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Items: 1 to 50 of 66

1.

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, Hoehn KL.

Redox Biol. 2019 Nov 5;28:101374. doi: 10.1016/j.redox.2019.101374. [Epub ahead of print]

2.

UGCG influences glutamine metabolism of breast cancer cells.

Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS.

Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7.

3.

CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms.

Xu Y, Mak HY, Lukmantara I, Li YE, Hoehn KL, Huang X, Du X, Yang H.

J Biol Chem. 2019 Nov 8;294(45):16740-16755. doi: 10.1074/jbc.RA119.009992. Epub 2019 Sep 23.

PMID:
31548309
4.

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs.

Huo Y, Buckton LK, Bennett JL, Smith EC, Byrne FL, Hoehn KL, Rahimi MN, McAlpine SR.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):728-739. doi: 10.1080/14756366.2019.1580276.

5.

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.

Caruana BT, Byrne FL, Knights AJ, Quinlan KGR, Hoehn KL.

J Immunol. 2019 Mar 15;202(6):1826-1832. doi: 10.4049/jimmunol.1801063. Epub 2019 Jan 30.

PMID:
30700586
6.

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.

Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL Jr, Hoehn KL, Rathmell JC, Bullock TNJ.

Sci Immunol. 2019 Jan 25;4(31). pii: eaap9520. doi: 10.1126/sciimmunol.aap9520.

7.

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass.

Cantley J, Davenport A, Vetterli L, Nemes NJ, Whitworth PT, Boslem E, Thai LM, Mellett N, Meikle PJ, Hoehn KL, James DE, Biden TJ.

Diabetologia. 2019 Jan;62(1):99-111. doi: 10.1007/s00125-018-4743-7. Epub 2018 Oct 17.

8.

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth.

Byrne FL, Hargett SR, Lahiri S, Roy RJ, Berr SS, Caldwell SH, Hoehn KL.

Cancers (Basel). 2018 Sep 5;10(9). pii: E312. doi: 10.3390/cancers10090312.

9.

Defining Eosinophil Function in Adiposity and Weight Loss.

Knights AJ, Vohralik EJ, Hoehn KL, Crossley M, Quinlan KGR.

Bioessays. 2018 Oct;40(10):e1800098. doi: 10.1002/bies.201800098. Epub 2018 Aug 22. Review.

PMID:
30132936
10.

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS.

Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7.

11.

Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice.

Byrne FL, Olzomer EM, Brink R, Hoehn KL.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E286-E293. doi: 10.1152/ajpendo.00082.2018. Epub 2018 Apr 17.

12.

Analysis of the circular RNA transcriptome in endometrial cancer.

Chen BJ, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL, Janitz M.

Oncotarget. 2017 Dec 20;9(5):5786-5796. doi: 10.18632/oncotarget.23534. eCollection 2018 Jan 19.

13.

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

Burchfield JG, Kebede MA, Meoli CC, Stöckli J, Whitworth PT, Wright AL, Hoffman NJ, Minard AY, Ma X, Krycer JR, Nelson ME, Tan SX, Yau B, Thomas KC, Wee NKY, Khor EC, Enriquez RF, Vissel B, Biden TJ, Baldock PA, Hoehn KL, Cantley J, Cooney GJ, James DE, Fazakerley DJ.

J Biol Chem. 2018 Apr 13;293(15):5731-5745. doi: 10.1074/jbc.RA117.000808. Epub 2018 Feb 13.

14.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE.

Elife. 2018 Feb 6;7. pii: e32111. doi: 10.7554/eLife.32111.

15.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes.

Chaudhuri R, Krycer JR, Fazakerley DJ, Fisher-Wellman KH, Su Z, Hoehn KL, Yang JYH, Kuncic Z, Vafaee F, James DE.

Sci Rep. 2018 Jan 29;8(1):1774. doi: 10.1038/s41598-018-20104-x.

16.

Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition.

Serasinghe MN, Gelles JD, Li K, Zhao L, Abbate F, Syku M, Mohammed JN, Badal B, Rangel CA, Hoehn KL, Celebi JT, Chipuk JE.

Cell Death Dis. 2018 Jan 18;9(2):29. doi: 10.1038/s41419-017-0044-1.

