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Items: 45

1.

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide.

Snyder NA, Kim A, Kester L, Gale AN, Studer C, Hoepfner D, Roggo S, Helliwell SB, Cunningham KW.

G3 (Bethesda). 2019 Mar 7;9(3):829-840. doi: 10.1534/g3.118.200748.

2.

Discovery of a ZIP7 inhibitor from a Notch pathway screen.

Nolin E, Gans S, Llamas L, Bandyopadhyay S, Brittain SM, Bernasconi-Elias P, Carter KP, Loureiro JJ, Thomas JR, Schirle M, Yang Y, Guo N, Roma G, Schuierer S, Beibel M, Lindeman A, Sigoillot F, Chen A, Xie KX, Ho S, Reece-Hoyes J, Weihofen WA, Tyskiewicz K, Hoepfner D, McDonald RI, Guthrie N, Dogra A, Guo H, Shao J, Ding J, Canham SM, Boynton G, George EL, Kang ZB, Antczak C, Porter JA, Wallace O, Tallarico JA, Palmer AE, Jenkins JL, Jain RK, Bushell SM, Fryer CJ.

Nat Chem Biol. 2019 Feb;15(2):179-188. doi: 10.1038/s41589-018-0200-7. Epub 2019 Jan 14.

PMID:
30643281
3.

CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells.

Hoepfner D, McAllister G, Hoffman GR.

Methods Mol Biol. 2019;1888:153-174. doi: 10.1007/978-1-4939-8891-4_9.

PMID:
30519946
4.

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.

Rusch M, Thevenon A, Hoepfner D, Aust T, Studer C, Patoor M, Rollin P, Livendahl M, Ranieri B, Schmitt E, Spanka C, Gademann K, Bouchez LC.

Chembiochem. 2019 Mar 1;20(5):644-649. doi: 10.1002/cbic.201800587. Epub 2019 Feb 4.

PMID:
30462880
5.

Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action.

Wang AC, Pham HT, Lipps JM, Brittain SM, Harrington E, Wang Y, King FJ, Russ C, Pan X, Hoepfner D, Tallarico J, Feng Y, Jain RK, Schirle M, Thomas JR.

ACS Chem Biol. 2019 Jan 18;14(1):20-26. doi: 10.1021/acschembio.8b00656. Epub 2018 Dec 18.

PMID:
30461263
6.

Cladosporin Derivatives Obtained by Biotransformation Provide Guidance for the Focused Derivatization of this Antimalarial Lead Compound.

Fredenhagen A, Schroer K, Schröder H, Hoepfner D, Ligibel M, Porchet Zemp L, Radoch C, Freund E, Meishammer A.

Chembiochem. 2019 Mar 1;20(5):650-654. doi: 10.1002/cbic.201800588. Epub 2018 Dec 11.

PMID:
30347507
7.

Yeast Chemogenomic Profiling Reveals Iron Chelation To Be the Principle Cell Inhibitory Mode of Action of Gossypol.

Prescott TAK, Jaeg T, Hoepfner D.

J Med Chem. 2018 Aug 23;61(16):7381-7386. doi: 10.1021/acs.jmedchem.8b00692. Epub 2018 Aug 6.

PMID:
30016095
8.

Biosynthesis of fragin is controlled by a novel quorum sensing signal.

Jenul C, Sieber S, Daeppen C, Mathew A, Lardi M, Pessi G, Hoepfner D, Neuburger M, Linden A, Gademann K, Eberl L.

Nat Commun. 2018 Mar 30;9(1):1297. doi: 10.1038/s41467-018-03690-2.

PMID:
29602945
Free PMC Article
9.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D.

Cell Chem Biol. 2018 Mar 15;25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. Epub 2018 Jan 4.

10.

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.

Michlits G, Hubmann M, Wu SH, Vainorius G, Budusan E, Zhuk S, Burkard TR, Novatchkova M, Aichinger M, Lu Y, Reece-Hoyes J, Nitsch R, Schramek D, Hoepfner D, Elling U.

Nat Methods. 2017 Dec;14(12):1191-1197. doi: 10.1038/nmeth.4466. Epub 2017 Oct 16.

PMID:
29039415
11.

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti MA, Potting C, Cerino R, Pfeifer M, Krastel P, Hoepfner D, Bastien J, Koehler CM, Helliwell SB.

Nat Chem Biol. 2017 Dec;13(12):1239-1244. doi: 10.1038/nchembio.2493. Epub 2017 Oct 9.

12.

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, Schuller N, Wetzel E, van de Loo N, Martinez JAZ, Estoppey D, Riedl R, Yang F, Fu B, Dechat T, Ivics Z, Agu CA, Bell O, Blaas D, Gerhardt H, Hoepfner D, Stark A, Penninger JM.

Nature. 2017 Oct 5;550(7674):114-118. doi: 10.1038/nature24027. Epub 2017 Sep 27.

13.

Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.

Filipuzzi I, Thomas JR, Pries V, Estoppey D, Salcius M, Studer C, Schirle M, Hoepfner D.

