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Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research.

Hoeflich A, Pintar J, Forbes B.

Front Endocrinol (Lausanne). 2018 Nov 20;9:667. doi: 10.3389/fendo.2018.00667. eCollection 2018. No abstract available.


Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse.

Hesse D, Trost J, Schäfer N, Schwerbel K, Hoeflich A, Schürmann A, Brockmann GA.

Growth Factors. 2018 Apr;36(1-2):78-88. doi: 10.1080/08977194.2018.1497621.


Current IGFBP-Related Biomarker Research in Cardiovascular Disease-We Need More Structural and Functional Information in Clinical Studies.

Hoeflich A, David R, Hjortebjerg R.

Front Endocrinol (Lausanne). 2018 Jul 16;9:388. doi: 10.3389/fendo.2018.00388. eCollection 2018. Review.


Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows.

Mense K, Heidekorn-Dettmer J, Wirthgen E, Brockelmann Y, Bortfeldt R, Peter S, Jung M, Höflich C, Hoeflich A, Schmicke M.

Front Endocrinol (Lausanne). 2018 Jun 12;9:310. doi: 10.3389/fendo.2018.00310. eCollection 2018.


Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression.

Nipkow M, Wirthgen E, Luft P, Rebl A, Hoeflich A, Goldammer T.

Growth Horm IGF Res. 2018 Jun;40:32-43. doi: 10.1016/j.ghir.2018.04.003. Epub 2018 Apr 25.


Potential Functions of IGFBP-2 for Ovarian Folliculogenesis and Steroidogenesis.

Spitschak M, Hoeflich A.

Front Endocrinol (Lausanne). 2018 Apr 13;9:119. doi: 10.3389/fendo.2018.00119. eCollection 2018. Review.


Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.


Cytokines in milk and the role of TGF-beta.

Brenmoehl J, Ohde D, Wirthgen E, Hoeflich A.

Best Pract Res Clin Endocrinol Metab. 2018 Jan;32(1):47-56. doi: 10.1016/j.beem.2018.01.006. Epub 2018 Feb 2. Review.


Hormones in milk-new directions.

Hoeflich A, Kiess W.

Best Pract Res Clin Endocrinol Metab. 2018 Jan;32(1):1-3. doi: 10.1016/j.beem.2018.01.008. Epub 2018 Feb 3. No abstract available.


Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs.

Wirthgen E, Goumon S, Kunze M, Walz C, Spitschak M, Tuchscherer A, Brown J, Höflich C, Faucitano L, Hoeflich A.

Front Endocrinol (Lausanne). 2018 Feb 13;9:36. doi: 10.3389/fendo.2018.00036. eCollection 2018.


Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions.

Wirthgen E, Hoeflich A, Rebl A, Günther J.

Front Immunol. 2018 Jan 10;8:1957. doi: 10.3389/fimmu.2017.01957. eCollection 2017. Review.


Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves.

Frieten D, Gerbert C, Koch C, Dusel G, Eder K, Hoeflich A, Mielenz B, Hammon HM.

J Dairy Sci. 2018 Feb;101(2):1661-1672. doi: 10.3168/jds.2017-13603. Epub 2017 Dec 14.


Functional analysis of the IGF-system in milk.

Hoeflich A, Meyer Z.

Best Pract Res Clin Endocrinol Metab. 2017 Aug;31(4):409-418. doi: 10.1016/j.beem.2017.10.002. Epub 2017 Oct 20. Review.


Hormones in milk.

Hoeflich A, Kiess W.

Best Pract Res Clin Endocrinol Metab. 2017 Aug;31(4):363-365. doi: 10.1016/j.beem.2017.11.003. No abstract available.


Partial phenotype conversion and differential trait response to conditions of husbandry in mice.

Brenmoehl J, Walz C, Spitschak M, Wirthgen E, Walz M, Langhammer M, Tuchscherer A, Naumann R, Hoeflich A.

J Comp Physiol B. 2018 May;188(3):527-539. doi: 10.1007/s00360-017-1138-x. Epub 2017 Dec 6.


Interference of stress with the somatotropic axis in pigs - lights on new biomarkers.

Wirthgen E, Kunze M, Goumon S, Walz C, Höflich C, Spitschak M, Brenmoehl J, Kanitz E, Tuchscherer M, Otten W, Gimsa U, Schön P, Manteuffel C, Tuchscherer A, Pfuhl R, Metges CC, Stabenow B, Erdmann S, Schluricke K, Faucitano L, Hoeflich A.

Sci Rep. 2017 Sep 21;7(1):12055. doi: 10.1038/s41598-017-11521-5.


