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Items: 39


Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis.

Booth AJ, Yue Z, Eykelenboom JK, Stiff T, Luxton GG, Hochegger H, Tanaka TU.

Elife. 2019 Jul 3;8. pii: e46902. doi: 10.7554/eLife.46902.


Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis.

Eykelenboom JK, Gierliński M, Yue Z, Hegarat N, Pollard H, Fukagawa T, Hochegger H, Tanaka TU.

J Cell Biol. 2019 May 6;218(5):1531-1552. doi: 10.1083/jcb.201807125. Epub 2019 Mar 11.


Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells.

Rata S, Suarez Peredo Rodriguez MF, Joseph S, Peter N, Echegaray Iturra F, Yang F, Madzvamuse A, Ruppert JG, Samejima K, Platani M, Alvarez-Fernandez M, Malumbres M, Earnshaw WC, Novak B, Hochegger H.

Curr Biol. 2018 Dec 3;28(23):3824-3832.e6. doi: 10.1016/j.cub.2018.09.059. Epub 2018 Nov 15.


DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.

Lemmens B, Hegarat N, Akopyan K, Sala-Gaston J, Bartek J, Hochegger H, Lindqvist A.

Mol Cell. 2018 Jul 5;71(1):117-128.e3. doi: 10.1016/j.molcel.2018.05.026. Epub 2018 Jun 28.


Interlinked bistable mechanisms generate robust mitotic transitions.

Hutter LH, Rata S, Hochegger H, Novák B.

Cell Cycle. 2017 Oct 18;16(20):1885-1892. doi: 10.1080/15384101.2017.1371885. Epub 2017 Sep 13. Review.


Characterisation of a stably integrated expression system for exogenous protein expression in DT40.

Skouteri M, Hochegger H, Carr AM.

Wellcome Open Res. 2017 Jun 8;2:40. doi: 10.12688/wellcomeopenres.11816.2. eCollection 2017.


A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.

Ocasio CA, Rajasekaran MB, Walker S, Le Grand D, Spencer J, Pearl FM, Ward SE, Savic V, Pearl LH, Hochegger H, Oliver AW.

Oncotarget. 2016 Nov 1;7(44):71182-71197. doi: 10.18632/oncotarget.11511.


Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.

Hégarat N, Rata S, Hochegger H.

Bioessays. 2016 Jul;38(7):627-43. doi: 10.1002/bies.201600057. Epub 2016 May 27. Review.


PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.

Bailey LJ, Bianchi J, Hégarat N, Hochegger H, Doherty AJ.

Cell Cycle. 2016;15(7):908-18. doi: 10.1080/15384101.2015.1128597. Epub 2015 Dec 22.


Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.

Mannino M, Gomez-Roman N, Hochegger H, Chalmers AJ.

Stem Cell Res. 2014 Jul;13(1):135-43. doi: 10.1016/j.scr.2014.05.001. Epub 2014 May 11.


Proteomics of a fuzzy organelle: interphase chromatin.

Kustatscher G, Hégarat N, Wills KL, Furlan C, Bukowski-Wills JC, Hochegger H, Rappsilber J.

EMBO J. 2014 Mar 18;33(6):648-64. doi: 10.1002/embj.201387614. Epub 2014 Feb 16.


PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.

Hégarat N, Vesely C, Vinod PK, Ocasio C, Peter N, Gannon J, Oliver AW, Novák B, Hochegger H.

PLoS Genet. 2014 Jan;10(1):e1004004. doi: 10.1371/journal.pgen.1004004. Epub 2014 Jan 2. Erratum in: PLoS Genet. 2014 Feb;10(2):e1004259.


Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.

Hochegger H, Hégarat N, Pereira-Leal JB.

Open Biol. 2013 Mar 20;3(3):120185. doi: 10.1098/rsob.120185. Review.


DNA synthesis is required for reprogramming mediated by stem cell fusion.

Tsubouchi T, Soza-Ried J, Brown K, Piccolo FM, Cantone I, Landeira D, Bagci H, Hochegger H, Merkenschlager M, Fisher AG.

Cell. 2013 Feb 14;152(4):873-83. doi: 10.1016/j.cell.2013.01.012.


Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

Hégarat N, Smith E, Nayak G, Takeda S, Eyers PA, Hochegger H.

J Cell Biol. 2011 Dec 26;195(7):1103-13. doi: 10.1083/jcb.201105058. Epub 2011 Dec 19.


Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

Silva MC, Bodor DL, Stellfox ME, Martins NM, Hochegger H, Foltz DR, Jansen LE.

