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A Life in Bacillus subtilis Signal Transduction.

Hoch JA.

Annu Rev Microbiol. 2017 Sep 8;71:1-19. doi: 10.1146/annurev-micro-030117-020355.


Two-step functionalization of oligosaccharides using glycosyl iodide and trimethylene oxide and its applications to multivalent glycoconjugates.

Hsieh HW, Davis RA, Hoch JA, Gervay-Hague J.

Chemistry. 2014 May 19;20(21):6444-54. doi: 10.1002/chem.201400024. Epub 2014 Apr 8.


Evidence that YycJ is a novel 5'-3' double-stranded DNA exonuclease acting in Bacillus anthracis mismatch repair.

Yang H, Yung M, Li L, Hoch JA, Ryan CM, Kar UK, Souda P, Whitelegge JP, Miller JH.

DNA Repair (Amst). 2013 May 1;12(5):334-46. doi: 10.1016/j.dnarep.2013.02.002. Epub 2013 Mar 13.


Statistical analyses of protein sequence alignments identify structures and mechanisms in signal activation of sensor histidine kinases.

Szurmant H, Hoch JA.

Mol Microbiol. 2013 Feb;87(4):707-12. doi: 10.1111/mmi.12128. Epub 2012 Dec 28.


Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis.

Dago AE, Schug A, Procaccini A, Hoch JA, Weigt M, Szurmant H.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1733-42. doi: 10.1073/pnas.1201301109. Epub 2012 Jun 5.


Dynamics and activation in response regulators: the β4-α4 loop.

Bobay BG, Hoch JA, Cavanagh J.

Biomol Concepts. 2012 Feb 1;3(2):175-182.


Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum.

Steiner E, Dago AE, Young DI, Heap JT, Minton NP, Hoch JA, Young M.

Mol Microbiol. 2011 May;80(3):641-54. doi: 10.1111/j.1365-2958.2011.07608.x. Epub 2011 Mar 14.


Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity.

Schellinger JG, Danan-Leon LM, Hoch JA, Kassa A, Srivastava I, Davis D, Gervay-Hague J.

J Am Chem Soc. 2011 Mar 16;133(10):3230-3. doi: 10.1021/ja1083915. Epub 2011 Feb 22.


A role for the essential YycG sensor histidine kinase in sensing cell division.

Fukushima T, Furihata I, Emmins R, Daniel RA, Hoch JA, Szurmant H.

Mol Microbiol. 2011 Jan;79(2):503-22. doi: 10.1111/j.1365-2958.2010.07464.x. Epub 2010 Nov 29.


Computational modeling of phosphotransfer complexes in two-component signaling.

Schug A, Weigt M, Hoch JA, Onuchic JN, Hwa T, Szurmant H.

Methods Enzymol. 2010;471:43-58. doi: 10.1016/S0076-6879(10)71003-X. Epub 2010 Mar 1.


Inference of direct residue contacts in two-component signaling.

Lunt B, Szurmant H, Procaccini A, Hoch JA, Hwa T, Weigt M.

Methods Enzymol. 2010;471:17-41. doi: 10.1016/S0076-6879(10)71002-8. Epub 2010 Mar 1.


Long range dynamic effects of point-mutations trap a response regulator in an active conformation.

Bobay BG, Thompson RJ, Hoch JA, Cavanagh J.

FEBS Lett. 2010 Oct 8;584(19):4203-7. doi: 10.1016/j.febslet.2010.08.051. Epub 2010 Sep 7.


Retraction: The bicarbonate transporter is essential for Bacillus anthracis lethality.

Wilson AC, Soyer M, Hoch JA, Perego M.

PLoS Pathog. 2010 Mar 16;6(3). doi: 10.1371/annotation/26144e46-0873-48d9-890f-7ae3136a79d4. No abstract available.


Interaction fidelity in two-component signaling.

Szurmant H, Hoch JA.

Curr Opin Microbiol. 2010 Apr;13(2):190-7. doi: 10.1016/j.mib.2010.01.007. Epub 2010 Feb 3. Review.


Crystal structure of the transcriptional repressor PagR of Bacillus anthracis.

Zhao H, Volkov A, Veldore VH, Hoch JA, Varughese KI.

Microbiology. 2010 Feb;156(Pt 2):385-91. doi: 10.1099/mic.0.033548-0. Epub 2009 Nov 19.


Two small c-type cytochromes affect virulence gene expression in Bacillus anthracis.

Wilson AC, Hoch JA, Perego M.

Mol Microbiol. 2009 Apr;72(1):109-23. doi: 10.1111/j.1365-2958.2009.06627.x. Epub 2009 Feb 15.


Identification of direct residue contacts in protein-protein interaction by message passing.

Weigt M, White RA, Szurmant H, Hoch JA, Hwa T.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):67-72. doi: 10.1073/pnas.0805923106. Epub 2008 Dec 30.


The bicarbonate transporter is essential for Bacillus anthracis lethality.

Wilson AC, Soyer M, Hoch JA, Perego M.

PLoS Pathog. 2008 Nov;4(11):e1000210. doi: 10.1371/journal.ppat.1000210. Epub 2008 Nov 21. Retraction in: Wilson AC, Soyer M, Hoch JA, Perego M. PLoS Pathog. 2010 Mar;6(3). doi: 10.1371/annotation/26144e46-0873-48d9-890f-7ae3136a79d4.


A unique GTP-dependent sporulation sensor histidine kinase in Bacillus anthracis.

Scaramozzino F, White A, Perego M, Hoch JA.

J Bacteriol. 2009 Feb;191(3):687-92. doi: 10.1128/JB.01184-08. Epub 2008 Oct 17.


