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Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, Zimmer T, Thiel V, Janke C, Guggemos W, Seilmaier M, Drosten C, Vollmar P, Zwirglmaier K, Zange S, Wölfel R, Hoelscher M.

N Engl J Med. 2020 Mar 5;382(10):970-971. doi: 10.1056/NEJMc2001468. Epub 2020 Jan 30. No abstract available.


High turnaround times and low viral resuppression rates after reinforced adherence counselling following a confirmed virological failure diagnostic algorithm in HIV-infected patients on first-line antiretroviral therapy from Tanzania.

Kroidl A, Burger T, Urio A, Mugeniwalwo R, Mgaya J, Mlagalila F, Hoelscher M, Däumer M, Salehe O, Sangare A, Lennemann T, Maganga L.

Trop Med Int Health. 2020 Jan 27. doi: 10.1111/tmi.13373. [Epub ahead of print]


Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan.

Tukhanova N, Shin A, Abdiyeva K, Turebekov N, Yeraliyeva L, Yegemberdiyeva R, Shapiyeva Z, Froeschl G, Hoelscher M, Wagner E, Rösel K, Zhalmagambetova A, Musralina L, Frey S, Essbauer S.

Zoonoses Public Health. 2020 Jan 19. doi: 10.1111/zph.12683. [Epub ahead of print]


Wuchereria bancrofti infection is linked to systemic activation of CD4 and CD8 T cells.

Kroidl I, Chachage M, Mnkai J, Nsojo A, Berninghoff M, Verweij JJ, Maganga L, Ntinginya NE, Maboko L, Clowes P, Hoelscher M, Saathoff E, Geldmacher C.

PLoS Negl Trop Dis. 2019 Aug 19;13(8):e0007623. doi: 10.1371/journal.pntd.0007623. eCollection 2019 Aug.


Accelerating the transition of new tuberculosis drug combinations from Phase II to Phase III trials: New technologies and innovative designs.

Davies G, Boeree M, Hermann D, Hoelscher M.

PLoS Med. 2019 Jul 9;16(7):e1002851. doi: 10.1371/journal.pmed.1002851. eCollection 2019 Jul.


Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence.

Nadai Y, Held K, Joseph S, Ahmed MIM, Hoffmann VS, Peterhoff D, Missanga M, Bauer A, Joachim A, Reimer U, Zerweck J, McCormack S, Cope AV, Tatoud R, Shattock RJ, Robb ML, Sandstroem EG, Hoelscher M, Maboko L, Bakari M, Kroidl A, Wagner R, Weber J, Pollakis G, Geldmacher C.

Front Immunol. 2019 Apr 24;10:717. doi: 10.3389/fimmu.2019.00717. eCollection 2019.


Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.

Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D, Dheda K.

Lancet Glob Health. 2019 Jun;7(6):e798-e807. doi: 10.1016/S2214-109X(19)30164-0. Erratum in: Lancet Glob Health. 2019 Sep;7(9):e1179.


Prevalence of Rickettsia species in ticks including identification of unknown species in two regions in Kazakhstan.

Turebekov N, Abdiyeva K, Yegemberdiyeva R, Dmitrovsky A, Yeraliyeva L, Shapiyeva Z, Amirbekov A, Oradova A, Kachiyeva Z, Ziyadina L, Hoelscher M, Froeschl G, Dobler G, Zinner J, Frey S, Essbauer S.

Parasit Vectors. 2019 May 3;12(1):197. doi: 10.1186/s13071-019-3440-9.


Contributions of Neuroscience Knowledge to Teachers and Their Practice.

Dubinsky JM, Guzey SS, Schwartz MS, Roehrig G, MacNabb C, Schmied A, Hinesley V, Hoelscher M, Michlin M, Schmitt L, Ellingson C, Chang Z, Cooper JL.

Neuroscientist. 2019 Oct;25(5):394-407. doi: 10.1177/1073858419835447. Epub 2019 Mar 21.


A Phenomenological Account of HIV Disclosure Experiences of Children and Adolescents from Northern and Southern Ghana.

Appiah SCY, Kroidl I, Hoelscher M, Ivanova O, Dapaah JM.

Int J Environ Res Public Health. 2019 Feb 18;16(4). pii: E595. doi: 10.3390/ijerph16040595.


Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis.

