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Items: 1 to 50 of 160

1.

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer.

Martin NT, Roy DG, Workenhe ST, van den Wollenberg DJM, Hoeben RC, Mossman KL, Bell JC, Bourgeois-Daigneault MC.

Sci Rep. 2019 Feb 12;9(1):1865. doi: 10.1038/s41598-018-38385-7.

2.

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

Eggers R, de Winter F, Hoyng SA, Hoeben RC, Malessy MJA, Tannemaat MR, Verhaagen J.

Brain. 2019 Feb 1;142(2):295-311. doi: 10.1093/brain/awy340.

PMID:
30649249
3.

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Kracht MJL, de Koning EJP, Hoeben RC, Roep BO, Zaldumbide A.

Sci Rep. 2018 Dec 10;8(1):17738. doi: 10.1038/s41598-018-36142-4.

4.

Arming oncolytic reovirus with GM-CSF gene to enhance immunity.

Kemp V, van den Wollenberg DJM, Camps MGM, van Hall T, Kinderman P, Pronk-van Montfoort N, Hoeben RC.

Cancer Gene Ther. 2018 Nov 23. doi: 10.1038/s41417-018-0063-9. [Epub ahead of print]

PMID:
30467340
5.

An Adaptable Platform for Directed Evolution in Human Cells.

Berman C, Papa LJ, Hendel SJ, Moore CL, Suen PH, Weickhardt AF, Doan ND, Kumar CM, Uil TG, Butty VL, Hoeben RC, Shoulders MD.

J Am Chem Soc. 2018 Nov 14. doi: 10.1021/jacs.8b10937. [Epub ahead of print]

PMID:
30427676
6.

Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy.

Berkeley RA, Steele LP, Mulder AA, van den Wollenberg DJM, Kottke TJ, Thompson J, Coffey M, Hoeben RC, Vile RG, Melcher A, Ilett EJ.

Cancer Immunol Res. 2018 Oct;6(10):1161-1173. doi: 10.1158/2326-6066.CIR-18-0309. Epub 2018 Sep 12.

PMID:
30209061
7.

Characterization of a replicating expanded tropism oncolytic reovirus carrying the adenovirus E4orf4 gene.

Kemp V, Dautzenberg IJC, Cramer SJ, Hoeben RC, van den Wollenberg DJM.

Gene Ther. 2018 Aug;25(5):331-344. doi: 10.1038/s41434-018-0032-9. Epub 2018 Jul 16.

PMID:
30013187
8.

Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot.

Messemaker TC, van Leeuwen SM, van den Berg PR, 't Jong AEJ, Palstra RJ, Hoeben RC, Semrau S, Mikkers HMM.

Sci Rep. 2018 Jan 10;8(1):386. doi: 10.1038/s41598-017-18649-4.

9.

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

Döhner K, Ramos-Nascimento A, Bialy D, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hügel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B.

PLoS Pathog. 2018 Jan 5;14(1):e1006823. doi: 10.1371/journal.ppat.1006823. eCollection 2018 Jan.

10.

Baculovirus-assisted Reovirus Infection in Monolayer and Spheroid Cultures of Glioma cells.

Dautzenberg IJC, van den Hengel SK, de Vrij J, Ravesloot L, Cramer SJ, Hong SS, van den Wollenberg DJM, Boulanger P, Hoeben RC.

Sci Rep. 2017 Dec 15;7(1):17654. doi: 10.1038/s41598-017-17709-z.

11.

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure.

Gram AM, Sun C, Landman SL, Oosenbrug T, Koppejan HJ, Kwakkenbos MJ, Hoeben RC, Paludan SR, Ressing ME.

Mol Immunol. 2017 Nov;91:225-237. doi: 10.1016/j.molimm.2017.08.025. Epub 2017 Sep 30.

12.

Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery.

Kemp V, Dautzenberg IJC, Limpens RW, van den Wollenberg DJM, Hoeben RC.

Viruses. 2017 Sep 21;9(10). pii: E266. doi: 10.3390/v9100266.

13.

Herpesvirus microRNAs for use in gene therapy immune-evasion strategies.

Bots STF, Hoeben RC.

Gene Ther. 2017 Jul;24(7):385-391. doi: 10.1038/gt.2017.37. Epub 2017 May 9. Review.

PMID:
28485720
14.

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.