Dev Cell. 2012 Jan 17;22(1):52-63. doi: 10.1016/j.devcel.2011.10.014. Epub 2011 Dec 8.


Centrosome amplification in CHO and DT40 cells by inactivation of cyclin-dependent kinases.

Steere N, Wagner M, Beishir S, Smith E, Breslin L, Morrison CG, Hochegger H, Kuriyama R.

Cytoskeleton (Hoboken). 2011 Aug;68(8):446-58. doi: 10.1002/cm.20523. Epub 2011 Jul 29.


Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1.

Smith E, Hégarat N, Vesely C, Roseboom I, Larch C, Streicher H, Straatman K, Flynn H, Skehel M, Hirota T, Kuriyama R, Hochegger H.

EMBO J. 2011 Jun 1;30(11):2233-45. doi: 10.1038/emboj.2011.120. Epub 2011 Apr 26.


Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

Xu N, Hegarat N, Black EJ, Scott MT, Hochegger H, Gillespie DA.

J Cell Biol. 2010 Aug 9;190(3):297-305. doi: 10.1083/jcb.201003004. Epub 2010 Aug 2.


DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

Bourke E, Brown JA, Takeda S, Hochegger H, Morrison CG.

Oncogene. 2010 Jan 28;29(4):616-24. doi: 10.1038/onc.2009.340. Epub 2009 Oct 19.


Cellular contractility requires ubiquitin mediated proteolysis.

Cinnamon Y, Feine O, Hochegger H, Bershadsky A, Brandeis M.

PLoS One. 2009 Jul 14;4(7):e6155. doi: 10.1371/journal.pone.0006155.


Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

Hochegger H, Takeda S, Hunt T.

Nat Rev Mol Cell Biol. 2008 Nov;9(11):910-6. doi: 10.1038/nrm2510. Epub 2008 Sep 24. Review.


Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann A, Zhao GY, Hochegger H, Boulton SJ, Takeda S.

Cancer Res. 2007 Sep 15;67(18):8536-43.


An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells.

Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T, Takeda S.

J Cell Biol. 2007 Jul 16;178(2):257-68.


Phenotypic analysis of cellular responses to DNA damage.

Hochegger H, Takeda S.

Subcell Biochem. 2006;40:313-25. Review.


Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.

Fisher AE, Hochegger H, Takeda S, Caldecott KW.

Mol Cell Biol. 2007 Aug;27(15):5597-605. Epub 2007 Jun 4.


RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Zeng W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S.

Mol Cell Biol. 2007 Apr;27(7):2562-71. Epub 2007 Jan 22.


Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.

Yoshimura M, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S.

Mol Cell. 2006 Oct 6;24(1):115-25.


Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.

Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S.

DNA Repair (Amst). 2006 Sep 8;5(9-10):1021-9. Epub 2006 Jun 27. Review.


Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.

Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, Koyama H, de Murcia G, Takeda S.

EMBO J. 2006 Mar 22;25(6):1305-14. Epub 2006 Feb 23.


Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.

Wu X, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S, Yamazoe M.

Cancer Res. 2006 Jan 15;66(2):748-54.


Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli BJ, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA, Hashimoto N, Takeda S, Sonoda E.

Cancer Res. 2005 Dec 15;65(24):11704-11.


Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage.

Yonetani Y, Hochegger H, Sonoda E, Shinya S, Yoshikawa H, Takeda S, Yamazoe M.

Nucleic Acids Res. 2005 Aug 10;33(14):4544-52. Print 2005.


Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends.

Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N, Matsuzaki Y, Koyama H, van Gent DC, Jasin M, Takeda S.

Mol Cell Biol. 2005 Aug;25(16):6948-55.


Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

Yamazoe M, Sonoda E, Hochegger H, Takeda S.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1175-85. Review.


Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells.

Mizutani A, Okada T, Shibutani S, Sonoda E, Hochegger H, Nishigori C, Miyachi Y, Takeda S, Yamazoe M.

Cancer Res. 2004 May 1;64(9):3144-7.


Post-replication repair in DT40 cells: translesion polymerases versus recombinases.

Hochegger H, Sonoda E, Takeda S.

Bioessays. 2004 Feb;26(2):151-8. Review.


New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation.

Hochegger H, Klotzbücher A, Kirk J, Howell M, le Guellec K, Fletcher K, Duncan T, Sohail M, Hunt T.

Development. 2001 Oct;128(19):3795-807.


Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo.

Sohail M, Hochegger H, Klotzbücher A, Guellec RL, Hunt T, Southern EM.

Nucleic Acids Res. 2001 May 15;29(10):2041-51.

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