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The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters.

van Hoek ML, Prickett MD, Settlage RE, Kang L, Michalak P, Vliet KA, Bishop BM.

BMC Genomics. 2019 Aug 30;20(1):684. doi: 10.1186/s12864-019-6029-y.


Spearman's hypothesis tested comparing Korean young adults with various other groups of young adults on the items of the Advanced Progressive Matrices - Erratum.

Nijenhuis JT, Choi YY, van den Hoek M, Valueva E, Lee KH.

J Biosoc Sci. 2019 Jul 24:1. doi: 10.1017/S0021932019000361. [Epub ahead of print] No abstract available.


PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy.

Zhou X, Muise ES, Haimbach R, Sebhat IK, Zhu Y, Liu F, Souza SC, Kan Y, Pinto S, Kelley DE, Hoek M.

J Pharmacol Exp Ther. 2019 Oct;371(1):45-55. doi: 10.1124/jpet.119.258244. Epub 2019 Jul 12.


Evidence for Helical Hinge Zero Modes in an Fe-Based Superconductor.

Gray MJ, Freudenstein J, Zhao SYF, O'Connor R, Jenkins S, Kumar N, Hoek M, Kopec A, Huh S, Taniguchi T, Watanabe K, Zhong R, Kim C, Gu GD, Burch KS.

Nano Lett. 2019 Aug 14;19(8):4890-4896. doi: 10.1021/acs.nanolett.9b00844. Epub 2019 Jul 9.


Two-Component Systems in Francisella Species.

van Hoek ML, Hoang KV, Gunn JS.

Front Cell Infect Microbiol. 2019 Jun 12;9:198. doi: 10.3389/fcimb.2019.00198. eCollection 2019. Review.


Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.

Liu K, Kurukulasuriya R, Dykstra K, DiMichelle L, Liu J, Vachal P, Ogawa A, DeVita RJ, Shen DM, Tan Q, Chen Y, Gauthier D, Verras A, Crespo A, Zamlynny B, Madwed J, Hoek M, Bateman T, Yang YF, Houk KN, Krska S, Cernak T.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1854-1858. doi: 10.1016/j.bmcl.2019.04.024. Epub 2019 Apr 15.


Spearman's hypothesis tested comparing Korean young adults with various other groups of young adults on the items of the Advanced Progressive Matrices.

Te Nijenhuis J, Choi YY, van den Hoek M, Valueva E, Lee KH.

J Biosoc Sci. 2019 Apr 22:1-38. doi: 10.1017/S0021932019000026. [Epub ahead of print]


Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring.

van der Hoek M, den Haan L, Kaspers A, Steenbergen W, Bosschaart N.

Physiol Meas. 2019 Jun 4;40(5):05NT01. doi: 10.1088/1361-6579/ab1ad7.


APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.

Ryu JH, Ge M, Merscher S, Rosenberg AZ, Desante M, Roshanravan H, Okamoto K, Shin MK, Hoek M, Fornoni A, Kopp JB.

PLoS One. 2019 Apr 18;14(4):e0211559. doi: 10.1371/journal.pone.0211559. eCollection 2019.


Efficacy of Antibiotic Agents after Spill of Bile and Gallstones during Laparoscopic Cholecystectomy.

van Dijk AH, van der Hoek M, Rutgers M, van Duijvendijk P, Donkervoort SC, de Reuver PR, Boermeester MA.

Surg Infect (Larchmt). 2019 May/Jun;20(4):298-304. doi: 10.1089/sur.2018.195. Epub 2019 Feb 22.


The MemTrax Test Compared to the Montreal Cognitive Assessment Estimation of Mild Cognitive Impairment.

van der Hoek MD, Nieuwenhuizen A, Keijer J, Ashford JW.

J Alzheimers Dis. 2019;67(3):1045-1054. doi: 10.3233/JAD-181003.


