(11):1395-1405. doi: 10.1002/jcph.746.

PMID:: 27060341

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Select item 259754233.

Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial.

Kakuda TN, Leopold L, Nijs S, Vandevoorde A, Crauwels HM, Bertelsen KM, Stevens M, Witek J, van Delft Y, Tomaka F, Hoetelmans RM.

J Clin Pharmacol. 2014 May;54(5):563-73. doi: 10.1002/jcph.245.

PMID:: 25975423

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Select item 271290064.

Pharmacokinetics of darunavir after administration of an oral suspension with low-dose ritonavir and with or without food.

Kakuda TN, Sekar V, Lavreys L, De Paepe E, Stevens T, Vanstockem M, Vangeneugden T, Hoetelmans RM.

Clin Pharmacol Drug Dev. 2014 Sep;3(5):346-52. doi: 10.1002/cpdd.88. Epub 2014 Feb 10.

PMID:: 27129006

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Select item 251095105.

Bioavailability and bioequivalence of a darunavir 800-mg tablet formulation compared with the 400-mg tablet formulation.

Kakuda TN, Leopold L, Timmers M, Van De Casteele T, Hillewaert V, Tomaka FL, Hoetelmans RM.

Int J Clin Pharmacol Ther. 2014 Sep;52(9):805-16.

PMID:: 25109510

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Select item 249643926.

Bioequivalence of a darunavir/cobicistat fixed-dose combination tablet versus single agents and food effect in healthy volunteers.

Kakuda TN, Van De Casteele T, Petrovic R, Neujens M, Salih H, Opsomer M, Hoetelmans RM.

Antivir Ther. 2014;19(6):597-606. doi: 10.3851/IMP2814. Epub 2014 Jun 25.

PMID:: 24964392

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Select item 249515337.

Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir.

Kakuda TN, Brochot A, Tomaka FL, Vangeneugden T, Van De Casteele T, Hoetelmans RM.

J Antimicrob Chemother. 2014 Oct;69(10):2591-605. doi: 10.1093/jac/dku193. Epub 2014 Jun 20. Review.

PMID:: 24951533

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Select item 248601548.

Bedaquiline: a review of human pharmacokinetics and drug-drug interactions.

van Heeswijk RP, Dannemann B, Hoetelmans RM.

J Antimicrob Chemother. 2014 Sep;69(9):2310-8. doi: 10.1093/jac/dku171. Epub 2014 May 23. Review.

PMID:: 24860154

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Select item 246440959.

Pharmacokinetics of darunavir in fixed-dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy volunteers.

Kakuda TN, Opsomer M, Timmers M, Iterbeke K, Van De Casteele T, Hillewaert V, Petrovic R, Hoetelmans RM.

J Clin Pharmacol. 2014 Aug;54(8):949-57. doi: 10.1002/jcph.290. Epub 2014 Mar 26.

PMID:: 24644095

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Select item 2420351010.

The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers.

Crauwels HM, van Heeswijk RP, Vandevoorde A, Buelens A, Stevens M, Hoetelmans RM.

J Clin Pharmacol. 2014 Feb;54(2):133-40. doi: 10.1002/jcph.222. Epub 2013 Nov 23.

PMID:: 24203510

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Select item 2416588411.

The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.

Kakuda TN, Van Solingen-Ristea RM, Onkelinx J, Stevens T, Aharchi F, De Smedt G, Peeters M, Leopold L, Hoetelmans RM.

J Clin Pharmacol. 2014 Apr;54(4):422-31. doi: 10.1002/jcph.214. Epub 2013 Nov 19.

PMID:: 24165884

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Select item 2416116012.

Lack of an effect of rilpivirine on the pharmacokinetics of ethinylestradiol and norethindrone in healthy volunteers.

Crauwels HM, van Heeswijk RP, Buelens A, Stevens M, Hoetelmans RM.

Int J Clin Pharmacol Ther. 2014 Feb;52(2):118-28. doi: 10.5414/CP201943.

PMID:: 24161160

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Select item 2415505813.

Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies.

Kakuda TN, Woodfall B, De Marez T, Peeters M, Vandermeulen K, Aharchi F, Hoetelmans RM.

J Antimicrob Chemother. 2014 Mar;69(3):728-34. doi: 10.1093/jac/dkt421. Epub 2013 Oct 23.

PMID:: 24155058

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Select item 2412175714.

Safety and pharmacokinetics of the HIV-1 protease inhibitor TMC310911 coadministered with ritonavir in healthy participants: results from 2 phase 1 studies.

