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Items: 1 to 50 of 63

1.

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6. Epub 2018 Dec 12.

PMID:
30542156
2.

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.

Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE.

Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub 2018 May 18.

PMID:
29800827
3.

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.

Tessema SK, Utama D, Chesnokov O, Hodder AN, Lin CS, Harrison GLA, Jespersen JS, Petersen B, Tavul L, Siba P, Kwiatkowski D, Lavstsen T, Hansen DS, Oleinikov AV, Mueller I, Barry AE.

Infect Immun. 2018 Jul 23;86(8). pii: e00485-17. doi: 10.1128/IAI.00485-17. Print 2018 Aug.

4.

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.

McCallum FJ, Persson KE, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.

J Leukoc Biol. 2017 Apr;101(4):913-925. doi: 10.1189/jlb.5MA0716-294R. Epub 2016 Nov 11.

5.

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens.

Drew DR, Wilson DW, Elliott SR, Cross N, Terheggen U, Hodder AN, Siba PM, Chelimo K, Dent AE, Kazura JW, Mueller I, Beeson JG.

BMC Med. 2016 Sep 23;14(1):144.

6.

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE.

Bioorg Med Chem. 2016 May 1;24(9):1993-2010. doi: 10.1016/j.bmc.2016.03.027. Epub 2016 Mar 16.

PMID:
27021426
7.

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF.

Nat Commun. 2016 Feb 1;7:10470. doi: 10.1038/ncomms10470.

8.

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF.

Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27.

PMID:
26214367
9.

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria.

Chiu CY, Hodder AN, Lin CS, Hill DL, Li Wai Suen CS, Schofield L, Siba PM, Mueller I, Cowman AF, Hansen DS.

J Infect Dis. 2015 Aug 1;212(3):406-15. doi: 10.1093/infdis/jiv057. Epub 2015 Feb 2.

PMID:
25646353
10.

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.

Terheggen U, Drew DR, Hodder AN, Cross NJ, Mugyenyi CK, Barry AE, Anders RF, Dutta S, Osier FH, Elliott SR, Senn N, Stanisic DI, Marsh K, Siba PM, Mueller I, Richards JS, Beeson JG.

BMC Med. 2014 Oct 16;12:183. doi: 10.1186/s12916-014-0183-5.

11.

The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum.

Lin CS, Uboldi AD, Marapana D, Czabotar PE, Epp C, Bujard H, Taylor NL, Perugini MA, Hodder AN, Cowman AF.

J Biol Chem. 2014 Sep 12;289(37):25655-69. doi: 10.1074/jbc.M114.586495. Epub 2014 Jul 29.

12.

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA.

PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul.

13.

Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development.

Kanodia S, Kumar G, Rizzi L, Pedretti A, Hodder AN, Romeo S, Malhotra P.

Biochim Biophys Acta. 2014 Sep;1840(9):2765-75. doi: 10.1016/j.bbagen.2014.04.013. Epub 2014 Apr 25.

PMID:
24769454
14.

Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum.

Boyle MJ, Langer C, Chan JA, Hodder AN, Coppel RL, Anders RF, Beeson JG.

Infect Immun. 2014 Mar;82(3):924-36. doi: 10.1128/IAI.00866-13. Epub 2013 Nov 11.

15.

Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum.

Healer J, Thompson JK, Riglar DT, Wilson DW, Chiu YH, Miura K, Chen L, Hodder AN, Long CA, Hansen DS, Baum J, Cowman AF.

PLoS One. 2013 Sep 10;8(9):e72504. doi: 10.1371/journal.pone.0072504. eCollection 2013.

16.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG.

J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17.

17.

Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF.

Traffic. 2013 May;14(5):532-50. doi: 10.1111/tra.12053. Epub 2013 Feb 27.

18.

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.

Drew DR, Hodder AN, Wilson DW, Foley M, Mueller I, Siba PM, Dent AE, Cowman AF, Beeson JG.

PLoS One. 2012;7(12):e51023. doi: 10.1371/journal.pone.0051023. Epub 2012 Dec 5.

19.

Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41.

