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Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host.

Tavalire HF, Hoal EG, le Roex N, van Helden PD, Ezenwa VO, Jolles AE.

Proc Biol Sci. 2019 Jul 24;286(1907):20190914. doi: 10.1098/rspb.2019.0914. Epub 2019 Jul 17.


Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population.

Schurz H, Müller SJ, van Helden PD, Tromp G, Hoal EG, Kinnear CJ, Möller M.

Front Genet. 2019 Feb 5;10:34. doi: 10.3389/fgene.2019.00034. eCollection 2019.


A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array.

Schurz H, Kinnear CJ, Gignoux C, Wojcik G, van Helden PD, Tromp G, Henn B, Hoal EG, Möller M.

Front Genet. 2019 Jan 18;9:678. doi: 10.3389/fgene.2018.00678. eCollection 2018.


The X chromosome and sex-specific effects in infectious disease susceptibility.

Schurz H, Salie M, Tromp G, Hoal EG, Kinnear CJ, Möller M.

Hum Genomics. 2019 Jan 8;13(1):2. doi: 10.1186/s40246-018-0185-z. Review.


Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host.

Tavalire HF, Beechler BR, Buss PE, Gorsich EE, Hoal EG, le Roex N, Spaan JM, Spaan RS, van Helden PD, Ezenwa VO, Jolles AE.

Ecol Evol. 2018 Dec 6;8(24):12712-12726. doi: 10.1002/ece3.4699. eCollection 2018 Dec.


Rapid evolution of a skin-lightening allele in southern African KhoeSan.

Lin M, Siford RL, Martin AR, Nakagome S, Möller M, Hoal EG, Bustamante CD, Gignoux CR, Henn BM.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13324-13329. doi: 10.1073/pnas.1801948115. Epub 2018 Dec 10.


Neutrophils: Innate Effectors of TB Resistance?

Kroon EE, Coussens AK, Kinnear C, Orlova M, Möller M, Seeger A, Wilkinson RJ, Hoal EG, Schurr E.

Front Immunol. 2018 Nov 14;9:2637. doi: 10.3389/fimmu.2018.02637. eCollection 2018. Review.


Genetic Resistance to Mycobacterium tuberculosis Infection and Disease.

Möller M, Kinnear CJ, Orlova M, Kroon EE, van Helden PD, Schurr E, Hoal EG.

Front Immunol. 2018 Sep 27;9:2219. doi: 10.3389/fimmu.2018.02219. eCollection 2018. Review.


The critical needs and challenges for genetic architecture studies in Africa.

Martin AR, Teferra S, Möller M, Hoal EG, Daly MJ.

Curr Opin Genet Dev. 2018 Dec;53:113-120. doi: 10.1016/j.gde.2018.08.005. Epub 2018 Sep 18. Review.


Primary immunodeficiency diseases in a tuberculosis endemic region: challenges and opportunities.

Glanzmann B, Uren C, de Villiers N, van Coller A, Glashoff RH, Urban M, Hoal EG, Esser MM, Möller M, Kinnear CJ.

Genes Immun. 2019 Jul;20(6):447-454. doi: 10.1038/s41435-018-0041-0. Epub 2018 Sep 6.


Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient.

Glanzmann B, Möller M, Moncada-Velez M, Peter J, Urban M, van Helden PD, Hoal EG, de Villiers N, Glashoff RH, Nortje R, Bustamante J, Abel L, Casanova JL, Boisson-Dupuis S, Esser M, Kinnear CJ.

J Clin Immunol. 2018 May;38(4):460-463. doi: 10.1007/s10875-018-0509-8. Epub 2018 May 18. No abstract available.


Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa.

Nemat-Gorgani N, Hilton HG, Henn BM, Lin M, Gignoux CR, Myrick JW, Werely CJ, Granka JM, Möller M, Hoal EG, Yawata M, Yawata N, Boelen L, Asquith B, Parham P, Norman PJ.

