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Items: 1 to 50 of 59

1.

Compensated Interferometry Measures of CYFRA 21-1 Improve Diagnosis of Lung Cancer.

Kammer MN, Kussrow AK, Webster RL, Chen H, Hoeksema M, Christenson R, Massion PP, Bornhop DJ.

ACS Comb Sci. 2019 Jun 10;21(6):465-472. doi: 10.1021/acscombsci.9b00022. Epub 2019 May 10.

PMID:
31022347
2.

Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli.

Hoeksema M, Jonker MJ, Brul S, Ter Kuile BH.

BMC Genomics. 2019 Apr 11;20(1):284. doi: 10.1186/s12864-019-5648-7.

3.

Correction: Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.

Udyavar AR, Wooten DJ, Hoeksema M, Bansal M, Califano A, Estrada L, Schnell S, Irish JM, Massion PP, Quaranta V.

Cancer Res. 2019 Mar 1;79(5):1014. doi: 10.1158/0008-5472.CAN-19-0069. No abstract available.

4.

Genome rearrangements in Escherichia coli during de novo acquisition of resistance to a single antibiotic or two antibiotics successively.

Hoeksema M, Jonker MJ, Bel K, Brul S, Ter Kuile BH.

BMC Genomics. 2018 Dec 27;19(1):973. doi: 10.1186/s12864-018-5353-y.

5.

Nature and nurture of tissue-specific macrophage phenotypes.

Hoeksema MA, Glass CK.

Atherosclerosis. 2019 Feb;281:159-167. doi: 10.1016/j.atherosclerosis.2018.10.005. Epub 2018 Oct 6. Review.

6.

Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer.

Lehman JM, Hoeksema MD, Staub J, Qian J, Harris B, Callison JC, Miao J, Shi C, Eisenberg R, Chen H, Chen SC, Massion PP.

Int J Cancer. 2019 Mar 1;144(5):1104-1114. doi: 10.1002/ijc.31771. Epub 2018 Oct 9.

7.

Myeloid Kdm6b deficiency results in advanced atherosclerosis.

Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ.

Atherosclerosis. 2018 Aug;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. Epub 2018 Jun 1.

8.

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP.

Oncogene. 2018 Sep;37(36):5007-5019. doi: 10.1038/s41388-018-0307-z. Epub 2018 May 23.

9.

Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.

Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK.

Cell. 2018 Jun 14;173(7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. Epub 2018 May 17.

10.

NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes.

Fei J, Ishii H, Hoeksema MA, Meitinger F, Kassavetis GA, Glass CK, Ren B, Kadonaga JT.

Genes Dev. 2018 May 1;32(9-10):682-694. doi: 10.1101/gad.313973.118. Epub 2018 May 14.

11.

Influence of Reactive Oxygen Species on De Novo Acquisition of Resistance to Bactericidal Antibiotics.

Hoeksema M, Brul S, Ter Kuile BH.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02354-17. doi: 10.1128/AAC.02354-17. Print 2018 Jun.

12.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

13.

Antibiotic Killing through Incomplete DNA Repair.

Ter Kuile BH, Hoeksema M.

Trends Microbiol. 2018 Jan;26(1):2-4. doi: 10.1016/j.tim.2017.11.006. Epub 2017 Nov 17.

PMID:
29157966
14.

Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma.

Codreanu SG, Hoeksema MD, Slebos RJC, Zimmerman LJ, Rahman SMJ, Li M, Chen SC, Chen H, Eisenberg R, Liebler DC, Massion PP.

J Proteome Res. 2017 Sep 1;16(9):3266-3276. doi: 10.1021/acs.jproteome.7b00245. Epub 2017 Aug 8.

15.

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia.

Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema MA, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG.

Eur Heart J. 2017 May 21;38(20):1584-1593. doi: 10.1093/eurheartj/ehx002.

PMID:
28329114
16.

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells.

Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP.

Epigenomics. 2017 Apr;9(4):383-391. doi: 10.2217/epi-2016-0152. Epub 2017 Mar 21.

PMID:
28322580
17.

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.

Udyavar AR, Wooten DJ, Hoeksema M, Bansal M, Califano A, Estrada L, Schnell S, Irish JM, Massion PP, Quaranta V.

Cancer Res. 2017 Mar 1;77(5):1063-1074. doi: 10.1158/0008-5472.CAN-16-1467. Epub 2016 Dec 8. Erratum in: Cancer Res. 2019 Mar 1;79(5):1014.

