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Items: 1 to 50 of 176

1.

Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.

Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G.

Cardiovasc Res. 2019 May 6. pii: cvz119. doi: 10.1093/cvr/cvz119. [Epub ahead of print]

PMID:
31166588
2.

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.

Caraffini V, Geiger O, Rosenberger A, Hatzl S, Perfler B, Berg JL, Lim C, Strobl H, Kashofer K, Schauer S, Beham-Schmid C, Hoefler G, Geissler K, Quehenberger F, Kolch W, Athineos D, Blyth K, Wölfler A, Sill H, Zebisch A.

Haematologica. 2019 May 16. pii: haematol.2018.209650. doi: 10.3324/haematol.2018.209650. [Epub ahead of print]

3.

Neoplastic cell percentage estimation in tissue samples for molecular oncology: recommendations from a modified Delphi study.

Dufraing K, van Krieken JH, De Hertogh G, Hoefler G, Oniscu A, Kuhlmann TP, Weichert W, Marchiò C, Ristimäki A, Ryška A, Scoazec JY, Dequeker E.

Histopathology. 2019 May 4. doi: 10.1111/his.13891. [Epub ahead of print]

PMID:
31054167
4.

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.

Pajed L, Wagner C, Taschler U, Schreiber R, Kolleritsch S, Fawzy N, Pototschnig I, Schoiswohl G, Pusch LM, Wieser BI, Vesely P, Hoefler G, Eichmann TO, Zimmermann R, Lass A.

J Biol Chem. 2019 Jun 7;294(23):9118-9133. doi: 10.1074/jbc.RA118.007201. Epub 2019 Apr 25.

5.

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function.

Vanichkitrungruang S, Chuang CY, Hawkins CL, Hammer A, Hoefler G, Malle E, Davies MJ.

Free Radic Biol Med. 2019 May 20;136:118-134. doi: 10.1016/j.freeradbiomed.2019.04.003. Epub 2019 Apr 5.

PMID:
30959171
6.

Hedgehog pathway proteins SMO and GLI expression as prognostic markers in head and neck squamous cell carcinoma.

Richtig G, Aigelsreiter AM, Asslaber M, Weiland T, Pichler M, Eberhard K, Sygulla S, Schauer S, Hoefler G, Aigelsreiter A.

Histopathology. 2019 Jul;75(1):118-127. doi: 10.1111/his.13860. Epub 2019 May 28.

PMID:
30861166
7.

Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.

Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser BI, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G.

Hepatol Commun. 2018 Dec 17;3(2):227-245. doi: 10.1002/hep4.1292. eCollection 2019 Feb.

8.

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors.

Schwarzenbacher D, Klec C, Pasculli B, Cerk S, Rinner B, Karbiener M, Ivan C, Barbano R, Ling H, Wulf-Goldenberg A, Stanzer S, Rinnerthaler G, Stoeger H, Bauernhofer T, Haybaeck J, Hoefler G, Jahn SW, Parrella P, Calin GA, Pichler M.

Breast Cancer Res. 2019 Feb 1;21(1):20. doi: 10.1186/s13058-019-1104-5.

9.

Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.

Leopold C, Duta-Mare M, Sachdev V, Goeritzer M, Maresch LK, Kolb D, Reicher H, Wagner B, Stojakovic T, Ruelicke T, Haemmerle G, Hoefler G, Sattler W, Kratky D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):500-511. doi: 10.1016/j.bbalip.2019.01.007. Epub 2019 Jan 9.

10.

Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase.

Nybo T, Dieterich S, Gamon LF, Chuang CY, Hammer A, Hoefler G, Malle E, Rogowska-Wrzesinska A, Davies MJ.

Redox Biol. 2019 Jan;20:496-513. doi: 10.1016/j.redox.2018.10.022. Epub 2018 Nov 3.

11.

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

Al-Zoughbi W, Schauer S, Pichler M, Hoefler G.

Pathobiology. 2018;85(5-6):342-347. doi: 10.1159/000492433. Epub 2018 Sep 18.

12.

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, Graier WF, Madl T, Vander Heiden MG, Bogner-Strauss JG.

Cell Metab. 2018 Nov 6;28(5):706-720.e6. doi: 10.1016/j.cmet.2018.07.021. Epub 2018 Aug 16.

13.

Atypical "hairy cell-like" presentation of leukemic mantle cell lymphoma.

Robier C, Hoefler G, Egger M, Hubmann E.

Clin Chem Lab Med. 2018 Dec 19;57(2):e34-e36. doi: 10.1515/cclm-2018-0633. No abstract available.

PMID:
30032129
14.

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration.