J Immunol. 2018 Apr 15;200(8):2640-2655. doi: 10.4049/jimmunol.1701780. Epub 2018 Mar 16.


Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency.

Schlechter N, Glanzmann B, Hoal EG, Schoeman M, Petersen BS, Franke A, Lau YL, Urban M, van Helden PD, Esser MM, Möller M, Kinnear C.

Front Immunol. 2017 Nov 27;8:1624. doi: 10.3389/fimmu.2017.01624. eCollection 2017.


An Unexpectedly Complex Architecture for Skin Pigmentation in Africans.

Martin AR, Lin M, Granka JM, Myrick JW, Liu X, Sockell A, Atkinson EG, Werely CJ, Möller M, Sandhu MS, Kingsley DM, Hoal EG, Liu X, Daly MJ, Feldman MW, Gignoux CR, Bustamante CD, Henn BM.

Cell. 2017 Nov 30;171(6):1340-1353.e14. doi: 10.1016/j.cell.2017.11.015.


An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation.

Jabot-Hanin F, Cobat A, Feinberg J, Orlova M, Niay J, Deswarte C, Poirier C, Theodorou I, Bustamante J, Boisson-Dupuis S, Casanova JL, Alcaïs A, Hoal EG, Delacourt C, Schurr E, Abel L.

Sci Rep. 2017 Oct 9;7(1):12800. doi: 10.1038/s41598-017-13017-8.


The arms race between man and Mycobacterium tuberculosis: Time to regroup.

Hoal EG, Dippenaar A, Kinnear C, van Helden PD, Möller M.

Infect Genet Evol. 2018 Dec;66:361-375. doi: 10.1016/j.meegid.2017.08.021. Epub 2017 Aug 23. Review.


The role of human host genetics in tuberculosis resistance.

Kinnear C, Hoal EG, Schurz H, van Helden PD, Möller M.

Expert Rev Respir Med. 2017 Sep;11(9):721-737. doi: 10.1080/17476348.2017.1354700. Epub 2017 Jul 20. Review.


A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis.

Shah JA, Musvosvi M, Shey M, Horne DJ, Wells RD, Peterson GJ, Cox JS, Daya M, Hoal EG, Lin L, Gottardo R, Hanekom WA, Scriba TJ, Hatherill M, Hawn TR.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):502-511. doi: 10.1164/rccm.201611-2346OC.


A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility.

Uren C, Henn BM, Franke A, Wittig M, van Helden PD, Hoal EG, Möller M.

PLoS One. 2017 Apr 6;12(4):e0174738. doi: 10.1371/journal.pone.0174738. eCollection 2017.


Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa.

Kinnear C, Glanzmann B, Banda E, Schlechter N, Durrheim G, Neethling A, Nel E, Schoeman M, Johnson G, van Helden PD, Hoal EG, Esser M, Urban M, Möller M.

BMC Med Genet. 2017 Mar 14;18(1):26. doi: 10.1186/s12881-017-0388-5.


Population structure and infectious disease risk in southern Africa.

Uren C, Möller M, van Helden PD, Henn BM, Hoal EG.

Mol Genet Genomics. 2017 Jun;292(3):499-509. doi: 10.1007/s00438-017-1296-2. Epub 2017 Feb 22. Review.


The complete genome sequence of the African buffalo (Syncerus caffer).

Glanzmann B, Möller M, le Roex N, Tromp G, Hoal EG, van Helden PD.

BMC Genomics. 2016 Dec 7;17(1):1001.


Disease Control in Wildlife: Evaluating a Test and Cull Programme for Bovine Tuberculosis in African Buffalo.

le Roex N, Cooper D, van Helden PD, Hoal EG, Jolles AE.

Transbound Emerg Dis. 2016 Dec;63(6):647-657. doi: 10.1111/tbed.12329. Epub 2015 Jan 24.


Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries.

Uren C, Kim M, Martin AR, Bobo D, Gignoux CR, van Helden PD, Möller M, Hoal EG, Henn BM.