18.

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

Rahman SMJ, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, Young JD, Massion PP.

JCI Insight. 2016 Nov 17;1(19):e88814. doi: 10.1172/jci.insight.88814.

19.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC.

Cell Metab. 2017 Jan 10;25(1):197-207. doi: 10.1016/j.cmet.2016.10.013. Epub 2016 Nov 17.

20.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA.

Cancer Prev Res (Phila). 2016 Nov;9(11):855-865. Epub 2016 Aug 23.

21.

Epigenetic Regulation of Monocyte and Macrophage Function.

Hoeksema MA, de Winther MP.

Antioxid Redox Signal. 2016 Nov 10;25(14):758-774. Epub 2016 Apr 25. Review.

22.

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP.

Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008.

23.

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.

Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC.

J Immunol Methods. 2016 Nov;438:51-58. doi: 10.1016/j.jim.2016.08.013. Epub 2016 Sep 2.

24.

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema MA, Aerts JM, Bogan JS, Dorn GW 2nd, Argmann CA, Verhoeven AJ.

Diabetes. 2016 Sep;65(9):2591-605. doi: 10.2337/db16-0243. Epub 2016 Jun 20.

25.

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling.

Hoeksema MA, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G.

FASEB J. 2016 Aug;30(8):2826-36. doi: 10.1096/fj.201600343R. Epub 2016 Apr 19.

26.

Histones as mediators of host defense, inflammation and thrombosis.

Hoeksema M, van Eijk M, Haagsman HP, Hartshorn KL.

Future Microbiol. 2016;11(3):441-53. doi: 10.2217/fmb.15.151. Epub 2016 Mar 4. Review.

27.

Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.

Boshuizen MC, Neele AE, Gijbels MJ, van der Velden S, Hoeksema MA, Forman RA, Muller W, Van den Bossche J, de Winther MP.

Atherosclerosis. 2016 Mar;246:325-33. doi: 10.1016/j.atherosclerosis.2016.01.026. Epub 2016 Jan 19.

PMID:
26828750
28.

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N.

J Biol Chem. 2016 Feb 26;291(9):4813-25. doi: 10.1074/jbc.M115.698688. Epub 2015 Dec 30.

29.

Effects of Stress, Reactive Oxygen Species, and the SOS Response on De Novo Acquisition of Antibiotic Resistance in Escherichia coli.

Händel N, Hoeksema M, Freijo Mata M, Brul S, ter Kuile BH.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1319-27. doi: 10.1128/AAC.02684-15.

30.

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms.

Boshuizen MC, Hoeksema MA, Neele AE, van der Velden S, Hamers AA, Van den Bossche J, Lutgens E, de Winther MP.

Cytokine. 2016 Jan;77:220-6. doi: 10.1016/j.cyto.2015.09.016. Epub 2015 Oct 1.

PMID:
26427927
31.

Arginine-rich histones have strong antiviral activity for influenza A viruses.

Hoeksema M, Tripathi S, White M, Qi L, Taubenberger J, van Eijk M, Haagsman H, Hartshorn KL.

Innate Immun. 2015 Oct;21(7):736-45. doi: 10.1177/1753425915593794. Epub 2015 Jul 2.

32.

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis.

Neele AE, Van den Bossche J, Hoeksema MA, de Winther MP.

Eur J Pharmacol. 2015 Sep 15;763(Pt A):79-89. doi: 10.1016/j.ejphar.2015.03.101. Epub 2015 May 21. Review.

PMID:
26004034
33.

Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer.

Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC.

Mol Imaging Biol. 2016 Feb;18(1):18-23. doi: 10.1007/s11307-015-0862-4.

34.

Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.

Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP.

Int J Cancer. 2015 Oct 1;137(7):1587-97. doi: 10.1002/ijc.29535. Epub 2015 May 6.

35.

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.

Hoeksema MA, Scicluna BP, Boshuizen MC, van der Velden S, Neele AE, Van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MP.

J Immunol. 2015 Apr 15;194(8):3909-16. doi: 10.4049/jimmunol.1402077. Epub 2015 Mar 6.

36.

The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers.

Qian J, Hassanein M, Hoeksema MD, Harris BK, Zou Y, Chen H, Lu P, Eisenberg R, Wang J, Espinosa A, Ji X, Harris FT, Rahman SM, Massion PP.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3469-74. doi: 10.1073/pnas.1421975112. Epub 2015 Mar 2.

37.

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.

