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Items: 1 to 50 of 361

1.

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering.

Milanese C, Bombardieri CR, Sepe S, Barnhoorn S, Payán-Goméz C, Caruso D, Audano M, Pedretti S, Vermeij WP, Brandt RMC, Gyenis A, Wamelink MM, de Wit AS, Janssens RC, Leen R, van Kuilenburg ABP, Mitro N, Hoeijmakers JHJ, Mastroberardino PG.

Nat Commun. 2019 Oct 25;10(1):4887. doi: 10.1038/s41467-019-12640-5.

2.

The DNA damage response to transcription stress.

Lans H, Hoeijmakers JHJ, Vermeulen W, Marteijn JA.

Nat Rev Mol Cell Biol. 2019 Sep 26. doi: 10.1038/s41580-019-0169-4. [Epub ahead of print] Review.

PMID:
31558824
3.

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.

Theil AF, Botta E, Raams A, Smith DEC, Mendes MI, Caligiuri G, Giachetti S, Bione S, Carriero R, Liberi G, Zardoni L, Swagemakers SMA, Salomons GS, Sarasin A, Lehmann A, van der Spek PJ, Ogi T, Hoeijmakers JHJ, Vermeulen W, Orioli D.

Am J Hum Genet. 2019 Aug 1;105(2):434-440. doi: 10.1016/j.ajhg.2019.06.017.

PMID:
31374204
4.

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.

Alyodawi K, Vermeij WP, Omairi S, Kretz O, Hopkinson M, Solagna F, Joch B, Brandt RMC, Barnhoorn S, van Vliet N, Ridwan Y, Essers J, Mitchell R, Morash T, Pasternack A, Ritvos O, Matsakas A, Collins-Hooper H, Huber TB, Hoeijmakers JHJ, Patel K.

J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):662-686. doi: 10.1002/jcsm.12404. Epub 2019 Mar 27.

5.

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

Ribeiro-Silva C, Aydin ÖZ, Mesquita-Ribeiro R, Slyskova J, Helfricht A, Marteijn JA, Hoeijmakers JHJ, Lans H, Vermeulen W.

Nat Commun. 2018 Oct 4;9(1):4067. doi: 10.1038/s41467-018-06402-y.

6.

DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.

Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

EMBO Rep. 2018 Oct;19(10). pii: e45566. doi: 10.15252/embr.201745566. Epub 2018 Aug 13.

7.

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.

Milanese C, Cerri S, Ulusoy A, Gornati SV, Plat A, Gabriels S, Blandini F, Di Monte DA, Hoeijmakers JH, Mastroberardino PG.

Cell Death Dis. 2018 Jul 26;9(8):818. doi: 10.1038/s41419-018-0848-7.

8.

Nuclear Genomic Instability and Aging.

Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD.

Annu Rev Biochem. 2018 Jun 20;87:295-322. doi: 10.1146/annurev-biochem-062917-012239. Review.

PMID:
29925262
9.

Vitamin E Supplementation Reduces Cellular Loss in the Brain of a Premature Aging Mouse Model.

La Fata G, van Vliet N, Barnhoorn S, Brandt RMC, Etheve S, Chenal E, Grunenwald C, Seifert N, Weber P, Hoeijmakers JHJ, Mohajeri MH, Vermeij WP.

J Prev Alzheimers Dis. 2017;4(4):226-235. doi: 10.14283/jpad.2017.30.

10.

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

Sci Rep. 2017 Nov 10;7(1):15353. doi: 10.1038/s41598-017-15194-y.

11.

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.

Theil AF, Mandemaker IK, van den Akker E, Swagemakers SMA, Raams A, Wüst T, Marteijn JA, Giltay JC, Colombijn RM, Moog U, Kotzaeridou U, Ghazvini M, von Lindern M, Hoeijmakers JHJ, Jaspers NGJ, van der Spek PJ, Vermeulen W.

Hum Mol Genet. 2017 Dec 1;26(23):4689-4698. doi: 10.1093/hmg/ddx351.

12.

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/- mice.

Wu H, van Thiel BS, Bautista-Niño PK, Reiling E, Durik M, Leijten FPJ, Ridwan Y, Brandt RMC, van Steeg H, Dollé MET, Vermeij WP, Hoeijmakers JHJ, Essers J, van der Pluijm I, Danser AHJ, Roks AJM.

Clin Sci (Lond). 2017 Jul 13;131(15):1941-1953. doi: 10.1042/CS20170026. Print 2017 Aug 1.

PMID:
28620011
13.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

14.

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ.

Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031.

15.

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.

Jongbloed F, Saat TC, Verweij M, Payan-Gomez C, Hoeijmakers JH, van den Engel S, van Oostrom CT, Ambagtsheer G, Imholz S, Pennings JL, van Steeg H, IJzermans JN, Dollé ME, de Bruin RW.

Sci Rep. 2017 Jan 19;7:40901. doi: 10.1038/srep40901.

16.

After surviving cancer, what about late life effects of the cure?

Nonnekens J, Hoeijmakers JH.

