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Factors correlating with shorter survival after treatment: aiding oncologists to choose who (not) to receive palliative systemic therapy.

Ho PYP, Lee HFV.

Ann Palliat Med. 2019 Sep 26. pii: apm.2019.09.06. doi: 10.21037/apm.2019.09.06. [Epub ahead of print]


AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.

Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR.

Am J Physiol Renal Physiol. 2019 Sep 30. doi: 10.1152/ajprenal.00592.2018. [Epub ahead of print]


The Important Role of Coordination Geometry on Photophysical Properties of Blue-Green Emitting Ruthenium(II) Diisocyano Complexes Bearing 2-Benzoxazol-2-ylphenolate.

Ho PY, Cheng SC, Yiu SM, Au VK, Xiang J, Leung CF, Ko CC.

Inorg Chem. 2019 Sep 3;58(17):11372-11381. doi: 10.1021/acs.inorgchem.9b00560. Epub 2019 Aug 14.


Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression.

Li X, Tian Y, Tu MJ, Ho PY, Batra N, Yu AM.

Acta Pharm Sin B. 2019 May;9(3):639-647. doi: 10.1016/j.apsb.2018.12.002. Epub 2018 Dec 11.


Bioengineering of a single long noncoding RNA molecule that carries multiple small RNAs.

Petrek H, Batra N, Ho PY, Tu MJ, Yu AM.

Appl Microbiol Biotechnol. 2019 Aug;103(15):6107-6117. doi: 10.1007/s00253-019-09934-5. Epub 2019 Jun 11.


Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis.

Xu J, Sun J, Ho PY, Luo Z, Ma W, Zhao W, Rathod SB, Fernandez CA, Venkataramanan R, Xie W, Yu AM, Li S.

Biomaterials. 2019 Jul;210:25-40. doi: 10.1016/j.biomaterials.2019.04.025. Epub 2019 Apr 26.


Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study.

Khodaverdian V, Tapadar S, MacDonald IA, Xu Y, Ho PY, Bridges A, Rajpurohit P, Sanghani BA, Fan Y, Thangaraju M, Hathaway NA, Oyelere AK.

Sci Rep. 2019 Mar 18;9(1):4802. doi: 10.1038/s41598-019-39214-1.


Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity.

Jilek JL, Zhang QY, Tu MJ, Ho PY, Duan Z, Qiu JX, Yu AM.

Mol Ther Nucleic Acids. 2019 Mar 1;14:498-508. doi: 10.1016/j.omtn.2019.01.007. Epub 2019 Jan 24.


Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.

Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM.

Cancer Lett. 2019 Feb 1;442:82-90. doi: 10.1016/j.canlet.2018.10.038. Epub 2018 Oct 30.


A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models.

Willingham SB, Ho PY, Hotson A, Hill C, Piccione EC, Hsieh J, Liu L, Buggy JJ, McCaffery I, Miller RA.

Cancer Immunol Res. 2018 Oct;6(10):1136-1149. doi: 10.1158/2326-6066.CIR-18-0056. Epub 2018 Aug 21.


Panchromatic Sensitization with ZnII Porphyrin-Based Photosensitizers for Light-Driven Hydrogen Production.

Ho PY, Mark MF, Wang Y, Yiu SC, Yu WH, Ho CL, McCamant DW, Eisenberg R, Huang S.

ChemSusChem. 2018 Aug 9;11(15):2517-2528. doi: 10.1002/cssc.201801255. Epub 2018 Jul 25.


Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo.

Zhang QY, Ho PY, Tu MJ, Jilek JL, Chen QX, Zeng S, Yu AM.

Int J Pharm. 2018 Aug 25;547(1-2):537-544. doi: 10.1016/j.ijpharm.2018.06.026. Epub 2018 Jun 9.


β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells.

Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR.

J Biol Chem. 2018 Jul 20;293(29):11612-11624. doi: 10.1074/jbc.RA118.003082. Epub 2018 Jun 1.