Caraffini V, Perfler B, Berg JL, Uhl B, Schauer S, Kashofer K, Ghaffari-Tabrizi-Wizsy N, Strobl H, Wölfler A, Hoefler G, Sill H, Zebisch A.

Blood. 2018 Feb 15;131(7):826-830. doi: 10.1182/blood-2017-09-804906. Epub 2018 Jan 2. No abstract available.

15.

Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function.

Degendorfer G, Chuang CY, Mariotti M, Hammer A, Hoefler G, Hägglund P, Malle E, Wise SG, Davies MJ.

Free Radic Biol Med. 2018 Feb 1;115:219-231. doi: 10.1016/j.freeradbiomed.2017.11.019. Epub 2017 Nov 27.

PMID:
29191462
16.

Next-Generation Sequencing in Diagnostics and Clinical Research.

Hoefler G.

Pathobiology. 2017;84(6):289-291. doi: 10.1159/000485366. Epub 2017 Dec 12. No abstract available.

17.

SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.

Richtig G, Aigelsreiter A, Schwarzenbacher D, Ress AL, Adiprasito JB, Stiegelbauer V, Hoefler G, Schauer S, Kiesslich T, Kornprat P, Winder T, Eisner F, Gerger A, Stoeger H, Stauber R, Lackner C, Pichler M.

PLoS One. 2017 Nov 9;12(11):e0187814. doi: 10.1371/journal.pone.0187814. eCollection 2017.

18.

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia.

Gaksch L, Kashofer K, Heitzer E, Quehenberger F, Daga S, Hofer S, Halbwedl I, Graf R, Krisper N, Hoefler G, Zebisch A, Sill H, Wölfler A.

Am J Hematol. 2018 Jan;93(1):23-30. doi: 10.1002/ajh.24922. Epub 2017 Oct 19.

19.

Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.

Edlinger L, Berger-Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, Bago-Horvath Z, Al-Zoughbi W, Hoefler G, Brostjan C, Gille L, Moriggl R, Spittler A, Sexl V, Hoelbl-Kovacic A.

Br J Haematol. 2017 Oct;179(2):229-241. doi: 10.1111/bjh.14833. Epub 2017 Jul 14.

20.

Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing.

Kashofer K, Gornicec M, Lind K, Caraffini V, Schauer S, Beham-Schmid C, Wölfler A, Hoefler G, Sill H, Zebisch A.

Leuk Lymphoma. 2018 Feb;59(2):501-504. doi: 10.1080/10428194.2017.1339879. Epub 2017 Jun 20. No abstract available.

21.

APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.

Pessentheiner AR, Huber K, Pelzmann HJ, Prokesch A, Radner FPW, Wolinski H, Lindroos-Christensen J, Hoefler G, Rülicke T, Birner-Gruenberger R, Bilban M, Bogner-Strauss JG.

FASEB J. 2017 Sep;31(9):4088-4103. doi: 10.1096/fj.201601337R. Epub 2017 May 30.

22.

miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.

Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, Pehserl AM, Reicher A, Resel M, Heitzer E, Ivan C, Bullock M, Ling H, Deutsch A, Wulf-Goldenberg A, Adiprasito JB, Stoeger H, Haybaeck J, Svoboda M, Stotz M, Hoefler G, Slaby O, Calin GA, Gerger A, Pichler M.

Clin Cancer Res. 2017 Sep 1;23(17):5255-5266. doi: 10.1158/1078-0432.CCR-17-0023. Epub 2017 May 22.

23.

Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer.

El-Heliebi A, Kashofer K, Fuchs J, Jahn SW, Viertler C, Matak A, Sedlmayr P, Hoefler G.

Histochem Cell Biol. 2017 Aug;148(2):105-115. doi: 10.1007/s00418-017-1557-5. Epub 2017 Mar 20.

24.

Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia.

Lal R, Lind K, Heitzer E, Ulz P, Aubell K, Kashofer K, Middeke JM, Thiede C, Schulz E, Rosenberger A, Hofer S, Feilhauer B, Rinner B, Svendova V, Schimek MG, Rücker FG, Hoefler G, Döhner K, Zebisch A, Wölfler A, Sill H.

Blood. 2017 May 4;129(18):2587-2591. doi: 10.1182/blood-2016-11-751008. Epub 2017 Mar 3. No abstract available.

25.

The TP53 Pro72Arg SNP in de novo acute myeloid leukaemia - results of two cohort studies involving 215 patients and 3759 controls.

Schulz E, Lind K, Renner W, Petersen BS, Quehenberger F, Dill C, Hofer S, Lal R, Hoefler G, Schlenke P, Ehninger G, Schetelig J, Middeke JM, Stölzel F, Sill H.