EMBO Mol Med. 2017 Jan;9(1):4-6. doi: 10.15252/emmm.201607062. No abstract available.

17.

Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice.

van Beek AA, Sovran B, Hugenholtz F, Meijer B, Hoogerland JA, Mihailova V, van der Ploeg C, Belzer C, Boekschoten MV, Hoeijmakers JH, Vermeij WP, de Vos P, Wells JM, Leenen PJ, Nicoletti C, Hendriks RW, Savelkoul HF.

Front Immunol. 2016 Oct 7;7:408. eCollection 2016.

18.

Menopause: Genome stability as new paradigm.

Laven JSE, Visser JA, Uitterlinden AG, Vermeij WP, Hoeijmakers JHJ.

Maturitas. 2016 Oct;92:15-23. doi: 10.1016/j.maturitas.2016.07.006. Epub 2016 Jul 9. Review.

PMID:
27621233
19.

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.

20.

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice.

van Beek AA, Hugenholtz F, Meijer B, Sovran B, Perdijk O, Vermeij WP, Brandt RM, Barnhoorn S, Hoeijmakers JH, de Vos P, Leenen PJ, Hendriks RW, Savelkoul HF.

J Leukoc Biol. 2017 Apr;101(4):811-821. doi: 10.1189/jlb.1HI0216-062RR. Epub 2016 Jul 14.

21.

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson's Disease.

Sepe S, Milanese C, Gabriels S, Derks KW, Payan-Gomez C, van IJcken WF, Rijksen YM, Nigg AL, Moreno S, Cerri S, Blandini F, Hoeijmakers JH, Mastroberardino PG.

Cell Rep. 2016 May 31;15(9):1866-75. doi: 10.1016/j.celrep.2016.04.071. Epub 2016 May 19.

22.

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.

Visser WE, Bombardieri CR, Zevenbergen C, Barnhoorn S, Ottaviani A, van der Pluijm I, Brandt R, Kaptein E, van Heerebeek R, van Toor H, Garinis GA, Peeters RP, Medici M, van Ham W, Vermeij WP, de Waard MC, de Krijger RR, Boelen A, Kwakkel J, Kopchick JJ, List EO, Melis JP, Darras VM, Dollé ME, van der Horst GT, Hoeijmakers JH, Visser TJ.

PLoS One. 2016 Mar 8;11(3):e0149941. doi: 10.1371/journal.pone.0149941. eCollection 2016.

23.

Altered lipid metabolism in the aging kidney identified by three layered omic analysis.

Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JH, Schumacher B, Dollé ME, Müller RU, Benzing T, Schermer B, Kurschat CE.

Aging (Albany NY). 2016 Mar;8(3):441-57.

24.

Tumor slice culture system to assess drug response of primary breast cancer.

Naipal KA, Verkaik NS, Sánchez H, van Deurzen CH, den Bakker MA, Hoeijmakers JH, Kanaar R, Vreeswijk MP, Jager A, van Gent DC.

BMC Cancer. 2016 Feb 9;16:78. doi: 10.1186/s12885-016-2119-2.

25.

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.

Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JHJ, Sung P, Wiese C, Campisi J, Cooper PK.

Mol Cell. 2016 Feb 18;61(4):535-546. doi: 10.1016/j.molcel.2015.12.026. Epub 2016 Jan 28.

26.

Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.

Vermeij WP, Hoeijmakers JH, Pothof J.

Annu Rev Pharmacol Toxicol. 2016;56:427-45. doi: 10.1146/annurev-pharmtox-010814-124316. Epub 2015 Oct 28. Review.

PMID:
26514200
27.

Phosphodiesterase 1 regulation is a key mechanism in vascular aging.

Bautista Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ.

Clin Sci (Lond). 2015 Dec;129(12):1061-75. doi: 10.1042/CS20140753. Epub 2015 Jun 25.

PMID:
26464516
28.

Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair.

Marteijn JA, Hoeijmakers JH, Vermeulen W.

Mol Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.

29.

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.

Kruiswijk F, Hasenfuss SC, Sivapatham R, Baar MP, Putavet D, Naipal KA, van den Broek NJ, Kruit W, van der Spek PJ, van Gent DC, Brenkman AB, Campisi J, Burgering BM, Hoeijmakers JH, de Keizer PL.

Oncogene. 2016 Apr 28;35(17):2166-77. doi: 10.1038/onc.2015.282. Epub 2015 Aug 17.

30.

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

31.

The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex.

Faridounnia M, Wienk H, Kovačič L, Folkers GE, Jaspers NG, Kaptein R, Hoeijmakers JH, Boelens R.

J Biol Chem. 2015 Aug 14;290(33):20541-55. doi: 10.1074/jbc.M114.635169. Epub 2015 Jun 17.

32.

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.

Naipal KA, Raams A, Bruens ST, Brandsma I, Verkaik NS, Jaspers NG, Hoeijmakers JH, van Leenders GJ, Pothof J, Kanaar R, Boormans J, van Gent DC.