What is the best lateral radiograph positioning technique for assessment of sagittal balance: A biomechanical study on influence of different arm positions.

Sieh KM, Chan YY, Ho PY, Fung KY.

J Orthop Surg (Hong Kong). 2018 May-Aug;26(2):2309499018770932. doi: 10.1177/2309499018770932.


Efficacy of recombinant protein vaccines for protection against Nocardia seriolae infection in the largemouth bass Micropterus salmoides.

Ho PY, Chen YC, Maekawa S, Hu HH, Tsai AW, Chang YF, Wang PC, Chen SC.

Fish Shellfish Immunol. 2018 Jul;78:35-41. doi: 10.1016/j.fsi.2018.04.024. Epub 2018 Apr 14.


Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy.

Ho PY, Duan Z, Batra N, Jilek JL, Tu MJ, Qiu JX, Hu Z, Wun T, Lara PN, DeVere White RW, Chen HW, Yu AM.

J Pharmacol Exp Ther. 2018 Jun;365(3):494-506. doi: 10.1124/jpet.118.247775. Epub 2018 Mar 30.


Modeling Cell Size Regulation: From Single-Cell-Level Statistics to Molecular Mechanisms and Population-Level Effects.

Ho PY, Lin J, Amir A.

Annu Rev Biophys. 2018 May 20;47:251-271. doi: 10.1146/annurev-biophys-070317-032955. Epub 2018 Mar 8. Review.


Archaeal cells share common size control with bacteria despite noisier growth and division.

Eun YJ, Ho PY, Kim M, LaRussa S, Robert L, Renner LD, Schmid A, Garner E, Amir A.

Nat Microbiol. 2018 Feb;3(2):148-154. doi: 10.1038/s41564-017-0082-6. Epub 2017 Dec 18.


Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.

Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL.

Nat Immunol. 2018 Jan;19(1):76-84. doi: 10.1038/s41590-017-0004-z. Epub 2017 Nov 27.


Details Matter: Noise and Model Structure Set the Relationship between Cell Size and Cell Cycle Timing.

Barber F, Ho PY, Murray AW, Amir A.

Front Cell Dev Biol. 2017 Nov 3;5:92. doi: 10.3389/fcell.2017.00092. eCollection 2017.


A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization.

Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB.

Curr Biol. 2017 Nov 6;27(21):3367-3374.e7. doi: 10.1016/j.cub.2017.09.046. Epub 2017 Oct 26.


Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells.

Li PC, Tu MJ, Ho PY, Jilek JL, Duan Z, Zhang QY, Yu AX, Yu AM.

Drug Metab Dispos. 2018 Jan;46(1):2-10. doi: 10.1124/dmd.117.078741. Epub 2017 Oct 23.


Catalyst displacement assay: a supramolecular approach for the design of smart latent catalysts for pollutant monitoring and removal.

Chow CF, Ho PY, Wong WL, Lu YJ, Tang Q, Gong CB.

Chem Sci. 2017 May 1;8(5):3812-3820. doi: 10.1039/c6sc05584b. Epub 2017 Mar 2.


Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models.

Jian C, Tu MJ, Ho PY, Duan Z, Zhang Q, Qiu JX, DeVere White RW, Wun T, Lara PN, Lam KS, Yu AX, Yu AM.

Oncotarget. 2017 May 9;8(19):30742-30755. doi: 10.18632/oncotarget.16372.


Starburst Triarylamine Donor-Based Metal-Free Photosensitizers for Photocatalytic Hydrogen Production from Water.

Ho PY, Wang Y, Yiu SC, Yu WH, Ho CL, Huang S.

Org Lett. 2017 Mar 3;19(5):1048-1051. doi: 10.1021/acs.orglett.7b00042. Epub 2017 Feb 10.


Assessing exercise cardiac reserve using real-time cardiovascular magnetic resonance.

