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Items: 1 to 50 of 78

1.

Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines.

Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME.

Front Pharmacol. 2019 Nov 28;10:1423. doi: 10.3389/fphar.2019.01423. eCollection 2019.

2.

Pharmacological profiles of compounds in preworkout supplements ("boosters").

Rickli A, Hoener MC, Liechti ME.

Eur J Pharmacol. 2019 Sep 15;859:172515. doi: 10.1016/j.ejphar.2019.172515. Epub 2019 Jun 29.

PMID:
31265842
3.

TAAR1 levels and sub-cellular distribution are cell line but not breast cancer subtype specific.

Pitts MS, McShane JN, Hoener MC, Christian SL, Berry MD.

Histochem Cell Biol. 2019 Aug;152(2):155-166. doi: 10.1007/s00418-019-01791-7. Epub 2019 May 21.

PMID:
31111198
4.

Monoamine receptor interaction profiles of 4-aryl-substituted 2,5-dimethoxyphenethylamines (2C-BI derivatives).

Luethi D, Widmer R, Trachsel D, Hoener MC, Liechti ME.

Eur J Pharmacol. 2019 Jul 15;855:103-111. doi: 10.1016/j.ejphar.2019.05.014. Epub 2019 May 4.

PMID:
31063768
5.

Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.

Luethi D, Kolaczynska KE, Walter M, Suzuki M, Rice KC, Blough BE, Hoener MC, Baumann MH, Liechti ME.

J Psychopharmacol. 2019 Jul;33(7):831-841. doi: 10.1177/0269881119844185. Epub 2019 Apr 30.

PMID:
31038382
6.

Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use.

Luethi D, Hoener MC, Krähenbühl S, Liechti ME, Duthaler U.

Biochem Pharmacol. 2019 Jun;164:129-138. doi: 10.1016/j.bcp.2019.04.013. Epub 2019 Apr 11.

PMID:
30981875
7.

Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.

Goonawardena AV, Morairty SR, Dell R, Orellana GA, Hoener MC, Wallace TL, Kilduff TS.

Neuropsychopharmacology. 2019 Jul;44(8):1485-1493. doi: 10.1038/s41386-019-0386-8. Epub 2019 Apr 6.

PMID:
30954024
8.

Electrophysiological Phenotype in Angelman Syndrome Differs Between Genotypes.

Frohlich J, Miller MT, Bird LM, Garces P, Purtell H, Hoener MC, Philpot BD, Sidorov MS, Tan WH, Hernandez MC, Rotenberg A, Jeste SS, Krishnan M, Khwaja O, Hipp JF.

Biol Psychiatry. 2019 May 1;85(9):752-759. doi: 10.1016/j.biopsych.2019.01.008. Epub 2019 Jan 19.

9.

Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR.

Rickli A, Kolaczynska K, Hoener MC, Liechti ME.

Neurotoxicology. 2019 May;72:95-100. doi: 10.1016/j.neuro.2019.02.011. Epub 2019 Feb 15.

PMID:
30776375
10.

Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter.

Mayer FP, Cintulova D, Pittrich DA, Wimmer L, Luethi D, Holy M, Jaentsch K, Tischberger S, Gmeiner G, Hoener MC, Liechti ME, Mihovilovic MD, Sitte HH.

Neuropharmacology. 2019 Apr;148:199-209. doi: 10.1016/j.neuropharm.2018.12.032. Epub 2019 Jan 2.

PMID:
30610839
11.

Activation of trace amine-associated receptor 1 attenuates schedule-induced polydipsia in rats.

Sukhanov I, Dorotenko A, Dolgorukova A, Hoener MC, Gainetdinov RR, Bespalov AY.

Neuropharmacology. 2019 Jan;144:184-192. doi: 10.1016/j.neuropharm.2018.10.034. Epub 2018 Oct 24.

PMID:
30366004
12.

How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest.

Harmeier A, Meyer CA, Staempfli A, Casagrande F, Petrinovic MM, Zhang YP, Künnecke B, Iglesias A, Höner OP, Hoener MC.

Front Pharmacol. 2018 Aug 15;9:924. doi: 10.3389/fphar.2018.00924. eCollection 2018.

13.

Trace Amines and Their Receptors.

Gainetdinov RR, Hoener MC, Berry MD.

Pharmacol Rev. 2018 Jul;70(3):549-620. doi: 10.1124/pr.117.015305. Review.

PMID:
29941461
14.

The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters.

Maier J, Mayer FP, Luethi D, Holy M, Jäntsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH.

Neuropharmacology. 2018 Aug;138:282-291. doi: 10.1016/j.neuropharm.2018.06.018. Epub 2018 Jun 23.

15.

Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects.

Liu JF, Seaman R Jr, Siemian JN, Bhimani R, Johnson B, Zhang Y, Zhu Q, Hoener MC, Park J, Dietz DM, Li JX.

Neuropsychopharmacology. 2018 Nov;43(12):2435-2444. doi: 10.1038/s41386-018-0017-9. Epub 2018 Feb 5.

