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Items: 32

1.

Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability.

Knejzlík Z, Herkommerová K, Hocková D, Pichová I.

J Bacteriol. 2020 Feb 11;202(5). pii: e00710-19. doi: 10.1128/JB.00710-19. Print 2020 Feb 11.

PMID:
31818925
2.

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

Klejch T, Keough DT, Chavchich M, Travis J, Skácel J, Pohl R, Janeba Z, Edstein MD, Avery VM, Guddat LW, Hocková D.

Eur J Med Chem. 2019 Dec 1;183:111667. doi: 10.1016/j.ejmech.2019.111667. Epub 2019 Sep 4.

PMID:
31536893
3.

Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.

Terán D, Doleželová E, Keough DT, Hocková D, Zíková A, Guddat LW.

FEBS J. 2019 Dec;286(23):4721-4736. doi: 10.1111/febs.14987. Epub 2019 Jul 24.

PMID:
31287615
4.

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.

Doleželová E, Terán D, Gahura O, Kotrbová Z, Procházková M, Keough D, Špaček P, Hocková D, Guddat L, Zíková A.

PLoS Negl Trop Dis. 2018 Feb 26;12(2):e0006301. doi: 10.1371/journal.pntd.0006301. eCollection 2018 Feb.

5.

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

Keough DT, Rejman D, Pohl R, Zborníková E, Hocková D, Croll T, Edstein MD, Birrell GW, Chavchich M, Naesens LMJ, Pierens GK, Brereton IM, Guddat LW.

ACS Chem Biol. 2018 Jan 19;13(1):82-90. doi: 10.1021/acschembio.7b00916. Epub 2017 Dec 5.

PMID:
29161011
6.

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

Špaček P, Keough DT, Chavchich M, Dračínský M, Janeba Z, Naesens L, Edstein MD, Guddat LW, Hocková D.

J Med Chem. 2017 Sep 14;60(17):7539-7554. doi: 10.1021/acs.jmedchem.7b00926. Epub 2017 Aug 30.

PMID:
28813147
7.

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Baszczyňski O, Hocková D, Poštová-Slavětínská L, Dračínský M, Keough DT, Guddat LW, Janeba Z.

ChemMedChem. 2017 Jul 20;12(14):1133-1141. doi: 10.1002/cmdc.201700293. Epub 2017 Jul 11.

PMID:
28628279
8.

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.

Špaček P, Keough DT, Chavchich M, Dračínský M, Janeba Z, Naesens L, Edstein MD, Guddat LW, Hocková D.

Bioorg Med Chem. 2017 Aug 1;25(15):4008-4030. doi: 10.1016/j.bmc.2017.05.048. Epub 2017 May 24.

PMID:
28601510
9.

Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.

Eng WS, Keough DT, Hockova D, Winzor DJ, Guddat LW.

Biochimie. 2017 Apr;135:6-14. doi: 10.1016/j.biochi.2016.12.020. Epub 2017 Jan 9.

PMID:
28082125
10.

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.

Terán D, Hocková D, Česnek M, Zíková A, Naesens L, Keough DT, Guddat LW.

Sci Rep. 2016 Oct 27;6:35894. doi: 10.1038/srep35894.

11.

Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Hocková D, Wang TH, Dračínský M, Poštová-Slavětínská L, Procházková E, Edstein MD, Chavchich M, Keough DT, Guddat LW, Janeba Z.

ChemMedChem. 2015 Oct;10(10):1707-23. doi: 10.1002/cmdc.201500322. Epub 2015 Aug 25.

PMID:
26368337
12.

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.

Hocková D, Janeba Z, Naesens L, Edstein MD, Chavchich M, Keough DT, Guddat LW.

Bioorg Med Chem. 2015 Sep 1;23(17):5502-10. doi: 10.1016/j.bmc.2015.07.038. Epub 2015 Jul 27.

PMID:
26275679
13.

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.

Eng WS, Hocková D, Špaček P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW.

J Med Chem. 2015 Jun 11;58(11):4822-38. doi: 10.1021/acs.jmedchem.5b00611. Epub 2015 May 13.

PMID:
25915781
14.

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.

