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Items: 41

1.

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.

Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM.

Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12.

PMID:
31189647
2.

Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.

Li Z, Solomonidis EG, Meloni M, Taylor RS, Duffin R, Dobie R, Magalhaes MS, Henderson BEP, Louwe PA, D'Amico G, Hodivala-Dilke KM, Shah AM, Mills NL, Simons BD, Gray GA, Henderson NC, Baker AH, Brittan M.

Eur Heart J. 2019 Aug 7;40(30):2507-2520. doi: 10.1093/eurheartj/ehz305.

3.

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.

Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang TY, Shaw PE, Reynolds LE, McKay TR, Wang HW, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I, Sharp TV.

EMBO Mol Med. 2018 Aug;10(8). pii: e8304. doi: 10.15252/emmm.201708304.

4.

Dual role of pericyte α6β1-integrin in tumour blood vessels.

Reynolds LE, D'Amico G, Lechertier T, Papachristodoulou A, Muñoz-Félix JM, De Arcangelis A, Baker M, Serrels B, Hodivala-Dilke KM.

J Cell Sci. 2017 May 1;130(9):1583-1595. doi: 10.1242/jcs.197848. Epub 2017 Mar 13.

5.

Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment.

Wong PP, Bodrug N, Hodivala-Dilke KM.

Curr Biol. 2016 Nov 7;26(21):R1161-R1166. doi: 10.1016/j.cub.2016.09.043. Review.

6.

Endothelial FAK is required for tumour angiogenesis.

Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM.

EMBO Mol Med. 2016 Oct 4;8(10):1229. doi: 10.15252/emmm.201606907. Print 2016 Oct. No abstract available.

7.

Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.

Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MR, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM, Hodivala-Dilke KM.

Cancer Cell. 2015 Jan 12;27(1):123-37. doi: 10.1016/j.ccell.2014.10.015.

8.

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.

Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong PP, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, Hodivala-Dilke KM.

Nature. 2014 Oct 2;514(7520):112-6. doi: 10.1038/nature13541. Epub 2014 Jul 27.

9.

Fascin 1 is dispensable for developmental and tumour angiogenesis.

Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM.

Biol Open. 2013 Sep 19;2(11):1187-91. doi: 10.1242/bio.20136031. eCollection 2013.

10.

Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice.

Steri V, Ellison TS, Gontarczyk AM, Weilbaecher K, Schneider JG, Edwards D, Fruttiger M, Hodivala-Dilke KM, Robinson SD.

Circ Res. 2014 Jan 3;114(1):79-91. doi: 10.1161/CIRCRESAHA.114.301591. Epub 2013 Oct 8.

PMID:
24103390
11.

Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.

Martino-Echarri E, Fernández-Rodríguez R, Rodríguez-Baena FJ, Barrientos-Durán A, Torres-Collado AX, Plaza-Calonge Mdel C, Amador-Cubero S, Cortés J, Reynolds LE, Hodivala-Dilke KM, Rodríguez-Manzaneque JC.

Int J Cancer. 2013 Nov 15;133(10):2315-24. doi: 10.1002/ijc.28271. Epub 2013 Jun 13.

12.

Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice.

Jones DT, Lechertier T, Reynolds LE, Mitter R, Robinson SD, Kirn-Safran CB, Hodivala-Dilke KM.

Dis Model Mech. 2013 Jan;6(1):115-24. doi: 10.1242/dmm.009183. Epub 2012 Nov 1.

13.

The role of β3-integrins in tumor angiogenesis: context is everything.

Robinson SD, Hodivala-Dilke KM.

Curr Opin Cell Biol. 2011 Oct;23(5):630-7. doi: 10.1016/j.ceb.2011.03.014. Epub 2011 May 10. Review.

PMID:
21565482
14.

Endothelial FAK is required for tumour angiogenesis.

Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM.

EMBO Mol Med. 2010 Dec;2(12):516-28. doi: 10.1002/emmm.201000106. Erratum in: EMBO Mol Med. 2016 Oct 4;8(10 ):1229.

15.

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM.

Am J Pathol. 2010 Sep;177(3):1534-48. doi: 10.2353/ajpath.2010.100043. Epub 2010 Jul 16.

16.

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.

17.

Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent.

D'Amico G, Robinson SD, Germain M, Reynolds LE, Thomas GJ, Elia G, Saunders G, Fruttiger M, Tybulewicz V, Mavria G, Hodivala-Dilke KM.

PLoS One. 2010 Mar 22;5(3):e9766. doi: 10.1371/journal.pone.0009766.

18.

Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization.

