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J Clin Microbiol. 2016 Mar;54(3):798-801. doi: 10.1128/JCM.02972-15. Epub 2015 Dec 30.

Chemotherapy-Induced Intestinal Mucosal Barrier Damage: a Cause of Falsely Elevated Serum 1,3-Beta-d-Glucan Levels?

Author information

1
Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria.
2
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.
3
Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences University Hospital Leuven, Leuven, Belgium.
4
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
5
Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
6
Division of Hematology, Medical University of Graz, Graz, Austria.
7
Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria Division of Infectious Diseases, Department of Medicine, University of California, San Diego, San Diego, California, USA Division of Pulmonology, Medical University of Graz, Graz, Austria martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.

Abstract

Blood citrulline and intestinal fatty acid binding protein were determined as biomarkers for intestinal mucositis. Biomarker levels were correlated with corresponding serum 1,3-beta-D-glucan levels in 56 samples obtained from 33 cases with underlying hematological malignancies receiving induction chemotherapy. No correlation between biomarkers of intestinal mucositis and BDG levels was observed. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.).

PMID:
26719433
PMCID:
PMC4767967
DOI:
10.1128/JCM.02972-15
[Indexed for MEDLINE]
Free PMC Article

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