17.

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE.

Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085.

18.

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential.

Childress ES, Alexopoulos SJ, Hoehn KL, Santos WL.

J Med Chem. 2018 Jun 14;61(11):4641-4655. doi: 10.1021/acs.jmedchem.7b01182. Epub 2017 Dec 8. Review.

PMID:
29156129
19.

Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer.

Chen BJ, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL, Janitz M.

Gynecol Oncol. 2017 Dec;147(3):654-662. doi: 10.1016/j.ygyno.2017.10.006. Epub 2017 Oct 17.

PMID:
29050779
20.

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS.

Endocrine. 2017 Jun;56(3):528-537. doi: 10.1007/s12020-017-1297-2. Epub 2017 Apr 12.

21.

The race to find endometrial cancer biomarkers.

Caruana BT, Hoehn KL.

Surg Obes Relat Dis. 2017 May;13(5):869-870. doi: 10.1016/j.soard.2017.01.042. Epub 2017 Feb 8. No abstract available.

PMID:
28291681
22.

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.

Nelson ME, Lahiri S, Chow JD, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, Hoehn KL.

Nat Commun. 2017 Mar 14;8:14689. doi: 10.1038/ncomms14689.

23.

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.

Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL.

Sci Rep. 2017 Mar 9;7(1):127. doi: 10.1038/s41598-017-00210-y.

24.

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis.

Laker RC, Taddeo EP, Akhtar YN, Zhang M, Hoehn KL, Yan Z.

PLoS One. 2016 Dec 22;11(12):e0167910. doi: 10.1371/journal.pone.0167910. eCollection 2016.

25.

The emerging role of long non-coding RNAs in endometrial cancer.

Takenaka K, Chen BJ, Modesitt SC, Byrne FL, Hoehn KL, Janitz M.

Cancer Genet. 2016 Oct;209(10):445-455. doi: 10.1016/j.cancergen.2016.09.005. Epub 2016 Sep 13. Review.

PMID:
27810073
26.

Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.

Narayanan S, Nieh AH, Kenwood BM, Davis CA, Tosello-Trampont AC, Elich TD, Breazeale SD, Ward E, Anderson RJ, Caldwell SH, Hoehn KL, Hahn YS.

PLoS One. 2016 Jun 9;11(6):e0156996. doi: 10.1371/journal.pone.0156996. eCollection 2016.

27.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.

Biwer LA, Taddeo EP, Kenwood BM, Hoehn KL, Straub AC, Isakson BE.

Biochim Biophys Acta. 2016 Jul;1861(7):671-9. doi: 10.1016/j.bbalip.2016.04.014. Epub 2016 Apr 19.

28.

Dietary sugar intake increases liver tumor incidence in female mice.

Healy ME, Lahiri S, Hargett SR, Chow JD, Byrne FL, Breen DS, Kenwood BM, Taddeo EP, Lackner C, Caldwell SH, Hoehn KL.

Sci Rep. 2016 Feb 29;6:22292. doi: 10.1038/srep22292.

29.

Subclassification of fatty liver by its pathogenesis: cIEFing is believing.

Byrne FL, Hoehn KL.

J Pathol. 2016 May;239(1):3-5. doi: 10.1002/path.4702. Epub 2016 Mar 30.

30.

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.

Brandon AE, Stuart E, Leslie SJ, Hoehn KL, James DE, Kraegen EW, Turner N, Cooney GJ.

J Endocrinol. 2016 Mar;228(3):127-34. doi: 10.1530/JOE-15-0444. Epub 2015 Dec 14.

31.

Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity.

Chaudhuri R, Khoo PS, Tonks K, Junutula JR, Kolumam G, Modrusan Z, Samocha-Bonet D, Meoli CC, Hocking S, Fazakerley DJ, Stöckli J, Hoehn KL, Greenfield JR, Yang JYH, James DE.

NPJ Syst Biol Appl. 2015 Nov 12;1:15010. doi: 10.1038/npjsba.2015.10. eCollection 2015.

32.

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.

Lee JE, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y.

PLoS One. 2015 Sep 14;10(9):e0137776. doi: 10.1371/journal.pone.0137776. eCollection 2015.

33.

