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Items: 45

1.

Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion.

La HM, Hobbs RM.

Cell Mol Life Sci. 2019 Jun 28. doi: 10.1007/s00018-019-03201-6. [Epub ahead of print] Review.

PMID:
31254043
2.

Molecular regulation of spermatogonial stem cell renewal and differentiation.

Mäkelä JA, Hobbs RM.

Reproduction. 2019 Jun 1. pii: REP-18-0476.R2. doi: 10.1530/REP-18-0476. [Epub ahead of print] Review.

PMID:
31247585
3.

Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions.

Tichy AM, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak H.

J Mol Biol. 2019 Aug 9;431(17):3046-3055. doi: 10.1016/j.jmb.2019.05.033. Epub 2019 May 29.

PMID:
31150735
4.

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia.

Legrand JMD, Chan AL, La HM, Rossello FJ, Änkö ML, Fuller-Pace FV, Hobbs RM.

Nat Commun. 2019 May 23;10(1):2278. doi: 10.1038/s41467-019-09972-7.

5.

Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing.

Liao J, Ng SH, Luk AC, Suen HC, Qian Y, Lee AWT, Tu J, Fung JCL, Tang NLS, Feng B, Chan WY, Fouchet P, Hobbs RM, Lee TL.

Development. 2019 Mar 27;146(6). pii: dev174953. doi: 10.1242/dev.174953.

PMID:
30824552
6.

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance.

La HM, Chan AL, Legrand JMD, Rossello FJ, Gangemi CG, Papa A, Cheng Q, Morand EF, Hobbs RM.

Development. 2018 Sep 18;145(18). pii: dev165324. doi: 10.1242/dev.165324.

7.

Identification of dynamic undifferentiated cell states within the male germline.

La HM, Mäkelä JA, Chan AL, Rossello FJ, Nefzger CM, Legrand JMD, De Seram M, Polo JM, Hobbs RM.

Nat Commun. 2018 Jul 19;9(1):2819. doi: 10.1038/s41467-018-04827-z.

8.

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.

Sinha D, Kalimutho M, Bowles J, Chan AL, Merriner DJ, Bain AL, Simmons JL, Freire R, Lopez JA, Hobbs RM, O'Bryan MK, Khanna KK.

FASEB J. 2018 Sep;32(9):4984-4999. doi: 10.1096/fj.201701096RR. Epub 2018 Apr 17.

PMID:
29683733
9.

RNA processing in the male germline: Mechanisms and implications for fertility.

Legrand JMD, Hobbs RM.

Semin Cell Dev Biol. 2018 Jul;79:80-91. doi: 10.1016/j.semcdb.2017.10.006. Epub 2017 Oct 20. Review.

PMID:
29024760
10.

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes.

Chan AL, La HM, Legrand JMD, Mäkelä JA, Eichenlaub M, De Seram M, Ramialison M, Hobbs RM.

Stem Cell Reports. 2017 Sep 12;9(3):956-971. doi: 10.1016/j.stemcr.2017.08.001. Epub 2017 Aug 31.

11.

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

Hakim S, Dyson JM, Feeney SJ, Davies EM, Sriratana A, Koenig MN, Plotnikova OV, Smyth IM, Ricardo SD, Hobbs RM, Mitchell CA.

Hum Mol Genet. 2016 Jun 1;25(11):2295-2313. Epub 2016 Apr 7.

PMID:
27056978
12.

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP.

Nat Commun. 2015 Oct 8;6:8325. doi: 10.1038/ncomms9325.

13.

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.

Hobbs RM, La HM, Mäkelä JA, Kobayashi T, Noda T, Pandolfi PP.

EMBO Rep. 2015 Apr;16(4):467-80. doi: 10.15252/embr.201439379. Epub 2015 Feb 19.

14.

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.

Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP.

Cancer Discov. 2015 May;5(5):550-63. doi: 10.1158/2159-8290.CD-13-1050. Epub 2015 Feb 4.

15.

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

Guarnerio J, Riccardi L, Taulli R, Maeda T, Wang G, Hobbs RM, Song MS, Sportoletti P, Bernardi R, Bronson RT, Castillo-Martin M, Cordon-Cardo C, Lunardi A, Pandolfi PP.

Cancer Discov. 2015 Apr;5(4):396-409. doi: 10.1158/2159-8290.CD-14-1022. Epub 2015 Jan 22.

16.

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM, Nardella C, Clohessy JG, Cantley LC, Pandolfi PP.

Cancer Discov. 2014 Aug;4(8):896-904. doi: 10.1158/2159-8290.CD-13-0230. Epub 2014 May 27.

17.

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP.

Cell. 2014 Apr 24;157(3):595-610. doi: 10.1016/j.cell.2014.03.027.

18.

Reprogramming can be a transforming experience.

Hobbs RM, Polo JM.

Cell Stem Cell. 2014 Mar 6;14(3):269-71. doi: 10.1016/j.stem.2014.02.003.