Br J Haematol. 2018 Apr;181(1):148-151. doi: 10.1111/bjh.14527. Epub 2017 Jan 20. No abstract available.

PMID:
28106906
26.

Testing and clinical implications for non-V600 BRAF mutations in metastatic NRASmt melanoma.

Richtig G, Richtig E, Kashofer K, Koch L, Winter G, Hoefler G, Pichler M, Ehall B, Grübler MR, Heinemann A, Aigelsreiter A.

Br J Dermatol. 2017 Sep;177(3):860-861. doi: 10.1111/bjd.15222. Epub 2017 Jul 21. No abstract available.

PMID:
27925152
27.

KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients.

Kammerer S, Sokolowski A, Hackl H, Platzer D, Jahn SW, El-Heliebi A, Schwarzenbacher D, Stiegelbauer V, Pichler M, Rezania S, Fiegl H, Peintinger F, Regitnig P, Hoefler G, Schreibmayer W, Bauernhofer T.

Oncotarget. 2016 Dec 20;7(51):84705-84717. doi: 10.18632/oncotarget.13224.

28.

Integrated line-by-line optical pulse shaper for high-fidelity and rapidly reconfigurable RF-filtering.

Metcalf AJ, Kim HJ, Leaird DE, Jaramillo-Villegas JA, McKinzie KA, Lal V, Hosseini A, Hoefler GE, Kish F, Weiner AM.

Opt Express. 2016 Oct 17;24(21):23925-23940. doi: 10.1364/OE.24.023925.

PMID:
27828227
29.

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.

Grond S, Radner FPW, Eichmann TO, Kolb D, Grabner GF, Wolinski H, Gruber R, Hofer P, Heier C, Schauer S, Rülicke T, Hoefler G, Schmuth M, Elias PM, Lass A, Zechner R, Haemmerle G.

J Invest Dermatol. 2017 Feb;137(2):403-413. doi: 10.1016/j.jid.2016.09.025. Epub 2016 Oct 7.

30.

Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

Pichler M, Stiegelbauer V, Vychytilova-Faltejskova P, Ivan C, Ling H, Winter E, Zhang X, Goblirsch M, Wulf-Goldenberg A, Ohtsuka M, Haybaeck J, Svoboda M, Okugawa Y, Gerger A, Hoefler G, Goel A, Slaby O, Calin GA.

Clin Cancer Res. 2017 Mar 1;23(5):1323-1333. doi: 10.1158/1078-0432.CCR-16-0497. Epub 2016 Sep 6.

31.

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.

Cancer Cell. 2016 Aug 8;30(2):359-360. doi: 10.1016/j.ccell.2016.07.003. Epub 2016 Aug 8. No abstract available.

32.

Tumour heterogeneity: principles and practical consequences.

Stanta G, Jahn SW, Bonin S, Hoefler G.

Virchows Arch. 2016 Oct;469(4):371-84. doi: 10.1007/s00428-016-1987-9. Epub 2016 Jul 13. Review.

PMID:
27412632
33.

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.

Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1132-1141. doi: 10.1016/j.bbalip.2016.06.014. Epub 2016 Jun 23.

34.

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

Ulz P, Belic J, Graf R, Auer M, Lafer I, Fischereder K, Webersinke G, Pummer K, Augustin H, Pichler M, Hoefler G, Bauernhofer T, Geigl JB, Heitzer E, Speicher MR.

Nat Commun. 2016 Jun 22;7:12008. doi: 10.1038/ncomms12008.

35.

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.

Al-Zoughbi W, Pichler M, Gorkiewicz G, Guertl-Lackner B, Haybaeck J, Jahn SW, Lackner C, Liegl-Atzwanger B, Popper H, Schauer S, Nusshold E, Kindt AS, Trajanoski Z, Speicher MR, Haemmerle G, Zimmermann R, Zechner R, Vesely PW, Hoefler G.

Oncotarget. 2016 Jun 7;7(23):33832-40. doi: 10.18632/oncotarget.9418.

36.

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

Huang J, Li L, Lian J, Schauer S, Vesely PW, Kratky D, Hoefler G, Lehner R.

Cell Rep. 2016 Apr 12;15(2):336-48. doi: 10.1016/j.celrep.2016.03.020. Epub 2016 Mar 31.

37.

Serotonin signalling is crucial in the induction of PUVA-induced systemic suppression of delayed-type hypersensitivity but not local apoptosis or inflammation of the skin.

Wolf P, Byrne SN, Limon-Flores AY, Hoefler G, Ullrich SE.

Exp Dermatol. 2016 Jul;25(7):537-43. doi: 10.1111/exd.12990. Epub 2016 Apr 18.