Di Tanna GL, Khaki AR, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Zijenah LS, Mason P, Bandason T, Durovni B, Bara W, Hoelscher M, Clowes P, Mangu C, Chanda D, Pym A, Mwaba P, Cobelens F, Nicol MP, Dheda K, Churchyard G, Fielding K, Metcalfe JZ.

Lancet Glob Health. 2019 Feb;7(2):e191-e199. doi: 10.1016/S2214-109X(18)30458-3. Erratum in: Lancet Glob Health. 2019 Apr;7(4):e419.


Epidemiological characteristics, clinical manifestations, and treatment outcome of 139 paediatric Ebola patients treated at a Sierra Leone Ebola treatment center.

Kangbai JB, Heumann C, Hoelscher M, Sahr F, Froeschl G.

BMC Infect Dis. 2019 Jan 24;19(1):81. doi: 10.1186/s12879-019-3727-7.


TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol.

Rachow A, Ivanova O, Wallis R, Charalambous S, Jani I, Bhatt N, Kampmann B, Sutherland J, Ntinginya NE, Evans D, Lönnroth K, Niemann S, Schaible UE, Geldmacher C, Sanne I, Hoelscher M, Churchyard G.

BMC Pulm Med. 2019 Jan 7;19(1):4. doi: 10.1186/s12890-018-0777-3.


Seroepidemiological and molecular investigations of infections with Crimean-Congo haemorrhagic fever virus in Kazakhstan.

Abdiyeva K, Turebekov N, Dmitrovsky A, Tukhanova N, Shin A, Yeraliyeva L, Heinrich N, Hoelscher M, Yegemberdiyeva R, Shapiyeva Z, Kachiyeva Z, Zhalmagambetova A, Montag J, Dobler G, Zinner J, Wagner E, Frey S, Essbauer S.

Int J Infect Dis. 2019 Jan;78:121-127. doi: 10.1016/j.ijid.2018.10.015. Epub 2018 Oct 25.


Identifying Dormant Growth State of Mycobacteria by Orthogonal Analytical Approaches on a Single Cell and Ensemble Basis.

Neumann AC, Bauer D, Hoelscher M, Haisch C, Wieser A.

Anal Chem. 2019 Jan 2;91(1):881-887. doi: 10.1021/acs.analchem.8b03646. Epub 2018 Dec 17.


Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design.

Viegas EO, Kroidl A, Munseri PJ, Missanga M, Nilsson C, Tembe N, Bauer A, Joachim A, Joseph S, Mann P, Geldmacher C, Fleck S, Stöhr W, Scarlatti G, Aboud S, Bakari M, Maboko L, Hoelscher M, Wahren B, Robb ML, Weber J, McCormack S, Biberfeld G, Jani IV, Sandström E, Lyamuya E; TaMoVac study group.

PLoS One. 2018 Nov 29;13(11):e0206838. doi: 10.1371/journal.pone.0206838. eCollection 2018.


Using a composite adherence tool to assess ART response and risk factors of poor adherence in pregnant and breastfeeding HIV-positive Cameroonian women at 6 and 12 months after initiating option B.

Atanga PN, Ndetan HT, Fon PN, Meriki HD, Muffih TP, Achidi EA, Hoelscher M, Kroidl A.

BMC Pregnancy Childbirth. 2018 Oct 25;18(1):418. doi: 10.1186/s12884-018-2058-9.


Prevalence and antibiotic susceptibility pattern of CTX-M type extended-spectrum β-lactamases among clinical isolates of gram-negative bacilli in Jimma, Ethiopia.

Zeynudin A, Pritsch M, Schubert S, Messerer M, Liegl G, Hoelscher M, Belachew T, Wieser A.

BMC Infect Dis. 2018 Oct 20;18(1):524. doi: 10.1186/s12879-018-3436-7.


Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy.

Ahmed MIM, Ntinginya NE, Kibiki G, Mtafya BA, Semvua H, Mpagama S, Mtabho C, Saathoff E, Held K, Loose R, Kroidl I, Chachage M, von Both U, Haule A, Mekota AM, Boeree MJ, Gillespie SH, Hoelscher M, Heinrich N, Geldmacher C.

Front Immunol. 2018 Sep 28;9:2247. doi: 10.3389/fimmu.2018.02247. eCollection 2018.


