Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 174


The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors.

Beckmann JF, Sharma GD, Mendez L, Chen H, Hochstrasser M.

Elife. 2019 Nov 27;8. pii: e50026. doi: 10.7554/eLife.50026.


AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation.

Li J, Breker M, Graham M, Schuldiner M, Hochstrasser M.

PLoS Genet. 2019 Nov 18;15(11):e1008387. doi: 10.1371/journal.pgen.1008387. eCollection 2019 Nov.


Endoplasmic reticulum stress differentially inhibits endoplasmic reticulum and inner nuclear membrane protein quality control degradation pathways.

Buchanan BW, Mehrtash AB, Broshar CL, Runnebohm AM, Snow BJ, Scanameo LN, Hochstrasser M, Rubenstein EM.

J Biol Chem. 2019 Nov 13. pii: jbc.RA119.010295. doi: 10.1074/jbc.RA119.010295. [Epub ahead of print]


A Wolbachia nuclease and its binding partner provide a distinct mechanism for cytoplasmic incompatibility.

Chen H, Ronau JA, Beckmann JF, Hochstrasser M.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22314-22321. doi: 10.1073/pnas.1914571116. Epub 2019 Oct 15.


The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation.

Ryu HY, Su D, Wilson-Eisele NR, Zhao D, López-Giráldez F, Hochstrasser M.

EMBO J. 2019 Aug 15;38(16):e102003. doi: 10.15252/embj.2019102003. Epub 2019 Jul 17.


Caution Does Not Preclude Predictive and Testable Models of Cytoplasmic Incompatibility: A Reply to Shropshire et al.

Beckmann JF, Bonneau M, Chen H, Hochstrasser M, Poinsot D, Merçot H, Weill M, Sicard M, Charlat S.

Trends Genet. 2019 Jun;35(6):399-400. doi: 10.1016/j.tig.2019.03.002. Epub 2019 Apr 9. No abstract available.



Hochstrasser M.

Methods Enzymol. 2019;618:xvii-xix. doi: 10.1016/S0076-6879(19)30079-5. No abstract available.


The Toxin-Antidote Model of Cytoplasmic Incompatibility: Genetics and Evolutionary Implications.

Beckmann JF, Bonneau M, Chen H, Hochstrasser M, Poinsot D, Merçot H, Weill M, Sicard M, Charlat S.

Trends Genet. 2019 Mar;35(3):175-185. doi: 10.1016/j.tig.2018.12.004. Epub 2019 Jan 23. Review.


Clinical applications of CRISPR-based genome editing and diagnostics.

Foss DV, Hochstrasser ML, Wilson RC.

Transfusion. 2019 Apr;59(4):1389-1399. doi: 10.1111/trf.15126. Epub 2019 Jan 2. Review.


Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease.

Ryu HY, López-Giráldez F, Knight J, Hwang SS, Renner C, Kreft SG, Hochstrasser M.

Nat Commun. 2018 Dec 21;9(1):5417. doi: 10.1038/s41467-018-07836-0.


Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.

Sharpe LJ, Howe V, Scott NA, Luu W, Phan L, Berk JM, Hochstrasser M, Brown AJ.

J Biol Chem. 2019 Feb 15;294(7):2436-2448. doi: 10.1074/jbc.RA118.005069. Epub 2018 Dec 13.


Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia.

Kanaujiya J, Bastow E, Luxmi R, Hao Z, Zattas D, Hochstrasser M, Reichenberger EJ, Chen IP.

Sci Rep. 2018 Oct 24;8(1):15710. doi: 10.1038/s41598-018-34157-5.


Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope.

Mehrtash AB, Hochstrasser M.

Semin Cell Dev Biol. 2019 Sep;93:111-124. doi: 10.1016/j.semcdb.2018.09.013. Epub 2018 Oct 9. Review.


Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms.

Farboud B, Jarvis E, Roth TL, Shin J, Corn JE, Marson A, Meyer BJ, Patel NH, Hochstrasser ML.