Kracht MJ, van Lummel M, Nikolic T, Joosten AM, Laban S, van der Slik AR, van Veelen PA, Carlotti F, de Koning EJ, Hoeben RC, Zaldumbide A, Roep BO.

Nat Med. 2017 Apr;23(4):501-507. doi: 10.1038/nm.4289. Epub 2017 Feb 27.

PMID:
28263308
15.

Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice.

Eby JM, Barse L, Henning SW, Rabelink MJ, Klarquist J, Gilbert ER, Hammer AM, Fernandez MF, Yung N, Khan S, Miller HG, Kessler ER, Garrett-Mayer E, Dilling DF, Hoeben RC, Le Poole IC.

Cancer Immunol Immunother. 2017 Jan;66(1):63-75. doi: 10.1007/s00262-016-1920-8. Epub 2016 Oct 27.

PMID:
27787577
16.

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells.

Gram AM, Oosenbrug T, Lindenbergh MF, Büll C, Comvalius A, Dickson KJ, Wiegant J, Vrolijk H, Lebbink RJ, Wolterbeek R, Adema GJ, Griffioen M, Heemskerk MH, Tscharke DC, Hutt-Fletcher LM, Wiertz EJ, Hoeben RC, Ressing ME.

PLoS Pathog. 2016 Apr 14;12(4):e1005550. doi: 10.1371/journal.ppat.1005550. eCollection 2016 Apr.

17.

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus.

Kemp V, Hoeben RC, van den Wollenberg DJ.

Viruses. 2015 Dec 24;8(1). pii: E4. doi: 10.3390/v8010004. Review.

18.

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.

Hoelen H, Zaldumbide A, van Leeuwen WF, Torfs EC, Engelse MA, Hassan C, Lebbink RJ, de Koning EJ, Resssing ME, de Ru AH, van Veelen PA, Hoeben RC, Roep BO, Wiertz EJ.

PLoS One. 2015 Jun 24;10(6):e0128206. doi: 10.1371/journal.pone.0128206. eCollection 2015.

19.

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.

Kerkman PF, Fabre E, van der Voort EI, Zaldumbide A, Rombouts Y, Rispens T, Wolbink G, Hoeben RC, Spits H, Baeten DL, Huizinga TW, Toes RE, Scherer HU.

Ann Rheum Dis. 2016 Jun;75(6):1170-6. doi: 10.1136/annrheumdis-2014-207182. Epub 2015 Jun 1.

PMID:
26034045
20.

Replicating reoviruses with a transgene replacing the codons for the head domain of the viral spike.

van den Wollenberg DJ, Dautzenberg IJ, Ros W, Lipińska AD, van den Hengel SK, Hoeben RC.

Gene Ther. 2015 Mar;22(3):267-79. doi: 10.1038/gt.2014.126. Epub 2015 Jan 15.

PMID:
25588743
21.

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.

Rombouts Y, Willemze A, van Beers JJ, Shi J, Kerkman PF, van Toorn L, Janssen GM, Zaldumbide A, Hoeben RC, Pruijn GJ, Deelder AM, Wolbink G, Rispens T, van Veelen PA, Huizinga TW, Wuhrer M, Trouw LA, Scherer HU, Toes RE.

Ann Rheum Dis. 2016 Mar;75(3):578-85. doi: 10.1136/annrheumdis-2014-206598. Epub 2015 Jan 13.

PMID:
25587188
22.

Off-label prescription of genetically modified organism medicines in europe: emerging conflicts of interest?

Schagen FH, Hoeben RC, Hospers GA.

Hum Gene Ther. 2014 Oct;25(10):893-6. doi: 10.1089/hum.2014.090. Review.

PMID:
25268158
23.

Cell replacement therapies: is it time to reprogram?

Mikkers HM, Freund C, Mummery CL, Hoeben RC.

Hum Gene Ther. 2014 Oct;25(10):866-74. doi: 10.1089/hum.2014.097. Epub 2014 Sep 17. Review. Erratum in: Hum Gene Ther. 2014 Dec;25(12):1061.

24.

Changing faces in virology: the dutch shift from oncogenic to oncolytic viruses.

Belcaid Z, Lamfers ML, van Beusechem VW, Hoeben RC.

Hum Gene Ther. 2014 Oct;25(10):875-84. doi: 10.1089/hum.2014.092. Epub 2014 Sep 17. Review.

25.

Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma.

Balvers RK, Belcaid Z, van den Hengel SK, Kloezeman J, de Vrij J, Wakimoto H, Hoeben RC, Debets R, Leenstra S, Dirven C, Lamfers ML.

