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Items: 1 to 50 of 289

1.

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T cell responses and immune regulation.

Kuehlwein JM, Borsche M, Korir PJ, Risch F, Mueller AK, Hübner MP, Hildner K, Hoerauf A, Dunay IR, Schumak B.

Immunology. 2019 Oct 21. doi: 10.1111/imm.13137. [Epub ahead of print]

PMID:
31631339
2.

In vitro maintenance of Mansonella perstans microfilariae and its relevance for drug screening.

Njouendou AJ, Kien CA, Esum ME, Ritter M, Chounna Ndongmo WP, Fombad FF, Gandjui NVT, Njiokou F, Enyong P, Pfarr K, Turner J, Layland LE, Hoerauf A, Wanji S.

Exp Parasitol. 2019 Nov;206:107769. doi: 10.1016/j.exppara.2019.107769. Epub 2019 Sep 30.

PMID:
31580876
3.

Comparison of repeated doses of ivermectin versus ivermectin plus albendazole for treatment of onchocerciasis - a randomized open-label clinical trial.

Batsa Debrah L, Klarmann-Schulz U, Osei-Mensah J, Dubben B, Fischer K, Mubarik Y, Ayisi-Boateng NK, Ricchiuto A, Fimmers R, Konadu P, Nadal J, Gruetzmacher B, Weil G, Kazura JW, King CL, Debrah AY, Hoerauf A.

Clin Infect Dis. 2019 Sep 19. pii: ciz889. doi: 10.1093/cid/ciz889. [Epub ahead of print]

PMID:
31536624
4.

IgG4 antibodies from patients with asymptomatic bancroftian filariasis inhibit the binding of IgG1 and IgG2 to C1q in a Fc-Fc-dependent mechanism.

Prodjinotho UF, Hoerauf A, Adjobimey T.

Parasitol Res. 2019 Oct;118(10):2957-2968. doi: 10.1007/s00436-019-06451-2. Epub 2019 Sep 4.

5.

IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.

Fercoq F, Remion E, Frohberger SJ, Vallarino-Lhermitte N, Hoerauf A, Le Quesne J, Landmann F, Hübner MP, Carlin LM, Martin C.

PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007691. doi: 10.1371/journal.pntd.0007691. eCollection 2019 Aug.

6.

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, Hoerauf A.

PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007636. doi: 10.1371/journal.pntd.0007636. eCollection 2019 Aug.

7.

Multicenter evaluation of the new QIAstat Gastrointestinal Panel for the rapid syndromic testing of acute gastroenteritis.

Hannet I, Engsbro AL, Pareja J, Schneider UV, Lisby JG, Pružinec-Popović B, Hoerauf A, Parčina M.

Eur J Clin Microbiol Infect Dis. 2019 Nov;38(11):2103-2112. doi: 10.1007/s10096-019-03646-4. Epub 2019 Jul 27.

PMID:
31352670
8.

Review of Dancing Parasites in Lymphatic Filariasis.

Dietrich CF, Chaubal N, Hoerauf A, Kling K, Piontek MS, Steffgen L, Mand S, Dong Y.

Ultrasound Int Open. 2019 Mar;5(2):E65-E74. doi: 10.1055/a-0918-3678. Epub 2019 Jul 15. Review.

9.

The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana.

Batsa Debrah L, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, Debrah AY, Hoerauf A.

Am J Trop Med Hyg. 2019 Jul;101(1):84-92. doi: 10.4269/ajtmh.18-0491.

10.

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections.

Loeper N, Graspeuntner S, Ledig S, Kaufhold I, Hoellen F, Schiefer A, Henrichfreise B, Pfarr K, Hoerauf A, Shima K, Rupp J.

Front Microbiol. 2019 May 7;10:943. doi: 10.3389/fmicb.2019.00943. eCollection 2019.

11.

Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment.

Ritter M, Osei-Mensah J, Debrah LB, Kwarteng A, Mubarik Y, Debrah AY, Pfarr K, Hoerauf A, Layland LE.

PLoS Negl Trop Dis. 2019 May 23;13(5):e0007436. doi: 10.1371/journal.pntd.0007436. eCollection 2019 May.

12.

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.

Frohberger SJ, Ajendra J, Surendar J, Stamminger W, Ehrens A, Buerfent BC, Gentil K, Hoerauf A, Hübner MP.

Parasit Vectors. 2019 May 20;12(1):248. doi: 10.1186/s13071-019-3502-z.

13.

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW.

