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Items: 42


4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell derived intestinal organoids.

Schöneberg J, Dambournet D, Liu TL, Forster R, Hockemeyer D, Betzig E, Drubin DG.

Mol Biol Cell. 2018 Sep 6:mbcE18060375. doi: 10.1091/mbc.E18-06-0375. [Epub ahead of print]


Genetically engineered human cortical spheroid models of tuberous sclerosis.

Blair JD, Hockemeyer D, Bateup HS.

Nat Med. 2018 Oct;24(10):1568-1578. doi: 10.1038/s41591-018-0139-y. Epub 2018 Aug 20.


Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiation.

Dambournet D, Sochacki KA, Cheng AT, Akamatsu M, Taraska JW, Hockemeyer D, Drubin DG.

J Cell Biol. 2018 Sep 3;217(9):3301-3311. doi: 10.1083/jcb.201710084. Epub 2018 Jul 6.


Single Molecule Imaging in Live Embryos Using Lattice Light-Sheet Microscopy.

Mir M, Reimer A, Stadler M, Tangara A, Hansen AS, Hockemeyer D, Eisen MB, Garcia H, Darzacq X.

Methods Mol Biol. 2018;1814:541-559. doi: 10.1007/978-1-4939-8591-3_32.


Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E.

Science. 2018 Apr 20;360(6386). pii: eaaq1392. doi: 10.1126/science.aaq1392.


Widespread Translational Remodeling during Human Neuronal Differentiation.

Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN.

Cell Rep. 2017 Nov 14;21(7):2005-2016. doi: 10.1016/j.celrep.2017.10.095.


Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.

Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D.

Science. 2017 Sep 29;357(6358):1416-1420. doi: 10.1126/science.aao0535. Epub 2017 Aug 17.


Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV.

Stem Cell Reports. 2017 Jun 6;8(6):1770-1783. doi: 10.1016/j.stemcr.2017.04.027. Epub 2017 May 25.


Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.

Chiba K, Vogan JM, Wu RA, Gill MS, Zhang X, Collins K, Hockemeyer D.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00541-16. doi: 10.1128/MCB.00541-16. Print 2017 Feb 1.


Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.

Vogan JM, Zhang X, Youmans DT, Regalado SG, Johnson JZ, Hockemeyer D, Collins K.

Elife. 2016 Aug 15;5. pii: e18221. doi: 10.7554/eLife.18221.


Induced Pluripotent Stem Cells Meet Genome Editing.

Hockemeyer D, Jaenisch R.

Cell Stem Cell. 2016 May 5;18(5):573-86. doi: 10.1016/j.stem.2016.04.013. Review.


Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation.

Blair JD, Bateup HS, Hockemeyer DF.

J Vis Exp. 2016 Feb 2;(108):e53583. doi: 10.3791/53583.


Control of telomerase action at human telomeres.

Hockemeyer D, Collins K.

Nat Struct Mol Biol. 2015 Nov;22(11):848-52. doi: 10.1038/nsmb.3083.


Human stem cell-based disease modeling: prospects and challenges.

Johnson JZ, Hockemeyer D.

Curr Opin Cell Biol. 2015 Dec;37:84-90. doi: 10.1016/ Epub 2015 Nov 11. Review.


Cancer-associated TERT promoter mutations abrogate telomerase silencing.

Chiba K, Johnson JZ, Vogan JM, Wagner T, Boyle JM, Hockemeyer D.

Elife. 2015 Jul 21;4. doi: 10.7554/eLife.07918.


TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.

Kabir S, Hockemeyer D, de Lange T.

Cell Rep. 2014 Nov 20;9(4):1273-80. doi: 10.1016/j.celrep.2014.10.014. Epub 2014 Nov 6.


Genome editing in human pluripotent stem cells using site-specific nucleases.

Chiba K, Hockemeyer D.