Insulin-Like Growth Factor Bioactivity, Stanniocalcin-2, Pregnancy-Associated Plasma Protein-A, and IGF-Binding Protein-4 in Pleural Fluid and Serum From Patients With Pulmonary Disease.

Espelund US, Bjerre M, Hjortebjerg R, Rasmussen TR, Lundby A, Hoeflich A, Folkersen BH, Oxvig C, Frystyk J.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3526-3534. doi: 10.1210/jc.2017-00033.


Analysis of the IGF-system in milk from farm animals - Occurrence, regulation, and biomarker potential.

Meyer Z, Höflich C, Wirthgen E, Olm S, Hammon HM, Hoeflich A.

Growth Horm IGF Res. 2017 Aug;35:1-7. doi: 10.1016/j.ghir.2017.05.004. Epub 2017 May 12. Review.


Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves.

Schäff CT, Gruse J, Maciej J, Mielenz M, Wirthgen E, Hoeflich A, Schmicke M, Pfuhl R, Jawor P, Stefaniak T, Hammon HM.

PLoS One. 2016 Dec 30;11(12):e0168974. doi: 10.1371/journal.pone.0168974. eCollection 2016.


Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour.

Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A.

Growth Horm IGF Res. 2017 Apr;33:1-8. doi: 10.1016/j.ghir.2016.11.003. Epub 2016 Nov 16.


Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.

López IP, Piñeiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG.

PLoS One. 2016 Nov 18;11(11):e0166388. doi: 10.1371/journal.pone.0166388. eCollection 2016.


Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities.

Ohde D, Brenmoehl J, Walz C, Tuchscherer A, Wirthgen E, Hoeflich A.

J Comp Physiol B. 2016 Dec;186(8):1067-1078. Epub 2016 Jun 9.


Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29.


Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice.

Brenmoehl J, Ohde D, Albrecht E, Walz C, Tuchscherer A, Hoeflich A.

J Comp Physiol B. 2017 Feb;187(2):361-373. doi: 10.1007/s00360-016-1036-7. Epub 2016 Sep 30.


Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis.

Fischer J, Ortel M, Hagmann S, Hoeflich A, Richter W.

J Cell Physiol. 2016 Dec;231(12):2673-81. doi: 10.1002/jcp.25369. Epub 2016 Mar 21.


Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice.

Kammel A, Saussenthaler S, Jähnert M, Jonas W, Stirm L, Hoeflich A, Staiger H, Fritsche A, Häring HU, Joost HG, Schürmann A, Schwenk RW.

Hum Mol Genet. 2016 Jun 15;25(12):2588-2599. Epub 2016 Apr 28.


Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone.

Ohde D, Moeller M, Brenmoehl J, Walz C, Ponsuksili S, Schwerin M, Fuellen G, Hoeflich A.

PLoS One. 2016 Jan 22;11(1):e0146748. doi: 10.1371/journal.pone.0146748. eCollection 2016.


Dynamics of Fat Mass in DUhTP Mice Selected for Running Performance - Fat Mobilization in a Walk.

Brenmoehl J, Ohde D, Walz C, Schultz J, Tuchscherer A, Rieder F, Renne U, Hoeflich A.

Obes Facts. 2015;8(6):373-85. doi: 10.1159/000442399. Epub 2015 Dec 3.


Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS.

Kunze M, Wirthgen E, Walz C, Spitschak M, Brenmoehl J, Vanselow J, Schwerin M, Wimmers K, Hoeflich A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:132-9. doi: 10.1016/j.jchromb.2015.10.010. Epub 2015 Nov 7.


Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species.

Wirthgen E, Höflich C, Spitschak M, Helmer C, Brand B, Langbein J, Metzger F, Hoeflich A.

Growth Horm IGF Res. 2016 Feb;26:42-9. doi: 10.1016/j.ghir.2015.11.001. Epub 2015 Nov 10.


Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - consensus and dissent on metabolic control and malignant potential.

Hoeflich A, Russo VC.

Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):685-700. doi: 10.1016/j.beem.2015.07.002. Epub 2015 Jul 8. Review.


Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.

Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E.

Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28.


Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy.

Meyerholz MM, Mense K, Lietzau M, Kassens A, Linden M, Knaack H, Wirthgen E, Hoeflich A, Raliou M, Richard C, Sandra O, Schuberth HJ, Hoedemaker M, Schmicke M.

J Vet Sci. 2015;16(4):413-21. doi: 10.4142/jvs.2015.16.4.413.


Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight.

Oster M, Nuchchanart W, Trakooljul N, Muráni E, Zeyner A, Wirthgen E, Hoeflich A, Ponsuksili S, Wimmers K.

