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Items: 15

1.

Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.

Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, Mattson GK, Peng Y, Wong H, Grace JE, Lentz KA, Qian-Cutrone J, Zhuo X, Shu YZ, Lodge NJ, Zaczek R, Combs AP, Olson RE, Bronson JJ, Mattson RJ, Macor JE.

J Med Chem. 2009 Jul 23;52(14):4173-91. doi: 10.1021/jm900301y.

PMID:
19552437
2.

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors.

Wityak J, Hobbs FW, Gardner DS, Santella JB 3rd, Petraitis JJ, Sun JH, Favata MF, Daulerio AJ, Horiuchi KY, Copeland RA, Scherle PA, Jaffe BD, Trzaskos JM, Magolda RL, Trainor GL, Duncia JV.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1483-6.

PMID:
15006386
3.

Oxazolidinones mechanism of action: inhibition of the first peptide bond formation.

Patel U, Yan YP, Hobbs FW Jr, Kaczmarczyk J, Slee AM, Pompliano DL, Kurilla MG, Bobkova EV.

J Biol Chem. 2001 Oct 5;276(40):37199-205. Epub 2001 Aug 1.

4.

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists.

Cocuzza AJ, Hobbs FW, Arnold CR, Chidester DR, Yarem JA, Culp S, Fitzgerald L, Gilligan PJ.

Bioorg Med Chem Lett. 1999 Apr 5;9(7):1057-62.

PMID:
10230640
5.

Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.

Chorvat RJ, Bakthavatchalam R, Beck JP, Gilligan PJ, Wilde RG, Cocuzza AJ, Hobbs FW, Cheeseman RS, Curry M, Rescinito JP, Krenitsky P, Chidester D, Yarem JA, Klaczkiewicz JD, Hodge CN, Aldrich PE, Wasserman ZR, Fernandez CH, Zaczek R, Fitzgerald LW, Huang SM, Shen HL, Wong YN, Chien BM, Arvanitis A, et al.

J Med Chem. 1999 Mar 11;42(5):833-48.

PMID:
10072681
6.

Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.

Arvanitis AG, Gilligan PJ, Chorvat RJ, Cheeseman RS, Christos TE, Bakthavatchalam R, Beck JP, Cocuzza AJ, Hobbs FW, Wilde RG, Arnold C, Chidester D, Curry M, He L, Hollis A, Klaczkiewicz J, Krenitsky PJ, Rescinito JP, Scholfield E, Culp S, De Souza EB, Fitzgerald L, Grigoriadis D, Tam SW, Shen HL, et al.

J Med Chem. 1999 Mar 11;42(5):805-18.

PMID:
10072679
7.

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

Duncia JV, Santella JB 3rd, Higley CA, Pitts WJ, Wityak J, Frietze WE, Rankin FW, Sun JH, Earl RA, Tabaka AC, Teleha CA, Blom KF, Favata MF, Manos EJ, Daulerio AJ, Stradley DA, Horiuchi K, Copeland RA, Scherle PA, Trzaskos JM, Magolda RL, Trainor GL, Wexler RR, Hobbs FW, Olson RE.

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44.

PMID:
9873633
8.

Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.

Ho SP, Britton DH, Stone BA, Behrens DL, Leffet LM, Hobbs FW, Miller JA, Trainor GL.

Nucleic Acids Res. 1996 May 15;24(10):1901-7.

9.

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. II. 3',5'-blocked oligonucleotides.

Sands H, Gorey-Feret LJ, Ho SP, Bao Y, Cocuzza AJ, Chidester D, Hobbs FW.

Mol Pharmacol. 1995 Mar;47(3):636-46.

PMID:
7700261
10.

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

Sands H, Gorey-Feret LJ, Cocuzza AJ, Hobbs FW, Chidester D, Trainor GL.

Mol Pharmacol. 1994 May;45(5):932-43.

PMID:
8190109
12.
13.

Detection of single base differences using biotinylated nucleotides with very long linker arms.

Livak KJ, Hobbs FW, Zagursky RJ.

Nucleic Acids Res. 1992 Sep 25;20(18):4831-7.

14.

Cytotoxicity of synthetic racemic ptilocaulin: a novel cyclic guanidine.

Ruben RL, Snider BB, Hobbs FW Jr, Confalone PN, Dusak BA.

Invest New Drugs. 1989 Jul;7(2-3):147-54.

PMID:
2793367
15.

A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides.

Prober JM, Trainor GL, Dam RJ, Hobbs FW, Robertson CW, Zagursky RJ, Cocuzza AJ, Jensen MA, Baumeister K.

Science. 1987 Oct 16;238(4825):336-41.

PMID:
2443975

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