Goal Setting in Teams: Goal Clarity and Team Performance in the Public Sector.

van der Hoek M, Groeneveld S, Kuipers B.

Rev Public Pers Adm. 2018 Dec;38(4):472-493. doi: 10.1177/0734371X16682815. Epub 2016 Dec 19.


APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018.


Plasma protein N-glycan signatures of type 2 diabetes.

Dotz V, Lemmers RFH, Reiding KR, Hipgrave Ederveen AL, Lieverse AG, Mulder MT, Sijbrands EJG, Wuhrer M, van Hoek M.

Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2613-2622. doi: 10.1016/j.bbagen.2018.08.005. Epub 2018 Aug 6.


First Measurement of the Q^{2} Dependence of the Beam-Normal Single Spin Asymmetry for Elastic Scattering off Carbon.

Esser A, Thiel M, Achenbach P, Aulenbacher K, Baunack S, Beričič J, Bosnar D, Correa L, Dehn M, Distler MO, Fonvieille H, Friščić I, Gorchtein M, Heidrich S, Herrmann P, Hoek M, Kegel S, Kohl Y, Kolar T, Kreidel HJ, Maas FE, Merkel H, Mihovilovič M, Müller J, Müller U, Nillius F, Palatchi C, Paschke KD, Pochodzalla J, Schlimme BS, Schoth M, Schulz F, Širca S, Spruck B, Štajner S, Tioukine V, Tyukin A, Weber A, Sfienti C.

Phys Rev Lett. 2018 Jul 13;121(2):022503. doi: 10.1103/PhysRevLett.121.022503.


Concurrent Daily Cisplatin and High-Dose Radiation Therapy in Patients With Stage III Non-Small Cell Lung Cancer.

Dieleman EMT, Uitterhoeve ALJ, van Hoek MW, van Os RM, Wiersma J, Koolen MGJ, Kolff MW, Koning CCE, Adam JA, Verberne HJ, Annema JT, Rasch CRN.

Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):543-551. doi: 10.1016/j.ijrobp.2018.07.188. Epub 2018 Jul 25.



Te Nijenhuis J, van den Hoek M.

J Biosoc Sci. 2018 Nov;50(6):870-871. doi: 10.1017/S0021932018000160. Epub 2018 Jul 17.


Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants.

van der Hoek MD, Madsen O, Keijer J, van der Leij FR.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Aug;1863(8):909-918. doi: 10.1016/j.bbalip.2018.05.001. Epub 2018 May 4.


Enhanced pharmaceutical removal from water in a three step bio-ozone-bio process.

de Wilt A, van Gijn K, Verhoek T, Vergnes A, Hoek M, Rijnaarts H, Langenhoff A.

Water Res. 2018 Jul 1;138:97-105. doi: 10.1016/j.watres.2018.03.028. Epub 2018 Mar 12.


An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.

Zhou X, Zhang J, Haimbach R, Zhu W, Mayer-Ezell R, Garcia-Calvo M, Smith E, Price O, Kan Y, Zycband E, Zhu Y, Hoek M, Cox JM, Ma L, Kelley DE, Pinto S.

Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.354.


Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.

Barf T, Covey T, Izumi R, van de Kar B, Gulrajani M, van Lith B, van Hoek M, de Zwart E, Mittag D, Demont D, Verkaik S, Krantz F, Pearson PG, Ulrich R, Kaptein A.

J Pharmacol Exp Ther. 2017 Nov;363(2):240-252. doi: 10.1124/jpet.117.242909. Epub 2017 Sep 7.


A Method for Next-Generation Sequencing of Paired Diagnostic and Remission Samples to Detect Mitochondrial DNA Mutations Associated with Leukemia.

Pagani IS, Kok CH, Saunders VA, Van der Hoek MB, Heatley SL, Schwarer AP, Hahn CN, Hughes TP, White DL, Ross DM.

