Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 44

1.

Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.

Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y.

J Med Chem. 2008 Sep 25;51(18):5650-62. doi: 10.1021/jm800456k. Epub 2008 Aug 30.

2.

An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.

Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP.

J Med Chem. 2007 May 31;50(11):2622-39. Epub 2007 May 10. Erratum in: J Med Chem. 2008 Oct 9;51(19):6236. Ye, Mao [added].

3.

Determinants of retinoid X receptor transcriptional antagonism.

Cavasotto CN, Liu G, James SY, Hobbs PD, Peterson VJ, Bhattacharya AA, Kolluri SK, Zhang XK, Leid M, Abagyan R, Liddington RC, Dawson MI.

J Med Chem. 2004 Aug 26;47(18):4360-72.

PMID:
15317450
4.

Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.

Dawson MI, Harris DL, Liu G, Hobbs PD, Lange CW, Jong L, Bruey-Sedano N, James SY, Zhang XK, Peterson VJ, Leid M, Farhana L, Rishi AK, Fontana JA.

J Med Chem. 2004 Jul 1;47(14):3518-36.

PMID:
15214780
5.

Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.

Dawson MI, Hobbs PD, Peterson VJ, Leid M, Lange CW, Feng KC, Chen Gq, Gu J, Li H, Kolluri SK, Zhang Xk, Zhang Y, Fontana JA.

Cancer Res. 2001 Jun 15;61(12):4723-30.

6.

Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.

Dawson MI, Park JH, Chen G, Chao W, Dousman L, Waleh N, Hobbs PD, Jong L, Toll L, Zhang X, Gu J, Agadir A, Merchant JL, Bai L, Verma AK, Thacher SM, Chandraratna RA, Shroot B, Hill DL.

Int J Cancer. 2001 Jan 1;91(1):8-21.

7.

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang X.

Science. 2000 Aug 18;289(5482):1159-64.

8.

4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.

Dawson MI, Jong L, Hobbs PD, Xiao D, Feng KC, Chao WR, Pan C, Fontana JA, Zhang XK.

Bioorg Med Chem Lett. 2000 Jun 19;10(12):1311-3.

PMID:
10890153
9.

sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity.

Dawson MI, Hobbs PD, Jong L, Xiao D, Chao WR, Pan C, Zhang XK.

Bioorg Med Chem Lett. 2000 Jun 19;10(12):1307-10.

PMID:
10890152
10.

Antioxidant activity of michellamine alkaloids.

White EL, Ross LJ, Hobbs PD, Upender V, Dawson MI.

Anticancer Res. 1999 Mar-Apr;19(2A):1033-5.

PMID:
10368651
11.

Kinetic and thermodynamic analysis of 9-cis-retinoic acid binding to retinoid X receptor alpha.

Schimerlik MI, Peterson VJ, Hobbs PD, Dawson MI, Leid M.

Biochemistry. 1999 May 25;38(21):6732-40.

PMID:
10346893
12.

Michellamine alkaloids inhibit protein kinase C.

White EL, Chao WR, Ross LJ, Borhani DW, Hobbs PD, Upender V, Dawson MI.

Arch Biochem Biophys. 1999 May 1;365(1):25-30.

PMID:
10222035
13.

Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.

Shiohara M, Dawson MI, Hobbs PD, Sawai N, Higuchi T, Koike K, Komiyama A, Koeffler HP.

Blood. 1999 Mar 15;93(6):2057-66.

PMID:
10068679
15.

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

Li Y, Lin B, Agadir A, Liu R, Dawson MI, Reed JC, Fontana JA, Bost F, Hobbs PD, Zheng Y, Chen GQ, Shroot B, Mercola D, Zhang XK.

Mol Cell Biol. 1998 Aug;18(8):4719-31.

16.
17.

Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids.

Wu Q, Dawson MI, Zheng Y, Hobbs PD, Agadir A, Jong L, Li Y, Liu R, Lin B, Zhang XK.

Mol Cell Biol. 1997 Nov;17(11):6598-608.

18.
19.

The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal.

La Vista-Picard N, Hobbs PD, Pfahl M, Dawson MI, Pfahl M.

Mol Cell Biol. 1996 Aug;16(8):4137-46.

20.

A novel class of retinoid antagonists and their mechanism of action.

Lee MO, Dawson MI, Picard N, Hobbs PD, Pfahl M.

J Biol Chem. 1996 May 17;271(20):11897-903.

21.

Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.

Dawson MI, Chao WR, Pine P, Jong L, Hobbs PD, Rudd CK, Quick TC, Niles RM, Zhang XK, Lombardo A, et al.

Cancer Res. 1995 Oct 1;55(19):4446-51.

22.

Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.

Dawson MI, Jong L, Hobbs PD, Cameron JF, Chao WR, Pfahl M, Lee MO, Shroot B, Pfahl M.

J Med Chem. 1995 Aug 18;38(17):3368-83.

PMID:
7650690
23.

