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Items: 17


In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.

Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ESJ, Rahman T.

Biochem Pharmacol. 2020 Feb 3;174:113834. doi: 10.1016/j.bcp.2020.113834. [Epub ahead of print]


Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.

Hockley JR, Barker KH, Taylor TS, Callejo G, Husson ZM, Bulmer DC, Smith ESJ.

Mol Pain. 2020 Jan-Dec;16:1744806920903150. doi: 10.1177/1744806920903150. No abstract available.


Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.

Taylor TS, Konda P, John SS, Bulmer DC, Hockley JRF, Smith ESJ.

Physiol Rep. 2020 Jan;8(2):e14326. doi: 10.14814/phy2.14326.


Using transfer learning from prior reference knowledge to improve the clustering of single-cell RNA-Seq data.

Mieth B, Hockley JRF, Görnitz N, Vidovic MM, Müller KR, Gutteridge A, Ziemek D.

Sci Rep. 2019 Dec 30;9(1):20353. doi: 10.1038/s41598-019-56911-z.


Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?

Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA, Sanger GJ, Knowles CH, Araujo EJA, Winchester WJ, Bulmer DC.

Pain. 2019 Nov 27. doi: 10.1097/j.pain.0000000000001764. [Epub ahead of print]


5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N.

Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.


Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.

Chakrabarti S, Pattison LA, Singhal K, Hockley JRF, Callejo G, Smith ESJ.

Neuropharmacology. 2018 Dec;143:49-62. doi: 10.1016/j.neuropharm.2018.09.014. Epub 2018 Sep 18.


Human visceral nociception: findings from translational studies in human tissue.

Hockley JRF, Smith ESJ, Bulmer DC.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G464-G472. doi: 10.1152/ajpgi.00398.2017. Epub 2018 May 31. Review.


Single-cell RNAseq reveals seven classes of colonic sensory neuron.

Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ.

Gut. 2019 Apr;68(4):633-644. doi: 10.1136/gutjnl-2017-315631. Epub 2018 Feb 26.


Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.

Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG.

Cell Rep. 2017 Dec 12;21(11):3102-3115. doi: 10.1016/j.celrep.2017.11.066.


Peripheral KV7 channels regulate visceral sensory function in mouse and human colon.

Peiris M, Hockley JR, Reed DE, Smith ESJ, Bulmer DC, Blackshaw LA.

Mol Pain. 2017 Jan-Dec;13:1744806917709371. doi: 10.1177/1744806917709371.


Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC, Cendán CM, McMurray G.

J Physiol. 2017 Apr 15;595(8):2661-2679. doi: 10.1113/JP272837. Epub 2017 Mar 1.


Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus.

Jones AV, Hockley JR, Hyde C, Gorman D, Sredic-Rhodes A, Bilsland J, McMurray G, Furlotte NA, Hu Y, Hinds DA, Cox PJ, Scollen S.

Pain. 2016 Nov;157(11):2571-2581.


Ex vivo study of human visceral nociceptors.

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC.

Gut. 2018 Jan;67(1):86-96. doi: 10.1136/gutjnl-2016-311629. Epub 2016 Sep 21.


P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.

Hockley JR, Tranter MM, McGuire C, Boundouki G, Cibert-Goton V, Thaha MA, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, Bulmer DC.

J Neurosci. 2016 Feb 24;36(8):2364-76. doi: 10.1523/JNEUROSCI.3369-15.2016.


The voltage-gated sodium channel NaV 1.9 in visceral pain.

Hockley JR, Winchester WJ, Bulmer DC.

Neurogastroenterol Motil. 2016 Mar;28(3):316-26. doi: 10.1111/nmo.12698. Epub 2015 Oct 14. Review.


Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli.

Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC.

Pain. 2014 Oct;155(10):1962-75. doi: 10.1016/j.pain.2014.06.015. Epub 2014 Jun 24.

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