Hoetelmans RM, Dierynck I, Smyej I, Meyvisch P, Jacquemyn B, Marien K, Simmen K, Verloes R.

J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):299-305. doi: 10.1097/QAI.0000000000000011.

PMID:: 24121757

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Select item 2412175615.

Antiviral activity, pharmacokinetics, and safety of the HIV-1 protease inhibitor TMC310911, coadministered with ritonavir, in treatment-naive HIV-1-infected patients.

Stellbrink HJ, Arastéh K, Schürmann D, Stephan C, Dierynck I, Smyej I, Hoetelmans RM, Truyers C, Meyvisch P, Jacquemyn B, Mariën K, Simmen K, Verloes R.

J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):283-9. doi: 10.1097/QAI.0000000000000003.

PMID:: 24121756

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Select item 2392467916.

Single-dose pharmacokinetics of pediatric and adult formulations of etravirine and swallowability of the 200-mg tablet: results from three Phase 1 studies.

Kakuda TN, Berckmans C, De Smedt G, Leemans R, Leopold L, Peeters M, Nijs S, Vyncke V, van Solingen-Ristea R, Hoetelmans RM.

Int J Clin Pharmacol Ther. 2013 Sep;51(9):725-37. doi: 10.5414/CP201770.

PMID:: 23924679

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Select item 2372013617.

Impact of food and different meal types on the pharmacokinetics of rilpivirine.

Crauwels HM, van Heeswijk RP, Buelens A, Stevens M, Boven K, Hoetelmans RM.

J Clin Pharmacol. 2013 Aug;53(8):834-40. doi: 10.1002/jcph.107. Epub 2013 May 30.

PMID:: 23720136

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Select item 2343626518.

Steady-state pharmacokinetics of etravirine and lopinavir/ritonavir melt extrusion formulation, alone and in combination, in healthy HIV-negative volunteers.

Schöller-Gyüre M, Kakuda TN, Witek J, Akuma SH, De Smedt G, Spittaels K, Vyncke V, Hoetelmans RM.

J Clin Pharmacol. 2013 Feb;53(2):202-10. doi: 10.1177/0091270012445205. Epub 2013 Jan 24.

PMID:: 23436265

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Select item 2340074219.

Pharmacokinetics and short-term safety of etravirine in combination with fluconazole or voriconazole in HIV-negative volunteers.

Kakuda TN, Van Solingen-Ristea R, Aharchi F, Smedt GD, Witek J, Nijs S, Vyncke V, Hoetelmans RM.

J Clin Pharmacol. 2013 Jan;53(1):41-50. doi: 10.1177/0091270011433329. Epub 2013 Jan 24.

PMID:: 23400742

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Select item 2138309820.

Pharmacokinetic interactions of maraviroc with darunavir-ritonavir, etravirine, and etravirine-darunavir-ritonavir in healthy volunteers: results of two drug interaction trials.

Kakuda TN, Abel S, Davis J, Hamlin J, Schöller-Gyüre M, Mack R, Ndongo N, Petit W, Ridgway C, Sekar V, Tweedy S, Hoetelmans RM.

Antimicrob Agents Chemother. 2011 May;55(5):2290-6. doi: 10.1128/AAC.01046-10. Epub 2011 Mar 7.

PMID:: 21383098

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Select item 2114226621.

Pharmacokinetic interactions between etravirine and non-antiretroviral drugs.

Kakuda TN, Schöller-Gyüre M, Hoetelmans RM.

Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. Review.

PMID:: 21142266

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Select item 2088195822.

Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients.

Kakuda TN, Wade JR, Snoeck E, Vis P, Schöller-Gyüre M, Peeters MP, Corbett C, Nijs S, Vingerhoets J, Leopold L, De Smedt G, Woodfall BJ, Hoetelmans RM.

Clin Pharmacol Ther. 2010 Nov;88(5):695-703. doi: 10.1038/clpt.2010.181. Epub 2010 Sep 29.

PMID:: 20881958

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Select item 2083409423.

Clinical perspective on antiretroviral drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine.

Kakuda TN, Schöller-Gyüre M, Hoetelmans RM.

Antivir Ther. 2010;15(6):817-29. doi: 10.3851/IMP1652. Review.

PMID:: 20834094

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Select item 2038439624.

Pharmacokinetics of multiple-dose darunavir in combination with low-dose ritonavir in individuals with mild-to-moderate hepatic impairment.

Sekar V, Spinosa-Guzman S, De Paepe E, Stevens T, Tomaka F, De Pauw M, Hoetelmans RM.