Morbidity profile and sociodemographic characteristics of unaccompanied refugee minors seen by paediatric practices between October 2014 and February 2016 in Bavaria, Germany.

Kloning T, Nowotny T, Alberer M, Hoelscher M, Hoffmann A, Froeschl G.

BMC Public Health. 2018 Aug 7;18(1):983. doi: 10.1186/s12889-018-5878-7.


Retrospective clinical case series study in 2017 identifies Plasmodium knowlesi as most frequent Plasmodium species in returning travellers from Thailand to Germany.

Froeschl G, Nothdurft HD, von Sonnenburg F, Bretzel G, Polanetz R, Kroidl I, Seilmaier M, Orth HM, Jordan S, Kremsner P, Vygen-Bonnet S, Pritsch M, Hoelscher M, Rothe C.

Euro Surveill. 2018 Jul;23(29). doi: 10.2807/1560-7917.ES.2018.23.29.1700619.


Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study.

Sabi I, Rachow A, Mapamba D, Clowes P, Ntinginya NE, Sasamalo M, Kamwela L, Haraka F, Hoelscher M, Paris DH, Saathoff E, Reither K.

J Infect. 2018 Oct;77(4):321-327. doi: 10.1016/j.jinf.2018.07.002. Epub 2018 Jul 20.


Accuracy and Operational Characteristics of Xpert Human Immunodeficiency Virus Point-of-Care Testing at Birth and Until Week 6 in Human Immunodeficiency Virus-exposed Neonates in Tanzania.

Sabi I, Mahiga H, Mgaya J, Geisenberger O, Kastner S, Olomi W, Saathoff E, Njovu L, Lueer C, France J, Maboko L, Ntinginya NE, Hoelscher M, Kroidl A.

Clin Infect Dis. 2019 Feb 1;68(4):615-622. doi: 10.1093/cid/ciy538.


High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves.

Hoelscher M, Tiller N, Teh AY, Wu GZ, Ma JK, Bock R.

Plant Mol Biol. 2018 Jul;97(4-5):357-370. doi: 10.1007/s11103-018-0744-7. Epub 2018 Jun 9.


Reduction of malaria prevalence after introduction of artemisinin-combination-therapy in Mbeya Region, Tanzania: results from a cohort study with 6773 participants.

Froeschl G, Saathoff E, Kroidl I, Berens-Riha N, Clowes P, Maboko L, Assisya W, Mwalongo W, Gerhardt M, Ntinginya EN, Hoelscher M.

Malar J. 2018 Jun 26;17(1):245. doi: 10.1186/s12936-018-2389-z.


The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.

Svensson EM, Svensson RJ, Te Brake LHM, Boeree MJ, Heinrich N, Konsten S, Churchyard G, Dawson R, Diacon AH, Kibiki GS, Minja LT, Ntingiya NE, Sanne I, Gillespie SH, Hoelscher M, Phillips PPJ, Simonsson USH, Aarnoutse R.

Clin Infect Dis. 2018 Jun 18;67(1):34-41. doi: 10.1093/cid/ciy026.


The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay.

Rachow A, Saathoff E, Mtafya B, Mapamba D, Mangu C, Rojas-Ponce G, Ntinginya NE, Boeree M, Heinrich N, Gillespie SH, Hoelscher M; PanACEA-Consortium.

Tuberculosis (Edinb). 2018 May;110:56-58. doi: 10.1016/ Epub 2018 Apr 5.


Adherence to reporting guidelines and clinical trial registration policies in oncology journals: a cross-sectional review.

Wayant C, Moore G, Hoelscher M, Cook C, Vassar M.

BMJ Evid Based Med. 2018 Jun;23(3):104-110. doi: 10.1136/bmjebm-2017-110855. Epub 2018 Apr 13.


Plasmodium knowlesi infection in a returning German traveller from Thailand: a case report on an emerging malaria pathogen in a popular low-risk travel destination.

Froeschl G, Beissner M, Huber K, Bretzel G, Hoelscher M, Rothe C.

BMC Infect Dis. 2018 Apr 2;18(1):148. doi: 10.1186/s12879-018-3059-z.


Control of Retrograde Signaling by Rapid Turnover of GENOMES UNCOUPLED1.

Wu GZ, Chalvin C, Hoelscher M, Meyer EH, Wu XN, Bock R.