J Mol Diagn. 2017 Sep;19(5):711-721. doi: 10.1016/j.jmoldx.2017.05.009. Epub 2017 Jul 18.


IgG glycan patterns are associated with type 2 diabetes in independent European populations.

Lemmers RFH, Vilaj M, Urda D, Agakov F, Šimurina M, Klaric L, Rudan I, Campbell H, Hayward C, Wilson JF, Lieverse AG, Gornik O, Sijbrands EJG, Lauc G, van Hoek M.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2240-2249. doi: 10.1016/j.bbagen.2017.06.020. Epub 2017 Jun 28.


Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound.

Chung EMC, Dean SN, Propst CN, Bishop BM, van Hoek ML.

NPJ Biofilms Microbiomes. 2017 Apr 11;3:9. doi: 10.1038/s41522-017-0017-2. eCollection 2017.


Negative body experience in women with early childhood trauma: associations with trauma severity and dissociation.

Scheffers M, Hoek M, Bosscher RJ, van Duijn MAJ, Schoevers RA, van Busschbach JT.

Eur J Psychotraumatol. 2017 May 31;8(1):1322892. doi: 10.1080/20008198.2017.1322892. eCollection 2017.


Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes.

van Herpt TTW, Lemmers RFH, van Hoek M, Langendonk JG, Erdtsieck RJ, Bravenboer B, Lucas A, Mulder MT, Haak HR, Lieverse AG, Sijbrands EJG.

Diabetol Metab Syndr. 2017 Jun 19;9:47. doi: 10.1186/s13098-017-0245-x. eCollection 2017.


Contemplative Listening in Moral Issues: Moral Counseling Redefined in Principles and Method.

de Groot J, van Hoek MEC.

J Pastoral Care Counsel. 2017 Jun;71(2):106-113. doi: 10.1177/1542305017708155.


[Hypertension en orthostatic hypotension during use of monoamine oxidase (MAO) inhibitors].

Zandee WT, Alsma J, Birkenhäger TK, den Meiracker AHV, van Hoek M, Versmissen J.

Tijdschr Psychiatr. 2017;59(6):366-371. Dutch.


Emergence of microbial diversity due to cross-feeding interactions in a spatial model of gut microbial metabolism.

Hoek MJAV, Merks RMH.

BMC Syst Biol. 2017 May 16;11(1):56. doi: 10.1186/s12918-017-0430-4.


The anti-inflammatory function of high-density lipoprotein in type II diabetes: A systematic review.

Lemmers RFH, van Hoek M, Lieverse AG, Verhoeven AJM, Sijbrands EJG, Mulder MT.

J Clin Lipidol. 2017 May - Jun;11(3):712-724.e5. doi: 10.1016/j.jacl.2017.03.013. Epub 2017 Mar 31. Review.


Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte.

Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i65-i70. doi: 10.1093/ndt/gfw402. Review.


Cathelicidin peptide rescues G. mellonella infected with B. anthracis.

Blower RJ, Popov SG, van Hoek ML.

Virulence. 2018 Jan 1;9(1):287-293. doi: 10.1080/21505594.2017.1293227. Epub 2017 Mar 8. No abstract available.


Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry.

Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML.

J Proteome Res. 2017 Apr 7;16(4):1470-1482. doi: 10.1021/acs.jproteome.6b00857. Epub 2017 Feb 24.


Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae.

Barksdale SM, Hrifko EJ, van Hoek ML.

Dev Comp Immunol. 2017 May;70:135-144. doi: 10.1016/j.dci.2017.01.011. Epub 2017 Jan 13.


ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study.

de Vries PS, van Herpt TT, Ligthart S, Hofman A, Ikram MA, van Hoek M, Sijbrands EJ, Franco OH, de Maat MP, Leebeek FW, Dehghan A.

Diabetologia. 2017 Feb;60(2):280-286. doi: 10.1007/s00125-016-4139-5. Epub 2016 Oct 27.


Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M, Mihailov E, Liu C, Kraja AT, Fallgaard Nielsen S, Rasheed A, Samuel M, Zhao W, Bonnycastle LL, Jackson AU, Narisu N, Swift AJ, Southam L, Marten J, Huyghe JR, Stančáková A, Fava C, Ohlsson T, Matchan A, Stirrups KE, Bork-Jensen J, Gjesing AP, Kontto J, Perola M, Shaw-Hawkins S, Havulinna AS, Zhang H, Donnelly LA, Groves CJ, Rayner NW, Neville MJ, Robertson NR, Yiorkas AM, Herzig KH, Kajantie E, Zhang W, Willems SM, Lannfelt L, Malerba G, Soranzo N, Trabetti E, Verweij N, Evangelou E, Moayyeri A, Vergnaud AC, Nelson CP, Poveda A, Varga TV, Caslake M, de Craen AJ, Trompet S, Luan J, Scott RA, Harris SE, Liewald DC, Marioni R, Menni C, Farmaki AE, Hallmans G, Renström F, Huffman JE, Hassinen M, Burgess S, Vasan RS, Felix JF; CHARGE-Heart Failure Consortium, Uria-Nickelsen M, Malarstig A, Reily DF, Hoek M, Vogt T, Lin H, Lieb W; EchoGen Consortium, Traylor M, Markus HF; METASTROKE Consortium, Highland HM, Justice AE, Marouli E; GIANT Consortium, Lindström J, Uusitupa M, Komulainen P, Lakka TA, Rauramaa R, Polasek O, Rudan I, Rolandsson O, Franks PW, Dedoussis G, Spector TD; EPIC-InterAct Consortium, Jousilahti P, Männistö S, Deary IJ, Starr JM, Langenberg C, Wareham NJ, Brown MJ, Dominiczak AF, Connell JM, Jukema JW, Sattar N, Ford I, Packard CJ, Esko T, Mägi R, Metspalu A, de Boer RA, van der Meer P, van der Harst P; Lifelines Cohort Study, Gambaro G, Ingelsson E, Lind L, de Bakker PI, Numans ME, Brandslund I, Christensen C, Petersen ER, Korpi-Hyövälti E, Oksa H, Chambers JC, Kooner JS, Blakemore AI, Franks S, Jarvelin MR, Husemoen LL, Linneberg A, Skaaby T, Thuesen B, Karpe F, Tuomilehto J, Doney AS, Morris AD, Palmer CN, Holmen OL, Hveem K, Willer CJ, Tuomi T, Groop L, Käräjämäki A, Palotie A, Ripatti S, Salomaa V, Alam DS, Shafi Majumder AA, Di Angelantonio E, Chowdhury R, McCarthy MI, Poulter N, Stanton AV, Sever P, Amouyel P, Arveiler D, Blankenberg S, Ferrières J, Kee F, Kuulasmaa K, Müller-Nurasyid M, Veronesi G, Virtamo J, Deloukas P; Wellcome Trust Case Control Consortium, Elliott P; Understanding Society Scientific Group, Zeggini E, Kathiresan S, Melander O, Kuusisto J, Laakso M, Padmanabhan S, Porteous D, Hayward C, Scotland G, Collins FS, Mohlke KL, Hansen T, Pedersen O, Boehnke M, Stringham HM; EPIC-CVD Consortium, Frossard P, Newton-Cheh C; CHARGE+ Exome Chip Blood Pressure Consortium, Tobin MD, Nordestgaard BG; T2D-GENES Consortium; GoT2DGenes Consortium; ExomeBP Consortium; CHD Exome+ Consortium, Caulfield MJ, Mahajan A, Morris AP, Tomaszewski M, Samani NJ, Saleheen D, Asselbergs FW, Lindgren CM, Danesh J, Wain LV, Butterworth AS, Howson JM, Munroe PB.