Van den Bossche J, Neele AE, Hoeksema MA, de Heij F, Boshuizen MC, van der Velden S, de Boer VC, Reedquist KA, de Winther MP.

Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):396-402. doi: 10.1016/j.bbrc.2014.11.029. Epub 2014 Nov 18.

PMID:
25446073
38.

Macrophage polarization: the epigenetic point of view.

Van den Bossche J, Neele AE, Hoeksema MA, de Winther MP.

Curr Opin Lipidol. 2014 Oct;25(5):367-73. doi: 10.1097/MOL.0000000000000109. Review.

PMID:
25188918
39.

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.

Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP.

EMBO Mol Med. 2014 Sep;6(9):1124-32. doi: 10.15252/emmm.201404170.

40.

Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry.

Olmsted IR, Hassanein M, Kussrow A, Hoeksema M, Li M, Massion PP, Bornhop DJ.

Anal Chem. 2014 Aug 5;86(15):7566-74. doi: 10.1021/ac501355q. Epub 2014 Jul 7.

41.

Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.

Harris FT, Rahman SM, Hassanein M, Qian J, Hoeksema MD, Chen H, Eisenberg R, Chaurand P, Caprioli RM, Shiota M, Massion PP.

Cancer Prev Res (Phila). 2014 Jul;7(7):748-57. doi: 10.1158/1940-6207.CAPR-14-0057. Epub 2014 May 12.

42.

Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer.

Udyavar AR, Hoeksema MD, Clark JE, Zou Y, Tang Z, Li Z, Li M, Chen H, Statnikov A, Shyr Y, Liebler DC, Field J, Eisenberg R, Estrada L, Massion PP, Quaranta V.

BMC Syst Biol. 2013;7 Suppl 5:S1. doi: 10.1186/1752-0509-7-S5-S1. Epub 2013 Dec 9.

43.

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis.

Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E.

FASEB J. 2014 May;28(5):2202-13. doi: 10.1096/fj.13-243105. Epub 2014 Jan 30.

PMID:
24481967
44.

Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia.

Wijnands KA, Hoeksema MA, Meesters DM, van den Akker NM, Molin DG, Briedé JJ, Ghosh M, Köhler SE, van Zandvoort MA, de Winther MP, Buurman WA, Lamers WH, Poeze M.

PLoS One. 2014 Jan 21;9(1):e86135. doi: 10.1371/journal.pone.0086135. eCollection 2014.

45.

Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung.

Wang J, Qian J, Hoeksema MD, Zou Y, Espinosa AV, Rahman SM, Zhang B, Massion PP.

Clin Cancer Res. 2013 Oct 15;19(20):5580-90. doi: 10.1158/1078-0432.CCR-13-0594. Epub 2013 Aug 1.

46.

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP.

Clin Cancer Res. 2013 Feb 1;19(3):560-70. doi: 10.1158/1078-0432.CCR-12-2334. Epub 2012 Dec 4.

47.

Cardiac output measured by uncalibrated arterial pressure waveform analysis by recently released software version 3.02 versus thermodilution in septic shock.

Slagt C, de Leeuw MA, Beute J, Rijnsburger E, Hoeksema M, Mulder JW, Malagon I, Groeneveld AB.

J Clin Monit Comput. 2013 Apr;27(2):171-7. doi: 10.1007/s10877-012-9410-9. Epub 2012 Nov 15.

PMID:
23154918
48.

In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers.

Kikuchi T, Hassanein M, Amann JM, Liu Q, Slebos RJ, Rahman SM, Kaufman JM, Zhang X, Hoeksema MD, Harris BK, Li M, Shyr Y, Gonzalez AL, Zimmerman LJ, Liebler DC, Massion PP, Carbone DP.

Mol Cell Proteomics. 2012 Oct;11(10):916-32. Epub 2012 Jul 3.

49.

Molecular pathways regulating macrophage polarization: implications for atherosclerosis.

Hoeksema MA, Stöger JL, de Winther MP.

Curr Atheroscler Rep. 2012 Jun;14(3):254-63. doi: 10.1007/s11883-012-0240-5. Review.

50.

Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques.

Goossens P, Vergouwe MN, Gijbels MJ, Curfs DM, van Woezik JH, Hoeksema MA, Xanthoulea S, Leenen PJ, Rupec RA, Hofker MH, de Winther MP.

PLoS One. 2011;6(7):e22327. doi: 10.1371/journal.pone.0022327. Epub 2011 Jul 21.

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