Methods Mol Biol. 2015;1239:267-80. doi: 10.1007/978-1-4939-1862-1_15.


Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.

Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D.

Genes Dev. 2014 Sep 1;28(17):1885-99. doi: 10.1101/gad.246819.114. Epub 2014 Aug 15.


Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.

Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.

Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016/j.stemcr.2014.05.001. eCollection 2014 Jun 3. Erratum in: Stem Cell Reports. 2014 Jul 8;3(1):215.


Genome editing 101: let's go digital.

Forster R, Hockemeyer D.

Nat Methods. 2014 Mar;11(3):248-9. doi: 10.1038/nmeth.2859. No abstract available.


Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.


Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Gao Q, Steine EJ, Barrasa MI, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell GW, Jaenisch R.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18061-6. doi: 10.1073/pnas.1114946108. Epub 2011 Oct 19.


Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.

Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V.

PLoS One. 2011;6(9):e24687. doi: 10.1371/journal.pone.0024687. Epub 2011 Sep 22.


Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R.

Cell. 2011 Jul 22;146(2):318-31. doi: 10.1016/j.cell.2011.06.019. Epub 2011 Jul 14. Erratum in: Cell. 2011 Aug 19;146(4):659.


Genetic engineering of human pluripotent cells using TALE nucleases.

Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.

Nat Biotechnol. 2011 Jul 7;29(8):731-4. doi: 10.1038/nbt.1927.


Gene targeting in human pluripotent cells.

Hockemeyer D, Jaenisch R.

Cold Spring Harb Symp Quant Biol. 2010;75:201-9. doi: 10.1101/sqb.2010.75.021. Epub 2011 Jan 5. Review.


Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23.


Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA.

Cell Stem Cell. 2010 Aug 6;7(2):249-57. doi: 10.1016/j.stem.2010.06.015.


Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD.

Genome Res. 2010 Aug;20(8):1133-42. doi: 10.1101/gr.106773.110. Epub 2010 May 27.


Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.

Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.

Nat Biotechnol. 2009 Sep;27(9):851-7. doi: 10.1038/nbt.1562. Epub 2009 Aug 13.


Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.

Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T.

Cell. 2009 Jul 10;138(1):90-103. doi: 10.1016/j.cell.2009.06.021.


Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R.

Cell. 2009 Mar 6;136(5):964-77. doi: 10.1016/j.cell.2009.02.013.


Functional dissection of human and mouse POT1 proteins.

Palm W, Hockemeyer D, Kibe T, de Lange T.

Mol Cell Biol. 2009 Jan;29(2):471-82. doi: 10.1128/MCB.01352-08. Epub 2008 Oct 27.


A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.

Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R.

Cell Stem Cell. 2008 Sep 11;3(3):346-353. doi: 10.1016/j.stem.2008.08.014.


Engineered telomere degradation models dyskeratosis congenita.

Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T.

Genes Dev. 2008 Jul 1;22(13):1773-85. doi: 10.1101/gad.1679208. Epub 2008 Jun 11.


Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD.

Nat Struct Mol Biol. 2007 Aug;14(8):754-61. Epub 2007 Jul 15. Erratum in: Nat Struct Mol Biol. 2009 May;16(5):572.


Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.

Hockemeyer D, Daniels JP, Takai H, de Lange T.

Cell. 2006 Jul 14;126(1):63-77.


POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.

Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T.

EMBO J. 2005 Jul 20;24(14):2667-78. Epub 2005 Jun 23.


POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.

Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T.

Genes Dev. 2004 Jul 15;18(14):1649-54. Epub 2004 Jul 1.


SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development.

Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A.

EMBO J. 2004 Apr 21;23(8):1834-44. Epub 2004 Apr 1.


Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.

Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN.

Nature. 2004 Mar 11;428(6979):185-9.


Potentiation of serum response factor activity by a family of myocardin-related transcription factors.

Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14855-60. Epub 2002 Oct 23.

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