Hocková D, Rosenbergová Š, Ménová P, Páv O, Pohl R, Novák P, Rosenberg I.

Org Biomol Chem. 2015 Apr 21;13(15):4449-58. doi: 10.1039/c4ob02265c.

PMID:
25766752
15.

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.

Keough DT, Hocková D, Janeba Z, Wang TH, Naesens L, Edstein MD, Chavchich M, Guddat LW.

J Med Chem. 2015 Jan 22;58(2):827-46. doi: 10.1021/jm501416t. Epub 2014 Dec 24.

PMID:
25494538
16.

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW.

J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27.

PMID:
23927482
17.

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.

Eur J Med Chem. 2013 Sep;67:81-9. doi: 10.1016/j.ejmech.2013.06.032. Epub 2013 Jun 22.

PMID:
23850568
18.

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19.

PMID:
23448281
19.

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.

Hocková D, Keough DT, Janeba Z, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2012 Jul 12;55(13):6209-23. doi: 10.1021/jm300662d. Epub 2012 Jun 22.

PMID:
22725979
20.

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.

Krečmerová M, Dračínský M, Hocková D, Holý A, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Feb 1;20(3):1222-30. doi: 10.1016/j.bmc.2011.12.034. Epub 2011 Dec 30.

PMID:
22249123
21.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Jan 15;20(2):1076-89. doi: 10.1016/j.bmc.2011.11.034. Epub 2011 Dec 1.

PMID:
22178188
22.

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.

Hocková D, Holý A, Andrei G, Snoeck R, Balzarini J.

Bioorg Med Chem. 2011 Aug 1;19(15):4445-53. doi: 10.1016/j.bmc.2011.06.045. Epub 2011 Jun 22.

PMID:
21745746
23.

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.

de Jersey J, Holý A, Hocková D, Naesens L, Keough DT, Guddat LW.

Curr Top Med Chem. 2011;11(16):2085-102. Review.

PMID:
21619515
24.

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.

Keough DT, Hocková D, Krecmerová M, Cesnek M, Holý A, Naesens L, Brereton IM, Winzor DJ, de Jersey J, Guddat LW.

Mol Biochem Parasitol. 2010 Oct;173(2):165-9. doi: 10.1016/j.molbiopara.2010.05.018. Epub 2010 Jun 1.

PMID:
20595032
25.

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Hocková D, Holý A, Masojídková M, Keough DT, de Jersey J, Guddat LW.

Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. doi: 10.1016/j.bmc.2009.07.044. Epub 2009 Jul 25.

PMID:
19666228
26.

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.

Keough DT, Hocková D, Holý A, Naesens LM, Skinner-Adams TS, Jersey Jd, Guddat LW.

J Med Chem. 2009 Jul 23;52(14):4391-9. doi: 10.1021/jm900267n.

PMID:
19527031
27.

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.

Balzarini J, Schols D, Van Laethem K, De Clercq E, Hocková D, Masojidkova M, Holý A.

J Antimicrob Chemother. 2007 Jan;59(1):80-6. Epub 2006 Nov 22.

PMID:
17124193
28.

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.

De Clercq E, Andrei G, Balzarini J, Leyssen P, Naesens L, Neyts J, Pannecouque C, Snoeck R, Ying C, Hocková D, Holý A.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):331-41.

PMID:
16247948
29.

Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.

Ying C, Holy A, Hocková D, Havlas Z, De Clercq E, Neyts J.

Antimicrob Agents Chemother. 2005 Mar;49(3):1177-80.

30.

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.

Balzarini J, Pannecouque C, Naesens L, Andrei G, Snoeck R, De Clercq E, Hocková D, Holý A.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1321-7.

PMID:
15571252
31.

Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.

Hocková D, Holý A, Masojídková M, Andrei G, Snoeck R, De Clercq E, Balzarini J.

Bioorg Med Chem. 2004 Jun 15;12(12):3197-202.

PMID:
15158787
32.

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.

Hocková D, Holý A, Masojídková M, Andrei G, Snoeck R, De Clercq E, Balzarini J.

J Med Chem. 2003 Nov 6;46(23):5064-73.

PMID:
14584956

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