Sci Transl Med. 2019 May 8;11(491). pii: eaav3523. doi: 10.1126/scitranslmed.aav3523.

PMID:
31068442
14.

Complete Genome Sequence of the Corallopyronin A-Producing Myxobacterium Corallococcus coralloides B035.

Bouhired S, Rupp O, Blom J, Schäberle TF, Schiefer A, Kehraus S, Pfarr K, Goesmann A, Hoerauf A, König G.

Microbiol Resour Announc. 2019 Apr 25;8(17). pii: e00050-19. doi: 10.1128/MRA.00050-19.

15.

Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans.

Wanji S, Tayong DB, Ebai R, Opoku V, Kien CA, Ndongmo WPC, Njouendou AJ, Ghani RN, Ritter M, Debrah YA, Layland LE, Enyong PA, Hoerauf A.

Parasit Vectors. 2019 Apr 11;12(1):166. doi: 10.1186/s13071-019-3432-9.

16.

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells.

Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G.

Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019.

17.

A prospective study on the effect of time-shifted telephone reporting of blood culture microscopy.

Gehring T, Kim H, Hoerauf A, Buechler C.

Eur J Clin Microbiol Infect Dis. 2019 May;38(5):973-975. doi: 10.1007/s10096-019-03544-9. Epub 2019 Mar 25.

PMID:
30911927
18.

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.

Taylor MJ, von Geldern TW, Ford L, Hübner MP, Marsh K, Johnston KL, Sjoberg HT, Specht S, Pionnier N, Tyrer HE, Clare RH, Cook DAN, Murphy E, Steven A, Archer J, Bloemker D, Lenz F, Koschel M, Ehrens A, Metuge HM, Chunda VC, Ndongmo Chounna PW, Njouendou AJ, Fombad FF, Carr R, Morton HE, Aljayyoussi G, Hoerauf A, Wanji S, Kempf DJ, Turner JD, Ward SA.

Sci Transl Med. 2019 Mar 13;11(483). pii: eaau2086. doi: 10.1126/scitranslmed.aau2086.

PMID:
30867321
19.

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ.

PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb.

20.

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice.

Kuehn C, Tauchi M, Furtmair R, Urschel K, Raaz-Schrauder D, Neumann AL, Frohberger SJ, Hoerauf A, Regus S, Lang W, Sagban TA, Stumpfe FM, Achenbach S, Hübner MP, Dietel B.

FASEB J. 2019 May;33(5):6497-6513. doi: 10.1096/fj.201800947RR. Epub 2019 Feb 26.

PMID:
30807258
21.

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.

Buerfent BC, Gölz L, Hofmann A, Rühl H, Stamminger W, Fricker N, Hess T, Oldenburg J, Nöthen MM, Schumacher J, Hübner MP, Hoerauf A.

Sci Rep. 2019 Feb 22;9(1):2562. doi: 10.1038/s41598-019-38985-x.

22.

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

Jacobs RT, Lunde CS, Freund YR, Hernandez V, Li X, Xia Y, Carter DS, Berry PW, Halladay J, Rock F, Stefanakis R, Easom E, Plattner JJ, Ford L, Johnston KL, Cook DAN, Clare R, Cassidy A, Myhill L, Tyrer H, Gamble J, Guimaraes AF, Steven A, Lenz F, Ehrens A, Frohberger SJ, Koschel M, Hoerauf A, Hübner MP, McNamara CW, Bakowski MA, Turner JD, Taylor MJ, Ward SA.

J Med Chem. 2019 Mar 14;62(5):2521-2540. doi: 10.1021/acs.jmedchem.8b01854. Epub 2019 Feb 26.

23.

Schistosoma mansoni PCR+ -infected individuals in the Sudan present elevated systemic levels of chemokines when compared to uninfected and egg+ cohorts.

Arndts K, Elfaki TEM, Jelden N, Ritter M, Wiszniewsky A, Katawa G, Goreish IA, Atti El Mekki MEYA, Doenhoff MJ, Hoerauf A, Layland LE.

Clin Exp Immunol. 2019 Jun;196(3):364-373. doi: 10.1111/cei.13270. Epub 2019 Mar 19.

PMID:
30724349
24.

Elimination of lymphatic filariasis in South East Asia.

Specht S, Suma TK, Pedrique B, Hoerauf A.

BMJ. 2019 Jan 22;364:k5198. doi: 10.1136/bmj.k5198. No abstract available.

25.

Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice.