Le TT, Bryant JA, Ting AE, Ho PY, Su B, Teo RC, Gan JS, Chung YC, O'Regan DP, Cook SA, Chin CW.

J Cardiovasc Magn Reson. 2017 Jan 23;19(1):7. doi: 10.1186/s12968-017-0322-1.


Interrogating the Escherichia coli cell cycle by cell dimension perturbations.

Zheng H, Ho PY, Jiang M, Tang B, Liu W, Li D, Yu X, Kleckner NE, Amir A, Liu C.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15000-15005. doi: 10.1073/pnas.1617932114. Epub 2016 Dec 12.


Bis(phenothiazyl-ethynylene)-Based Organic Dyes Containing Di-Anchoring Groups with Efficiency Comparable to N719 for Dye-Sensitized Solar Cells.

Siu CH, Lee LT, Ho PY, Ho CL, Chen T, Suramitr S, Hannongbua S, Xie Z, Wei M, Wong WY.

Chem Asian J. 2017 Feb 1;12(3):332-340. doi: 10.1002/asia.201601427. Epub 2016 Dec 27.


Development of sensitive and selective food sensors using new Re(I)-Pt(II) bimetallic complexes to detect volatile biogenic sulfides formed by meat spoilage.

Chow CF, Ho PY, Sun D, Lu YJ, Wong WL, Tang Q, Gong CB.

Food Chem. 2017 Feb 1;216:382-9. doi: 10.1016/j.foodchem.2016.08.046. Epub 2016 Aug 17.


Chromophoric Dyads for the Light-Driven Generation of Hydrogen: Investigation of Factors in the Design of Multicomponent Photosensitizers for Proton Reduction.

Ho PY, Zheng B, Mark D, Wong WY, McCamant DW, Eisenberg R.

Inorg Chem. 2016 Sep 6;55(17):8348-58. doi: 10.1021/acs.inorgchem.6b00496. Epub 2016 Aug 17.


Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy.

Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA.

Sci Transl Med. 2016 Aug 10;8(351):351ra105. doi: 10.1126/scitranslmed.aae0501.


Modelling High-temperature EBPR by Incorporating Glycogen and GAOs: Challenges from a Preliminary Study.

Liau KF, Yeoh HK, Shoji T, Chua AS, Ho PY.

Water Environ Res. 2017 Jan 1;89(1):62-72. doi: 10.2175/106143016X14504669768615. Epub 2016 Mar 2.


Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells.

Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1216-28. doi: 10.1152/ajprenal.00061.2016. Epub 2016 Feb 24.


Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake.

Dong F, Dong X, Zhou L, Xiao H, Ho PY, Wong MS, Wang Y.

Colloids Surf B Biointerfaces. 2016 Apr 1;140:324-331. doi: 10.1016/j.colsurfb.2015.12.048. Epub 2015 Dec 29.


Bioengineering of noncoding RNAs for research agents and therapeutics.

Ho PY, Yu AM.

Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):186-97. doi: 10.1002/wrna.1324. Epub 2016 Jan 13. Review.


Synthesis and Characterization of Phenothiazine-Based Platinum(II)-Acetylide Photosensitizers for Efficient Dye-Sensitized Solar Cells.

Siu CH, Lee LT, Yiu SC, Ho PY, Zhou P, Ho CL, Chen T, Liu J, Han K, Wong WY.

Chemistry. 2016 Mar 7;22(11):3750-7. doi: 10.1002/chem.201503828. Epub 2015 Dec 11.


MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy.

Yu AM, Tian Y, Tu MJ, Ho PY, Jilek JL.

Drug Metab Dispos. 2016 Mar;44(3):308-19. doi: 10.1124/dmd.115.067470. Epub 2015 Nov 13. Review.


Developing five-membered heterocycle substituted phosphinous acids as ligands for palladium-catalyzed Suzuki-Miyaura and Catellani reactions.

