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Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair.

Chantre CO, Gonzalez GM, Ahn S, Cera L, Campbell PH, Hoerstrup SP, Parker KK.

ACS Appl Mater Interfaces. 2019 Nov 22. doi: 10.1021/acsami.9b17322. [Epub ahead of print]


Autologous endothelialized small-caliber vascular grafts engineered from blood-derived induced pluripotent stem cells.

Generali M, Casanova EA, Kehl D, Wanner D, Hoerstrup SP, Cinelli P, Weber B.

Acta Biomater. 2019 Oct 1;97:333-343. doi: 10.1016/j.actbio.2019.07.032. Epub 2019 Jul 22.


Human cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements.

Motta SE, Lintas V, Fioretta ES, Dijkman PE, Putti M, Caliskan E, Rodriguez Cetina Biefer H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP, Emmert MY.

NPJ Regen Med. 2019 Jun 17;4:14. doi: 10.1038/s41536-019-0077-4. eCollection 2019.


Gestational Age-Dependent Fetal Fluid Dynamics in the Ovine Developmental Model: Establishment of Surrogate Markers for the Differentiation of Stem Cell Origin.

Kehl D, Görtz S, Wang C, Hoerstrup SP, Bleul U, Weber B.

Cells Tissues Organs. 2018;206(4-5):208-217. doi: 10.1159/000499504. Epub 2019 May 10.


Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction.

Spannbauer A, Traxler D, Lukovic D, Zlabinger K, Winkler J, Gugerell A, Ferdinandy P, Hausenloy DJ, Pavo N, Emmert MY, Hoerstrup SP, Jakab A, Gyöngyösi M, Riesenhuber M.

Int J Mol Sci. 2019 Apr 30;20(9). pii: E2140. doi: 10.3390/ijms20092140.


Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential.

Kehl D, Generali M, Mallone A, Heller M, Uldry AC, Cheng P, Gantenbein B, Hoerstrup SP, Weber B.

NPJ Regen Med. 2019 Apr 16;4:8. doi: 10.1038/s41536-019-0070-y. eCollection 2019.


Human Cardiac Organoids for Disease Modeling.

Nugraha B, Buono MF, von Boehmer L, Hoerstrup SP, Emmert MY.

Clin Pharmacol Ther. 2019 Jan;105(1):79-85. doi: 10.1002/cpt.1286. Epub 2018 Dec 21. Review.


Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study.

Lintas V, Fioretta ES, Motta SE, Dijkman PE, Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP, Emmert MY.

J Cardiovasc Transl Res. 2018 Dec;11(6):470-482. doi: 10.1007/s12265-018-9821-1. Epub 2018 Aug 13.


Cellular self-assembly into 3D microtissues enhances the angiogenic activity and functional neovascularization capacity of human cardiopoietic stem cells.

Wolint P, Bopp A, Woloszyk A, Tian Y, Evrova O, Hilbe M, Giovanoli P, Calcagni M, Hoerstrup SP, Buschmann J, Emmert MY.

Angiogenesis. 2019 Feb;22(1):37-52. doi: 10.1007/s10456-018-9635-4. Epub 2018 Jul 16.


Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model.

Emmert MY, Schmitt BA, Loerakker S, Sanders B, Spriestersbach H, Fioretta ES, Bruder L, Brakmann K, Motta SE, Lintas V, Dijkman PE, Frese L, Berger F, Baaijens FPT, Hoerstrup SP.

Sci Transl Med. 2018 May 9;10(440). pii: eaan4587. doi: 10.1126/scitranslmed.aan4587.


Cardiovascular tissue engineering: From basic science to clinical application.

Fioretta ES, von Boehmer L, Motta SE, Lintas V, Hoerstrup SP, Emmert MY.

Exp Gerontol. 2019 Mar;117:1-12. doi: 10.1016/j.exger.2018.03.022. Epub 2018 Mar 28. Review.


Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study.

Motta SE, Fioretta ES, Dijkman PE, Lintas V, Behr L, Hoerstrup SP, Emmert MY.

J Cardiovasc Transl Res. 2018 Jun;11(3):182-191. doi: 10.1007/s12265-018-9800-6. Epub 2018 Mar 20.


Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model.