Dual promoters control expression of the Bacillus anthracis virulence factor AtxA.

Bongiorni C, Fukushima T, Wilson AC, Chiang C, Mansilla MC, Hoch JA, Perego M.

J Bacteriol. 2008 Oct;190(19):6483-92. doi: 10.1128/JB.00766-08. Epub 2008 Aug 1.


Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis.

Szurmant H, Bobay BG, White RA, Sullivan DM, Thompson RJ, Hwa T, Hoch JA, Cavanagh J.

Biochemistry. 2008 Jul 29;47(30):7782-4. doi: 10.1021/bi8009604. Epub 2008 Jun 28.


A sensor histidine kinase co-ordinates cell wall architecture with cell division in Bacillus subtilis.

Fukushima T, Szurmant H, Kim EJ, Perego M, Hoch JA.

Mol Microbiol. 2008 Aug;69(3):621-32. doi: 10.1111/j.1365-2958.2008.06308.x. Epub 2008 Jun 28.


Virulence gene expression is independent of ResDE-regulated respiration control in Bacillus anthracis.

Wilson AC, Hoch JA, Perego M.

J Bacteriol. 2008 Aug;190(15):5522-5. doi: 10.1128/JB.00312-08. Epub 2008 Jun 6.


An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.

Szurmant H, Bu L, Brooks CL 3rd, Hoch JA.

Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5891-6. doi: 10.1073/pnas.0800247105. Epub 2008 Apr 11.


Commingling regulatory systems following acquisition of virulence plasmids by Bacillus anthracis.

Perego M, Hoch JA.

Trends Microbiol. 2008 May;16(5):215-21. doi: 10.1016/j.tim.2008.01.010. Epub 2008 Apr 18. Review.


Essentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria.

Winkler ME, Hoch JA.

J Bacteriol. 2008 Apr;190(8):2645-8. doi: 10.1128/JB.01682-07. Epub 2008 Feb 1. No abstract available.


New transposon delivery plasmids for insertional mutagenesis in Bacillus anthracis.

Wilson AC, Perego M, Hoch JA.

J Microbiol Methods. 2007 Dec;71(3):332-5. Epub 2007 Sep 21.


Sensor complexes regulating two-component signal transduction.

Szurmant H, White RA, Hoch JA.

Curr Opin Struct Biol. 2007 Dec;17(6):706-15. Epub 2007 Oct 29. Review.


The essential YycFG two-component system of Bacillus subtilis.

Szurmant H, Fukushima T, Hoch JA.

Methods Enzymol. 2007;422:396-417.


Features of protein-protein interactions in two-component signaling deduced from genomic libraries.

White RA, Szurmant H, Hoch JA, Hwa T.

Methods Enzymol. 2007;422:75-101.


Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition.

McLaughlin PD, Bobay BG, Regel EJ, Thompson RJ, Hoch JA, Cavanagh J.

FEBS Lett. 2007 Apr 3;581(7):1425-9. Epub 2007 Mar 5.


YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.

Szurmant H, Mohan MA, Imus PM, Hoch JA.

J Bacteriol. 2007 Apr;189(8):3280-9. Epub 2007 Feb 16.


The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.

Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H.

J Bacteriol. 2007 Apr;189(8):3290-5. Epub 2007 Feb 16.


Opposing effects of histidine phosphorylation regulate the AtxA virulence transcription factor in Bacillus anthracis.

Tsvetanova B, Wilson AC, Bongiorni C, Chiang C, Hoch JA, Perego M.

Mol Microbiol. 2007 Feb;63(3):644-55.


Phosphorylation and functional analysis of the sporulation initiation factor Spo0A from Clostridium botulinum.

Wörner K, Szurmant H, Chiang C, Hoch JA.

Mol Microbiol. 2006 Feb;59(3):1000-12.


Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for in vitro metalloregulation in the initiation of sporulation.

Kojetin DJ, Thompson RJ, Benson LM, Naylor S, Waterman J, Davies KG, Opperman CH, Stephenson K, Hoch JA, Cavanagh J.

Biometals. 2005 Oct;18(5):449-66.


Characterization of sporulation histidine kinases of Bacillus anthracis.

Brunsing RL, La Clair C, Tang S, Chiang C, Hancock LE, Perego M, Hoch JA.

J Bacteriol. 2005 Oct;187(20):6972-81.


YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.

Szurmant H, Nelson K, Kim EJ, Perego M, Hoch JA.

J Bacteriol. 2005 Aug;187(15):5419-26.


Functional genomics of gram-positive microorganisms.

Perego M, Hoch JA, Barrett JF.

J Bacteriol. 2004 Feb;186(4):903-9. Review. No abstract available.


Histidine kinase-mediated signal transduction systems of pathogenic microorganisms as targets for therapeutic intervention.

Stephenson K, Hoch JA.

Curr Drug Targets Infect Disord. 2002 Sep;2(3):235-46. Review.


Evolution of signalling in the sporulation phosphorelay.

Stephenson K, Hoch JA.

Mol Microbiol. 2002 Oct;46(2):297-304. Review.


Two-component and phosphorelay signal-transduction systems as therapeutic targets.

Stephenson K, Hoch JA.

Curr Opin Pharmacol. 2002 Oct;2(5):507-12. Review.


DNA complexed structure of the key transcription factor initiating development in sporulating bacteria.

Zhao H, Msadek T, Zapf J, Madhusudan, Hoch JA, Varughese KI.

Structure. 2002 Aug;10(8):1041-50.


Keeping signals straight in phosphorelay signal transduction.

Hoch JA, Varughese KI.

J Bacteriol. 2001 Sep;183(17):4941-9. Review. No abstract available.

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