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Items: 13


Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade.

Zboralski D, Hoehlig K, Eulberg D, Frömming A, Vater A.

Cancer Immunol Res. 2017 Nov;5(11):950-956. doi: 10.1158/2326-6066.CIR-16-0303. Epub 2017 Sep 28.


Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization.

Bujko K, Rzeszotek S, Hoehlig K, Yan J, Vater A, Ratajczak MZ.

Stem Cell Rev. 2017 Dec;13(6):793-800. doi: 10.1007/s12015-017-9769-6.


A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis.

Ajona D, Ortiz-Espinosa S, Moreno H, Lozano T, Pajares MJ, Agorreta J, Bértolo C, Lasarte JJ, Vicent S, Hoehlig K, Vater A, Lecanda F, Montuenga LM, Pio R.

Cancer Discov. 2017 Jul;7(7):694-703. doi: 10.1158/2159-8290.CD-16-1184. Epub 2017 Mar 13.


Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Yatime L, Maasch C, Hoehlig K, Klussmann S, Andersen GR, Vater A.

Nat Commun. 2015 Apr 22;6:6481. doi: 10.1038/ncomms7481.


Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.

Hoehlig K, Bethge L, Klussmann S.

PLoS One. 2015 Feb 13;10(2):e0115328. doi: 10.1371/journal.pone.0115328. eCollection 2015.


A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation.

Hoehlig K, Johnson KW, Pryazhnikov E, Maasch C, Clemens-Smith A, Purschke WG, Vauléon S, Buchner K, Jarosch F, Khiroug L, Vater A, Klussmann S.

Br J Pharmacol. 2015 Jun;172(12):3086-98. doi: 10.1111/bph.13110. Epub 2015 Mar 27.


Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis.

Purschke WG, Hoehlig K, Buchner K, Zboralski D, Schwoebel F, Vater A, Klussmann S.

Biochem J. 2014 Aug 15;462(1):153-62. doi: 10.1042/BJ20131422.


IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.

Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grützkau A, Grün JR, Horn K, Kühl AA, Dörner T, Bar-Or A, Kaufmann SHE, Anderton SM, Fillatreau S.

Nature. 2014 Mar 20;507(7492):366-370. doi: 10.1038/nature12979. Epub 2014 Feb 23.


A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis.

Hoehlig K, Maasch C, Shushakova N, Buchner K, Huber-Lang M, Purschke WG, Vater A, Klussmann S.

Mol Ther. 2013 Dec;21(12):2236-46. doi: 10.1038/mt.2013.178. Epub 2013 Jul 26.


Activation of CD4⁺ Foxp3⁺ regulatory T cells proceeds normally in the absence of B cells during EAE.

Hoehlig K, Shen P, Lampropoulou V, Roch T, Malissen B, O'Connor R, Ries S, Hilgenberg E, Anderton SM, Fillatreau S.

Eur J Immunol. 2012 May;42(5):1164-73. doi: 10.1002/eji.201142242.


Immune regulation by B cells and antibodies a view towards the clinic.

Hoehlig K, Lampropoulou V, Roch T, Neves P, Calderon-Gomez E, Anderton SM, Steinhoff U, Fillatreau S.

Adv Immunol. 2008;98:1-38. doi: 10.1016/S0065-2776(08)00401-X. Review.


TLR-activated B cells suppress T cell-mediated autoimmunity.

Lampropoulou V, Hoehlig K, Roch T, Neves P, Calderón Gómez E, Sweenie CH, Hao Y, Freitas AA, Steinhoff U, Anderton SM, Fillatreau S.

J Immunol. 2008 Apr 1;180(7):4763-73.


CD83 is a regulator of murine B cell function in vivo.

Breloer M, Kretschmer B, Lüthje K, Ehrlich S, Ritter U, Bickert T, Steeg C, Fillatreau S, Hoehlig K, Lampropoulou V, Fleischer B.

Eur J Immunol. 2007 Mar;37(3):634-48.

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