Chantre CO, Campbell PH, Golecki HM, Buganza AT, Capulli AK, Deravi LF, Dauth S, Sheehy SP, Paten JA, Gledhill K, Doucet YS, Abaci HE, Ahn S, Pope BD, Ruberti JW, Hoerstrup SP, Christiano AM, Parker KK.

Biomaterials. 2018 Jun;166:96-108. doi: 10.1016/j.biomaterials.2018.03.006. Epub 2018 Mar 5.


Puncturing of lyophilized tissue engineered vascular matrices enhances the efficiency of their recellularization.

Książek AA, Frese L, Dijkman PE, Sanders B, Motta SE, Weber B, Hoerstrup SP.

Acta Biomater. 2018 Apr 15;71:474-485. doi: 10.1016/j.actbio.2018.02.029. Epub 2018 Mar 2.


Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types.

Cambria E, Pasqualini FS, Wolint P, Günter J, Steiger J, Bopp A, Hoerstrup SP, Emmert MY.

NPJ Regen Med. 2017 Jun 13;2:17. doi: 10.1038/s41536-017-0024-1. eCollection 2017. Review.


Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions.

Slamecka J, Laurini J, Shirley T, Hoerstrup SP, Weber B, Owen L, McClellan S.

J Vis Exp. 2017 Nov 27;(129). doi: 10.3791/56003.


Off-the-shelf tissue engineered heart valves for in situ regeneration: current state, challenges and future directions.

Motta SE, Lintas V, Fioretta ES, Hoerstrup SP, Emmert MY.

Expert Rev Med Devices. 2018 Jan;15(1):35-45. doi: 10.1080/17434440.2018.1419865. Epub 2017 Dec 28. Review.


A Simple Modification Method to Obtain Anisotropic and Porous 3D Microfibrillar Scaffolds for Surgical and Biomedical Applications.

Hosseini V, Evrova O, Hoerstrup SP, Vogel V.

Small. 2018 Jan;14(4). doi: 10.1002/smll.201702650. Epub 2017 Dec 4.


Induced pluripotent stem cells derived from human amnion in chemically defined conditions.

Slamecka J, McClellan S, Wilk A, Laurini J, Manci E, Hoerstrup SP, Weber B, Owen L.

Cell Cycle. 2018;17(3):330-347. doi: 10.1080/15384101.2017.1403690. Epub 2018 Feb 7.


Challenges in translating tissue engineered heart valves into clinical practice.

Emmert MY, Hoerstrup SP.

Eur Heart J. 2017 Mar 1;38(9):619-621. doi: 10.1093/eurheartj/ehx075. No abstract available.


Next generation heart valve substitutes.

Emmert MY, Hoerstrup SP.

Eur Heart J. 2017 Mar 1;38(9):617-618. doi: 10.1093/eurheartj/ehx074. No abstract available.


Monitoring and manipulating cellular crosstalk during kidney fibrosis inside a 3D in vitro co-culture.

Nugraha B, Mohr MA, Ponti A, Emmert MY, Weibel F, Hoerstrup SP, Moll S, Certa U, Prunotto M, Pantazis P.

Sci Rep. 2017 Nov 3;7(1):14490. doi: 10.1038/s41598-017-12683-y.


Regenerative transcatheter valves.

Emmert MY, Hoerstrup SP.

Eur Heart J. 2017 Sep 21;38(36):2710-2713. doi: 10.1093/eurheartj/ehx476. No abstract available.


Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model.

Mallone A, Stenger C, Von Eckardstein A, Hoerstrup SP, Weber B.

Biomaterials. 2018 Jan;150:49-59. doi: 10.1016/j.biomaterials.2017.09.034. Epub 2017 Sep 28.


Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion.

Pavo N, Lukovic D, Zlabinger K, Lorant D, Goliasch G, Winkler J, Pils D, Auer K, Ankersmit HJ, Giricz Z, Sárközy M, Jakab A, Garamvölgyi R, Emmert MY, Hoerstrup SP, Hausenloy DJ, Ferdinandy P, Maurer G, Gyöngyösi M.

Oncotarget. 2017 Jun 12;8(40):67227-67240. doi: 10.18632/oncotarget.18438. eCollection 2017 Sep 15.