Nat Genet. 2016 Oct;48(10):1151-1161. doi: 10.1038/ng.3654. Epub 2016 Sep 12.


Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii.

Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML.

BMC Microbiol. 2016 Aug 19;16(1):189. doi: 10.1186/s12866-016-0799-z.


Request for organ donation without donor registration: a qualitative study of the perspectives of bereaved relatives.

de Groot J, van Hoek M, Hoedemaekers C, Hoitsma A, Schilderman H, Smeets W, Vernooij-Dassen M, van Leeuwen E.

BMC Med Ethics. 2016 Jul 11;17(1):38. doi: 10.1186/s12910-016-0120-6.


Francisella philomiragia Infection and Lethality in Mammalian Tissue Culture Cell Models, Galleria mellonella, and BALB/c Mice.

Propst CN, Pylypko SL, Blower RJ, Ahmad S, Mansoor M, van Hoek ML.

Front Microbiol. 2016 May 24;7:696. doi: 10.3389/fmicb.2016.00696. eCollection 2016.


Antimicrobial activity of mosquito cecropin peptides against Francisella.

Kaushal A, Gupta K, Shah R, van Hoek ML.

Dev Comp Immunol. 2016 Oct;63:171-80. doi: 10.1016/j.dci.2016.05.018. Epub 2016 May 26.


The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study.

van Herpt TT, Dehghan A, van Hoek M, Ikram MA, Hofman A, Sijbrands EJ, Franco OH.

Cardiovasc Diabetol. 2016 Apr 27;15:69. doi: 10.1186/s12933-016-0387-4.


Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida infection.

Propst CN, Nwabueze AO, Kanev IL, Pepin RE, Gutting BW, Morozov VN, van Hoek ML.

J Nanobiotechnology. 2016 Apr 18;14:29. doi: 10.1186/s12951-016-0182-0.


Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort.

Kozlitina J, Zhou H, Brown PN, Rohm RJ, Pan Y, Ayanoglu G, Du X, Rimmer E, Reilly DF, Roddy TP, Cully DF, Vogt TF, Blom D, Hoek M.

J Am Soc Nephrol. 2016 Oct;27(10):3204-3219. Epub 2016 Mar 22.


Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C.

Medchemcomm. 2016 Jan 1;7(1):128-131. Epub 2015 Sep 30.


Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora.

Kaushal A, Gupta K, van Hoek ML.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):955-60. doi: 10.1016/j.bbrc.2016.01.100. Epub 2016 Jan 21.


Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study.

Ligthart S, van Herpt TT, Leening MJ, Kavousi M, Hofman A, Stricker BH, van Hoek M, Sijbrands EJ, Franco OH, Dehghan A.

Lancet Diabetes Endocrinol. 2016 Jan;4(1):44-51. doi: 10.1016/S2213-8587(15)00362-9. Epub 2015 Nov 11.


Characterization of Pneumococcal Genes Involved in Bloodstream Invasion in a Mouse Model.

Mahdi LK, Van der Hoek MB, Ebrahimie E, Paton JC, Ogunniyi AD.

PLoS One. 2015 Nov 5;10(11):e0141816. doi: 10.1371/journal.pone.0141816. eCollection 2015.


Extracellular vesicles from infected cells: potential for direct pathogenesis.

Schwab A, Meyering SS, Lepene B, Iordanskiy S, van Hoek ML, Hakami RM, Kashanchi F.

Front Microbiol. 2015 Oct 20;6:1132. doi: 10.3389/fmicb.2015.01132. eCollection 2015. Review.


Decision making on organ donation: the dilemmas of relatives of potential brain dead donors.

de Groot J, van Hoek M, Hoedemaekers C, Hoitsma A, Smeets W, Vernooij-Dassen M, van Leeuwen E.

BMC Med Ethics. 2015 Sep 17;16(1):64. doi: 10.1186/s12910-015-0057-1. Review.

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