Genetics. 2016 Sep;204(1):303-14. doi: 10.1534/genetics.116.187369. Epub 2016 Jul 29.


Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis.

Bowker N, Salie M, Schurz H, van Helden PD, Kinnear CJ, Hoal EG, Möller M.

Lung. 2016 Oct;194(5):763-7. doi: 10.1007/s00408-016-9915-y. Epub 2016 Jun 30.


Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.

Jabot-Hanin F, Cobat A, Feinberg J, Grange G, Remus N, Poirier C, Boland-Auge A, Besse C, Bustamante J, Boisson-Dupuis S, Casanova JL, Schurr E, Alcaïs A, Hoal EG, Delacourt C, Abel L.

J Infect Dis. 2016 Apr 1;213(7):1173-9. doi: 10.1093/infdis/jiv757. Epub 2015 Dec 21.


The Risk of Tuberculosis Reinfection Soon after Cure of a First Disease Episode Is Extremely High in a Hyperendemic Community.

Uys P, Brand H, Warren R, van der Spuy G, Hoal EG, van Helden PD.

PLoS One. 2015 Dec 9;10(12):e0144487. doi: 10.1371/journal.pone.0144487. eCollection 2015.


Activating KIRs alter susceptibility to pulmonary tuberculosis in a South African population.

Salie M, Daya M, Möller M, Hoal EG.

Tuberculosis (Edinb). 2015 Dec;95(6):817-821. doi: 10.1016/ Epub 2015 Oct 17.


TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis.

Schurz H, Daya M, Möller M, Hoal EG, Salie M.

PLoS One. 2015 Oct 2;10(10):e0139711. doi: 10.1371/journal.pone.0139711. eCollection 2015. Review.


Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.

Salie M, Daya M, Lucas LA, Warren RM, van der Spuy GD, van Helden PD, Hoal EG, Möller M.

Infect Genet Evol. 2015 Aug;34:221-9. doi: 10.1016/j.meegid.2015.07.004. Epub 2015 Jul 6.


Selective breeding: the future of TB management in African buffalo?

le Roex N, Berrington CM, Hoal EG, van Helden PD.

Acta Trop. 2015 Sep;149:38-44. doi: 10.1016/j.actatropica.2015.05.012. Epub 2015 May 15. Review.


Investigating the Role of Gene-Gene Interactions in TB Susceptibility.

Daya M, van der Merwe L, van Helden PD, Möller M, Hoal EG.

PLoS One. 2015 Apr 28;10(4):e0123970. doi: 10.1371/journal.pone.0123970. eCollection 2014.


Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population.

Daya M, van der Merwe L, Gignoux CR, van Helden PD, Möller M, Hoal EG.

BMC Genomics. 2014 Nov 25;15:1021. doi: 10.1186/1471-2164-15-1021.


The role of ancestry in TB susceptibility of an admixed South African population.

Daya M, van der Merwe L, van Helden PD, Möller M, Hoal EG.

Tuberculosis (Edinb). 2014 Jul;94(4):413-20. doi: 10.1016/ Epub 2014 Apr 13.


Exome capture from saliva produces high quality genomic and metagenomic data.

Kidd JM, Sharpton TJ, Bobo D, Norman PJ, Martin AR, Carpenter ML, Sikora M, Gignoux CR, Nemat-Gorgani N, Adams A, Guadalupe M, Guo X, Feng Q, Li Y, Liu X, Parham P, Hoal EG, Feldman MW, Pollard KS, Wall JD, Bustamante CD, Henn BM.

BMC Genomics. 2014 Apr 4;15:262. doi: 10.1186/1471-2164-15-262.


Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method.

Chimusa ER, Daya M, Möller M, Ramesar R, Henn BM, van Helden PD, Mulder NJ, Hoal EG.

PLoS One. 2013 Sep 16;8(9):e73971. doi: 10.1371/journal.pone.0073971. eCollection 2013.


Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.

Chimusa ER, Zaitlen N, Daya M, Möller M, van Helden PD, Mulder NJ, Price AL, Hoal EG.

