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A bacteria-based genetic assay detects prion formation.

Fleming E, Yuan AH, Heller DM, Hochschild A.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4605-4610. doi: 10.1073/pnas.1817711116. Epub 2019 Feb 19.


Atomic insights into the genesis of cellular filaments by globular proteins.

McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR.

Nat Struct Mol Biol. 2018 Aug;25(8):705-714. doi: 10.1038/s41594-018-0096-7. Epub 2018 Aug 3.


A bacterial three-hybrid assay detects Escherichia coli Hfq-sRNA interactions in vivo.

Berry KE, Hochschild A.

Nucleic Acids Res. 2018 Jan 25;46(2):e12. doi: 10.1093/nar/gkx1086.


CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB.

Heller DM, Tavag M, Hochschild A.

PLoS Genet. 2017 Sep 20;13(9):e1007007. doi: 10.1371/journal.pgen.1007007. eCollection 2017 Sep.


A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site.

Wang Erickson AF, Deighan P, Chen S, Barrasso K, Garcia CP, Martínez-Lumbreras S, Alfano C, Krysztofinska EM, Thapaliya A, Camp AH, Isaacson RL, Hochschild A, Losick R.

Mol Microbiol. 2017 Aug;105(4):652-662. doi: 10.1111/mmi.13724. Epub 2017 Jun 19.


An Amino Acid Substitution in RNA Polymerase That Inhibits the Utilization of an Alternative Sigma Factor.

Wang Erickson AF, Deighan P, Garcia CP, Weinzierl ROJ, Hochschild A, Losick R.

J Bacteriol. 2017 Jun 27;199(14). pii: e00277-17. doi: 10.1128/JB.00277-17. Print 2017 Jul 15.


A bacterial global regulator forms a prion.

Yuan AH, Hochschild A.

Science. 2017 Jan 13;355(6321):198-201. doi: 10.1126/science.aai7776.


Nascent RNA length dictates opposing effects of NusA on antitermination.

Wells CD, Deighan P, Brigham M, Hochschild A.

Nucleic Acids Res. 2016 Jun 20;44(11):5378-89. doi: 10.1093/nar/gkw198. Epub 2016 Mar 28.


Bacterial RNA polymerase can retain σ70 throughout transcription.

Harden TT, Wells CD, Friedman LJ, Landick R, Hochschild A, Kondev J, Gelles J.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):602-7. doi: 10.1073/pnas.1513899113. Epub 2016 Jan 5.


Mastering Transcription: Multiplexed Analysis of Transcription Start Site Sequences.

Hochschild A.

Mol Cell. 2015 Dec 17;60(6):829-31. doi: 10.1016/j.molcel.2015.12.007.


The primary σ factor in Escherichia coli can access the transcription elongation complex from solution in vivo.

Goldman SR, Nair NU, Wells CD, Nickels BE, Hochschild A.

Elife. 2015 Sep 15;4. doi: 10.7554/eLife.10514.


Prion propagation can occur in a prokaryote and requires the ClpB chaperone.

Yuan AH, Garrity SJ, Nako E, Hochschild A.

Elife. 2014 Aug 13;3:e02949. doi: 10.7554/eLife.02949.


A bacterial export system for generating extracellular amyloid aggregates.

Sivanathan V, Hochschild A.

Nat Protoc. 2013;8(7):1381-90. doi: 10.1038/nprot.2013.081. Epub 2013 Jun 20.


Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.

Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA.

Nucleic Acids Res. 2013 Aug;41(15):7429-37. doi: 10.1093/nar/gkt520. Epub 2013 Jun 12.


Phage-encoded inhibitor of Staphylococcus aureus transcription exerts context-dependent effects on promoter function in a modified Escherichia coli-based transcription system.

Montero-Diez C, Deighan P, Osmundson J, Darst SA, Hochschild A.

J Bacteriol. 2013 Aug;195(16):3621-8. doi: 10.1128/JB.00499-13. Epub 2013 Jun 7.


Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.

Osmundson J, Montero-Diez C, Westblade LF, Hochschild A, Darst SA.

Cell. 2012 Nov 21;151(5):1005-16. doi: 10.1016/j.cell.2012.10.034.


Generating extracellular amyloid aggregates using E. coli cells.

Sivanathan V, Hochschild A.

Genes Dev. 2012 Dec 1;26(23):2659-67. doi: 10.1101/gad.205310.112. Epub 2012 Nov 19.


Genetic reporter system for positioning of proteins at the bacterial pole.

Fixen KR, Janakiraman A, Garrity S, Slade DJ, Gray AN, Karahan N, Hochschild A, Goldberg MB.

MBio. 2012 Feb 28;3(2). pii: e00251-11. doi: 10.1128/mBio.00251-11. Print 2012.


Crystal structure of the bacteriophage T4 late-transcription coactivator gp33 with the β-subunit flap domain of Escherichia coli RNA polymerase.

Twist KA, Campbell EA, Deighan P, Nechaev S, Jain V, Geiduschek EP, Hochschild A, Darst SA.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19961-6. doi: 10.1073/pnas.1113328108. Epub 2011 Dec 1.


Initial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex.

Deighan P, Pukhrambam C, Nickels BE, Hochschild A.

Genes Dev. 2011 Jan 1;25(1):77-88. doi: 10.1101/gad.1991811.


Conversion of a yeast prion protein to an infectious form in bacteria.

