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Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.

Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G.

Nat Commun. 2019 May 20;10(1):2240. doi: 10.1038/s41467-019-10152-w.


GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults.

Quevenco FC, Schreiner SJ, Preti MG, van Bergen JMG, Kirchner T, Wyss M, Steininger SC, Gietl A, Leh SE, Buck A, Pruessmann KP, Hock C, Nitsch RM, Henning A, Van De Ville D, Unschuld PG.

Neuroimage Clin. 2019;22:101776. doi: 10.1016/j.nicl.2019.101776. Epub 2019 Mar 12.


Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.

Hua J, Lee S, Blair NIS, Wyss M, van Bergen JMG, Schreiner SJ, Kagerer SM, Leh SE, Gietl AF, Treyer V, Buck A, Nitsch RM, Pruessmann KP, Lu H, Van Zijl PCM, Albert M, Hock C, Unschuld PG.

Neurobiol Aging. 2019 Apr;76:181-193. doi: 10.1016/j.neurobiolaging.2019.01.001. Epub 2019 Jan 10.


A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

Maier M, Welt T, Wirth F, Montrasio F, Preisig D, McAfoose J, Vieira FG, Kulic L, Späni C, Stehle T, Perrin S, Weber M, Hock C, Nitsch RM, Grimm J.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaah3924. doi: 10.1126/scitranslmed.aah3924.


Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age.

van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Meyer R, Buck A, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, Unschuld PG.

Neuroimage. 2018 Jul 1;174:308-316. doi: 10.1016/j.neuroimage.2018.03.021. Epub 2018 Mar 13.


Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.

Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C.

Stem Cell Res. 2018 Mar;27:121-130. doi: 10.1016/j.scr.2018.01.019. Epub 2018 Jan 28.


Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old.

van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Leh SE, Meyer R, Buck A, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, Unschuld PG.

Neurobiol Aging. 2018 Apr;64:68-75. doi: 10.1016/j.neurobiolaging.2017.12.014. Epub 2017 Dec 20.


Brain amyloid burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults.

Schreiner SJ, Kirchner T, Narkhede A, Wyss M, Van Bergen JMG, Steininger SC, Gietl A, Leh SE, Treyer V, Buck A, Pruessmann KP, Nitsch RM, Hock C, Henning A, Brickman AM, Unschuld PG.

Neurobiol Aging. 2018 Mar;63:152-161. doi: 10.1016/j.neurobiolaging.2017.12.004. Epub 2017 Dec 12.


Changes of Functional and Directed Resting-State Connectivity Are Associated with Neuronal Oscillations, ApoE Genotype and Amyloid Deposition in Mild Cognitive Impairment.

Michels L, Muthuraman M, Anwar AR, Kollias S, Leh SE, Riese F, Unschuld PG, Siniatchkin M, Gietl AF, Hock C.

Front Aging Neurosci. 2017 Sep 20;9:304. doi: 10.3389/fnagi.2017.00304. eCollection 2017.


Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809.


Comparison of Long-term Outcomes of Heparin Bonded Polytetrafluoroethylene and Autologous Vein Below Knee Femoropopliteal Bypasses in Patients with Critical Limb Ischaemia.

Uhl C, Grosch C, Hock C, Töpel I, Steinbauer M.

Eur J Vasc Endovasc Surg. 2017 Aug;54(2):203-211. doi: 10.1016/j.ejvs.2017.05.001. Epub 2017 Jun 3.


Impact of Small Molecules on β-Catenin and E-Cadherin Expression in HPV16-positive and -negative Squamous Cell Carcinomas.

Kramer B, Hock C, Schultz JD, Lammert A, Kuhlin B, Birk R, Hörmann K, Aderhold C.

Anticancer Res. 2017 Jun;37(6):2845-2852.


Effect of selective small molecule inhibitors on MMP-9 and VEGFR-1 expression in p16-positive and -negative squamous cell carcinoma.

Kramer B, Schultz JD, Hock C, Sauter A, Stuck BA, Hörmann K, Birk R, Aderhold C.

Oncol Lett. 2017 May;13(5):3269-3276. doi: 10.3892/ol.2017.5844. Epub 2017 Mar 13.


Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S.