ACS Chem Biol. 2017 Sep 15;12(9):2264-2269. doi: 10.1021/acschembio.7b00385. Epub 2017 Aug 15.

PMID:
28796488
14.

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

Petrovic K, Pfeifer M, Parker CN, Schuierer S, Tallarico J, Hoepfner D, Movva NR, Scheel G, Helliwell SB.

Microbiol Res. 2017 Jun;199:10-18. doi: 10.1016/j.micres.2017.02.004. Epub 2017 Feb 21.

15.

The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.

Estoppey D, Lee CM, Janoschke M, Lee BH, Wan KF, Dong H, Mathys P, Filipuzzi I, Schuhmann T, Riedl R, Aust T, Galuba O, McAllister G, Russ C, Spiess M, Bouwmeester T, Bonamy GMC, Hoepfner D.

Cell Rep. 2017 Apr 18;19(3):451-460. doi: 10.1016/j.celrep.2017.03.071.

16.

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.

Estoppey D, Hewett JW, Guy CT, Harrington E, Thomas JR, Schirle M, Cuttat R, Waldt A, Gerrits B, Yang Z, Schuierer S, Pan X, Xie K, Carbone W, Knehr J, Lindeman A, Russ C, Frias E, Hoffman GR, Varadarajan M, Ramadan N, Reece-Hoyes JS, Wang Q, Chen X, McAllister G, Roma G, Bouwmeester T, Hoepfner D.

Sci Rep. 2017 Feb 16;7:42728. doi: 10.1038/srep42728.

17.

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.

Filipuzzi I, Cotesta S, Perruccio F, Knapp B, Fu Y, Studer C, Pries V, Riedl R, Helliwell SB, Petrovic KT, Movva NR, Sanglard D, Tao J, Hoepfner D.

PLoS Genet. 2016 Nov 17;12(11):e1006374. doi: 10.1371/journal.pgen.1006374. eCollection 2016 Nov.

18.

PrP-containing aggresomes are cytosolic components of an ER quality control mechanism.

Dubnikov T, Ben-Gedalya T, Reiner R, Hoepfner D, Cabral WA, Marini JC, Cohen E.

J Cell Sci. 2016 Oct 1;129(19):3635-3647. Epub 2016 Aug 22.

19.

Dark chemical matter as a promising starting point for drug lead discovery.

Wassermann AM, Lounkine E, Hoepfner D, Le Goff G, King FJ, Studer C, Peltier JM, Grippo ML, Prindle V, Tao J, Schuffenhauer A, Wallace IM, Chen S, Krastel P, Cobos-Correa A, Parker CN, Davies JW, Glick M.

Nat Chem Biol. 2015 Dec;11(12):958-66. doi: 10.1038/nchembio.1936. Epub 2015 Oct 19.

PMID:
26479441
20.

Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.

Bürstner N, Roggo S, Ostermann N, Blank J, Delmas C, Freuler F, Gerhartz B, Hinniger A, Hoepfner D, Liechty B, Mihalic M, Murphy J, Pistorius D, Rottmann M, Thomas JR, Schirle M, Schmitt EK.

Chembiochem. 2015 Nov;16(17):2433-6. doi: 10.1002/cbic.201500472. Epub 2015 Oct 16.

PMID:
26472355
21.

Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors.

Pries V, Cotesta S, Riedl R, Aust T, Schuierer S, Tao J, Filipuzzi I, Hoepfner D.

J Biomol Screen. 2016 Mar;21(3):306-15. doi: 10.1177/1087057115610488. Epub 2015 Oct 12.

PMID:
26459507
22.

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Helliwell SB, Karkare S, Bergdoll M, Rahier A, Leighton-Davis JR, Fioretto C, Aust T, Filipuzzi I, Frederiksen M, Gounarides J, Hoepfner D, Hofmann A, Imbert PE, Jeker R, Knochenmuss R, Krastel P, Margerit A, Memmert K, Miault CV, Movva NR, Muller A, Naegeli HU, Oberer L, Prindle V, Riedl R, Schuierer S, Sexton JA, Tao J, Wagner T, Yin H, Zhang J, Roggo S, Reinker S, Parker CN.

Nat Commun. 2015 Oct 12;6:8613. doi: 10.1038/ncomms9613.

23.

Natural products as probes in pharmaceutical research.

Schmitt EK, Hoepfner D, Krastel P.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):249-60. doi: 10.1007/s10295-015-1691-9. Epub 2015 Oct 5. Review.

PMID:
26438431
24.

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.

Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F.

PLoS Pathog. 2015 Jul 17;11(7):e1005058. doi: 10.1371/journal.ppat.1005058. eCollection 2015 Jul.

25.

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.

Krastel P, Roggo S, Schirle M, Ross NT, Perruccio F, Aspesi P Jr, Aust T, Buntin K, Estoppey D, Liechty B, Mapa F, Memmert K, Miller H, Pan X, Riedl R, Thibaut C, Thomas J, Wagner T, Weber E, Xie X, Schmitt EK, Hoepfner D.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10149-54. doi: 10.1002/anie.201505069. Epub 2015 Jul 15.