Garrity SJ, Sivanathan V, Dong J, Lindquist S, Hochschild A.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10596-601. doi: 10.1073/pnas.0913280107. Epub 2010 May 19.


Direct activator/co-activator interaction is essential for bacteriophage T4 middle gene expression.

Yuan AH, Hochschild A.

Mol Microbiol. 2009 Nov;74(4):1018-30. doi: 10.1111/j.1365-2958.2009.06916.x. Epub 2009 Oct 15.


A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.

Rao X, Deighan P, Hua Z, Hu X, Wang J, Luo M, Wang J, Liang Y, Zhong G, Hochschild A, Shen L.

Genes Dev. 2009 Aug 1;23(15):1818-29. doi: 10.1101/gad.1784009.


CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.

Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS.

Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041.


The bacteriophage T4 AsiA protein contacts the beta-flap domain of RNA polymerase.

Yuan AH, Nickels BE, Hochschild A.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6597-602. doi: 10.1073/pnas.0812832106. Epub 2009 Apr 6.


The bacteriophage lambda CI protein finds an asymmetric solution.

Hochschild A, Lewis M.

Curr Opin Struct Biol. 2009 Feb;19(1):79-86. doi: 10.1016/ Epub 2009 Jan 30. Review.


The bacteriophage lambda Q antiterminator protein contacts the beta-flap domain of RNA polymerase.

Deighan P, Diez CM, Leibman M, Hochschild A, Nickels BE.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15305-10. doi: 10.1073/pnas.0805757105. Epub 2008 Oct 1.


Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor.

Yuan AH, Gregory BD, Sharp JS, McCleary KD, Dove SL, Hochschild A.

Mol Microbiol. 2008 Dec;70(5):1136-51. doi: 10.1111/j.1365-2958.2008.06462.x. Epub 2008 Sep 30.


Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding.

Stayrook S, Jaru-Ampornpan P, Ni J, Hochschild A, Lewis M.

Nature. 2008 Apr 24;452(7190):1022-5. doi: 10.1038/nature06831.


Gene-specific regulation by a transcript cleavage factor: facilitating promoter escape.

Hochschild A.

J Bacteriol. 2007 Dec;189(24):8769-71. Epub 2007 Oct 19. No abstract available.


A sigma-core interaction of the RNA polymerase holoenzyme that enhances promoter escape.

Leibman M, Hochschild A.

EMBO J. 2007 Mar 21;26(6):1579-90. Epub 2007 Mar 1.


Conformational toggle triggers a modulator of RNA polymerase activity.

Deighan P, Hochschild A.

Trends Biochem Sci. 2006 Aug;31(8):424-6. Epub 2006 Jul 11. Review.


The structural basis of cooperative regulation at an alternate genetic switch.

Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M.

Mol Cell. 2006 Mar 3;21(5):605-15.


Structural basis for bacterial transcription-coupled DNA repair.

Deaconescu AM, Chambers AL, Smith AJ, Nickels BE, Hochschild A, Savery NJ, Darst SA.

Cell. 2006 Feb 10;124(3):507-20.


An artificial activator that contacts a normally occluded surface of the RNA polymerase holoenzyme.

Gregory BD, Deighan P, Hochschild A.

J Mol Biol. 2005 Oct 28;353(3):497-506. Epub 2005 Sep 2.


An altered-specificity DNA-binding mutant of Escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo.

Gregory BD, Nickels BE, Darst SA, Hochschild A.

Mol Microbiol. 2005 Jun;56(5):1208-19.


Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.

Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M.

Mol Membr Biol. 2004 Nov-Dec;21(6):373-83.


The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation.

Nickels BE, Garrity SJ, Mekler V, Minakhin L, Severinov K, Ebright RH, Hochschild A.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4488-93. Epub 2005 Mar 10.


An open letter to Elias Zerhouni.

Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N.

Science. 2005 Mar 4;307(5714):1409-10. No abstract available.


A family of anti-sigma70 proteins in T4-type phages and bacteria that are similar to AsiA, a Transcription inhibitor and co-activator of bacteriophage T4.

Pineda M, Gregory BD, Szczypinski B, Baxter KR, Hochschild A, Miller ES, Hinton DM.

J Mol Biol. 2004 Dec 10;344(5):1183-97.


Regulation of RNA polymerase through the secondary channel.

Nickels BE, Hochschild A.

Cell. 2004 Aug 6;118(3):281-4. Review.


The sigma 70 subunit of RNA polymerase mediates a promoter-proximal pause at the lac promoter.

Nickels BE, Mukhopadhyay J, Garrity SJ, Ebright RH, Hochschild A.

Nat Struct Mol Biol. 2004 Jun;11(6):544-50. Epub 2004 May 2.


A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme.

Gregory BD, Nickels BE, Garrity SJ, Severinova E, Minakhin L, Urbauer RJ, Urbauer JL, Heyduk T, Severinov K, Hochschild A.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4554-9. Epub 2004 Mar 22.


A bacterial two-hybrid system based on transcription activation.

Dove SL, Hochschild A.

Methods Mol Biol. 2004;261:231-46. Review.


Cooperativity in long-range gene regulation by the lambda CI repressor.

Dodd IB, Shearwin KE, Perkins AJ, Burr T, Hochschild A, Egan JB.

Genes Dev. 2004 Feb 1;18(3):344-54.


Structure of a ternary transcription activation complex.

Jain D, Nickels BE, Sun L, Hochschild A, Darst SA.

Mol Cell. 2004 Jan 16;13(1):45-53.

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