19.

Glucocorticoid-induced leucine zipper (GILZ) regulates testicular FOXO1 activity and spermatogonial stem cell (SSC) function.

Ngo D, Cheng Q, O'Connor AE, DeBoer KD, Lo CY, Beaulieu E, De Seram M, Hobbs RM, O'Bryan MK, Morand EF.

PLoS One. 2013;8(3):e59149. doi: 10.1371/journal.pone.0059149. Epub 2013 Mar 14.

20.

CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice.

Ventelä S, Côme C, Mäkelä JA, Hobbs RM, Mannermaa L, Kallajoki M, Chan EK, Pandolfi PP, Toppari J, Westermarck J.

PLoS One. 2012;7(3):e33209. doi: 10.1371/journal.pone.0033209. Epub 2012 Mar 26.

21.

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.

Cell. 2012 Mar 30;149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6.

22.

Functional antagonism between Sall4 and Plzf defines germline progenitors.

Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP.

Cell Stem Cell. 2012 Mar 2;10(3):284-98. doi: 10.1016/j.stem.2012.02.004.

23.

Shape-shifting and tumor suppression by PLZF.

Hobbs RM, Pandolfi PP.

Oncotarget. 2010 May;1(1):3-5. No abstract available.

24.

Plzf regulates germline progenitor self-renewal by opposing mTORC1.

Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.

Cell. 2010 Aug 6;142(3):468-79. doi: 10.1016/j.cell.2010.06.041.

25.

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.

Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP.

Sci Signal. 2010 Apr 13;3(117):ra29. doi: 10.1126/scisignal.2000594. Erratum in: Sci Signal. 2010;3(123):er6.

26.

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.

Stem Cells Dev. 2010 Aug;19(8):1183-94. doi: 10.1089/scd.2009.0496.

PMID:
20331356
27.

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E.

Mol Biol Cell. 2010 Mar 1;21(5):704-11. doi: 10.1091/mbc.E09-08-0744. Epub 2010 Jan 6.

28.

Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.

Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB.

J Immunol. 2010 Feb 1;184(3):1268-79. doi: 10.4049/jimmunol.0903218. Epub 2009 Dec 28.

29.

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss MJ, Pandolfi PP.

Dev Cell. 2009 Oct;17(4):527-40. doi: 10.1016/j.devcel.2009.09.005.

30.

Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Nardella C, Carracedo A, Alimonti A, Hobbs RM, Clohessy JG, Chen Z, Egia A, Fornari A, Fiorentino M, Loda M, Kozma SC, Thomas G, Cordon-Cardo C, Pandolfi PP.

Sci Signal. 2009 Jan 27;2(55):ra2. doi: 10.1126/scisignal.2000189.

31.

The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.

Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB.

Nat Immunol. 2008 Sep;9(9):1055-64. doi: 10.1038/ni.1641. Epub 2008 Jul 27.

32.

Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.

Costoya JA, Hobbs RM, Pandolfi PP.

Oncogene. 2008 Jun 19;27(27):3789-96. doi: 10.1038/onc.2008.7. Epub 2008 Feb 4.

PMID:
18246121
33.

RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.

Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de Thé H, Solomon E, Grimwade D.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18694-9. Epub 2007 Nov 13.

34.

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.

Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S.

Nature. 2007 Sep 20;449(7160):346-50.

35.

Repression of kit expression by Plzf in germ cells.

Filipponi D, Hobbs RM, Ottolenghi S, Rossi P, Jannini EA, Pandolfi PP, Dolci S.

Mol Cell Biol. 2007 Oct;27(19):6770-81. Epub 2007 Jul 30.

36.

Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques.

Hermann BP, Sukhwani M, Lin CC, Sheng Y, Tomko J, Rodriguez M, Shuttleworth JJ, McFarland D, Hobbs RM, Pandolfi PP, Schatten GP, Orwig KE.

Stem Cells. 2007 Sep;25(9):2330-8. Epub 2007 Jun 21.

37.

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP.

Science. 2007 May 11;316(5826):860-6.

38.

A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein.

Schefe JH, Menk M, Reinemund J, Effertz K, Hobbs RM, Pandolfi PP, Ruiz P, Unger T, Funke-Kaiser H.

Circ Res. 2006 Dec 8;99(12):1355-66. Epub 2006 Nov 2.

PMID:
17082479
39.

The transcription factor Pokemon: a new key player in cancer pathogenesis.

Maeda T, Hobbs RM, Pandolfi PP.

Cancer Res. 2005 Oct 1;65(19):8575-8. Review.

40.

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.

Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.

Nature. 2005 Jan 20;433(7023):278-85.

41.
42.
43.

Essential role of Plzf in maintenance of spermatogonial stem cells.

Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP.

Nat Genet. 2004 Jun;36(6):653-9. Epub 2004 May 23.

45.

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.

Haase I, Hobbs RM, Romero MR, Broad S, Watt FM.

J Clin Invest. 2001 Aug;108(4):527-36.

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