Viruses. 2014 Aug 12;6(8):3080-96. doi: 10.3390/v6083080.

26.

Successful RAG1-SCID gene therapy depends on the level of RAG1 expression.

Pike-Overzet K, Baum C, Bredius RG, Cavazzana M, Driessen GJ, Fibbe WE, Gaspar HB, Hoeben RC, Lagresle-Peyrou C, Lankester A, Meij P, Schambach A, Thrasher A, Van Dongen JJ, Zwaginga JJ, Staal FJ.

J Allergy Clin Immunol. 2014 Jul;134(1):242-3. doi: 10.1016/j.jaci.2014.04.033. Epub 2014 Jun 26. No abstract available.

PMID:
25117803
27.

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies.

Suurmond J, Rivellese F, Dorjée AL, Bakker AM, Rombouts YJ, Rispens T, Wolbink G, Zaldumbide A, Hoeben RC, Huizinga TW, Toes RE.

Ann Rheum Dis. 2015 Oct;74(10):1915-23. doi: 10.1136/annrheumdis-2014-205562. Epub 2014 May 12.

PMID:
24818634
28.

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ.

Nat Commun. 2014 May 8;5:3832. doi: 10.1038/ncomms4832.

29.

Optimizing reporter constructs for in vivo bioluminescence imaging of interferon-γ stimulated mesenchymal stromal cells.

Perez-Galarza J, Carlotti F, Rabelink MJ, Cramer S, Hoeben RC, Fibbe WE, van Pel M.

Exp Hematol. 2014 Sep;42(9):793-803.e1. doi: 10.1016/j.exphem.2014.04.004. Epub 2014 Apr 15.

PMID:
24746876
30.

Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A.

Dautzenberg IJ, van den Wollenberg DJ, van den Hengel SK, Limpens RW, Bárcena M, Koster AJ, Hoeben RC.

Gene Ther. 2014 Jun;21(6):609-17. doi: 10.1038/gt.2014.34. Epub 2014 Apr 17.

PMID:
24739522
31.

Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve.

Hoyng SA, Gnavi S, de Winter F, Eggers R, Ozawa T, Zaldumbide A, Hoeben RC, Malessy MJ, Verhaagen J.

Gene Ther. 2014 Jun;21(6):549-57. doi: 10.1038/gt.2014.22. Epub 2014 Apr 3.

PMID:
24694534
32.

Biosafety of non-human therapeutic viruses in clinical gene therapy.

Hoeben RC, Louz D, Koppers-Lalic D.

Curr Gene Ther. 2013 Dec;13(6):492-9. Review.

PMID:
24397530
33.

Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

Blumensatt M, Wronkowitz N, Wiza C, Cramer A, Mueller H, Rabelink MJ, Hoeben RC, Eckel J, Sell H, Ouwens DM.

Biochim Biophys Acta. 2014 Feb;1842(2):275-83. doi: 10.1016/j.bbadis.2013.12.001. Epub 2013 Dec 9.

34.

New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation.

Oliveira CC, Querido B, Sluijter M, de Groot AF, van der Zee R, Rabelink MJ, Hoeben RC, Ossendorp F, van der Burg SH, van Hall T.

J Immunol. 2013 Oct 15;191(8):4020-8. doi: 10.4049/jimmunol.1301496. Epub 2013 Sep 18.

35.

Heterogeneous reovirus susceptibility in human glioblastoma stem-like cell cultures.

van den Hengel SK, Balvers RK, Dautzenberg IJ, van den Wollenberg DJ, Kloezeman JJ, Lamfers ML, Sillivis-Smit PA, Hoeben RC.

Cancer Gene Ther. 2013 Sep;20(9):507-13. doi: 10.1038/cgt.2013.47. Epub 2013 Aug 2.

PMID:
23907517
36.

Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143.

Blumensatt M, Greulich S, Herzfeld de Wiza D, Mueller H, Maxhera B, Rabelink MJ, Hoeben RC, Akhyari P, Al-Hasani H, Ruige JB, Ouwens DM.

Cardiovasc Res. 2013 Nov 1;100(2):201-10. doi: 10.1093/cvr/cvt173. Epub 2013 Jun 28.

PMID:
23812417
37.

Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo.

Zaldumbide A, Alkemade G, Carlotti F, Nikolic T, Abreu JR, Engelse MA, Skowera A, de Koning EJ, Peakman M, Roep BO, Hoeben RC, Wiertz EJ.

