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Items: 1 to 50 of 90

1.

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW.

Diabetologia. 2020 Feb;63(2):313-323. doi: 10.1007/s00125-019-05029-y. Epub 2019 Nov 15.

2.

Genetic modification of primary human B cells to model high-grade lymphoma.

Caeser R, Di Re M, Krupka JA, Gao J, Lara-Chica M, Dias JML, Cooke SL, Fenner R, Usheva Z, Runge HFP, Beer PA, Eldaly H, Pak HK, Park CS, Vassiliou GS, Huntly BJP, Mupo A, Bashford-Rogers RJM, Hodson DJ.

Nat Commun. 2019 Oct 4;10(1):4543. doi: 10.1038/s41467-019-12494-x.

3.

Informing β-cell regeneration strategies using studies of heterogeneity.

Nasteska D, Viloria K, Everett L, Hodson DJ.

Mol Metab. 2019 Sep;27S:S49-S59. doi: 10.1016/j.molmet.2019.06.004. Review.

4.

Dimerization of the Sodium/Iodide Symporter.

Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NHF, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ.

Thyroid. 2019 Oct;29(10):1485-1498. doi: 10.1089/thy.2019.0034. Epub 2019 Aug 30.

5.

RNA-binding proteins in hematopoiesis and hematological malignancy.

Hodson DJ, Screen M, Turner M.

Blood. 2019 May 30;133(22):2365-2373. doi: 10.1182/blood-2018-10-839985. Epub 2019 Apr 9. Review.

6.

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons.

Yip SH, Romanò N, Gustafson P, Hodson DJ, Williams EJ, Kokay IC, Martin AO, Mollard P, Grattan DR, Bunn SJ.

Cell Rep. 2019 Feb 12;26(7):1787-1799.e5. doi: 10.1016/j.celrep.2019.01.067.

7.

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.

O'Reilly MW, Westgate CS, Hornby C, Botfield H, Taylor AE, Markey K, Mitchell JL, Scotton WJ, Mollan SP, Yiangou A, Jenkinson C, Gilligan LC, Sherlock M, Gibney J, Tomlinson JW, Lavery GG, Hodson DJ, Arlt W, Sinclair AJ.

JCI Insight. 2019 Mar 21;4(6). pii: 125348. doi: 10.1172/jci.insight.125348. eCollection 2019 Mar 21.

8.

Optical tools for understanding the complexity of β-cell signalling and insulin release.

Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ.

Nat Rev Endocrinol. 2018 Dec;14(12):721-737. doi: 10.1038/s41574-018-0105-2. Review.

PMID:
30356209
9.

Targeting MEK in vemurafenib-resistant hairy cell leukemia.

Caeser R, Collord G, Yao WQ, Chen Z, Vassiliou GS, Beer PA, Du MQ, Scott MA, Follows GA, Hodson DJ.

Leukemia. 2019 Feb;33(2):541-545. doi: 10.1038/s41375-018-0270-2. Epub 2018 Oct 19. No abstract available.

10.

A Niche Mechanism for β-Cell Regeneration in Type 1 Diabetes.

Hodson DJ.

Bioessays. 2018 Nov;40(11):e1800177. doi: 10.1002/bies.201800177. Epub 2018 Oct 9. No abstract available.

PMID:
30298934
11.

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

Benninger RKP, Dorrell C, Hodson DJ, Rutter GA.

Curr Diab Rep. 2018 Sep 24;18(11):112. doi: 10.1007/s11892-018-1085-2. Review.

12.

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I.

Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5.

13.

Non-Hodgkin lymphoma.

Bowzyk Al-Naeeb A, Ajithkumar T, Behan S, Hodson DJ.

BMJ. 2018 Aug 22;362:k3204. doi: 10.1136/bmj.k3204. Review. No abstract available.

PMID:
30135071
14.

Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D.

Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16.

PMID:
30013061
15.

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F.

JCI Insight. 2018 Jun 21;3(12). pii: 98607. doi: 10.1172/jci.insight.98607. eCollection 2018 Jun 21.

16.