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.

Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu XP, Pfahl M.

Nature. 1994 Nov 3;372(6501):107-11.

PMID:
7969403
24.

A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter.

Lee MO, Hobbs PD, Zhang XK, Dawson MI, Pfahl M.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5632-6. Erratum in: Proc Natl Acad Sci U S A 1994 Nov 22;91(24):11767.

25.

Recombinant human retinoic acid receptor beta. Binding of synthetic retinoids and transcriptional activation.

Lombardo A, Costa E, Chao WR, Toll L, Hobbs PD, Jong L, Lee MO, Pfahl M, Ely KR, Dawson MI.

J Biol Chem. 1994 Mar 11;269(10):7297-303.

26.

Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.

Jong L, Lehmann JM, Hobbs PD, Harlev E, Huffman JC, Pfahl M, Dawson MI.

J Med Chem. 1993 Sep 3;36(18):2605-13.

PMID:
8410972
27.

Identification of retinoids with nuclear receptor subtype-selective activities.

Lehmann JM, Dawson MI, Hobbs PD, Husmann M, Pfahl M.

Cancer Res. 1991 Sep 15;51(18):4804-9.

28.

Synthesis and characterization of a ribavirin-3',5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine.

Dawson MI, Jina AN, Torkelson S, Rhee S, Moore M, Zarling DA, Hobbs PD.

Nucleic Acids Res. 1990 Mar 11;18(5):1099-102.

29.

Synthetic retinoid acid analogs: handling and characterization.

Dawson MI, Hobbs PD.

Methods Enzymol. 1990;189:15-43. No abstract available.

PMID:
2292930
30.

Biologically active aromatic retinoids bearing azido photoaffinity-labeling groups and their binding to cellular retinoic acid-binding protein.

Sani BP, Wille JJ Jr, Dawson MI, Hobbs PD, Bupp J, Rhee S, Chao WR, Dorsky A, Morimoto H.

Chem Biol Interact. 1990;75(3):293-304.

PMID:
2165870
31.

Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids.

Dawson MI, Hobbs PD, Derdzinski KA, Chao WR, Frenking G, Loew GH, Jetten AM, Napoli JL, Williams JB, Sani BP, et al.

J Med Chem. 1989 Jul;32(7):1504-17.

PMID:
2738885
32.

Inhibition of mammary carcinoma growth by retinoidal benzoic acid derivatives.

Fontana JA, Hobbs PD, Dawson MI.

Exp Cell Biol. 1988;56(5):254-63.

PMID:
3229553
33.

Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin.

Dawson MI, O'Krongly D, Hobbs PD, Barrueco JR, Sirotnak FM.

J Pharm Sci. 1987 Aug;76(8):635-8.

PMID:
11002823
34.
35.

Conformational restrictions of the retinoid skeleton.

Dawson MI, Hobbs PD, Chan R, Derdzinski K, Helmes CT, Chao W, Meierhenry E, Schiff LJ.

Ciba Found Symp. 1985;113:6-28.

PMID:
2411481
36.

Conformationally restricted retinoids.

Dawson MI, Hobbs PD, Derdzinski K, Chan RL, Gruber J, Chao WR, Smith S, Thies RW, Schiff LJ.

J Med Chem. 1984 Nov;27(11):1516-31.

PMID:
6208361
37.

Biological evaluation of some ionophore-polymeric chelator combinations for reducing iron overload.

Tyson CA, LeValley SE, Chan R, Hobbs PD, Dawson MI.

J Pharmacol Exp Ther. 1984 Mar;228(3):676-81.

PMID:
6707917
38.
40.

Aromatic retinoic acid analogues. 2. Synthesis and pharmacological activity.

Dawson MI, Chan R, Hobbs PD, Chao WR, Schiff LJ.

J Med Chem. 1983 Sep;26(9):1282-93.

PMID:
6887203
41.

Retinoic acid analogues with ring modifications. Synthesis and pharmacological activity.

Dawson MI, Hobbs PD, Chan RL, Chao WR.

J Med Chem. 1981 Oct;24(10):1214-23.

PMID:
7328582
42.

Aromatic retinoic acid analogues. Synthesis and pharmacological activity.

Dawson MI, Hobbs PD, Chan RL, Chao WR, Fung VA.

J Med Chem. 1981 May;24(5):583-92.

PMID:
7241516
43.

Retinoic acid analogues. Synthesis and potential as cancer chemopreventive agents.

Dawson MI, Hobbs PD, Kuhlmann K, Fung VA, Helmes CT, Chao WR.

J Med Chem. 1980 Sep;23(9):1013-22.

PMID:
7411544
44.

Studies on terpenes. 4. Synthesis of optically active grandisol, the boll weevil pheromone.

Hobbs PD, Magnus PD.

J Am Chem Soc. 1976 Jul 21;98(15):4594-4600. No abstract available.

PMID:
945309

Supplemental Content

Loading ...
Support Center