Mol Ther. 2013 Aug;21(8):1592-601. doi: 10.1038/mt.2013.105. Epub 2013 May 21.

38.

Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth.

Dambrot C, van de Pas S, van Zijl L, Brändl B, Wang JW, Schalij MJ, Hoeben RC, Atsma DE, Mikkers HM, Mummery CL, Freund C.

Differentiation. 2013 Feb;85(3):101-9. doi: 10.1016/j.diff.2013.01.001. Epub 2013 May 7.

PMID:
23665895
39.

Conversion of mature human β-cells into glucagon-producing α-cells.

Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ.

Diabetes. 2013 Jul;62(7):2471-80. doi: 10.2337/db12-1001. Epub 2013 Apr 8.

40.

Adenovirus DNA replication.

Hoeben RC, Uil TG.

Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a013003. doi: 10.1101/cshperspect.a013003. Review.

41.

Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.

Zaldumbide A, Carlotti F, Gonçalves MA, Knaän-Shanzer S, Cramer SJ, Roep BO, Wiertz EJ, Hoeben RC.

PLoS One. 2012;7(10):e48093. doi: 10.1371/journal.pone.0048093. Epub 2012 Oct 26.

42.

Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

van den Wollenberg DJ, Dautzenberg IJ, van den Hengel SK, Cramer SJ, de Groot RJ, Hoeben RC.

PLoS One. 2012;7(10):e48064. doi: 10.1371/journal.pone.0048064. Epub 2012 Oct 24.

43.

Animal models in virus research: their utility and limitations.

Louz D, Bergmans HE, Loos BP, Hoeben RC.

Crit Rev Microbiol. 2013 Nov;39(4):325-61. doi: 10.3109/1040841X.2012.711740. Epub 2012 Sep 14. Review.

PMID:
22978742
44.

[Stem cells: therapeutic applications and experimental techniques].

Mikkers HM, Hoeben RC.

Ned Tijdschr Geneeskd. 2011;155(47):A3565. Review. Dutch.

PMID:
22129808
45.

The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses.

Durupt F, Koppers-Lalic D, Balme B, Budel L, Terrier O, Lina B, Thomas L, Hoeben RC, Rosa-Calatrava M.

Cancer Gene Ther. 2012 Jan;19(1):58-68. doi: 10.1038/cgt.2011.68. Epub 2011 Oct 21.

PMID:
22015640
46.

A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction.

de Vrij J, Dautzenberg IJ, van den Hengel SK, Magnusson MK, Uil TG, Cramer SJ, Vellinga J, Verissimo CS, Lindholm L, Koppers-Lalic D, Hoeben RC.

Gene Ther. 2012 Sep;19(9):899-906. doi: 10.1038/gt.2011.162. Epub 2011 Oct 20.

PMID:
22011643
47.

β-Cell Generation: Can Rodent Studies Be Translated to Humans?

Carlotti F, Zaldumbide A, Ellenbroek JH, Spijker HS, Hoeben RC, de Koning EJ.

J Transplant. 2011;2011:892453. doi: 10.1155/2011/892453. Epub 2011 Oct 5.

48.

A transductionally retargeted adenoviral vector for virotherapy of Her2/neu-expressing prostate cancer.

Magnusson MK, Kraaij R, Leadley RM, De Ridder CM, van Weerden WM, Van Schie KA, Van der Kroeg M, Hoeben RC, Maitland NJ, Lindholm L.

Hum Gene Ther. 2012 Jan;23(1):70-82. doi: 10.1089/hum.2011.016. Epub 2011 Oct 12.

49.

Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.

Pike-Overzet K, Rodijk M, Ng YY, Baert MR, Lagresle-Peyrou C, Schambach A, Zhang F, Hoeben RC, Hacein-Bey-Abina S, Lankester AC, Bredius RG, Driessen GJ, Thrasher AJ, Baum C, Cavazzana-Calvo M, van Dongen JJ, Staal FJ.

Leukemia. 2011 Sep;25(9):1471-83. doi: 10.1038/leu.2011.106. Epub 2011 May 27.

PMID:
21617701
50.

Non-human viruses developed as therapeutic agent for use in humans.

Koppers-Lalic D, Hoeben RC.

Rev Med Virol. 2011 Jul;21(4):227-39. doi: 10.1002/rmv.694. Epub 2011 May 11. Review.

PMID:
21560181

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