Safi S, Frommholz D, Reimann S, Götz W, Bourauel C, Neumann AL, Hoerauf A, Ilges H, Safi AF, Jäger A, Hübner MP, Gölz L.

Int J Rheum Dis. 2019 Apr;22(4):636-645. doi: 10.1111/1756-185X.13486. Epub 2019 Jan 21. Erratum in: Int J Rheum Dis. 2019 Jul;22(7):1348.

PMID:
30666791
26.

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

Hübner MP, Ehrens A, Koschel M, Dubben B, Lenz F, Frohberger SJ, Specht S, Quirynen L, Lachau-Durand S, Tekle F, Baeten B, Engelen M, Mackenzie CD, Hoerauf A.

PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006320. doi: 10.1371/journal.pntd.0006320. eCollection 2019 Jan.

27.

The central adaptor molecule TRIF influences L. sigmodontis worm development.

Wiszniewsky A, Ritter M, Krupp V, Schulz S, Arndts K, Weighardt H, Wanji S, Hoerauf A, Layland LE.

Parasitol Res. 2019 Feb;118(2):539-549. doi: 10.1007/s00436-018-6159-1. Epub 2019 Jan 15.

PMID:
30643971
28.

Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents.

Fombad FF, Njouendou AJ, Ndongmo PC, Ritter M, Chunda VC, Metuge HM, Gandjui NVT, Enyong P, Njiokou F, Hoerauf A, Mackenzie CD, Wanji S.

Parasit Vectors. 2019 Jan 8;12(1):14. doi: 10.1186/s13071-018-3282-x.

29.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.

30.

Staphylococcus aureus versus Staphylococcus epidermidis in periprosthetic joint infection-Outcome analysis of methicillin-resistant versus methicillin-susceptible strains.

Hischebeth GT, Randau TM, Ploeger MM, Friedrich MJ, Kaup E, Jacobs C, Molitor E, Hoerauf A, Gravius S, Wimmer MD.

Diagn Microbiol Infect Dis. 2019 Feb;93(2):125-130. doi: 10.1016/j.diagmicrobio.2018.08.012. Epub 2018 Sep 1.

PMID:
30266398
31.

IL-6 is required for protective immune responses against early filarial infection.

Muhsin M, Ajendra J, Gentil K, Berbudi A, Neumann AL, Klaas L, Schmidt KE, Hoerauf A, Hübner MP.

Int J Parasitol. 2018 Oct;48(12):925-935. doi: 10.1016/j.ijpara.2018.05.011. Epub 2018 Sep 1.

PMID:
30176234
32.

Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent.

Mukherjee S, Joardar N, Mondal S, Schiefer A, Hoerauf A, Pfarr K, Babu SPS.

Sci Rep. 2018 Aug 13;8(1):12073. doi: 10.1038/s41598-018-30610-7.

33.

Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A.

Shima K, Ledig S, Loeper N, Schiefer A, Pfarr K, Hoerauf A, Graspeuntner S, Rupp J.

Int J Antimicrob Agents. 2018 Oct;52(4):523-524. doi: 10.1016/j.ijantimicag.2018.07.025. Epub 2018 Aug 6. No abstract available.

PMID:
30092271
34.

Absence of IL-17A in Litomosoides sigmodontis-infected mice influences worm development and drives elevated filarial-specific IFN-γ.

Ritter M, Krupp V, Wiszniewsky K, Wiszniewsky A, Katawa G, Tamadaho RSE, Hoerauf A, Layland LE.

Parasitol Res. 2018 Aug;117(8):2665-2675. doi: 10.1007/s00436-018-5959-7. Epub 2018 Jun 22.

35.

Correction: ESBL Detection: Comparison of a Commercially Available Chromogenic Test for Third Generation Cephalosporine Resistance and Automated Susceptibility Testing in Enterobactericeae.

El-Jade MR, Parcina M, Schmithausen RM, Stein C, Meilaender A, Hoerauf A, Molitor E, Bekeredjian-Ding I.

PLoS One. 2018 Jun 7;13(6):e0198959. doi: 10.1371/journal.pone.0198959. eCollection 2018.

36.

Activity of ceftobiprole against Staphylococcus spec. isolates derived from foreign body associated infections.

Hischebeth GTR, Gravius S, Molitor E, Kohlhof H, Hoerauf A, Hilgers C, Randau TM.

Diagn Microbiol Infect Dis. 2018 Jun;91(2):175-178. doi: 10.1016/j.diagmicrobio.2018.01.010. Epub 2018 Jan 31.

37.