Plant Physiol. 2018 Mar;176(3):2472-2495. doi: 10.1104/pp.18.00009. Epub 2018 Jan 24.


Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.

Patel K, Nagel M, Wesolowski M, Dees S, Rivera-Milla E, Geldmacher C, Dheda K, Hoelscher M, Labugger I.

J Mol Diagn. 2018 Mar;20(2):215-224. doi: 10.1016/j.jmoldx.2017.11.005. Epub 2017 Dec 18.


O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis.

Mekonnen SA, Beissner M, Saar M, Ali S, Zeynudin A, Tesfaye K, Adbaru MG, Battke F, Poppert S, Hoelscher M, Löscher T, Bretzel G, Herbinger KH.

Parasit Vectors. 2017 Oct 2;10(1):451. doi: 10.1186/s13071-017-2382-3.


Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

Rademeyer C, Korber B, Seaman MS, Giorgi EE, Thebus R, Robles A, Sheward DJ, Wagh K, Garrity J, Carey BR, Gao H, Greene KM, Tang H, Bandawe GP, Marais JC, Diphoko TE, Hraber P, Tumba N, Moore PL, Gray GE, Kublin J, McElrath MJ, Vermeulen M, Middelkoop K, Bekker LG, Hoelscher M, Maboko L, Makhema J, Robb ML, Karim SA, Karim QA, Kim JH, Hahn BH, Gao F, Swanstrom R, Morris L, Montefiori DC, Williamson C.

PLoS Pathog. 2017 Sep 25;13(9):e1006641. doi: 10.1371/journal.ppat.1006641. eCollection 2017 Sep.


Pharmacokinetics, Tolerability, and Bacteriological Response of Rifampin Administered at 600, 900, and 1,200 Milligrams Daily in Patients with Pulmonary Tuberculosis.

Aarnoutse RE, Kibiki GS, Reither K, Semvua HH, Haraka F, Mtabho CM, Mpagama SG, van den Boogaard J, Sumari-de Boer IM, Magis-Escurra C, Wattenberg M, Logger JGM, Te Brake LHM, Hoelscher M, Gillespie SH, Colbers A, Phillips PPJ, Plemper van Balen G, Boeree MJ; PanACEA Consortium.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01054-17. doi: 10.1128/AAC.01054-17. Print 2017 Nov.


Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen.

Bauer A, Podola L, Mann P, Missanga M, Haule A, Sudi L, Nilsson C, Kaluwa B, Lueer C, Mwakatima M, Munseri PJ, Maboko L, Robb ML, Tovanabutra S, Kijak G, Marovich M, McCormack S, Joseph S, Lyamuya E, Wahren B, Sandström E, Biberfeld G, Hoelscher M, Bakari M, Kroidl A, Geldmacher C.

J Virol. 2017 Aug 24;91(18). pii: e00730-17. doi: 10.1128/JVI.00730-17. Print 2017 Sep 15.


Nasal delivery of Protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice.

Cao W, Kim JH, Reber AJ, Hoelscher M, Belser JA, Lu X, Katz JM, Gangappa S, Plante M, Burt DS, Sambhara S.

Vaccine. 2017 Jun 5;35(25):3318-3325. doi: 10.1016/j.vaccine.2017.05.004. Epub 2017 May 9.


Comparison of four PCR methods for efficient detection of Trypanosoma cruzi in routine diagnostics.

Seiringer P, Pritsch M, Flores-Chavez M, Marchisio E, Helfrich K, Mengele C, Hohnerlein S, Bretzel G, Löscher T, Hoelscher M, Berens-Riha N.

Diagn Microbiol Infect Dis. 2017 Jul;88(3):225-232. doi: 10.1016/j.diagmicrobio.2017.04.003. Epub 2017 Apr 7.


Trichuris trichiura infection and its relation to environmental factors in Mbeya region, Tanzania: A cross-sectional, population-based study.

Manz KM, Clowes P, Kroidl I, Kowuor DO, Geldmacher C, Ntinginya NE, Maboko L, Hoelscher M, Saathoff E.

PLoS One. 2017 Apr 6;12(4):e0175137. doi: 10.1371/journal.pone.0175137. eCollection 2017.


First report on bla NDM-1-producing Acinetobacter baumannii in three clinical isolates from Ethiopia.