Clin Pharmacokinet. 2010 May;49(5):343-50. doi: 10.2165/11530690-000000000-00000.

PMID:: 20384396

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Select item 2020679025.

Effects of hepatic impairment on the steady-state pharmacokinetics of etravirine 200 mg BID: an open-label, multiple-dose, controlled Phase I study in adults.

Schöller-Gyüre M, Kakuda TN, De Smedt G, Woodfall B, Berckmans C, Peeters M, Hoetelmans RM.

Clin Ther. 2010 Feb;32(2):328-37. doi: 10.1016/j.clinthera.2010.02.013.

PMID:: 20206790

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Select item 2019768426.

Pharmacokinetic interaction between indinavir and darunavir with low-dose ritonavir in healthy volunteers.

Sekar V, Lefebvre E, De Marez T, De Pauw M, De Paepe E, Vangeneugden T, Hoetelmans RM.

Intervirology. 2010;53(3):176-82. doi: 10.1159/000289341. Epub 2010 Mar 3.

PMID:: 20197684

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Select item 1972559127.

Clinical pharmacokinetics and pharmacodynamics of etravirine.

Schöller-Gyüre M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM.

Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. Review.

PMID:: 19725591

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Select item 1966000928.

Pharmacokinetic interaction between nevirapine and darunavir with low-dose ritonavir in HIV-1-infected patients.

Sekar V, Lefebvre E, Mariën K, De Pauw M, Vangeneugden T, Pozniak A, Hoetelmans RM.

Br J Clin Pharmacol. 2009 Jul;68(1):116-9. doi: 10.1111/j.1365-2125.2009.03430.x.

PMID:: 19660009

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Select item 1950121529.

Effect of steady-state etravirine on the pharmacokinetics and pharmacodynamics of ethinylestradiol and norethindrone.

Schöller-Gyüre M, Kakuda TN, Woodfall B, Aharchi F, Peeters M, Vandermeulen K, Hoetelmans RM.

Contraception. 2009 Jul;80(1):44-52. doi: 10.1016/j.contraception.2009.01.009. Epub 2009 Mar 17.

PMID:: 19501215

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Select item 1920760130.

Assessment of the steady-state pharmacokinetic interaction between etravirine administered as two different formulations and tenofovir disoproxil fumarate in healthy volunteers.

Kakuda TN, Schöller-Gyüre M, De Smedt G, Beets G, Aharchi F, Peeters MP, Vandermeulen K, Woodfall BJ, Hoetelmans RM.

HIV Med. 2009 Mar;10(3):173-81. doi: 10.1111/j.1468-1293.2008.00668.x. Epub 2009 Jan 7.

PMID:: 19207601

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Select item 1883858631.

Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects.

Anderson MS, Kakuda TN, Hanley W, Miller J, Kost JT, Stoltz R, Wenning LA, Stone JA, Hoetelmans RM, Wagner JA, Iwamoto M.

Antimicrob Agents Chemother. 2008 Dec;52(12):4228-32. doi: 10.1128/AAC.00487-08. Epub 2008 Oct 6.

PMID:: 18838586

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Select item 1882321732.

Effects of different meal compositions and fasted state on the oral bioavailability of etravirine.

Schöller-Gyüre M, Boffito M, Pozniak AL, Leemans R, Kakuda TN, Woodfall B, Vyncke V, Peeters M, Vandermeulen K, Hoetelmans RM.

Pharmacotherapy. 2008 Oct;28(10):1215-22. doi: 10.1592/phco.28.10.1215.

PMID:: 18823217

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Select item 1877104933.

Single- and multiple-dose pharmacokinetics of etravirine administered as two different formulations in HIV-1-infected patients.

Kakuda TN, Schöller-Gyüre M, Workman C, Arasteh K, Pozniak AL, De Smedt G, Beets G, Peeters M, Vandermeulen K, Woodfall BJ, Hoetelmans RM.

Antivir Ther. 2008;13(5):655-61.

PMID:: 18771049

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Select item 1867253534.

Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women.

Sekar VJ, Lefebvre E, Guzman SS, Felicione E, De Pauw M, Vangeneugden T, Hoetelmans RM.

Antivir Ther. 2008;13(4):563-9.

PMID:: 18672535

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Select item 1859809335.

Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study.

Sekar V, Lefebvre E, De Marez T, De Pauw M, De Paepe E, Vangeneugden T, Hoetelmans RM.

Clin Drug Investig. 2008;28(8):479-85.

PMID:: 18598093

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Select item 1849212536.