Am J Pathol. 2017 Jun;187(6):1399-1412. doi: 10.1016/j.ajpath.2017.01.022. Epub 2017 Apr 11.


Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.

Quevenco FC, Preti MG, van Bergen JM, Hua J, Wyss M, Li X, Schreiner SJ, Steininger SC, Meyer R, Meier IB, Brickman AM, Leh SE, Gietl AF, Buck A, Nitsch RM, Pruessmann KP, van Zijl PC, Hock C, Van De Ville D, Unschuld PG.

Alzheimers Res Ther. 2017 Mar 31;9(1):24. doi: 10.1186/s13195-017-0249-7.


Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients.

Kälin AM, Park MT, Chakravarty MM, Lerch JP, Michels L, Schroeder C, Broicher SD, Kollias S, Nitsch RM, Gietl AF, Unschuld PG, Hock C, Leh SE.

Front Aging Neurosci. 2017 Mar 7;9:38. doi: 10.3389/fnagi.2017.00038. eCollection 2017.


Microstructural Integrity of Hippocampal Subregions Is Impaired after Mild Traumatic Brain Injury.

Leh SE, Schroeder C, Chen JK, Mallar Chakravarty M, Park MT, Cheung B, Huntgeburth SC, Gosselin N, Hock C, Ptito A, Petrides M.

J Neurotrauma. 2017 Apr 1;34(7):1402-1411. doi: 10.1089/neu.2016.4591. Epub 2016 Dec 2.


Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment.

van Bergen JM, Li X, Hua J, Schreiner SJ, Steininger SC, Quevenco FC, Wyss M, Gietl AF, Treyer V, Leh SE, Buck F, Nitsch RM, Pruessmann KP, van Zijl PC, Hock C, Unschuld PG.

Sci Rep. 2016 Oct 17;6:35514. doi: 10.1038/srep35514.


Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a 1H MRSI study at 7 Tesla.

Schreiner SJ, Kirchner T, Wyss M, Van Bergen JMG, Quevenco FC, Steininger SC, Griffith EY, Meier I, Michels L, Gietl AF, Leh SE, Brickman AM, Hock C, Nitsch RM, Pruessmann KP, Henning A, Unschuld PG.

Neurobiol Aging. 2016 Dec;48:195-203. doi: 10.1016/j.neurobiolaging.2016.08.022. Epub 2016 Aug 31.


Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals.

Schroeder C, Park MTM, Germann J, Chakravarty MM, Michels L, Kollias S, Kroll SL, Buck A, Treyer V, Savaskan E, Unschuld PG, Nitsch RM, Kälin AM, Hock C, Gietl AF, Leh SE.

Eur J Neurosci. 2017 May;45(10):1241-1251. doi: 10.1111/ejn.13408. Epub 2016 Oct 11.


The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323. Update in: Nature. 2017 Jun 21;546(7659):564.


The last phase of life with dementia in Swiss nursing homes: the study protocol of the longitudinal and prospective ZULIDAD study.

Eicher S, Theill N, Geschwindner H, Moor C, Wettstein A, Bieri-Brüning G, Hock C, Martin M, Wolf H, Riese F.

BMC Palliat Care. 2016 Aug 24;15(1):80. doi: 10.1186/s12904-016-0151-2.


Targeted Therapies in HPV-positive and -negative HNSCC - Alteration of EGFR and VEGFR-2 Expression In Vitro.

Kramer B, Hock C, Birk R, Sauter A, Stuck BA, Hörmann K, Schultz JD, Aderhold C.

Anticancer Res. 2016 Jun;36(6):2799-807.


The influence of lunar phases and zodiac sign 'Leo' on perioperative complications and outcome in elective spine surgery.

Joswig H, Stienen MN, Hock C, Hildebrandt G, Surbeck W.

Acta Neurochir (Wien). 2016 Jun;158(6):1095-101. doi: 10.1007/s00701-016-2802-8. Epub 2016 Apr 22.


Tibial and peroneal bypasses in octogenarians and nonoctogenarians with critical limb ischemia.

Uhl C, Hock C, Ayx I, Zorger N, Steinbauer M, Töpel I.

J Vasc Surg. 2016 Jun;63(6):1555-62. doi: 10.1016/j.jvs.2015.12.053. Epub 2016 Feb 28.