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.

Schmidt KE, Kuepper JM, Schumak B, Alferink J, Hofmann A, Howland SW, Rénia L, Limmer A, Specht S, Hoerauf A.

PLoS One. 2018 Feb 13;13(2):e0192717. doi: 10.1371/journal.pone.0192717. eCollection 2018.

38.

Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo.

Kock F, Hauptmann M, Osterloh A, Schäberle TF, Poppert S, Frickmann H, Menzel KD, Peschel G, Pfarr K, Schiefer A, König GM, Hoerauf A, Fleischer B, Keller C.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e01732-17. doi: 10.1128/AAC.01732-17. Print 2018 Apr.

39.

Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses.

Ritter M, Ndongmo WPC, Njouendou AJ, Nghochuzie NN, Nchang LC, Tayong DB, Arndts K, Nausch N, Jacobsen M, Wanji S, Layland LE, Hoerauf A.

PLoS Negl Trop Dis. 2018 Jan 11;12(1):e0006184. doi: 10.1371/journal.pntd.0006184. eCollection 2018 Jan.

40.

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A.

PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan.

41.

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction.

Hischebeth GTR, Gravius S, Buhr JK, Molitor E, Wimmer MD, Hoerauf A, Bekeredjian-Ding I, Randau TM.

J Vis Exp. 2017 Dec 3;(130). doi: 10.3791/55147.

42.

Highly sensitive and specific detection of Giardia duodenalis, Entamoeba histolytica, and Cryptosporidium spp. in human stool samples by the BD MAX™ Enteric Parasite Panel.

Parčina M, Reiter-Owona I, Mockenhaupt FP, Vojvoda V, Gahutu JB, Hoerauf A, Ignatius R.

Parasitol Res. 2018 Feb;117(2):447-451. doi: 10.1007/s00436-017-5720-7. Epub 2017 Dec 19.

PMID:
29260297
43.

Immunomodulatory effects of myeloid-derived suppressor cells in diseases: Role in cancer and infections.

Tamadaho RSE, Hoerauf A, Layland LE.

Immunobiology. 2018 Apr - May;223(4-5):432-442. doi: 10.1016/j.imbio.2017.07.001. Epub 2017 Jul 4. Review.

PMID:
29246400
44.

Rapid monitoring of vancomycin-resistant Enterococcus faecium in hospital departments by repetitive element palindromic polymerase chain reaction.

Froeschen F, Gajdiss M, Uebele J, Meilaender A, Hoerauf A, Exner M, Molitor E, Bierbaum G, Engelhart S, Bekeredjian-Ding I.

J Hosp Infect. 2018 Jun;99(2):208-217. doi: 10.1016/j.jhin.2017.11.017. Epub 2018 Jan 17.

PMID:
29203445
45.

Successful long-term maintenance of Mansonella perstans in an in vitro culture system.

Njouendou AJ, Ritter M, Ndongmo WPC, Kien CA, Narcisse GTV, Fombad FF, Tayong DB, Pfarr K, Layland LE, Hoerauf A, Wanji S.

Parasit Vectors. 2017 Nov 10;10(1):563. doi: 10.1186/s13071-017-2515-8.

46.

Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti.

Debrah LB, Albers A, Debrah AY, Brockschmidt FF, Becker T, Herold C, Hofmann A, Osei-Mensah J, Mubarik Y, Fröhlich H, Hoerauf A, Pfarr K.

Hum Genomics. 2017 Nov 9;11(1):26. doi: 10.1186/s40246-017-0121-7.

47.

IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity.

Ritter M, Tamadaho RS, Feid J, Vogel W, Wiszniewsky K, Perner S, Hoerauf A, Layland LE.

Int J Parasitol. 2017 Dec;47(14):951-960. doi: 10.1016/j.ijpara.2017.06.009. Epub 2017 Aug 30.

48.

AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster.

Wilmes M, Meier K, Schiefer A, Josten M, Otten CF, Klöckner A, Henrichfreise B, Vollmer W, Hoerauf A, Pfarr K.

Front Cell Infect Microbiol. 2017 Aug 4;7:353. doi: 10.3389/fcimb.2017.00353. eCollection 2017.

49.

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

50.

Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host.

Wewer V, Makepeace BL, Tanya VN, Peisker H, Pfarr K, Hoerauf A, Dörmann P.

Int J Parasitol. 2017 Dec;47(14):903-912. doi: 10.1016/j.ijpara.2017.06.001. Epub 2017 Jul 23.

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