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Items: 1 to 50 of 84

1.

Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.

Sliz A, Locker KCS, Lampe K, Godarova A, Plas DR, Janssen EM, Jones H, Herr AB, Hoebe K.

Sci Immunol. 2019 Aug 2;4(38). pii: eaav3866. doi: 10.1126/sciimmunol.aav3866.

PMID:
31375526
2.

Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4+ T-cell development and allergic airway disease.

Patterson AR, Bolcas P, Lampe K, Cantrell R, Ruff B, Lewkowich I, Hogan SP, Janssen EM, Bleesing J, Khurana Hershey GK, Hoebe K.

J Allergy Clin Immunol. 2019 Jan;143(1):245-257.e6. doi: 10.1016/j.jaci.2018.10.018. Epub 2018 Oct 25.

PMID:
30616774
3.

The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment.

Agresta L, Hoebe KHN, Janssen EM.

Front Immunol. 2018 Nov 28;9:2809. doi: 10.3389/fimmu.2018.02809. eCollection 2018. Review.

4.

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S.

JCI Insight. 2018 Mar 22;3(6). pii: 93626. doi: 10.1172/jci.insight.93626.

5.

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.

Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K.

Nat Commun. 2018 Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7.

6.

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.

Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B.

Sci Rep. 2017 Sep 15;7(1):11717. doi: 10.1038/s41598-017-10343-9.

7.

Lipopolysaccharide suppresses IgE-mast cell-mediated reactions.

Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Divanovic S, Hogan SP.

Clin Exp Allergy. 2017 Dec;47(12):1574-1585. doi: 10.1111/cea.13013. Epub 2017 Oct 10.

8.

Type I interferons regulate susceptibility to inflammation-induced preterm birth.

Cappelletti M, Presicce P, Lawson MJ, Chaturvedi V, Stankiewicz TE, Vanoni S, Harley IT, McAlees JW, Giles DA, Moreno-Fernandez ME, Rueda CM, Senthamaraikannan P, Sun X, Karns R, Hoebe K, Janssen EM, Karp CL, Hildeman DA, Hogan SP, Kallapur SG, Chougnet CA, Way SS, Divanovic S.

JCI Insight. 2017 Mar 9;2(5):e91288. doi: 10.1172/jci.insight.91288.

9.

Myeloid-derived NF-κB negative regulation of PU.1 and c/EBP-β-driven pro-inflammatory cytokine production restrains LPS-induced shock.

Vanoni S, Tsai YT, Waddell A, Waggoner L, Klarquist J, Divanovic S, Hoebe K, Steinbrecher KA, Hogan SP.

Innate Immun. 2017 Feb;23(2):175-187. doi: 10.1177/1753425916681444. Epub 2016 Dec 8.

10.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.

11.

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).

Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Mar 29;11(3):e0151837. doi: 10.1371/journal.pone.0151837. eCollection 2016.

12.

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.

Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2015 Oct 6;10(10):e0139019. doi: 10.1371/journal.pone.0139019. eCollection 2015.

13.

AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.

Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB.

Science. 2015 Jul 24;349(6246):436-40. doi: 10.1126/science.aaa1663.

14.

Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.

Endale M, Aksoylar HI, Hoebe K.

Mediators Inflamm. 2015;2015:436017. doi: 10.1155/2015/436017. Epub 2015 Apr 7. Review.

15.

Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.

Lampe K, Endale M, Cashman S, Fang H, Mattner J, Hildeman D, Hoebe K.

Eur J Immunol. 2015 Jul;45(7):2072-83. doi: 10.1002/eji.201445352. Epub 2015 May 22.

16.

The aged nonhematopoietic environment impairs natural killer cell maturation and function.

Shehata HM, Hoebe K, Chougnet CA.

Aging Cell. 2015 Apr;14(2):191-9. doi: 10.1111/acel.12303. Epub 2015 Feb 9.

17.

ATF3 is a novel regulator of mouse neutrophil migration.

Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CL.

Blood. 2014 Mar 27;123(13):2084-93. doi: 10.1182/blood-2013-06-510909. Epub 2014 Jan 27.

18.

Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice".

Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B.

Nat Immunol. 2013 Nov;14(11):1102-3. doi: 10.1038/ni.2734. No abstract available.

PMID:
24145779
19.

Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.

Tardif V, Manenkova Y, Berger M, Hoebe K, Zuo JP, Yuan C, Kono DH, Theofilopoulos AN, Lawson BR.

Clin Immunol. 2013 May;147(2):133-43. doi: 10.1016/j.clim.2013.02.018. Epub 2013 Mar 5.

20.
21.

ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.

22.

NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.

Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT.

J Immunol. 2012 May 1;188(9):4468-75. doi: 10.4049/jimmunol.1102643. Epub 2012 Mar 30.

23.

Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.

Aksoylar HI, Lampe K, Barnes MJ, Plas DR, Hoebe K.

J Immunol. 2012 Jan 1;188(1):146-54. doi: 10.4049/jimmunol.1101206. Epub 2011 Nov 21.

24.

C5a regulates NKT and NK cell functions in sepsis.

Fusakio ME, Mohammed JP, Laumonnier Y, Hoebe K, Köhl J, Mattner J.

J Immunol. 2011 Dec 1;187(11):5805-12. doi: 10.4049/jimmunol.1100338. Epub 2011 Nov 4.

25.

Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.

Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K.

PLoS One. 2011;6(7):e21979. doi: 10.1371/journal.pone.0021979. Epub 2011 Jul 7.

26.

STAT5 is critical to maintain effector CD8+ T cell responses.