Chang TW, Ho PY, Mao KC, Hong FE.

Dalton Trans. 2015 Oct 21;44(39):17129-42. doi: 10.1039/c5dt02611c. Epub 2015 Sep 15.


Simultaneous regulation of cell size and chromosome replication in bacteria.

Ho PY, Amir A.

Front Microbiol. 2015 Jul 10;6:662. doi: 10.3389/fmicb.2015.00662. eCollection 2015.


A Multifunctional Bimetallic Molecular Device for Ultrasensitive Detection, Naked-Eye Recognition, and Elimination of Cyanide Ions.

Chow CF, Ho PY, Wong WL, Gong CB.

Chemistry. 2015 Sep 7;21(37):12984-90. doi: 10.1002/chem.201501448. Epub 2015 Jul 17.


Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization.

Wang WP, Ho PY, Chen QX, Addepalli B, Limbach PA, Li MM, Wu WJ, Jilek JL, Qiu JX, Zhang HJ, Li T, Wun T, White RD, Lam KS, Yu AM.

J Pharmacol Exp Ther. 2015 Aug;354(2):131-41. doi: 10.1124/jpet.115.225631. Epub 2015 May 28.


LED 590 nm photomodulation reduces UVA-induced metalloproteinase-1 expression via upregulation of antioxidant enzyme catalase.

Lan CC, Ho PY, Wu CS, Yang RC, Yu HS.

J Dermatol Sci. 2015 May;78(2):125-32. doi: 10.1016/j.jdermsci.2015.02.018. Epub 2015 Mar 5.


Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.

Feng M, Chen JY, Weissman-Tsukamoto R, Volkmer JP, Ho PY, McKenna KM, Cheshier S, Zhang M, Guo N, Gip P, Mitra SS, Weissman IL.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2145-50. doi: 10.1073/pnas.1424907112. Epub 2015 Feb 2.


Synergistic Blockade of EGFR and HER2 by New-Generation EGFR Tyrosine Kinase Inhibitor Enhances Radiation Effect in Bladder Cancer Cells.

Tsai YC, Ho PY, Tzen KY, Tuan TF, Liu WL, Cheng AL, Pu YS, Cheng JC.

Mol Cancer Ther. 2015 Mar;14(3):810-20. doi: 10.1158/1535-7163.MCT-13-0951. Epub 2015 Jan 14.


Kinetic and stoichiometric characterization for efficient enhanced biological phosphorus removal (EBPR) process at high temperatures.

Liau KF, Shoji T, Ong YH, Chua AS, Yeoh HK, Ho PY.

Bioprocess Biosyst Eng. 2015 Apr;38(4):729-37. doi: 10.1007/s00449-014-1313-3. Epub 2014 Nov 9.


Calibrated Langevin-dynamics simulations of intrinsically disordered proteins.

Smith WW, Ho PY, O'Hern CS.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Oct;90(4):042709. Epub 2014 Oct 13.


Biweekly cetuximab and first-line chemotherapy in chinese patients with k-ras wild-type colorectal cancers.

Chan WL, Lee VH, Siu WK, Ho PY, Liu RK, Leung TW.

South Asian J Cancer. 2014 Jul;3(3):175-8. doi: 10.4103/2278-330X.136802.


An Ru(II)-Fe(III) bimetallic complex as a multifunctional device for detecting, signal amplifying, and degrading oxalate.

Chow CF, Ho PY, Gong CB.

Analyst. 2014 Sep 7;139(17):4256-63. doi: 10.1039/c4an00350k. Epub 2014 Jul 3.


Neonatal glucocorticoid treatment increased depression-like behaviour in adult rats.

Ko MC, Hung YH, Ho PY, Yang YL, Lu KT.

Int J Neuropsychopharmacol. 2014 Dec;17(12):1995-2004. doi: 10.1017/S1461145714000868. Epub 2014 Jun 19.


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