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

Du X, Zhang Y, Jo SR, Liu X, Qi Y, Osborne B, Byrne FL, Smith GC, Turner N, Hoehn KL, Brown AJ, Yang H.

Biochem J. 2015 Oct 15;471(2):243-53. doi: 10.1042/BJ20150602. Epub 2015 Aug 17.

PMID:
26283546
34.

Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.

Kenwood BM, Calderone JA, Taddeo EP, Hoehn KL, Santos WL.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4858-4861. doi: 10.1016/j.bmcl.2015.06.040. Epub 2015 Jun 16.

35.

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice.

Hargett SR, Walker NN, Hussain SS, Hoehn KL, Keller SR.

Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E233-45. doi: 10.1152/ajpendo.00007.2015. Epub 2015 May 26.

36.

Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy.

Cronk SM, Kelly-Goss MR, Ray HC, Mendel TA, Hoehn KL, Bruce AC, Dey BK, Guendel AM, Tavakol DN, Herman IM, Peirce SM, Yates PA.

Stem Cells Transl Med. 2015 May;4(5):459-67. doi: 10.5966/sctm.2014-0108. Epub 2015 Mar 13.

37.

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.

Kashatus JA, Nascimento A, Myers LJ, Sher A, Byrne FL, Hoehn KL, Counter CM, Kashatus DF.

Mol Cell. 2015 Feb 5;57(3):537-51. doi: 10.1016/j.molcel.2015.01.002.

38.

Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.

Healy ME, Chow JD, Byrne FL, Breen DS, Leitinger N, Li C, Lackner C, Caldwell SH, Hoehn KL.

J Hepatol. 2015 Mar;62(3):599-606. doi: 10.1016/j.jhep.2014.10.024. Epub 2014 Oct 23.

39.

Metabolic vulnerabilities in endometrial cancer.

Byrne FL, Poon IK, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, Moley KH, Ravichandran KS, Slack-Davis JK, Hoehn KL.

Cancer Res. 2014 Oct 15;74(20):5832-45. doi: 10.1158/0008-5472.CAN-14-0254. Epub 2014 Sep 9.

40.

Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.

Bajwa A, Rosin DL, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey GR, Stevens BK, Jobin K, Kenwood BM, Hoehn KL, Lynch KR, Okusa MD.

J Am Soc Nephrol. 2015 Apr;26(4):908-25. doi: 10.1681/ASN.2013121351. Epub 2014 Aug 21.

41.

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL.

Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016/j.molmet.2014.02.004. eCollection 2014 Jul.

42.

A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.

Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z.

J Biol Chem. 2014 Apr 25;289(17):12005-15. doi: 10.1074/jbc.M113.530527. Epub 2014 Mar 18.

43.

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.

Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL.

Mol Metab. 2013 Nov 26;3(2):124-34. doi: 10.1016/j.molmet.2013.11.003. eCollection 2014 Apr.

44.

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL.

Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.

45.

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity.

Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y.

J Immunol. 2014 Apr 1;192(7):3190-9. doi: 10.4049/jimmunol.1302985. Epub 2014 Feb 24.

46.

Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring.

Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan Z.

Diabetes. 2014 May;63(5):1605-11. doi: 10.2337/db13-1614. Epub 2014 Jan 15.

47.

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance.

Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z.

FASEB J. 2013 Oct;27(10):4184-93. doi: 10.1096/fj.13-228486. Epub 2013 Jun 27.

48.

The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil.

Caldwell S, Hoehn KL, Hahn YS.

Hepatology. 2013 May;57(5):1684-7. doi: 10.1002/hep.26091. Epub 2012 Dec 12. No abstract available.

49.

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.

Patel SA, Hoehn KL, Lawrence RT, Sawbridge L, Talbot NA, Tomsig JL, Turner N, Cooney GJ, Whitehead JP, Kraegen EW, Cleasby ME.

Endocrinology. 2012 Nov;153(11):5231-46. doi: 10.1210/en.2012-1368. Epub 2012 Sep 18.

50.

Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer.

Modesitt SC, Hsu JY, Chowbina SR, Lawrence RT, Hoehn KL.

Int J Gynecol Cancer. 2012 Jun;22(5):732-41. doi: 10.1097/IGC.0b013e3182510496.

PMID:
22635025

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