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TCR Repertoires of Thymic Conventional and Regulatory T Cells: Identification and Characterization of Both Unique and Shared TCR Sequences.

Ko A, Watanabe M, Nguyen T, Shi A, Achour A, Zhang B, Sun X, Wang Q, Zhuang Y, Weng NP, Hodes RJ.

J Immunol. 2020 Jan 10. pii: ji1901006. doi: 10.4049/jimmunol.1901006. [Epub ahead of print]


Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.

Sun L, Chiang JY, Choi JY, Xiong ZM, Mao X, Collins FS, Hodes RJ, Cao K.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18983-18993. doi: 10.1073/pnas.1907199116. Epub 2019 Sep 3.


The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments.

Mott MC, Austin CP, Bianchi DW, Cashion AK, Gordon JA, Heemskerk JE, Hodes RJ, Koob GF, Riley WT, Sieving PA, Shurtleff D, Somerman MJ, Volkow ND, Anderson KC, Owens DF, Koroshetz WJ.

J Neurosci. 2019 Jan 30;39(5):774-775. doi: 10.1523/JNEUROSCI.2742-18.2018. No abstract available.


Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans.

Lustig A, Liu HB, Metter EJ, An Y, Swaby MA, Elango P, Ferrucci L, Hodes RJ, Weng NP.

Front Immunol. 2017 Aug 24;8:1027. doi: 10.3389/fimmu.2017.01027. eCollection 2017.


Aging Research: Collaborations Forge a Promising Future.

Kelley MS, Bernard MA, Hodes RJ.

J Am Geriatr Soc. 2017 Nov;65(11):2441-2445. doi: 10.1111/jgs.15052. Epub 2017 Aug 30.


Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.

Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ.

J Exp Med. 2017 Sep 4;214(9):2795-2810. doi: 10.1084/jem.20161955. Epub 2017 Aug 2.


Disease drivers of aging.

Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, Cohen HJ, Demark-Wahnefried W, Ahles TA, Barzilai N, Hurria A, Hunt PW.

Ann N Y Acad Sci. 2016 Dec;1386(1):45-68. doi: 10.1111/nyas.13299. Review.


T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.

Chiang YJ, Hodes RJ.

Eur J Immunol. 2016 Oct;46(10):2401-2408. doi: 10.1002/eji.201646440. Epub 2016 Aug 29.


Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing.

Hodes RJ, Buckholtz N.

Expert Opin Ther Targets. 2016;20(4):389-91. doi: 10.1517/14728222.2016.1135132. Epub 2016 Feb 7. No abstract available.


Social protection: potential for improving HIV outcomes among adolescents.

Cluver LD, Hodes RJ, Sherr L, Orkin FM, Meinck F, Lim Ah Ken P, Winder-Rossi NE, Wolfe J, Vicari M.

J Int AIDS Soc. 2015 Dec 2;18(Suppl 6):20260. doi: 10.7448/IAS.18.7.20260. eCollection 2015.


ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.

Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL 3rd, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC 3rd, Ried T, Hodes RJ.

Blood. 2015 Nov 12;126(20):2291-301. doi: 10.1182/blood-2015-06-654749. Epub 2015 Sep 23.


'HIV is like a tsotsi. ARVs are your guns': associations between HIV-disclosure and adherence to antiretroviral treatment among adolescents in South Africa.

Cluver LD, Hodes RJ, Toska E, Kidia KK, Orkin FM, Sherr L, Meinck F.

AIDS. 2015 Jun;29 Suppl 1:S57-65. doi: 10.1097/QAD.0000000000000695.


Regulation of T cell development by c-Cbl: essential role of Lck.

Chiang YJ, Hodes RJ.

Int Immunol. 2015 May;27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4.


T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction.

Fujihara C, Williams JA, Watanabe M, Jeon H, Sharrow SO, Hodes RJ.

J Immunol. 2014 Dec 1;193(11):5534-44. doi: 10.4049/jimmunol.1401655. Epub 2014 Oct 24.


Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions.

Lin Y, Damjanovic A, Metter EJ, Nguyen H, Truong T, Najarro K, Morris C, Longo DL, Zhan M, Ferrucci L, Hodes RJ, Weng NP.

Clin Sci (Lond). 2015 Mar;128(6):367-77. doi: 10.1042/CS20140481.


Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses.

Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ.

Immunity. 2014 May 15;40(5):681-91. doi: 10.1016/j.immuni.2014.04.006. Epub 2014 May 1.


Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.


TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.


A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restriction.

Bowen S, Sun P, Livak F, Sharrow S, Hodes RJ.

J Immunol. 2014 Jan 1;192(1):169-77. doi: 10.4049/jimmunol.1302398. Epub 2013 Dec 4.


ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire.

Hathcock KS, Bowen S, Livak F, Hodes RJ.

PLoS One. 2013 Apr 23;8(4):e62188. doi: 10.1371/journal.pone.0062188. Print 2013.


The NIH toolbox: setting a standard for biomedical research.

Hodes RJ, Insel TR, Landis SC; NIH Blueprint for Neuroscience Research.

Neurology. 2013 Mar 12;80(11 Suppl 3):S1. doi: 10.1212/WNL.0b013e3182872e90.


Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.

Bowen S, Wangsa D, Ried T, Livak F, Hodes RJ.

Nucleic Acids Res. 2013 Apr;41(8):4535-48. doi: 10.1093/nar/gkt154. Epub 2013 Mar 6.


Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

Lucas CR, Cordero-Nieves HM, Erbe RS, McAlees JW, Bhatia S, Hodes RJ, Campbell KS, Sanders VM.

J Immunol. 2013 Jan 15;190(2):723-36. doi: 10.4049/jimmunol.1201646. Epub 2012 Dec 12.


Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.

Chiang YJ, Difilippantonio MJ, Tessarollo L, Morse HC, Hodes RJ.

PLoS One. 2012;7(11):e49305. doi: 10.1371/journal.pone.0049305. Epub 2012 Nov 14.


Editorial overview.

Akbar AN, Hodes RJ.

Curr Opin Immunol. 2012 Aug;24(4):467-9. doi: 10.1016/j.coi.2012.07.002. Epub 2012 Jul 23. No abstract available.


National Institute on Aging at middle age--its past, present, and future.

Nagy CL, Bernard MA, Hodes RJ.

J Am Geriatr Soc. 2012 Jun;60(6):1165-9. doi: 10.1111/j.1532-5415.2012.03994.x. Epub 2012 May 30.


The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.

PLoS One. 2011;6(6):e20639. doi: 10.1371/journal.pone.0020639. Epub 2011 Jun 3.


Cbl enforces Vav1 dependence and a restricted pathway of T cell development.

Chiang J, Hodes RJ.

PLoS One. 2011 Apr 7;6(4):e18542. doi: 10.1371/journal.pone.0018542.


Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.

Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21665-70. doi: 10.1073/pnas.1014376107. Epub 2010 Nov 22.


Telomere length is inherited with resetting of the telomere set-point.

Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10148-53. doi: 10.1073/pnas.0913125107. Epub 2010 May 17.


Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.

Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG.

J Biol Chem. 2010 Apr 2;285(14):11023-30. doi: 10.1074/jbc.M109.085381. Epub 2010 Feb 9.


Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.

Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ.

J Immunol. 2010 Feb 15;184(4):1821-8. doi: 10.4049/jimmunol.0902869. Epub 2010 Jan 11.


Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.

Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ.

J Biol Chem. 2009 Feb 13;284(7):4429-38. doi: 10.1074/jbc.M808679200. Epub 2008 Dec 11.


Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.

Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.

Epigenetics Chromatin. 2008 Nov 3;1(1):6. doi: 10.1186/1756-8935-1-6.


Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions.

Hodes RJ, Buckholtz N, Cahan V, Morrison-Bogorad M.

Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S37-47. doi: 10.1016/j.jalz.2007.11.002. Epub 2007 Dec 21. Review.


Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.

Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ.

PLoS One. 2008 Jul 9;3(7):e2639. doi: 10.1371/journal.pone.0002639.


Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.

Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ.

J Immunol. 2008 Jul 15;181(2):907-17.


Analysis of telomere length and telomerase activity.

Hathcock KS, Hodes RJ, Weng NP.

Curr Protoc Immunol. 2004 Sep;Chapter 10:Unit 10.30. doi: 10.1002/0471142735.im1030s62. Review.


Mouse endogenous superantigens: Ms and Mls-like determinants encoded by mouse retroviruses.

Hodes RJ, Abe R.

Curr Protoc Immunol. 2001 May;Appendix 1:Appendix 1F. doi: 10.1002/0471142735.ima01fs17.


ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.

Vacchio MS, Olaru A, Livak F, Hodes RJ.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6323-8. Epub 2007 Apr 3.


Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length.

Shen X, Zhou J, Hathcock KS, Robbins P, Powell DJ Jr, Rosenberg SA, Hodes RJ.

J Immunother. 2007 Jan;30(1):123-9.


National Institute on Aging. Interview by Vicki Glaser.

Hodes RJ.

Rejuvenation Res. 2006 Fall;9(3):419-22. No abstract available.


Public funding for Alzheimer disease research in the United States.

Hodes RJ.

Nat Med. 2006 Jul;12(7):770-3. No abstract available.


Abnormal differentiation of memory T cells in systemic lupus erythematosus.

Fritsch RD, Shen X, Illei GG, Yarboro CH, Prussin C, Hathcock KS, Hodes RJ, Lipsky PE.

Arthritis Rheum. 2006 Jul;54(7):2184-97.


Response to: "Rescuing the NIH before it is too late".

Alexander DF, Alving BM, Battey JF, Berg JM, Collins FS, Fauci AS, Gallin JI, Grady PA, Hodes RJ, Hrynkow SH, Insel TR, Jones JF, Katz SI, Landis SC, Li TK, Lindberg DA, Nabel EG, Niederhuber JE, Pettigrew RI, Rodgers GP, Ruffin J, Scarpa A, Schwartz DA, Sieving PA, Straus SE, Tabak LA, Volkow ND.

J Clin Invest. 2006 Jun;116(6):1462-3.


Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.

Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ.

Mol Cell Biol. 2006 Mar;26(6):2037-43.


Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.

Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18437-42. Epub 2005 Dec 12.


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