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Items: 8


The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition.

Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P.

Nucleic Acids Res. 2020 Feb 22. pii: gkaa109. doi: 10.1093/nar/gkaa109. [Epub ahead of print]


Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus.

Manfiolli AO, Siqueira FS, Dos Reis TF, Van Dijck P, Schrevens S, Hoefgen S, Föge M, Straßburger M, de Assis LJ, Heinekamp T, Rocha MC, Janevska S, Brakhage AA, Malavazi I, Goldman GH, Valiante V.

mBio. 2019 Mar 26;10(2). pii: e00215-19. doi: 10.1128/mBio.00215-19.


Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi.

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V.

Metab Eng. 2018 Jul;48:44-51. doi: 10.1016/j.ymben.2018.05.014. Epub 2018 May 26.


The amyloid precursor protein shows a pH-dependent conformational switch in its E1 domain.

Hoefgen S, Dahms SO, Oertwig K, Than ME.

J Mol Biol. 2015 Jan 30;427(2):433-42. doi: 10.1016/j.jmb.2014.12.005. Epub 2014 Dec 17.


Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.

Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms SO, Than ME.

J Struct Biol. 2014 Jul;187(1):30-37. doi: 10.1016/j.jsb.2014.05.006. Epub 2014 May 22.


The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture.

Coburger I, Hoefgen S, Than ME.

Biol Chem. 2014 May;395(5):485-98. doi: 10.1515/hsz-2013-0280. Review.


The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain.

Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR.

PLoS One. 2013 Aug 19;8(8):e72177. doi: 10.1371/journal.pone.0072177. eCollection 2013.


Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5381-6. doi: 10.1073/pnas.0911326107. Epub 2010 Mar 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2629.

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