Hum Mol Genet. 2014 Feb 1;23(3):796-809. doi: 10.1093/hmg/ddt462. Epub 2013 Sep 20.


Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.

Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG.

J Infect Dis. 2014 Jan 15;209(2):216-23. doi: 10.1093/infdis/jit443. Epub 2013 Aug 14.


Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.

Cobat A, Hoal EG, Gallant CJ, Simkin L, Black GF, Stanley K, Jaïs JP, Yu TH, Boland-Auge A, Grange G, Delacourt C, van Helden P, Casanova JL, Abel L, Alcaïs A, Schurr E.

Clin Infect Dis. 2013 Oct;57(7):963-70. doi: 10.1093/cid/cit438. Epub 2013 Jun 25.


Bovine TB in livestock and wildlife: what's in the genes?

le Roex N, van Helden PD, Koets AP, Hoal EG.

Physiol Genomics. 2013 Aug 1;45(15):631-7. doi: 10.1152/physiolgenomics.00061.2013. Epub 2013 Jun 11. Review.


Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.

le Roex N, Koets AP, van Helden PD, Hoal EG.

PLoS One. 2013 May 15;8(5):e64494. doi: 10.1371/journal.pone.0064494. Print 2013.


One world, one health. Humans, animals and the environment are inextricably linked--a fact that needs to be remembered and exploited in our modern approach to health.

van Helden PD, van Helden LS, Hoal EG.

EMBO Rep. 2013 Jun;14(6):497-501. doi: 10.1038/embor.2013.61. Epub 2013 May 17. No abstract available.


Novel SNP Discovery in African Buffalo, Syncerus caffer, using high-throughput Sequencing.

le Roex N, Noyes H, Brass A, Bradley DG, Kemp SJ, Kay S, van Helden PD, Hoal EG.

PLoS One. 2012;7(11):e48792. doi: 10.1371/journal.pone.0048792. Epub 2012 Nov 7.


BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population.

Hemmings SM, Martin LI, Klopper M, van der Merwe L, Aitken L, de Wit E, Black GF, Hoal EG, Walzl G, Seedat S.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:273-80. doi: 10.1016/j.pnpbp.2012.10.011. Epub 2012 Oct 26.


A new TB vaccine: fact or fiction?

van Helden PD, Hoal EG.

Comp Immunol Microbiol Infect Dis. 2013 May;36(3):287-94. doi: 10.1016/j.cimid.2012.07.003. Epub 2012 Aug 23.


Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants.

Müller A, Möller M, Adams LA, Warren RM, Hoal EG, van Helden PD.

Cytogenet Genome Res. 2012;136(2):117-22. doi: 10.1159/000335464. Epub 2012 Jan 25.


Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat analysis and Beijing/W family of Mycobacterium tuberculosis.

Carugati M, Zanini F, Schiroli C, Gori A, Franzetti F, Hanekom M, van der Spuy GD, Gey van Pittius NC, McEvoy CR, Ndabambi SL, Victor TC, Hoal EG, van Helden PD, Warren RM.

J Clin Microbiol. 2011 Jul;49(7):2780; author reply 2781. doi: 10.1128/JCM.02089-09. No abstract available.


Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.

Adams LA, Möller M, Nebel A, Schreiber S, van der Merwe L, van Helden PD, Hoal EG.

Eur J Hum Genet. 2011 Jun;19(6):676-81. doi: 10.1038/ejhg.2011.1. Epub 2011 Feb 2.


Gene-gene interaction between tuberculosis candidate genes in a South African population.

de Wit E, van der Merwe L, van Helden PD, Hoal EG.

Mamm Genome. 2011 Feb;22(1-2):100-10. doi: 10.1007/s00335-010-9280-8. Epub 2010 Aug 27.


Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence.

Gallant CJ, Cobat A, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Beyers N, Jaïs JP, van Helden P, Abel L, Alcaïs A, Hoal EG, Schurr E.

Int J Tuberc Lung Dis. 2010 Aug;14(8):952-9.


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