Taechalertpaisarn T, Crosnier C, Bartholdson SJ, Hodder AN, Thompson J, Bustamante LY, Wilson DW, Sanders PR, Wright GJ, Rayner JC, Cowman AF, Gilson PR, Crabb BS.

PLoS One. 2012;7(7):e41937. doi: 10.1371/journal.pone.0041937. Epub 2012 Jul 27.

20.

Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.

Hodder AN, Czabotar PE, Uboldi AD, Clarke OB, Lin CS, Healer J, Smith BJ, Cowman AF.

J Biol Chem. 2012 Sep 21;287(39):32922-39. Epub 2012 Jul 26.

21.

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.

Triglia T, Chen L, Lopaticki S, Dekiwadia C, Riglar DT, Hodder AN, Ralph SA, Baum J, Cowman AF.

PLoS Pathog. 2011 Jun;7(6):e1002075. doi: 10.1371/journal.ppat.1002075. Epub 2011 Jun 16.

22.

An aspartyl protease directs malaria effector proteins to the host cell.

Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, Pearce JA, de Koning-Ward TF, Simpson RJ, Crabb BS, Cowman AF.

Nature. 2010 Feb 4;463(7281):627-31. doi: 10.1038/nature08728.

23.

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.

Hodder AN, Malby RL, Clarke OB, Fairlie WD, Colman PM, Crabb BS, Smith BJ.

J Mol Biol. 2009 Sep 11;392(1):154-65. doi: 10.1016/j.jmb.2009.07.007. Epub 2009 Jul 8.

PMID:
19591843
24.

Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils.

Adda CG, Murphy VJ, Sunde M, Waddington LJ, Schloegel J, Talbo GH, Vingas K, Kienzle V, Masciantonio R, Howlett GJ, Hodder AN, Foley M, Anders RF.

Mol Biochem Parasitol. 2009 Aug;166(2):159-71. doi: 10.1016/j.molbiopara.2009.03.012. Epub 2009 Apr 9.

25.

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum.

Hodder AN, Maier AG, Rug M, Brown M, Hommel M, Pantic I, Puig-de-Morales-Marinkovic M, Smith B, Triglia T, Beeson J, Cowman AF.

Mol Microbiol. 2009 Jan;71(1):48-65. doi: 10.1111/j.1365-2958.2008.06508.x. Epub 2008 Nov 5.

26.

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

Fairlie WD, Spurck TP, McCoubrie JE, Gilson PR, Miller SK, McFadden GI, Malby R, Crabb BS, Hodder AN.

Infect Immun. 2008 Sep;76(9):4332-44. doi: 10.1128/IAI.00278-08. Epub 2008 Jun 30.

27.

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design.

McCoubrie JE, Miller SK, Sargeant T, Good RT, Hodder AN, Speed TP, de Koning-Ward TF, Crabb BS.

Infect Immun. 2007 Dec;75(12):5565-74. Epub 2007 Sep 24.

28.

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts.

Sanders PR, Cantin GT, Greenbaum DC, Gilson PR, Nebl T, Moritz RL, Yates JR 3rd, Hodder AN, Crabb BS.

Mol Biochem Parasitol. 2007 Aug;154(2):148-57. Epub 2007 Apr 27.

PMID:
17553576
29.

Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms.

Kedzierski L, Malby RL, Smith BJ, Perugini MA, Hodder AN, Ilg T, Colman PM, Handman E.

J Mol Biol. 2006 Oct 13;363(1):215-27. Epub 2006 Aug 12.

PMID:
16963079
30.

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.

Sanders PR, Gilson PR, Cantin GT, Greenbaum DC, Nebl T, Carucci DJ, McConville MJ, Schofield L, Hodder AN, Yates JR 3rd, Crabb BS.

J Biol Chem. 2005 Dec 2;280(48):40169-76. Epub 2005 Oct 3.

31.

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

Corbett AJ, Caminschi I, McKenzie BS, Brady JL, Wright MD, Mottram PL, Hogarth PM, Hodder AN, Zhan Y, Tarlinton DM, Shortman K, Lew AM.

Eur J Immunol. 2005 Oct;35(10):2815-25.

32.