Clot-entrapped blood cells in synergy with human mesenchymal stem cells create a pro-angiogenic healing response.

Burkhardt MA, Gerber I, Moshfegh C, Lucas MS, Waser J, Emmert MY, Hoerstrup SP, Schlottig F, Vogel V.

Biomater Sci. 2017 Sep 26;5(10):2009-2023. doi: 10.1039/c7bm00276a.


Amniotic Fluid Cells Show Higher Pluripotency-Related Gene Expression Than Allantoic Fluid Cells.

Kehl D, Generali M, Görtz S, Geering D, Slamecka J, Hoerstrup SP, Bleul U, Weber B.

Stem Cells Dev. 2017 Oct 1;26(19):1424-1437. doi: 10.1089/scd.2016.0352. Epub 2017 Aug 14.


Comparative analysis of poly-glycolic acid-based hybrid polymer starter matrices for in vitro tissue engineering.

Generali M, Kehl D, Capulli AK, Parker KK, Hoerstrup SP, Weber B.

Colloids Surf B Biointerfaces. 2017 Oct 1;158:203-212. doi: 10.1016/j.colsurfb.2017.06.046. Epub 2017 Jul 1.


High heparin content surface-modified polyurethane discs promote rapid and stable angiogenesis in full thickness skin defects through VEGF immobilization.

McLuckie M, Schmidt CA, Oosthuysen A, Sanchez-Macedo N, Merker H, Bezuidenhout D, Hoerstrup SP, Lindenblatt N.

J Biomed Mater Res A. 2017 Sep;105(9):2543-2550. doi: 10.1002/jbm.a.36108. Epub 2017 Jun 15.


JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK.

Biomaterials. 2017 Jul;133:229-241. doi: 10.1016/j.biomaterials.2017.04.033. Epub 2017 Apr 18.


Translational Challenges in Cardiovascular Tissue Engineering.

Emmert MY, Fioretta ES, Hoerstrup SP.

J Cardiovasc Transl Res. 2017 Apr;10(2):139-149. doi: 10.1007/s12265-017-9728-2. Epub 2017 Mar 9. Review.


Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling.

Pavo N, Lukovic D, Zlabinger K, Zimba A, Lorant D, Goliasch G, Winkler J, Pils D, Auer K, Jan Ankersmit H, Giricz Z, Baranyai T, Sárközy M, Jakab A, Garamvölgyi R, Emmert MY, Hoerstrup SP, Hausenloy DJ, Ferdinandy P, Maurer G, Gyöngyösi M.

Sci Rep. 2017 Mar 7;7:43958. doi: 10.1038/srep43958.


In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.

Kluin J, Talacua H, Smits AI, Emmert MY, Brugmans MC, Fioretta ES, Dijkman PE, Söntjens SH, Duijvelshoff R, Dekker S, Janssen-van den Broek MW, Lintas V, Vink A, Hoerstrup SP, Janssen HM, Dankers PY, Baaijens FP, Bouten CV.

Biomaterials. 2017 May;125:101-117. doi: 10.1016/j.biomaterials.2017.02.007. Epub 2017 Feb 8.


Surgical technique: establishing a pre-clinical large animal model to test aortic valve leaflet substitute.

Schweiger M, Knirsch W, Cesarovic N, Krüger B, Schmiady M, Frauenfelder T, Frese L, Dave H, Hoerstrup SP, Hübler M.

J Thorac Dis. 2016 Dec;8(12):3733-3738. doi: 10.21037/jtd.2016.12.72.


Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.

Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TDL, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyöngyösi M, Hoerstrup SP.

Biomaterials. 2017 Apr;122:48-62. doi: 10.1016/j.biomaterials.2016.11.029. Epub 2016 Nov 23.


Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression.

Templin C, Volkmann J, Emmert MY, Mocharla P, Müller M, Kraenkel N, Ghadri JR, Meyer M, Styp-Rekowska B, Briand S, Klingenberg R, Jaguszewski M, Matter CM, Djonov V, Mach F, Windecker S, Hoerstrup SP, Thum T, Lüscher TF, Landmesser U.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):341-349. doi: 10.1161/ATVBAHA.116.308695. Epub 2016 Dec 29.