Tripathi P, Kurtulus S, Wojciechowski S, Sholl A, Hoebe K, Morris SC, Finkelman FD, Grimes HL, Hildeman DA.

J Immunol. 2010 Aug 15;185(4):2116-24. doi: 10.4049/jimmunol.1000842. Epub 2010 Jul 19.

27.

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K.

J Immunol. 2010 Apr 1;184(7):3743-54. doi: 10.4049/jimmunol.0903164. Epub 2010 Feb 26.

28.

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA.

PLoS One. 2009 Oct 22;4(10):e7411. doi: 10.1371/journal.pone.0007411.

29.

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.

Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K.

Blood. 2009 Jun 25;113(26):6593-602. doi: 10.1182/blood-2009-01-201467. Epub 2009 Apr 30.

30.

Genetic dissection of Toll-like receptor signaling using ENU mutagenesis.

Hoebe K.

Methods Mol Biol. 2009;517:239-51. doi: 10.1007/978-1-59745-541-1_15.

PMID:
19378030
31.

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.

Barnes MJ, Krebs P, Harris N, Eidenschenk C, Gonzalez-Quintial R, Arnold CN, Crozat K, Sovath S, Moresco EM, Theofilopoulos AN, Beutler B, Hoebe K.

PLoS Biol. 2009 Mar 3;7(3):e51. doi: 10.1371/journal.pbio.1000051.

32.

Cutting edge: Priming of NK cells by IL-18.

Chaix J, Tessmer MS, Hoebe K, Fuséri N, Ryffel B, Dalod M, Alexopoulou L, Beutler B, Brossay L, Vivier E, Walzer T.

J Immunol. 2008 Aug 1;181(3):1627-31.

33.

ENU mutagenesis in mice.

Georgel P, Du X, Hoebe K, Beutler B.

Methods Mol Biol. 2008;415:1-16. doi: 10.1007/978-1-59745-570-1_1.

PMID:
18370145
34.

New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.

Huang YH, Hoebe K, Sauer K.

Expert Opin Ther Targets. 2008 Apr;12(4):391-413. doi: 10.1517/14728222.12.4.391 . Review.

PMID:
18348677
35.

Forward genetic analysis of TLR-signaling pathways: an evaluation.

Hoebe K, Beutler B.

Adv Drug Deliv Rev. 2008 Apr 29;60(7):824-9. doi: 10.1016/j.addr.2008.02.002. Epub 2008 Feb 15. Review.

PMID:
18331766
36.

Dissecting innate immunity by germline mutagenesis.

Rutschmann S, Hoebe K.

Immunology. 2008 Apr;123(4):459-68. doi: 10.1111/j.1365-2567.2007.02786.x. Epub 2008 Jan 18. Review.

37.

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.

Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN.

Nat Med. 2007 May;13(5):543-51. Review.

PMID:
17479100
38.

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM.

J Cell Biol. 2007 Apr 23;177(2):265-75.

39.

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.

Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E, Beutler B.

J Exp Med. 2007 Apr 16;204(4):853-63. Epub 2007 Apr 9. Erratum in: J Exp Med. 2008 Mar 17;205(3):737.

40.

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.

Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, Hoebe K, Bahram S, Oldstone MB, Beutler B.

Virology. 2007 Jun 5;362(2):304-13. Epub 2007 Feb 12.

41.

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.

Gavin AL, Hoebe K, Duong B, Ota T, Martin C, Beutler B, Nemazee D.

Science. 2006 Dec 22;314(5807):1936-8.

42.

TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy.

Hoebe K, Jiang Z, Georgel P, Tabeta K, Janssen E, Du X, Beutler B.

Curr Pharm Des. 2006;12(32):4123-34. Review.

PMID:
17100615
43.

Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN.

McBride S, Hoebe K, Georgel P, Janssen E.

J Immunol. 2006 Nov 1;177(9):6122-8.

44.

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.

Togbe D, Aurore G, Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Vasseur V, Akira S, Hoebe K, Beutler B, Ryffel B, Couillin I.

Lab Invest. 2006 Nov;86(11):1126-35. Epub 2006 Sep 18.

45.

Herpes simplex virus encephalitis in human UNC-93B deficiency.

Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, Alcais A, Picard C, Mahfoufi N, Nicolas N, Lorenzo L, Plancoulaine S, Sénéchal B, Geissmann F, Tabeta K, Hoebe K, Du X, Miller RL, Héron B, Mignot C, de Villemeur TB, Lebon P, Dulac O, Rozenberg F, Beutler B, Tardieu M, Abel L, Casanova JL.

Science. 2006 Oct 13;314(5797):308-12. Epub 2006 Sep 14.

46.

Genetic analysis of innate immunity.

Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K, Beutler B.

Adv Immunol. 2006;91:175-226. Review.

PMID:
16938541
47.

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.

Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, Tsuji M, Sellati TJ, Wong CH, Kronenberg M.

Nat Immunol. 2006 Sep;7(9):978-86. Epub 2006 Aug 20.

PMID:
16921381
48.

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.

Janssen E, Tabeta K, Barnes MJ, Rutschmann S, McBride S, Bahjat KS, Schoenberger SP, Theofilopoulos AN, Beutler B, Hoebe K.

Immunity. 2006 Jun;24(6):787-99.

49.

PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.

Rutschmann S, Hoebe K, Zalevsky J, Du X, Mann N, Dahiyat BI, Steed P, Beutler B.

J Immunol. 2006 Jun 15;176(12):7525-32.

50.

Immunology: Toll-like receptors and antibody responses.

Nemazee D, Gavin A, Hoebe K, Beutler B.

Nature. 2006 May 18;441(7091):E4; discussion E4.

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