38.

A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.

Bonin S, Donada M, Bussolati G, Nardon E, Annaratone L, Pichler M, Chiaravalli AM, Capella C, Hoefler G, Stanta G.

Tumour Biol. 2016 Jun;37(6):7295-303. doi: 10.1007/s13277-015-4543-3. Epub 2015 Dec 15.

PMID:
26666825
39.

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.

Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D.

Atherosclerosis. 2016 Jan;244:9-21. doi: 10.1016/j.atherosclerosis.2015.10.109. Epub 2015 Nov 2.

40.

Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia.

Geiger O, Hatzl S, Kashofer K, Hoefler G, Wölfler A, Sill H, Zebisch A.

Ann Hematol. 2015 Nov;94(11):1923-4. doi: 10.1007/s00277-015-2445-5. Epub 2015 Jul 25. No abstract available.

41.

Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.

Das SK, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, Zechner R, Hoefler G, Vesely PW.

Int J Mol Sci. 2015 Apr 16;16(4):8555-68. doi: 10.3390/ijms16048555.

42.

Low spinophilin expression enhances aggressive biological behavior of breast cancer.

Schwarzenbacher D, Stiegelbauer V, Deutsch A, Ress AL, Aigelsreiter A, Schauer S, Wagner K, Langsenlehner T, Resel M, Gerger A, Ling H, Ivan C, Calin GA, Hoefler G, Rinner B, Pichler M.

Oncotarget. 2015 May 10;6(13):11191-202.

43.

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Hoffmann J, Marsh LM, Pieper M, Stacher E, Ghanim B, Kovacs G, König P, Wilkens H, Haitchi HM, Hoefler G, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1002-13. doi: 10.1152/ajplung.00383.2014. Epub 2015 Apr 3.

44.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.

Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock M, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose J, Packham G, Liu K, Bojja K, Gafà R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S, Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami A, Calin GA, Nicoloso MS.

Gut. 2016 Jun;65(6):977-989. doi: 10.1136/gutjnl-2015-309372. Epub 2015 Mar 24.

45.

Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis.

Jahn SW, Kashofer K, Halbwedl I, Winter G, El-Shabrawi-Caelen L, Mentzel T, Hoefler G, Liegl-Atzwanger B.

Mod Pathol. 2015 Jul;28(7):895-903. doi: 10.1038/modpathol.2015.39. Epub 2015 Mar 13.

46.

Report from the OECI Oncology Days 2014.

van Harten W, Stanta G, Bussolati G, Riegman P, Hoefler G, Becker K, Folprecht G, Truini M, Haybaeck J, Buiga R, Dono M, Bagg A, López Guerrero J, Zupo S, Lemare F, de Lorenzo F, Goedbloed N, Razavi D, Lövey J, Cadariu P, Rollandi G, Paparo F, Pierotti M, Ciuleanu T, De Paoli P, Weiner G, Saghatchian M, Lombardo C.

Ecancermedicalscience. 2014 Dec 31;8:496. doi: 10.3332/ecancer.2014.496. eCollection 2014.

47.

A stress-induced early innate response causes multidrug tolerance in melanoma.

Menon DR, Das S, Krepler C, Vultur A, Rinner B, Schauer S, Kashofer K, Wagner K, Zhang G, Rad EB, Haass NK, Soyer HP, Gabrielli B, Somasundaram R, Hoefler G, Herlyn M, Schaider H.

Oncogene. 2015 Aug 20;34(34):4545. doi: 10.1038/onc.2014.432. Epub 2015 Jan 26.

PMID:
25619837
48.

A stress-induced early innate response causes multidrug tolerance in melanoma.

Ravindran Menon D, Das S, Krepler C, Vultur A, Rinner B, Schauer S, Kashofer K, Wagner K, Zhang G, Bonyadi Rad E, Haass NK, Soyer HP, Gabrielli B, Somasundaram R, Hoefler G, Herlyn M, Schaider H.

Oncogene. 2015 Aug 20;34(34):4448-59. doi: 10.1038/onc.2014.372. Epub 2014 Nov 24. Erratum in: Oncogene. 2015 Aug 20;34(34):4545.

49.

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer.

Stotz M, Szkandera J, Stojakovic T, Seidel J, Samonigg H, Kornprat P, Schaberl-Moser R, Seggewies F, Hoefler G, Gerger A, Pichler M.

Clin Chem Lab Med. 2015 Feb;53(3):499-506. doi: 10.1515/cclm-2014-0447.

PMID:
25389993
50.

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Boland CR, Kumanogoh A, Sill H.

Nat Commun. 2014 Oct 13;5:5191. doi: 10.1038/ncomms6191.

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