Watson AR, Pitchford SC, Reynolds LE, Direkze N, Brittan M, Alison MR, Rankin S, Wright NA, Hodivala-Dilke KM.

J Pathol. 2010 Mar;220(4):435-45. doi: 10.1002/path.2660.

PMID:
19967726
19.

Regulation of lymphatic-blood vessel separation by endothelial Rac1.

D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM.

Development. 2009 Dec;136(23):4043-53. doi: 10.1242/dev.035014. Erratum in: Development. 2010 Jan;137(2):359.

20.

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF, Hodivala-Dilke KM.

J Biol Chem. 2009 Dec 4;284(49):33966-81. doi: 10.1074/jbc.M109.030700. Epub 2009 Oct 16.

21.

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM.

Nat Med. 2009 Apr;15(4):392-400. doi: 10.1038/nm.1941. Epub 2009 Mar 22.

PMID:
19305413
22.

Integrins: the keys to unlocking angiogenesis.

Silva R, D'Amico G, Hodivala-Dilke KM, Reynolds LE.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1703-13. doi: 10.1161/ATVBAHA.108.172015. Epub 2008 Jul 24. Review.

PMID:
18658045
23.

alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.

Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E, Hart IR, Dipersio CM, Hodivala-Dilke KM.

J Clin Invest. 2008 Mar;118(3):965-74. doi: 10.1172/JCI33538.

24.

Regulation of COX-2 mediated signaling by alpha3 type IV noncollagenous domain in tumor angiogenesis.

Boosani CS, Mannam AP, Cosgrove D, Silva R, Hodivala-Dilke KM, Keshamouni VG, Sudhakar A.

Blood. 2007 Aug 15;110(4):1168-77. Epub 2007 Apr 10.

25.

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis.

Piqueras L, Reynolds AR, Hodivala-Dilke KM, Alfranca A, Redondo JM, Hatae T, Tanabe T, Warner TD, Bishop-Bailey D.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):63-9. Epub 2006 Oct 26.

PMID:
17068288
26.

Primary mouse endothelial cell culture for assays of angiogenesis.

Reynolds LE, Hodivala-Dilke KM.

Methods Mol Med. 2006;120:503-9.

PMID:
16491622
27.

Generation of genetically modified embryonic stem cells for the development of knockout mouse animal model systems.

Robinson SD, Wilson S, Hodivala-Dilke KM.

Methods Mol Med. 2006;120:465-77.

PMID:
16491619
28.

Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth.

Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M.

Cancer Res. 2005 Jul 1;65(13):5703-10.

29.

Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice.

Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ, Bodary SC, Hodivala-Dilke KM.

Cancer Res. 2004 Dec 1;64(23):8643-50.

30.

Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion.

Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA, Hodivala-Dilke KM.

J Pathol. 2005 Jan;205(1):1-13.

PMID:
15546160
31.

Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability.

Robinson SD, Reynolds LE, Wyder L, Hicklin DJ, Hodivala-Dilke KM.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2108-14. Epub 2004 Sep 2.

PMID:
15345507
32.

Integrins and angiogenesis: unlocking the route to gene therapy.

Mistry A, Harbottle R, Hart S, Hodivala-Dilke KM.

Curr Opin Mol Ther. 2003 Dec;5(6):603-10. Review.

PMID:
14755886
33.

A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.

Petiot A, Conti FJ, Grose R, Revest JM, Hodivala-Dilke KM, Dickson C.

Development. 2003 Nov;130(22):5493-501.

34.

Integrins in angiogenesis: multitalented molecules in a balancing act.

Hodivala-Dilke KM, Reynolds AR, Reynolds LE.

Cell Tissue Res. 2003 Oct;314(1):131-44. Epub 2003 Sep 10. Review.

PMID:
13680353
35.

Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes.

Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RA.

J Cell Sci. 2003 Oct 15;116(Pt 20):4239-48. Epub 2003 Sep 2.

36.

alpha3beta1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis.

Conti FJ, Rudling RJ, Robson A, Hodivala-Dilke KM.

J Cell Sci. 2003 Jul 1;116(Pt 13):2737-47. Epub 2003 May 20.

37.

Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.

Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM.

Nat Med. 2002 Jan;8(1):27-34.

PMID:
11786903
38.

Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia.

Hynes RO, Hodivala-Dilke KM.

Thromb Haemost. 1999 Aug;82(2):481-5. Review.

PMID:
10605739
39.

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S, Hynes RO.

J Clin Invest. 1999 Jan;103(2):229-38.

40.
41.

alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.

DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO.

J Cell Biol. 1997 May 5;137(3):729-42.

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