Pritsch M, Zeynudin A, Messerer M, Baumer S, Liegl G, Schubert S, Löscher T, Hoelscher M, Belachew T, Rachow A, Wieser A.

BMC Infect Dis. 2017 Mar 1;17(1):180. doi: 10.1186/s12879-017-2289-9.


Identifying children with tuberculosis among household contacts in The Gambia.

Egere U, Togun T, Sillah A, Mendy F, Otu J, Hoelscher M, Heinrich N, Hill PC, Kampmann B.

Int J Tuberc Lung Dis. 2017 Jan 1;21(1):46-52. doi: 10.5588/ijtld.16.0289.


Isoniazid preventive treatment among child contacts of adults with smear-positive tuberculosis in The Gambia.

Egere U, Sillah A, Togun T, Kandeh S, Cole F, Jallow A, Able-Thomas A, Hoelscher M, Heinrich N, Hill PC, Kampmann B.

Public Health Action. 2016 Dec 21;6(4):226-231. doi: 10.5588/pha.16.0073.


High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial.

Boeree MJ, Heinrich N, Aarnoutse R, Diacon AH, Dawson R, Rehal S, Kibiki GS, Churchyard G, Sanne I, Ntinginya NE, Minja LT, Hunt RD, Charalambous S, Hanekom M, Semvua HH, Mpagama SG, Manyama C, Mtafya B, Reither K, Wallis RS, Venter A, Narunsky K, Mekota A, Henne S, Colbers A, van Balen GP, Gillespie SH, Phillips PPJ, Hoelscher M; PanACEA consortium.

Lancet Infect Dis. 2017 Jan;17(1):39-49. doi: 10.1016/S1473-3099(16)30274-2. Epub 2016 Oct 26.


In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation.

Kloss F, Krchnak V, Krchnakova A, Schieferdecker S, Dreisbach J, Krone V, Möllmann U, Hoelscher M, Miller MJ.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2187-2191. doi: 10.1002/anie.201609737. Epub 2017 Jan 18.


Cross-sectional, descriptive study of Chagas disease among citizens of Bolivian origin living in Munich, Germany.

Navarro M, Berens-Riha N, Hohnerlein S, Seiringer P, von Saldern C, Garcia S, Blasco-Hernández T, Navaza B, Shock J, Bretzel G, Hoelscher M, Löscher T, Albajar-Viñas P, Pritsch M.

BMJ Open. 2017 Jan 16;7(1):e013960. doi: 10.1136/bmjopen-2016-013960.


Long-term kinetics of Zika virus RNA and antibodies in body fluids of a vasectomized traveller returning from Martinique: a case report.

Froeschl G, Huber K, von Sonnenburg F, Nothdurft HD, Bretzel G, Hoelscher M, Zoeller L, Trottmann M, Pan-Montojo F, Dobler G, Woelfel S.

BMC Infect Dis. 2017 Jan 10;17(1):55. doi: 10.1186/s12879-016-2123-9.


Virological efficacy of 24-week fozivudine-based regimen in ART-naive patients from Tanzania and Côte d'Ivoire.

Kroidl A, Ello F, Mgaya J, Lennemann T, Moh R, Maganga L, Eholie S, Pruvost A, Saathoff E, Girard PM, Zuhse R, von Massow F, Anglaret X, Hoelscher M, Danel C; FATI-1 study team.

AIDS. 2017 Feb 20;31(4):501-509. doi: 10.1097/QAD.0000000000001362.


Drug resistance and population structure of M.tuberculosis isolates from prisons and communities in Ethiopia.

Ali S, Beckert P, Haileamlak A, Wieser A, Pritsch M, Heinrich N, Löscher T, Hoelscher M, Niemann S, Rachow A.

BMC Infect Dis. 2016 Nov 21;16(1):687.


Retention in care and reasons for discontinuation of lifelong antiretroviral therapy in a cohort of Cameroonian pregnant and breastfeeding HIV-positive women initiating 'Option B+' in the South West Region.

Atanga PN, Ndetan HT, Achidi EA, Meriki HD, Hoelscher M, Kroidl A.

Trop Med Int Health. 2017 Feb;22(2):161-170. doi: 10.1111/tmi.12816. Epub 2016 Dec 18.

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