Eur J Nutr. 2016 Jun;55(4):1717-27. doi: 10.1007/s00394-015-0990-2. Epub 2015 Jul 14.


The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice.

Reyer A, Schindler N, Ohde D, Walz C, Kunze M, Tuchscherer A, Wirthgen E, Brenmoehl J, Hoeflich A.

Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E409-17. doi: 10.1152/ajpendo.00168.2015. Epub 2015 Jun 23.


Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.

Simon CM, Rauskolb S, Gunnersen JM, Holtmann B, Drepper C, Dombert B, Braga M, Wiese S, Jablonka S, Pühringer D, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka KV, Sendtner M.

Acta Neuropathol. 2015 Sep;130(3):373-87. doi: 10.1007/s00401-015-1446-8. Epub 2015 May 30.


Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows.

Piechotta M, Mysegades W, Ligges U, Lilienthal J, Hoeflich A, Miyamoto A, Bollwein H.

J Dairy Sci. 2015 May;98(5):3100-9. doi: 10.3168/jds.2014-8885. Epub 2015 Feb 20.


Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif.

Wiedmer P, Schwarz F, Große B, Schindler N, Tuchscherer A, Russo VC, Tschöp MH, Hoeflich A.

J Cell Commun Signal. 2015 Jun;9(2):143-50. doi: 10.1007/s12079-015-0264-z. Epub 2015 Feb 8.


Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits.

Bielohuby M, Zarkesh-Esfahani SH, Manolopoulou J, Wirthgen E, Walpurgis K, Toghiany Khorasgani M, Aghili ZS, Wilkinson IR, Hoeflich A, Thevis M, Ross RJ, Bidlingmaier M.

Dis Model Mech. 2014 Nov;7(11):1263-73. doi: 10.1242/dmm.016519. Epub 2014 Sep 19.


Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates.

Hoeflich A, Wirthgen E, David R, Classen CF, Spitschak M, Brenmoehl J.

Front Endocrinol (Lausanne). 2014 Apr 7;5:43. doi: 10.3389/fendo.2014.00043. eCollection 2014. Review.


Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1.

Krieger F, Elflein N, Saenger S, Wirthgen E, Rak K, Frantz S, Hoeflich A, Toyka KV, Metzger F, Jablonka S.

Brain. 2014 May;137(Pt 5):1374-93. doi: 10.1093/brain/awu059. Epub 2014 Mar 27.


Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise.

Brenmoehl J, Albrecht E, Komolka K, Schering L, Langhammer M, Hoeflich A, Maak S.

Int J Biol Sci. 2014 Mar 11;10(3):338-49. doi: 10.7150/ijbs.7972. eCollection 2014.


Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows.

Laeger T, Wirthgen E, Piechotta M, Metzger F, Metges CC, Kuhla B, Hoeflich A.

J Dairy Sci. 2014 May;97(5):2876-85. doi: 10.3168/jds.2013-7671. Epub 2014 Mar 5.


Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?

Komolka K, Albrecht E, Schering L, Brenmoehl J, Hoeflich A, Maak S.

PLoS One. 2014 Jan 31;9(1):e88060. doi: 10.1371/journal.pone.0088060. eCollection 2014.


High-fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility.

Langhammer M, Michaelis M, Hoeflich A, Sobczak A, Schoen J, Weitzel JM.

Reproduction. 2014 Mar 2;147(4):427-33. doi: 10.1530/REP-13-0425. Print 2014.


Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.

Renne U, Langhammer M, Brenmoehl J, Walz C, Zeissler A, Tuchscherer A, Piechotta M, Wiesner RJ, Bielohuby M, Hoeflich A.

PLoS One. 2013 Nov 13;8(11):e79788. doi: 10.1371/journal.pone.0079788. eCollection 2013.


In silico approaches and the role of ontologies in aging research.

Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D.

Rejuvenation Res. 2013 Dec;16(6):540-6. doi: 10.1089/rej.2013.1517.


Initial characterization of an outbreed mouse model for male factor (in)fertility.

Michaelis M, Langhammer M, Hoeflich A, Reinsch N, Schoen J, Weitzel JM.

Andrology. 2013 Sep;1(5):772-8. doi: 10.1111/j.2047-2927.2013.00108.x. Epub 2013 Jul 11.


Hepatic mRNA expression of acid labile subunit and deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy.

Piechotta M, Kedves K, Araujo MG, Hoeflich A, Metzger F, Heppelmann M, Muscher-Banse A, Wrenzycki C, Pfarrer C, Schuberth HJ, Hoedemaker M, Bollwein H, Kaske M.

J Dairy Sci. 2013 Jun;96(6):3737-49. doi: 10.3168/jds.2012-6341. Epub 2013 Apr 19.

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