PGA (polyglycolic acid)-P4HB (poly-4-hydroxybutyrate)-Based Bioengineered Valves in the Rat Aortic Circulation.

Książek AA, Mitchell KJ, Cesarovic N, Schwarzwald CC, Hoerstrup SP, Weber B.

J Heart Valve Dis. 2016 May;25(3):380-388.


Nogo-A regulates vascular network architecture in the postnatal brain.

Wälchli T, Ulmann-Schuler A, Hintermüller C, Meyer E, Stampanoni M, Carmeliet P, Emmert MY, Bozinov O, Regli L, Schwab ME, Vogel J, Hoerstrup SP.

J Cereb Blood Flow Metab. 2017 Feb;37(2):614-631. doi: 10.1177/0271678X16675182. Epub 2016 Nov 13.


Hemodynamic Assessment of a Murine Heterotopic Biventricularly Loaded Cardiac Transplant in vivo Model.

Książek AA, Mitchell KJ, Morax L, Schwarzwald CC, Hoerstrup SP, Weber B.

Eur Surg Res. 2016;57(3-4):171-185. Epub 2016 Jul 20.


Bioengineered valves for the venous circulation.

Weber B, Hafner J, Willenberg T, Hoerstrup SP.

Expert Rev Med Devices. 2016 Nov;13(11):1005-1011. Epub 2016 Oct 12. Review.


Quality Assurance in Biobanking for Pre-Clinical Research.

Simeon-Dubach D, Zeisberger SM, Hoerstrup SP.

Transfus Med Hemother. 2016 Sep;43(5):353-357. Epub 2016 Sep 17. Review.


Tissue Engineering and Regenerative Medicine - New Initiatives for Individual Treatment Offers.

Frey BM, Zeisberger SM, Hoerstrup SP.

Transfus Med Hemother. 2016 Sep;43(5):318-319. Epub 2016 Sep 27. No abstract available.


Cardiovascular Regenerative Technologies: Update and Future Outlook.

Mallone A, Weber B, Hoerstrup SP.

Transfus Med Hemother. 2016 Jul;43(4):291-296. Epub 2016 Jul 21. Review.


Heart Valve Replacements with Regenerative Capacity.

Dijkman PE, Fioretta ES, Frese L, Pasqualini FS, Hoerstrup SP.

Transfus Med Hemother. 2016 Jul;43(4):282-290. Epub 2016 Jul 26. Review.


Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells.

Cambria E, Steiger J, Günter J, Bopp A, Wolint P, Hoerstrup SP, Emmert MY.

Transfus Med Hemother. 2016 Jul;43(4):275-281. Epub 2016 Jul 26. Review.


Adipose Tissue-Derived Stem Cells in Regenerative Medicine.

Frese L, Dijkman PE, Hoerstrup SP.

Transfus Med Hemother. 2016 Jul;43(4):268-274. Epub 2016 Jul 26. Review.


Stem Cell Factories - the Rebirth of Tissue Engineering and Regenerative Medicine.

Frey BM, Zeisberger SM, Hoerstrup SP.

Transfus Med Hemother. 2016 Jul;43(4):244-246. Epub 2016 Jul 26. No abstract available.


Organ Chips: Quality Assurance Systems in Regenerative Medicine.

Pasqualini FS, Emmert MY, Parker KK, Hoerstrup SP.

Clin Pharmacol Ther. 2017 Jan;101(1):31-34. doi: 10.1002/cpt.527. Epub 2016 Nov 21.


The future of heart valve replacement: recent developments and translational challenges for heart valve tissue engineering.

Fioretta ES, Dijkman PE, Emmert MY, Hoerstrup SP.

J Tissue Eng Regen Med. 2018 Jan;12(1):e323-e335. doi: 10.1002/term.2326. Epub 2017 Mar 29. Review.


Percutaneous pulmonary valve replacement using completely tissue-engineered off-the-shelf heart valves: six-month in vivo functionality and matrix remodelling in sheep.

Schmitt B, Spriestersbach H, O H-Icí D, Radtke T, Bartosch M, Peters H, Sigler M, Frese L, Dijkman PE, Baaijens FP, Hoerstrup SP, Berger F.

EuroIntervention. 2016 May 17;12(1):62-70. doi: 10.4244/EIJV12I1A12.

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