J Vis Exp. 2018 May 25;(135). doi: 10.3791/57350.


DNA binding by the MATα2 transcription factor controls its access to alternative ubiquitin-modification pathways.

Hickey CM, Xie Y, Hochstrasser M.

Mol Biol Cell. 2018 Mar 1;29(5):542-556. doi: 10.1091/mbc.E17-10-0589. Epub 2018 Jan 3.


Proteasome Structure and Assembly.

Budenholzer L, Cheng CL, Li Y, Hochstrasser M.

J Mol Biol. 2017 Nov 10;429(22):3500-3524. doi: 10.1016/j.jmb.2017.05.027. Epub 2017 Jun 3. Review.


The DUB blade goes snicker-snack: Novel ubiquitin cleavage by a Legionella effector protein.

Ronau JA, Hochstrasser M.

Cell Res. 2017 Jul;27(7):845-846. doi: 10.1038/cr.2017.80. Epub 2017 Jun 2.


A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility.

Beckmann JF, Ronau JA, Hochstrasser M.

Nat Microbiol. 2017 Mar 1;2:17007. doi: 10.1038/nmicrobiol.2017.7.


Adaptive aneuploidy counters a dysregulated SUMO system.

Ryu HY, Hochstrasser M.

Cell Cycle. 2017 Mar 4;16(5):383-385. doi: 10.1080/15384101.2016.1256154. Epub 2016 Nov 18. No abstract available.


Gyre and gimble in the proteasome.

Hochstrasser M.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12896-12898. Epub 2016 Nov 3. No abstract available.


The Regulation of Chromatin by Dynamic SUMO Modifications.

Wilson NR, Hochstrasser M.

Methods Mol Biol. 2016;1475:23-38. doi: 10.1007/978-1-4939-6358-4_2. Review.


DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.

Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA.

Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027.


Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.

Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M.

Genes Dev. 2016 Aug 15;30(16):1881-94. doi: 10.1101/gad.282194.116. Epub 2016 Sep 1.


Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation.

Berk JM, Hochstrasser M.

Curr Biol. 2016 Jul 11;26(13):R539-R542. doi: 10.1016/j.cub.2016.05.032.


A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation.

Zattas D, Berk JM, Kreft SG, Hochstrasser M.

J Biol Chem. 2016 Jun 3;291(23):12105-18. doi: 10.1074/jbc.M116.726877. Epub 2016 Apr 11.


Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling.

Hu R, Hochstrasser M.

Cell Res. 2016 Apr;26(4):389-90. doi: 10.1038/cr.2016.43. No abstract available.


Substrate specificity of the ubiquitin and Ubl proteases.

Ronau JA, Beckmann JF, Hochstrasser M.

Cell Res. 2016 Apr;26(4):441-56. doi: 10.1038/cr.2016.38. Epub 2016 Mar 25. Review.


Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells.

Padmanabhan A, Vuong SA, Hochstrasser M.

Cell Rep. 2016 Mar 29;14(12):2962-74. doi: 10.1016/j.celrep.2016.02.068. Epub 2016 Mar 22.


A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.

Huber EM, Heinemeyer W, Li X, Arendt CS, Hochstrasser M, Groll M.

Nat Commun. 2016 Mar 11;7:10900. doi: 10.1038/ncomms10900.


SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae.

Gillies J, Hickey CM, Su D, Wu Z, Peng J, Hochstrasser M.

Genetics. 2016 Apr;202(4):1377-94. doi: 10.1534/genetics.116.187252. Epub 2016 Feb 2.


Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly.

Li X, Li Y, Arendt CS, Hochstrasser M.

J Biol Chem. 2016 Jan 22;291(4):1991-2003. doi: 10.1074/jbc.M115.677047. Epub 2015 Dec 1.


A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.

Tomko RJ Jr, Taylor DW, Chen ZA, Wang HW, Rappsilber J, Hochstrasser M.

Cell. 2015 Oct 8;163(2):432-44. doi: 10.1016/j.cell.2015.09.022.


STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites.

Hickey CM, Hochstrasser M.

Mol Biol Cell. 2015 Oct 1;26(19):3401-12. doi: 10.1091/mbc.E15-06-0436. Epub 2015 Aug 5.


Proteasomes: Isolation and Activity Assays.

Li Y, Tomko RJ Jr, Hochstrasser M.

Curr Protoc Cell Biol. 2015 Jun 1;67:3.43.1-3.43.20. doi: 10.1002/0471143030.cb0343s67.


Correction: Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing.

Klaips CL, Hochstrasser ML, Langlois CR, Serio TR.

Elife. 2015 Jan 28;4:e06494. doi: 10.7554/eLife.06494. No abstract available.


Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing.

Klaips CL, Hochstrasser ML, Langlois CR, Serio TR.

Elife. 2014 Dec 9;3. doi: 10.7554/eLife.04288. Erratum in: Elife. 2015;4:e06494.


Site-specific cation release drives actin filament severing by vertebrate cofilin.

Kang H, Bradley MJ, Cao W, Zhou K, Grintsevich EE, Michelot A, Sindelar CV, Hochstrasser M, De La Cruz EM.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17821-6. doi: 10.1073/pnas.1413397111. Epub 2014 Dec 2.


Cutting it close: CRISPR-associated endoribonuclease structure and function.

Hochstrasser ML, Doudna JA.

Trends Biochem Sci. 2015 Jan;40(1):58-66. doi: 10.1016/j.tibs.2014.10.007. Epub 2014 Nov 18. Review.


Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.

Zattas D, Hochstrasser M.

Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):1-17. doi: 10.3109/10409238.2014.959889. Epub 2014 Sep 18. Review.


CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6618-23. doi: 10.1073/pnas.1405079111. Epub 2014 Apr 18.


The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.

Tomko RJ Jr, Hochstrasser M.

Mol Cell. 2014 Feb 6;53(3):433-43. doi: 10.1016/j.molcel.2013.12.009. Epub 2014 Jan 9.


A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.

Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M.

J Biol Chem. 2013 Nov 22;288(47):33682-96. doi: 10.1074/jbc.M113.521088. Epub 2013 Oct 11.


A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.

Petti LM, Talbert-Slagle K, Hochstrasser ML, DiMaio D.

J Biol Chem. 2013 Sep 20;288(38):27273-86. doi: 10.1074/jbc.M113.470054. Epub 2013 Aug 1.


Comparative genome analysis of Streptococcus infantarius subsp. infantarius CJ18, an African fermented camel milk isolate with adaptations to dairy environment.

Jans C, Follador R, Hochstrasser M, Lacroix C, Meile L, Stevens MJ.

BMC Genomics. 2013 Mar 22;14:200. doi: 10.1186/1471-2164-14-200.


Assembly of the 20S proteasome.

Kunjappu MJ, Hochstrasser M.

Biochim Biophys Acta. 2014 Jan;1843(1):2-12. doi: 10.1016/j.bbamcr.2013.03.008. Epub 2013 Mar 16. Review.


Molecular architecture and assembly of the eukaryotic proteasome.

Tomko RJ Jr, Hochstrasser M.

Annu Rev Biochem. 2013;82:415-45. doi: 10.1146/annurev-biochem-060410-150257. Epub 2013 Mar 13. Review.


N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.


Function and regulation of SUMO proteases.

Hickey CM, Wilson NR, Hochstrasser M.

Nat Rev Mol Cell Biol. 2012 Dec;13(12):755-66. doi: 10.1038/nrm3478. Review.


Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene.

Stuerner E, Kuraku S, Hochstrasser M, Kreft SG.

PLoS One. 2012;7(10):e45194. doi: 10.1371/journal.pone.0045194. Epub 2012 Oct 4.


Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M.

J Cell Biol. 2012 Jun 11;197(6):761-73. doi: 10.1083/jcb.201203061.

Supplemental Content

Loading ...
Support Center