16.

Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine.

Schwartz MD, Palmerston JB, Lee DL, Hoener MC, Kilduff TS.

Front Pharmacol. 2018 Feb 2;9:35. doi: 10.3389/fphar.2018.00035. eCollection 2018.

17.

Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats.

Leo D, Sukhanov I, Zoratto F, Illiano P, Caffino L, Sanna F, Messa G, Emanuele M, Esposito A, Dorofeikova M, Budygin EA, Mus L, Efimova EV, Niello M, Espinoza S, Sotnikova TD, Hoener MC, Laviola G, Fumagalli F, Adriani W, Gainetdinov RR.

J Neurosci. 2018 Feb 21;38(8):1959-1972. doi: 10.1523/JNEUROSCI.1931-17.2018. Epub 2018 Jan 18.

18.

Effects of the new psychoactive substances diclofensine, diphenidine, and methoxphenidine on monoaminergic systems.

Luethi D, Hoener MC, Liechti ME.

Eur J Pharmacol. 2018 Jan 15;819:242-247. doi: 10.1016/j.ejphar.2017.12.012. Epub 2017 Dec 7.

PMID:
29225192
19.

Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome.

Rickli A, Liakoni E, Hoener MC, Liechti ME.

Br J Pharmacol. 2018 Feb;175(3):532-543. doi: 10.1111/bph.14105. Epub 2018 Jan 6.

20.

Interaction Between the Trace Amine-Associated Receptor 1 and the Dopamine D2 Receptor Controls Cocaine's Neurochemical Actions.

Asif-Malik A, Hoener MC, Canales JJ.

Sci Rep. 2017 Oct 24;7(1):13901. doi: 10.1038/s41598-017-14472-z.

21.

Pharmacological profile of methylphenidate-based designer drugs.

Luethi D, Kaeser PJ, Brandt SD, Krähenbühl S, Hoener MC, Liechti ME.

Neuropharmacology. 2018 May 15;134(Pt A):133-140. doi: 10.1016/j.neuropharm.2017.08.020. Epub 2017 Aug 18.

PMID:
28823611
22.

Pharmacological profile of mephedrone analogs and related new psychoactive substances.

Luethi D, Kolaczynska KE, Docci L, Krähenbühl S, Hoener MC, Liechti ME.

Neuropharmacology. 2018 May 15;134(Pt A):4-12. doi: 10.1016/j.neuropharm.2017.07.026. Epub 2017 Jul 26.

PMID:
28755886
23.

Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges.

Berry MD, Gainetdinov RR, Hoener MC, Shahid M.

Pharmacol Ther. 2017 Dec;180:161-180. doi: 10.1016/j.pharmthera.2017.07.002. Epub 2017 Jul 16. Review.

24.

Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs).

Luethi D, Trachsel D, Hoener MC, Liechti ME.

Neuropharmacology. 2018 May 15;134(Pt A):141-148. doi: 10.1016/j.neuropharm.2017.07.012. Epub 2017 Jul 15.

PMID:
28720478
25.

Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.

Black SW, Schwartz MD, Chen TM, Hoener MC, Kilduff TS.

Biol Psychiatry. 2017 Nov 1;82(9):623-633. doi: 10.1016/j.biopsych.2016.10.012. Epub 2016 Oct 18.

26.

The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats.

Ferragud A, Howell AD, Moore CF, Ta TL, Hoener MC, Sabino V, Cottone P.

Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. doi: 10.1038/npp.2016.233. Epub 2016 Oct 6.

27.

Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.

Schwartz MD, Black SW, Fisher SP, Palmerston JB, Morairty SR, Hoener MC, Kilduff TS.

Neuropsychopharmacology. 2017 May;42(6):1305-1314. doi: 10.1038/npp.2016.216. Epub 2016 Sep 23.

28.

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.

Rickli A, Moning OD, Hoener MC, Liechti ME.

Eur Neuropsychopharmacol. 2016 Aug;26(8):1327-37. doi: 10.1016/j.euroneuro.2016.05.001. Epub 2016 May 20.

PMID:
27216487
29.

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.

Galley G, Beurier A, Décoret G, Goergler A, Hutter R, Mohr S, Pähler A, Schmid P, Türck D, Unger R, Zbinden KG, Hoener MC, Norcross RD.

ACS Med Chem Lett. 2015 Dec 30;7(2):192-7. doi: 10.1021/acsmedchemlett.5b00449. eCollection 2016 Feb 11.

30.

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.

Raab S, Wang H, Uhles S, Cole N, Alvarez-Sanchez R, Künnecke B, Ullmer C, Matile H, Bedoucha M, Norcross RD, Ottaway-Parker N, Perez-Tilve D, Conde Knape K, Tschöp MH, Hoener MC, Sewing S.

Mol Metab. 2015 Nov 1;5(1):47-56. doi: 10.1016/j.molmet.2015.09.015. eCollection 2016 Jan.

31.

In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1.

Simmler LD, Buchy D, Chaboz S, Hoener MC, Liechti ME.