PLoS One. 2015 Apr 30;10(4):e0126029. doi: 10.1371/journal.pone.0126029. eCollection 2015.

33.

Deciphering the RNA landscape by RNAome sequencing.

Derks KW, Misovic B, van den Hout MC, Kockx CE, Gomez CP, Brouwer RW, Vrieling H, Hoeijmakers JH, van IJcken WF, Pothof J.

RNA Biol. 2015;12(1):30-42. doi: 10.1080/15476286.2015.1017202.

34.

MARK-AGE biomarkers of ageing.

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.

Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24. Review.

35.

Pollitt syndrome patients carry mutation in TTDN1.

Swagemakers SM, Jaspers NG, Raams A, Heijsman D, Vermeulen W, Troelstra C, Kremer A, Lincoln SE, Tearle R, Hoeijmakers JH, van der Spek PJ.

Meta Gene. 2014 Aug 30;2:616-8. doi: 10.1016/j.mgene.2014.08.001. eCollection 2014 Dec.

36.

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J.

Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11.

37.

A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.

Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A, Hoeijmakers JH, Baarends WM, Kanaar R, Essers J.

DNA Repair (Amst). 2015 Jan;25:27-40. doi: 10.1016/j.dnarep.2014.11.002. Epub 2014 Nov 18.

PMID:
25463395
38.

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.

Barnhoorn S, Uittenboogaard LM, Jaarsma D, Vermeij WP, Tresini M, Weymaere M, Menoni H, Brandt RM, de Waard MC, Botter SM, Sarker AH, Jaspers NG, van der Horst GT, Cooper PK, Hoeijmakers JH, van der Pluijm I.

PLoS Genet. 2014 Oct 9;10(10):e1004686. doi: 10.1371/journal.pgen.1004686. eCollection 2014 Oct.

39.

Aging: not all DNA damage is equal.

Vermeij WP, Hoeijmakers JH, Pothof J.

Curr Opin Genet Dev. 2014 Jun;26:124-30. doi: 10.1016/j.gde.2014.06.006. Epub 2014 Sep 15. Review.

PMID:
25222498
40.

TTDA: big impact of a small protein.

Theil AF, Hoeijmakers JH, Vermeulen W.

Exp Cell Res. 2014 Nov 15;329(1):61-8. doi: 10.1016/j.yexcr.2014.07.008. Epub 2014 Jul 10. Review.

PMID:
25016283
41.

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.

Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, Jager A, van Gent DC.

Clin Cancer Res. 2014 Sep 15;20(18):4816-26. doi: 10.1158/1078-0432.CCR-14-0571. Epub 2014 Jun 24.

42.

Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.

Jongbloed F, de Bruin RW, Pennings JL, Payán-Gómez C, van den Engel S, van Oostrom CT, de Bruin A, Hoeijmakers JH, van Steeg H, IJzermans JN, Dollé ME.

PLoS One. 2014 Jun 24;9(6):e100853. doi: 10.1371/journal.pone.0100853. eCollection 2014.

43.

Understanding nucleotide excision repair and its roles in cancer and ageing.

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH.

Nat Rev Mol Cell Biol. 2014 Jul;15(7):465-81. doi: 10.1038/nrm3822. Review.

PMID:
24954209
44.

Priming of microglia in a DNA-repair deficient model of accelerated aging.

Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW.

Neurobiol Aging. 2014 Sep;35(9):2147-60. doi: 10.1016/j.neurobiolaging.2014.03.025. Epub 2014 Mar 28.

45.

The DNA damage response: the omics era and its impact.

Derks KW, Hoeijmakers JH, Pothof J.

DNA Repair (Amst). 2014 Jul;19:214-20. doi: 10.1016/j.dnarep.2014.03.008. Epub 2014 Apr 30. Review.

46.

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P.

PLoS One. 2014 Apr 16;9(4):e93568. doi: 10.1371/journal.pone.0093568. eCollection 2014.

47.

DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity.

van Jaarsveld MT, Wouters MD, Boersma AW, Smid M, van Ijcken WF, Mathijssen RH, Hoeijmakers JH, Martens JW, van Laere S, Wiemer EA, Pothof J.

Mol Oncol. 2014 May;8(3):458-68. doi: 10.1016/j.molonc.2013.12.011. Epub 2013 Dec 31.

48.

Aging on a different scale--chronological versus pathology-related aging.

Melis JP, Jonker MJ, Vijg J, Hoeijmakers JH, Breit TM, van Steeg H.

Aging (Albany NY). 2013 Oct;5(10):782-8.

49.

BACH2: a marker of DNA damage and ageing.

Uittenboogaard LM, Payan-Gomez C, Pothof J, van Ijcken W, Mastroberardino PG, van der Pluijm I, Hoeijmakers JH, Tresini M.

DNA Repair (Amst). 2013 Nov;12(11):982-92. doi: 10.1016/j.dnarep.2013.08.016. Epub 2013 Sep 24.

50.

DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W.

Cell Death Differ. 2013 Dec;20(12):1709-18. doi: 10.1038/cdd.2013.126. Epub 2013 Sep 6.

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