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Items: 24


Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung.

Villalta PW, Hochalter JB, Hecht SS.

Anal Chem. 2017 Dec 5;89(23):12735-12742. doi: 10.1021/acs.analchem.7b02856. Epub 2017 Nov 17.


Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.

Hecht SS, Hochalter JB, Carmella SG, Zhang Y, Rauch DM, Fujioka N, Jensen J, Hatsukami DK.

Biomarkers. 2013 Mar;18(2):144-50. doi: 10.3109/1354750X.2012.753553. Epub 2013 Jan 22.


Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.

Wang J, Zhong Y, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Hecht SS, Zimmerman CL.

J Pharmacol Exp Ther. 2012 Sep;342(3):750-60. doi: 10.1124/jpet.112.194118. Epub 2012 Jun 6.


Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.

Zhong Y, Wang J, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Zimmerman C, Hecht SS.

J Pharmacol Exp Ther. 2011 Jul;338(1):353-61. doi: 10.1124/jpet.111.181719. Epub 2011 Apr 22.


Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.

Hochalter JB, Zhong Y, Han S, Carmella SG, Hecht SS.

Chem Res Toxicol. 2011 Feb 18;24(2):262-8. doi: 10.1021/tx100391z. Epub 2011 Jan 13.


Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides.

Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami D, Wang J, Zimmerman C, Hecht SS.

Chem Res Toxicol. 2011 Feb 18;24(2):246-52. doi: 10.1021/tx100345x. Epub 2010 Dec 27.


Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes.

Upadhyaya P, Hochalter JB, Balbo S, McIntee EJ, Hecht SS.

Drug Metab Dispos. 2010 Sep;38(9):1397-402. doi: 10.1124/dmd.110.034181. Epub 2010 Jun 14.


Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats.

Hecht SS, Han S, Kenney PM, Wang M, Lindgren B, Wang Y, Lao Y, Hochalter JB, Upadhyaya P.

Chem Res Toxicol. 2007 Mar;20(3):543-9. Epub 2007 Feb 10.


Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine.

Wang M, Yu N, Chen L, Villalta PW, Hochalter JB, Hecht SS.

Chem Res Toxicol. 2006 Feb;19(2):319-24.


2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.

Hecht SS, Hochalter JB, Villalta PW, Murphy SE.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12493-7.


Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.

Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS.

Carcinogenesis. 1999 Aug;20(8):1577-82.


Inhibition of beta-propiolactone-induced mutagenesis and neoplasia by sodium thiosulfate.

Wattenberg LW, Hochalter JB, Galbraith AR.

Cancer Res. 1987 Aug 15;47(16):4351-4.


Short time interval effects of butylated hydroxyanisole on the metabolism of benzo(a)pyrene.

Lam LK, Fladmoe AV, Hochalter JB, Wattenberg LW.

Cancer Res. 1980 Aug;40(8 Pt 1):2824-8. No abstract available.


Carnitine biosynthesis: the formation of glycine from carbons 1 and 2 of 6-N-trimethyl-L-lysine.

Hochalter JB, Henderson LM.

Biochem Biophys Res Commun. 1976 May 17;70(2):364-8. No abstract available.


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