Mouse models of peripheral metabolic disease.

da Silva Xavier G, Hodson DJ.

Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):299-315. doi: 10.1016/j.beem.2018.03.009. Epub 2018 Mar 31. Review.

PMID:
29779583
17.

The role of beta cell heterogeneity in islet function and insulin release.

Nasteska D, Hodson DJ.

J Mol Endocrinol. 2018 Jul;61(1):R43-R60. doi: 10.1530/JME-18-0011. Epub 2018 Apr 16. Review.

18.

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.

Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM.

N Engl J Med. 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445.

19.

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish.

Janjuha S, Singh SP, Tsakmaki A, Mousavy Gharavy SN, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov N.

Elife. 2018 Apr 6;7. pii: e32965. doi: 10.7554/eLife.32965.

20.

Optical control of GPR40 signalling in pancreatic β-cells.

Frank JA, Yushchenko DA, Fine NHF, Duca M, Citir M, Broichhagen J, Hodson DJ, Schultz C, Trauner D.

Chem Sci. 2017 Nov 1;8(11):7604-7610. doi: 10.1039/c7sc01475a. Epub 2017 Aug 30.

21.

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA.

Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084.

22.

New Understanding of β-Cell Heterogeneity and In Situ Islet Function.

Benninger RKP, Hodson DJ.

Diabetes. 2018 Apr;67(4):537-547. doi: 10.2337/dbi17-0040.

23.

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology.

Podewin T, Ast J, Broichhagen J, Fine NHF, Nasteska D, Leippe P, Gailer M, Buenaventura T, Kanda N, Jones BJ, M'Kadmi C, Baneres JL, Marie J, Tomas A, Trauner D, Hoffmann-Röder A, Hodson DJ.

ACS Cent Sci. 2018 Feb 28;4(2):166-179. doi: 10.1021/acscentsci.7b00237. Epub 2018 Jan 16.

24.

Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

Rutter GA, Hodson DJ.

Cell Mol Life Sci. 2018 Apr;75(7):1303-1305. doi: 10.1007/s00018-018-2767-2.

PMID:
29450573
25.

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion.

Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ.

Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4.

26.

A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus.

Botfield HF, Uldall MS, Westgate CSJ, Mitchell JL, Hagen SM, Gonzalez AM, Hodson DJ, Jensen RH, Sinclair AJ.

Sci Transl Med. 2017 Aug 23;9(404). pii: eaan0972. doi: 10.1126/scitranslmed.aan0972.

PMID:
28835515
27.

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor.

Jones BJ, Scopelliti R, Tomas A, Bloom SR, Hodson DJ, Broichhagen J.

ChemistryOpen. 2017 Jun 5;6(4):501-505. doi: 10.1002/open.201700062. eCollection 2017 Aug.

28.

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone.

Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A.

Chem Sci. 2017 Jun 1;8(6):4644-4653. doi: 10.1039/c6sc05044a. Epub 2017 Apr 19.

29.

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.

Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SR.

Endocrinology. 2017 Aug 1;158(8):2680-2693. doi: 10.1210/en.2016-1755.

30.

Local and regional control of calcium dynamics in the pancreatic islet.

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Review.

31.

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M.

Nat Immunol. 2017 Jun;18(6):683-693. doi: 10.1038/ni.3724. Epub 2017 Apr 10.

32.

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice.

Mitchell RK, Nguyen-Tu MS, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GA.

J Biol Chem. 2017 May 26;292(21):8892-8906. doi: 10.1074/jbc.M117.784629. Epub 2017 Apr 4.

33.

Remote control of glucose homeostasis in vivo using photopharmacology.

Mehta ZB, Johnston NR, Nguyen-Tu MS, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJ.

Sci Rep. 2017 Mar 22;7(1):291. doi: 10.1038/s41598-017-00397-0.

34.

Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms.

Romanò N, Guillou A, Hodson DJ, Martin AO, Mollard P.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2379-2382. doi: 10.1073/pnas.1616864114. Epub 2017 Feb 13.

35.

An updated view of hypothalamic-vascular-pituitary unit function and plasticity.

