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Items: 29

1.

siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.

Burke RS, Somasuntharam I, Rearden P, Brown D, Deshmukh SV, DiPietro MA, DiMuzio J, Eisenhandler R, Fauty SE, Gibson C, Gindy ME, Hamilton KA, Knemeyer I, Koeplinger KA, Kwon HW, Lifsted TQ, Menzel K, Patel M, Pudvah N, Rudd DJ, Seitzer J, Strapps WR, Prueksaritanont T, Thompson CD, Hochman JH, Carr BA.

Pharm Res. 2014 Dec;31(12):3445-60. doi: 10.1007/s11095-014-1433-0. Epub 2014 Jul 1.

PMID:
24980206
2.

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA.

Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22.

PMID:
21427169
3.

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.

Tang C, Kuo Y, Pudvah NT, Ellis JD, Michener MS, Egbertson M, Graham SL, Cook JJ, Hochman JH, Prueksaritanont T.

Biochem Pharmacol. 2009 Sep 15;78(6):642-7. doi: 10.1016/j.bcp.2009.05.026. Epub 2009 May 27.

PMID:
19481060
4.

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

Sankaranarayanan S, Holahan MA, Colussi D, Crouthamel MC, Devanarayan V, Ellis J, Espeseth A, Gates AT, Graham SL, Gregro AR, Hazuda D, Hochman JH, Holloway K, Jin L, Kahana J, Lai MT, Lineberger J, McGaughey G, Moore KP, Nantermet P, Pietrak B, Price EA, Rajapakse H, Stauffer S, Steinbeiser MA, Seabrook G, Selnick HG, Shi XP, Stanton MG, Swestock J, Tugusheva K, Tyler KX, Vacca JP, Wong J, Wu G, Xu M, Cook JJ, Simon AJ.

J Pharmacol Exp Ther. 2009 Jan;328(1):131-40. doi: 10.1124/jpet.108.143628. Epub 2008 Oct 14.

PMID:
18854490
5.

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Moore KP, Zhu H, Rajapakse HA, McGaughey GB, Colussi D, Price EA, Sankaranarayanan S, Simon AJ, Pudvah NT, Hochman JH, Allison T, Munshi SK, Graham SL, Vacca JP, Nantermet PG.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5831-5. Epub 2007 Aug 23.

PMID:
17827011
6.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Lindsley SR, Moore KP, Rajapakse HA, Selnick HG, Young MB, Zhu H, Munshi S, Kuo L, McGaughey GB, Colussi D, Crouthamel MC, Lai MT, Pietrak B, Price EA, Sankaranarayanan S, Simon AJ, Seabrook GR, Hazuda DJ, Pudvah NT, Hochman JH, Graham SL, Vacca JP, Nantermet PG.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4057-61. Epub 2007 Apr 27.

PMID:
17482814
7.

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Stauffer SR, Stanton MG, Gregro AR, Steinbeiser MA, Shaffer JR, Nantermet PG, Barrow JC, Rittle KE, Collusi D, Espeseth AS, Lai MT, Pietrak BL, Holloway MK, McGaughey GB, Munshi SK, Hochman JH, Simon AJ, Selnick HG, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1788-92. Epub 2006 Dec 21.

PMID:
17257835
8.

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Bell IM, Bednar RA, Fay JF, Gallicchio SN, Hochman JH, McMasters DR, Miller-Stein C, Moore EL, Mosser SD, Pudvah NT, Quigley AG, Salvatore CA, Stump CA, Theberge CR, Wong BK, Zartman CB, Zhang XF, Kane SA, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6165-9. Epub 2006 Oct 5.

PMID:
17027263
9.

Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.

Booth-Genthe CL, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M.

J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):78-89. Epub 2006 Mar 20.

PMID:
16545584
10.

Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.

Yamazaki M, Li B, Louie SW, Pudvah NT, Stocco R, Wong W, Abramovitz M, Demartis A, Laufer R, Hochman JH, Prueksaritanont T, Lin JH.

Xenobiotica. 2005 Jul;35(7):737-53.

PMID:
16316932
11.

Renal elimination of a novel and potent alphavbeta3 integrin antagonist in animals.

Prueksaritanont T, Hochman JH, Meng Y, Pudvah NT, Barrish A, Ma B, Yamazaki M, Fernandez-Metzler C, Lin JH.

Xenobiotica. 2004 Nov-Dec;34(11-12):1059-74.

PMID:
15801548
12.

Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin.

Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T.

Pharm Res. 2004 Sep;21(9):1686-91.

PMID:
15497697
13.

Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes.

Tang C, Hochman JH, Ma B, Subramanian R, Vyas KP.

Drug Metab Dispos. 2003 Jan;31(1):37-45.

PMID:
12485951
14.
15.

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4.

Hochman JH, Chiba M, Yamazaki M, Tang C, Lin JH.

J Pharmacol Exp Ther. 2001 Jul;298(1):323-30.

PMID:
11408558
16.

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH.

J Pharmacol Exp Ther. 2001 Mar;296(3):723-35.

PMID:
11181899
17.

Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.

Tang C, Chiba M, Nishime J, Hochman JH, Chen I, Williams TM, Lin JH.

Drug Metab Dispos. 2000 Jun;28(6):680-6.

PMID:
10820141
18.

Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes.

LeCluyse EL, Fix JA, Audus KL, Hochman JH.

Toxicol In Vitro. 2000 Apr;14(2):117-32.

PMID:
10793290
19.

Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4.

Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH.

J Pharmacol Exp Ther. 2000 Jan;292(1):310-8.

PMID:
10604964
20.

Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies.

Prueksaritanont T, Gorham LM, Ellis JD, Fernandez-Metzler C, Deluna P, Gehret JR, Strong KL, Hochman JH, Askew BC, Duggan ME, Gilbert JD, Lin JH, Vyas KP.

Drug Metab Dispos. 1996 Nov;24(11):1263-71.

PMID:
8937862
21.

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

Prueksaritanont T, Gorham LM, Hochman JH, Tran LO, Vyas KP.

Drug Metab Dispos. 1996 Jun;24(6):634-42.

PMID:
8781778
22.

Cultured rat hepatocytes.

LeCluyse EL, Bullock PL, Parkinson A, Hochman JH.

Pharm Biotechnol. 1996;8:121-59. Review. No abstract available.

PMID:
8791809
23.

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration.

LeCluyse EL, Audus KL, Hochman JH.

Am J Physiol. 1994 Jun;266(6 Pt 1):C1764-74.

PMID:
8023906
24.

In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.

Hochman JH, Fix JA, LeCluyse EL.

J Pharmacol Exp Ther. 1994 May;269(2):813-22.

PMID:
8182550
25.
26.

Endocytosis and dissociation of class I MHC molecules labeled with fluorescent beta-2 microglobulin.

Hochman JH, Jiang H, Matyus L, Edidin M, Pernis B.

J Immunol. 1991 Mar 15;146(6):1862-7.

PMID:
2005381
27.
28.

Lateral mobility of cytochrome c on intact mitochondrial membranes as determined by fluorescence redistribution after photobleaching.

Hochman JH, Schindler M, Lee JG, Ferguson-Miller S.

Proc Natl Acad Sci U S A. 1982 Nov;79(22):6866-70.

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