A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers.

Schöller-Gyüre M, Kakuda TN, De Smedt G, Vanaken H, Bouche MP, Peeters M, Woodfall B, Hoetelmans RM.

Br J Clin Pharmacol. 2008 Oct;66(4):508-16. doi: 10.1111/j.1365-2125.2008.03214.x. Epub 2008 Apr 25.

PMID:: 18492125

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Select item 1846003337.

Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.

Sekar VJ, Lefebvre E, De Pauw M, Vangeneugden T, Hoetelmans RM.

Br J Clin Pharmacol. 2008 Aug;66(2):215-21. doi: 10.1111/j.1365-2125.2008.03191.x. Epub 2008 Apr 8.

PMID:: 18460033

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Select item 1844570538.

Etravirine has no effect on QT and corrected QT interval in HIV-negative volunteers.

Peeters M, Janssen K, Kakuda TN, Schöller-Gyüre M, Lachaert R, Hoetelmans RM, Woodfall B, De Smedt G.

Ann Pharmacother. 2008 Jun;42(6):757-65. doi: 10.1345/aph.1K681. Epub 2008 Apr 29.

PMID:: 18445705

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Select item 1838989439.

Darunavir: pharmacokinetics and drug interactions.

Back D, Sekar V, Hoetelmans RM.

Antivir Ther. 2008;13(1):1-13. Review.

PMID:: 18389894

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Select item 1819505340.

Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers.

Schöller-Gyüre M, van den Brink W, Kakuda TN, Woodfall B, De Smedt G, Vanaken H, Stevens T, Peeters M, Vandermeulen K, Hoetelmans RM.

J Clin Pharmacol. 2008 Mar;48(3):322-9. doi: 10.1177/0091270007310387. Epub 2008 Jan 14.

PMID:: 18195053

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Select item 1809422041.

Darunavir/ritonavir pharmacokinetics following coadministration with clarithromycin in healthy volunteers.

Sekar VJ, Spinosa-Guzman S, De Paepe E, De Pauw M, Vangeneugden T, Lefebvre E, Hoetelmans RM.

J Clin Pharmacol. 2008 Jan;48(1):60-5.

PMID:: 18094220

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Select item 1804347842.

Pharmacokinetic interaction between darunavir and saquinavir in HIV-negative volunteers.

Sekar VJ, Lefebvre E, Mariën K, De Pauw M, Vangeneugden T, Hoetelmans RM.

Ther Drug Monit. 2007 Dec;29(6):795-801.

PMID:: 18043478

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Select item 1771316243.

Pharmacokinetics of darunavir/ritonavir and TMC125 alone and coadministered in HIV-negative volunteers.

Schöller-Gyüre M, Kakuda TN, Sekar V, Woodfall B, De Smedt G, Lefebvre E, Peeters M, Hoetelmans RM.

Antivir Ther. 2007;12(5):789-96.

PMID:: 17713162

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Select item 1766855944.

Pharmacokinetic interaction between TMC114/r and efavirenz in healthy volunteers.

Sekar VJ, De Pauw M, Mariën K, Peeters M, Lefebvre E, Hoetelmans RM.

Antivir Ther. 2007;12(4):509-14.

PMID:: 17668559

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Select item 1761052845.

Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers.

Hoetelmans RM, Mariën K, De Pauw M, Hill A, Peeters M, Sekar V, De Doncker P, Woodfall B, Lefebvre E.

Br J Clin Pharmacol. 2007 Nov;64(5):655-61. Epub 2007 Jul 4.

PMID:: 17610528

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Select item 1759611046.

Pharmacokinetics of darunavir (TMC114) and atazanavir during coadministration in HIV-negative, healthy volunteers.

Sekar VJ, Lefebvre E, De Marez T, Spinosa-Guzman S, De Pauw M, De Paepe E, Vangeneugden T, Hoetelmans RM.

Drugs R D. 2007;8(4):241-8.

PMID:: 17596110

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Select item 1741368447.

Efficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: primary 24-week analysis.

TMC125-C223 Writing Group, Nadler JP, Berger DS, Blick G, Cimoch PJ, Cohen CJ, Greenberg RN, Hicks CB, Hoetelmans RM, Iveson KJ, Jayaweera DS, Mills AM, Peeters MP, Ruane PJ, Shalit P, Schrader SR, Smith SM, Steinhart CR, Thompson M, Vingerhoets JH, Voorspoels E, Ward D, Woodfall B.

AIDS. 2007 Mar 30;21(6):F1-10.