PMID:
26179970
26.

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.

Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D.

J Cell Sci. 2015 Mar 15;128(6):1217-29. doi: 10.1242/jcs.165746. Epub 2015 Jan 22.

27.

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Hassan AQ, Kirby CA, Zhou W, Schuhmann T, Kityk R, Kipp DR, Baird J, Chen J, Chen Y, Chung F, Hoepfner D, Movva NR, Pagliarini R, Petersen F, Quinn C, Quinn D, Riedl R, Schmitt EK, Schitter A, Stams T, Studer C, Fortin PD, Mayer MP, Sadlish H.

Chem Biol. 2015 Jan 22;22(1):87-97. doi: 10.1016/j.chembiol.2014.11.007. Epub 2014 Dec 24.

28.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR.

Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004. Epub 2013 Dec 1.

29.

The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.

Kallifatidis G, Hoepfner D, Jaeg T, Guzmán EA, Wright AE.

Mar Drugs. 2013 Sep 17;11(9):3500-16. doi: 10.3390/md11093500. Erratum in: Mar Drugs. 2014;12(4):2305-7.

30.

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM.

Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.

31.

Organization of organelles within hyphae of Ashbya gossypii revealed by electron tomography.

Gibeaux R, Hoepfner D, Schlatter I, Antony C, Philippsen P.

Eukaryot Cell. 2013 Nov;12(11):1423-32. doi: 10.1128/EC.00106-13. Epub 2013 Jun 14.

32.

Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.

Sadlish H, Galicia-Vazquez G, Paris CG, Aust T, Bhullar B, Chang L, Helliwell SB, Hoepfner D, Knapp B, Riedl R, Roggo S, Schuierer S, Studer C, Porco JA Jr, Pelletier J, Movva NR.

ACS Chem Biol. 2013 Jul 19;8(7):1519-27. doi: 10.1021/cb400158t. Epub 2013 May 7.

33.

Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.

Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D.

Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11.

34.

Identification of elongation factor G as the conserved cellular target of argyrin B.

Nyfeler B, Hoepfner D, Palestrant D, Kirby CA, Whitehead L, Yu R, Deng G, Caughlan RE, Woods AL, Jones AK, Barnes SW, Walker JR, Gaulis S, Hauy E, Brachmann SM, Krastel P, Studer C, Riedl R, Estoppey D, Aust T, Movva NR, Wang Z, Salcius M, Michaud GA, McAllister G, Murphy LO, Tallarico JA, Wilson CJ, Dean CR.

PLoS One. 2012;7(9):e42657. doi: 10.1371/journal.pone.0042657. Epub 2012 Sep 10.

35.

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.

Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, Petersen F, Supek F, Glynne RJ, Tallarico JA, Porter JA, Fishman MC, Bodenreider C, Diagana TT, Movva NR, Winzeler EA.

Cell Host Microbe. 2012 Jun 14;11(6):654-63. doi: 10.1016/j.chom.2012.04.015.

36.

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Hoepfner D, Karkare S, Helliwell SB, Pfeifer M, Trunzer M, De Bonnechose S, Zimmerlin A, Tao J, Richie D, Hofmann A, Reinker S, Frederiksen M, Movva NR, Porter JA, Ryder NS, Parker CN.

Antimicrob Agents Chemother. 2012 Aug;56(8):4233-40. doi: 10.1128/AAC.06332-11. Epub 2012 May 21.

37.

MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.

Schlatter ID, Meira M, Ueberschlag V, Hoepfner D, Movva R, Hynes NE.

PLoS One. 2012;7(3):e32501. doi: 10.1371/journal.pone.0032501. Epub 2012 Mar 7.

38.

Formation of peroxisomes: present and past.

Tabak HF, Hoepfner D, Zand Av, Geuze HJ, Braakman I, Huynen MA.

Biochim Biophys Acta. 2006 Dec;1763(12):1647-54. Epub 2006 Sep 3. Review.

39.

Contribution of the endoplasmic reticulum to peroxisome formation.

Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF.

Cell. 2005 Jul 15;122(1):85-95.

40.
41.

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.

Hoepfner D, van den Berg M, Philippsen P, Tabak HF, Hettema EH.

J Cell Biol. 2001 Dec 10;155(6):979-90. Epub 2001 Dec 3.

42.

A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits.

Gadal O, Strauss D, Braspenning J, Hoepfner D, Petfalski E, Philippsen P, Tollervey D, Hurt E.

EMBO J. 2001 Jul 16;20(14):3695-704.

43.

Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii.

Alberti-Segui C, Dietrich F, Altmann-Jöhl R, Hoepfner D, Philippsen P.

J Cell Sci. 2001 Mar;114(Pt 5):975-86.

44.
45.

Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames.

Brachat A, Liebundguth N, Rebischung C, Lemire S, Schärer F, Hoepfner D, Demchyshyn V, Howald I, Düsterhöft A, Möstl D, Pöhlmann R, Kötter P, Hall MN, Wach A, Philippsen P.

Yeast. 2000 Feb;16(3):241-53.

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