J Pharmacol Exp Ther. 2016 Apr;357(1):134-44. doi: 10.1124/jpet.115.229765. Epub 2016 Jan 20.

PMID:
26791601
32.

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.

Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, Dernick G, Wettstein JG, Iglesias A, Rolink A, Bettler B, Hoener MC.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2049-61. doi: 10.1016/j.euroneuro.2015.08.011. Epub 2015 Aug 20.

PMID:
26372541
33.

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).

Rickli A, Luethi D, Reinisch J, Buchy D, Hoener MC, Liechti ME.

Neuropharmacology. 2015 Dec;99:546-53. doi: 10.1016/j.neuropharm.2015.08.034. Epub 2015 Aug 25.

PMID:
26318099
34.

Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds.

Pei Y, Mortas P, Hoener MC, Canales JJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015 Jun 3.

PMID:
26048337
35.

Pharmacological profile of novel psychoactive benzofurans.

Rickli A, Kopf S, Hoener MC, Liechti ME.

Br J Pharmacol. 2015 Jul;172(13):3412-25. doi: 10.1111/bph.13128. Epub 2015 Apr 24.

36.

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects.

Cotter R, Pei Y, Mus L, Harmeier A, Gainetdinov RR, Hoener MC, Canales JJ.

Front Neurosci. 2015 Feb 13;9:39. doi: 10.3389/fnins.2015.00039. eCollection 2015.

37.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.

Neuropsychopharmacology. 2015 Aug;40(9):2217-27. doi: 10.1038/npp.2015.65. Epub 2015 Mar 9.

38.

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones.

Rickli A, Hoener MC, Liechti ME.

Eur Neuropsychopharmacol. 2015 Mar;25(3):365-76. doi: 10.1016/j.euroneuro.2014.12.012. Epub 2015 Jan 5.

PMID:
25624004
39.

A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.

Fowler S, Kletzl H, Finel M, Manevski N, Schmid P, Tuerck D, Norcross RD, Hoener MC, Spleiss O, Iglesias VA.

J Pharmacol Exp Ther. 2015 Feb;352(2):358-67. doi: 10.1124/jpet.114.220194. Epub 2014 Dec 12.

PMID:
25503386
40.

TAAR1-dependent effects of apomorphine in mice.

Sukhanov I, Espinoza S, Yakovlev DS, Hoener MC, Sotnikova TD, Gainetdinov RR.

Int J Neuropsychopharmacol. 2014 Oct;17(10):1683-93. doi: 10.1017/S1461145714000509. Epub 2014 Jun 13.

41.

Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking.

Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ.

Neuropsychopharmacology. 2014 Sep;39(10):2299-308. doi: 10.1038/npp.2014.88. Epub 2014 Apr 11.

42.

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors.

Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR.

Neuropharmacology. 2014 Jun;81:283-91. doi: 10.1016/j.neuropharm.2014.02.007. Epub 2014 Feb 22.

PMID:
24565640
43.

Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives.

Simmler LD, Rickli A, Schramm Y, Hoener MC, Liechti ME.

Biochem Pharmacol. 2014 Mar 15;88(2):237-44. doi: 10.1016/j.bcp.2014.01.024. Epub 2014 Jan 28.

PMID:
24486525
44.

Monoamine transporter and receptor interaction profiles of a new series of designer cathinones.

Simmler LD, Rickli A, Hoener MC, Liechti ME.

Neuropharmacology. 2014 Apr;79:152-60. doi: 10.1016/j.neuropharm.2013.11.008. Epub 2013 Nov 22.

PMID:
24275046
45.

The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E.

PLoS One. 2013 Jul 3;8(7):e68722. doi: 10.1371/journal.pone.0068722. Print 2013.

46.

Pharmacological characterization of designer cathinones in vitro.

Simmler LD, Buser TA, Donzelli M, Schramm Y, Dieu LH, Huwyler J, Chaboz S, Hoener MC, Liechti ME.

Br J Pharmacol. 2013 Jan;168(2):458-70. doi: 10.1111/j.1476-5381.2012.02145.x.

47.

Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.

Galley G, Stalder H, Goergler A, Hoener MC, Norcross RD.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. doi: 10.1016/j.bmcl.2012.06.060. Epub 2012 Jun 23.

PMID:
22795332
48.

Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine.

Revel FG, Meyer CA, Bradaia A, Jeanneau K, Calcagno E, André CB, Haenggi M, Miss MT, Galley G, Norcross RD, Invernizzi RW, Wettstein JG, Moreau JL, Hoener MC.

Neuropsychopharmacology. 2012 Nov;37(12):2580-92. doi: 10.1038/npp.2012.109. Epub 2012 Jul 4.

49.

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, Canales JJ, Wallace TL, Wettstein JG, Hoener MC.

Biol Psychiatry. 2012 Dec 1;72(11):934-42. doi: 10.1016/j.biopsych.2012.05.014. Epub 2012 Jun 16.

PMID:
22705041
50.

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC.

Mol Psychiatry. 2013 May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29.

PMID:
22641180

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