Microscopic lumbar spinal stenosis decompression: is surgical education safe?

Joswig H, Hock C, Hildebrandt G, Schaller K, Stienen MN.

Acta Neurochir (Wien). 2016 Feb;158(2):357-66. doi: 10.1007/s00701-015-2667-2. Epub 2015 Dec 19.


Arterial spin labeling imaging reveals widespread and Aβ-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers.

Michels L, Warnock G, Buck A, Macauda G, Leh SE, Kaelin AM, Riese F, Meyer R, O'Gorman R, Hock C, Kollias S, Gietl AF.

J Cereb Blood Flow Metab. 2016 Mar;36(3):581-95. doi: 10.1177/0271678X15605847. Epub 2015 Sep 30.


Volumetric and shape analysis of the thalamus and striatum in amnestic mild cognitive impairment.

Leh SE, Kälin AM, Schroeder C, Park MT, Chakravarty MM, Freund P, Gietl AF, Riese F, Kollias S, Hock C, Michels L.

J Alzheimers Dis. 2016;49(1):237-49. doi: 10.3233/JAD-150080.


A comparison of tibial and peroneal venous and HePTFE bypasses in diabetics with critical limb ischemia.

Hock C, Betz T, Töpel I, Bröckner S, Steinbauer M, Uhl C.

Surgeon. 2017 Apr;15(2):69-75. doi: 10.1016/j.surge.2015.06.005. Epub 2015 Jul 9.


Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine.

Riede O, Seifert K, Oswald D, Endmann A, Hock C, Winkler A, Salguero FJ, Schroff M, Croft SL, Juhls C.

Gene Ther. 2015 Aug;22(8):628-35. doi: 10.1038/gt.2015.35. Epub 2015 Apr 30.


Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner.

Gietl AF, Warnock G, Riese F, Kälin AM, Saake A, Gruber E, Leh SE, Unschuld PG, Kuhn FP, Burger C, Mu L, Seifert B, Nitsch RM, Schibli R, Ametamey SM, Buck A, Hock C.

Neurobiol Aging. 2015 Apr;36(4):1619-1628. doi: 10.1016/j.neurobiolaging.2014.12.036. Epub 2015 Jan 7.


Comparison of venous and HePTFE tibial and peroneal bypasses in critical limb ischemia patients unsuitable for endovascular revascularization.

Uhl C, Hock C, Betz T, Greindl M, Töpel I, Steinbauer M.

Vascular. 2015 Dec;23(6):607-13. doi: 10.1177/1708538114568701. Epub 2015 Jan 26.


The impact of infrainguinal endovascular interventions on the results of subsequent femoro-tibial bypass procedures: a retrospective cohort study.

Uhl C, Hock C, Betz T, Bröckner S, Töpel I, Steinbauer M.

Int J Surg. 2015 Jan;13:261-266. doi: 10.1016/j.ijsu.2014.12.010. Epub 2014 Dec 18.


Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects.

Schreiner SJ, Liu X, Gietl AF, Wyss M, Steininger SC, Gruber E, Treyer V, Meier IB, Kälin AM, Leh SE, Buck A, Nitsch RM, Pruessmann KP, Hock C, Unschuld PG.

Front Aging Neurosci. 2014 Sep 9;6:240. doi: 10.3389/fnagi.2014.00240. eCollection 2014.


Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype.

Riese F, Gietl A, Zölch N, Henning A, O'Gorman R, Kälin AM, Leh SE, Buck A, Warnock G, Edden RA, Luechinger R, Hock C, Kollias S, Michels L.

Neurobiol Aging. 2015 Jan;36(1):53-9. doi: 10.1016/j.neurobiolaging.2014.07.030. Epub 2014 Jul 29.


Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease.

Kälin AM, Pflüger M, Gietl AF, Riese F, Jäncke L, Nitsch RM, Hock C.

Front Aging Neurosci. 2014 Jul 4;6:147. doi: 10.3389/fnagi.2014.00147. eCollection 2014.


Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System.

Steininger SC, Liu X, Gietl A, Wyss M, Schreiner S, Gruber E, Treyer V, Kälin A, Leh S, Buck A, Nitsch RM, Prüssmann KP, Hock C, Unschuld PG.