A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant.

Saul A, Lawrence G, Allworth A, Elliott S, Anderson K, Rzepczyk C, Martin LB, Taylor D, Eisen DP, Irving DO, Pye D, Crewther PE, Hodder AN, Murphy VJ, Anders RF.

Vaccine. 2005 Apr 27;23(23):3076-83.

PMID:
15811655
33.

Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains.

Healer J, Triglia T, Hodder AN, Gemmill AW, Cowman AF.

Infect Immun. 2005 Apr;73(4):2444-51.

34.

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast.

Foth BJ, Stimmler LM, Handman E, Crabb BS, Hodder AN, McFadden GI.

Mol Microbiol. 2005 Jan;55(1):39-53.

35.

The alanine-rich heptad repeats are intact in the processed form of Plasmodium falciparum MSP3.

Pearce JA, Hodder AN, Anders RF.

Exp Parasitol. 2004 Nov-Dec;108(3-4):186-9.

PMID:
15582517
36.

The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: the impact of GC content and reconciliation of gene and species trees.

Bourgon R, Delorenzi M, Sargeant T, Hodder AN, Crabb BS, Speed TP.

Mol Biol Evol. 2004 Nov;21(11):2161-71. Epub 2004 Aug 11.

PMID:
15306658
37.

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum.

Healer J, Murphy V, Hodder AN, Masciantonio R, Gemmill AW, Anders RF, Cowman AF, Batchelor A.

Mol Microbiol. 2004 Apr;52(1):159-68.

38.

Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen.

Pearce JA, Triglia T, Hodder AN, Jackson DC, Cowman AF, Anders RF.

Infect Immun. 2004 Apr;72(4):2321-8.

39.

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana.

Davis AJ, Perugini MA, Smith BJ, Stewart JD, Ilg T, Hodder AN, Handman E.

J Biol Chem. 2004 Mar 26;279(13):12462-8. Epub 2004 Jan 12.

40.

Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.

Hodder AN, Drew DR, Epa VC, Delorenzi M, Bourgon R, Miller SK, Moritz RL, Frecklington DF, Simpson RJ, Speed TP, Pike RN, Crabb BS.

J Biol Chem. 2003 Nov 28;278(48):48169-77. Epub 2003 Sep 17.

41.
42.

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1).

Nair M, Hinds MG, Coley AM, Hodder AN, Foley M, Anders RF, Norton RS.

J Mol Biol. 2002 Sep 27;322(4):741-53.

PMID:
12270711
43.

A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle.

Miller SK, Good RT, Drew DR, Delorenzi M, Sanders PR, Hodder AN, Speed TP, Cowman AF, de Koning-Ward TF, Crabb BS.

J Biol Chem. 2002 Dec 6;277(49):47524-32. Epub 2002 Sep 11.

44.

Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides.

Coley AM, Campanale NV, Casey JL, Hodder AN, Crewther PE, Anders RF, Tilley LM, Foley M.

Protein Eng. 2001 Sep;14(9):691-8.

PMID:
11707616
45.

Specificity of the protective antibody response to apical membrane antigen 1.

Hodder AN, Crewther PE, Anders RF.

Infect Immun. 2001 May;69(5):3286-94.

46.

Assignment of 1H, 13C and 15N resonances of domain III of the ectodomain of apical membrane antigen 1 from Plasmodium falciparum.

Nair M, Hodder AN, Hinds MG, Anders RF, Norton RS.

J Biomol NMR. 2001 Jan;19(1):85-6. No abstract available.

PMID:
11246861
47.

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species.

Triglia T, Healer J, Caruana SR, Hodder AN, Anders RF, Crabb BS, Cowman AF.

Mol Microbiol. 2000 Nov;38(4):706-18.

48.
50.

Idarubicin-145-2C11-F(ab')2 promotes peripheral tolerance and reduces chronic vascular disease in mouse cardiac allografts.

Han WR, Murray-Segal LJ, Gershenzon A, Zhang JG, Hodder AN, Pietersz GA, Mottram PL.

Transpl Immunol. 1999 Dec;7(4):207-13.

PMID:
10638833

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