Le Tissier P, Campos P, Lafont C, Romanò N, Hodson DJ, Mollard P.

Nat Rev Endocrinol. 2017 May;13(5):257-267. doi: 10.1038/nrendo.2016.193. Epub 2016 Dec 9. Review.

36.

Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.

Rui L, Drennan AC, Ceribelli M, Zhu F, Wright GW, Huang DW, Xiao W, Li Y, Grindle KM, Lu L, Hodson DJ, Shaffer AL, Zhao H, Xu W, Yang Y, Staudt LM.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267. Epub 2016 Oct 31.

37.

Challenging perspectives on the cellular origins of lymphoma.

Malcolm TI, Hodson DJ, Macintyre EA, Turner SD.

Open Biol. 2016 Sep;6(9). pii: 160232.

38.

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D.

Nat Chem Biol. 2016 Sep;12(9):755-62. doi: 10.1038/nchembio.2141. Epub 2016 Jul 25.

39.

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ.

Cell Metab. 2016 Sep 13;24(3):389-401. doi: 10.1016/j.cmet.2016.06.020. Epub 2016 Jul 21.

40.

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.

Science. 2016 Apr 22;352(6284):453-9. doi: 10.1126/science.aad5978.

41.

Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons.

Osterstock G, Mitutsova V, Barre A, Granier M, Fontanaud P, Chazalon M, Carmignac D, Robinson IC, Low MJ, Plesnila N, Hodson DJ, Mollard P, Méry PF.

Sci Rep. 2016 Apr 13;6:24394. doi: 10.1038/srep24394.

42.

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJ.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5865-8. doi: 10.1002/anie.201600957. Epub 2016 Apr 5.

43.

Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.

Hodson DJ, Shaffer AL, Xiao W, Wright GW, Schmitz R, Phelan JD, Yang Y, Webster DE, Rui L, Kohlhammer H, Nakagawa M, Waldmann TA, Staudt LM.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2039-46. doi: 10.1073/pnas.1600557113. Epub 2016 Mar 18.

44.

Optical Control of Insulin Secretion Using an Incretin Switch.

Broichhagen J, Podewin T, Meyer-Berg H, von Ohlen Y, Johnston NR, Jones BJ, Bloom SR, Rutter GA, Hoffmann-Röder A, Hodson DJ, Trauner D.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15565-9. doi: 10.1002/anie.201506384. Epub 2015 Nov 2.

45.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, Bellomo EA, Carzaniga R, Collinson LM, Li WH, Hodson DJ, Rutter GA.

Mol Endocrinol. 2016 Jan;30(1):77-91. doi: 10.1210/me.2015-1227. Epub 2015 Nov 19.

46.

Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo.

Michau A, Hodson DJ, Fontanaud P, Guillou A, Espinosa-Carrasco G, Molino F, Peters CJ, Robinson IC, Le Tissier P, Mollard P, Schaeffer M.

Diabetes. 2016 Feb;65(2):463-75. doi: 10.2337/db15-1168. Epub 2015 Nov 18.

47.

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells.

Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA.

Mol Metab. 2015 Jun 25;4(9):619-30. doi: 10.1016/j.molmet.2015.06.007. eCollection 2015 Sep.

48.

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Rutter GA, Chabosseau P, Bellomo EA, Maret W, Mitchell RK, Hodson DJ, Solomou A, Hu M.

Proc Nutr Soc. 2016 Feb;75(1):61-72. Epub 2015 Sep 14.

PMID:
26365743
49.

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Li SM, Philippe E, Herrera PL, Magnan C, Rutter GA.

J Biol Chem. 2015 Aug 28;290(35):21432-42. doi: 10.1074/jbc.M115.645291. Epub 2015 Jul 15.

50.

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

Swisa A, Granot Z, Tamarina N, Sayers S, Bardeesy N, Philipson L, Hodson DJ, Wikstrom JD, Rutter GA, Leibowitz G, Glaser B, Dor Y.

J Biol Chem. 2015 Aug 21;290(34):20934-46. doi: 10.1074/jbc.M115.639237. Epub 2015 Jul 2.

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