Front Aging Neurosci. 2014 Mar 18;6:52. doi: 10.3389/fnagi.2014.00052. eCollection 2014.


Photoelectron imaging spectroscopy of the small sodium cluster anions Na3(-), Na5(-), and Na7(-).

Bartels C, Hock C, Kuhnen R, Issendorff Bv.

J Phys Chem A. 2014 Sep 18;118(37):8270-6. doi: 10.1021/jp5010902. Epub 2014 Mar 21.


Pedal bypass surgery after crural endovascular intervention.

Uhl C, Hock C, Betz T, Töpel I, Steinbauer M.

J Vasc Surg. 2014 Jun;59(6):1583-7. doi: 10.1016/j.jvs.2013.11.071. Epub 2014 Jan 11.


Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography.

Laurig M, Liu X, Wyss M, Gietl A, Jellestad L, Nitsch RM, Prüssmann K, Hock C, Unschuld PG.

Brain Behav. 2013 Sep;3(5):515-8. doi: 10.1002/brb3.154. Epub 2013 Jul 14.


Resonances in the entrance channel of the elementary chemical reaction of fluorine and methane.

Westermann T, Kim JB, Weichman ML, Hock C, Yacovitch TI, Palma J, Neumark DM, Manthe U.

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1122-6. doi: 10.1002/anie.201307822. Epub 2013 Dec 4.


Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.

Riese F, Grinschgl S, Gersbacher MT, Russi N, Hock C, Nitsch RM, Konietzko U.

PLoS One. 2013 Sep 25;8(9):e76094. doi: 10.1371/journal.pone.0076094. eCollection 2013.


Prefrontal executive function associated coupling relates to Huntington's disease stage.

Unschuld PG, Liu X, Shanahan M, Margolis RL, Bassett SS, Brandt J, Schretlen DJ, Redgrave GW, Hua J, Hock C, Reading SA, van Zijl PC, Pekar JJ, Ross CA.

Cortex. 2013 Nov-Dec;49(10):2661-73. doi: 10.1016/j.cortex.2013.05.015. Epub 2013 Jun 26.


Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.

Unschuld PG, Buchholz AS, Varvaris M, van Zijl PC, Ross CA, Pekar JJ, Hock C, Sweeney JA, Tamminga CA, Keshavan MS, Pearlson GD, Thaker GK, Schretlen DJ.

Schizophr Bull. 2014 May;40(3):653-64. doi: 10.1093/schbul/sbt077. Epub 2013 Jun 18.


Vibrational spectroscopy of bisulfate/sulfuric acid/water clusters: structure, stability, and infrared multiple-photon dissociation intensities.

Yacovitch TI, Heine N, Brieger C, Wende T, Hock C, Neumark DM, Asmis KR.

J Phys Chem A. 2013 Aug 15;117(32):7081-90. doi: 10.1021/jp400154v. Epub 2013 May 29.


Superresolution imaging of amyloid fibrils with binding-activated probes.

Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L.

ACS Chem Neurosci. 2013 Jul 17;4(7):1057-61. doi: 10.1021/cn400091m. Epub 2013 Apr 22.


Slow photoelectron velocity-map imaging spectroscopy of cold thiozonide (S3(-)).

Kim JB, Hock C, Yacovitch TI, Neumark DM.

J Phys Chem A. 2013 Aug 29;117(34):8126-31. doi: 10.1021/jp401083u. Epub 2013 Mar 20.


Slow photoelectron velocity-map imaging spectroscopy of cold negative ions.

Hock C, Kim JB, Weichman ML, Yacovitch TI, Neumark DM.

J Chem Phys. 2012 Dec 28;137(24):244201. doi: 10.1063/1.4772406.


Vibrationally resolved transition state spectroscopy of the F + H2 and F + CH4 reactions.

Yacovitch TI, Garand E, Kim JB, Hock C, Theis T, Neumark DM.

Faraday Discuss. 2012;157:399-414; discussion 475-500.


Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.

Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, Glabe C, Hock C, Nitsch RM.

Transl Psychiatry. 2012 Nov 13;2:e183. doi: 10.1038/tp.2012.109.

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