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Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism.

Ho PWM, Chan AS, Pavlos NJ, Sims NA, Martin TJ.

Biochem Pharmacol. 2019 Nov;169:113627. doi: 10.1016/j.bcp.2019.113627. Epub 2019 Aug 30.


The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease.

Pang SY, Ho PW, Liu HF, Leung CT, Li L, Chang EES, Ramsden DB, Ho SL.

Transl Neurodegener. 2019 Aug 16;8:23. doi: 10.1186/s40035-019-0165-9. eCollection 2019. Review.


Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).

Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL.

Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14.


IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis.

McGregor NE, Murat M, Elango J, Poulton IJ, Walker EC, Crimeen-Irwin B, Ho PWM, Gooi JH, Martin TJ, Sims NA.

J Biol Chem. 2019 May 10;294(19):7850-7863. doi: 10.1074/jbc.RA119.008074. Epub 2019 Mar 28.


Forcing fermentation: Profiling proteins, peptides and polyphenols in lab-scale cocoa bean fermentation.

John WA, Böttcher NL, Aßkamp M, Bergounhou A, Kumari N, Ho PW, D'Souza RN, Nevoigt E, Ullrich MS.

Food Chem. 2019 Apr 25;278:786-794. doi: 10.1016/j.foodchem.2018.11.108. Epub 2018 Dec 2.


Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53.

Walia MK, Taylor S, Ho PWM, Martin TJ, Walkley CR.

Cell Death Dis. 2018 Aug 28;9(9):844. doi: 10.1038/s41419-018-0944-8.


Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner.

Johnson RW, Sun Y, Ho PWM, Chan ASM, Johnson JA, Pavlos NJ, Sims NA, Martin TJ.

Front Endocrinol (Lausanne). 2018 May 16;9:241. doi: 10.3389/fendo.2018.00241. eCollection 2018.


Glycerol positive promoters for tailored metabolic engineering of the yeast Saccharomyces cerevisiae.

Ho PW, Klein M, Futschik M, Nevoigt E.

FEMS Yeast Res. 2018 May 1;18(3). doi: 10.1093/femsyr/foy019.


Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system.

Wang B, Li A, Li X, Ho PW, Wu D, Wang X, Liu Z, Wu KK, Yau SS, Xu A, Cheng KK.

EMBO Rep. 2018 Apr;19(4). pii: e44977. doi: 10.15252/embr.201744977. Epub 2018 Feb 21.


Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR.

Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.


Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.

Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Divieti Pajevic P, Gooi JH, Martin TJ, Sims NA.

J Bone Miner Res. 2018 Jan;33(1):137-153. doi: 10.1002/jbmr.3291. Epub 2017 Oct 3.


Urinary Mitochondrial DNA Level as a Biomarker of Acute Kidney Injury Severity.

Ho PW, Pang WF, Luk CC, Ng JK, Chow KM, Kwan BC, Li PK, Szeto CC.

Kidney Dis (Basel). 2017 Jul;3(2):78-83. doi: 10.1159/000475883. Epub 2017 May 17.


Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.

Kukalev A, Ng YM, Ju L, Saidi A, Lane S, Mondragon A, Dormann D, Walker SE, Grey W, Ho PW, Stephens DN, Carr AM, Lamsa K, Tse E, Yu VPCC.

Cereb Cortex. 2017 Jan 1;27(1):11-23. doi: 10.1093/cercor/bhw354.


Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2017 Feb 1;144(3):530. doi: 10.1242/dev.148460. No abstract available.


Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.

Liu HF, Ho PW, Leung GC, Lam CS, Pang SY, Li L, Kung MH, Ramsden DB, Ho SL.

Sci Rep. 2017 Jan 18;7:40887. doi: 10.1038/srep40887.


Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms.

Swinnen S, Henriques SF, Shrestha R, Ho PW, Sá-Correia I, Nevoigt E.

Microb Cell Fact. 2017 Jan 9;16(1):7. doi: 10.1186/s12934-016-0621-5.


The sole introduction of two single-point mutations establishes glycerol utilization in Saccharomyces cerevisiae CEN.PK derivatives.

Ho PW, Swinnen S, Duitama J, Nevoigt E.

Biotechnol Biofuels. 2017 Jan 3;10:10. doi: 10.1186/s13068-016-0696-6. eCollection 2017.


Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.

Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, Xu A, Lam KS, Chan KH.

Mol Neurodegener. 2016 Nov 25;11(1):71.


Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR.

Biochem J. 2016 Sep 1;473(17):2671-85. doi: 10.1042/BCJ20160557. Epub 2016 Jul 29.


Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach.

Xu EG, Ho PW, Tse Z, Ho SL, Leung KMY.

Environ Pollut. 2016 Aug;215:103-112. doi: 10.1016/j.envpol.2016.04.090. Epub 2016 May 11.


Genetic determinants for enhanced glycerol growth of Saccharomyces cerevisiae.

Swinnen S, Ho PW, Klein M, Nevoigt E.

Metab Eng. 2016 Jul;36:68-79. doi: 10.1016/j.ymben.2016.03.003. Epub 2016 Mar 10.


Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2016 Feb 15;143(4):648-57. doi: 10.1242/dev.125625. Epub 2016 Jan 11. Erratum in: Development. 2017 Feb 1;144(3):530.


Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA.

Lee YK, Lau YM, Ng KM, Lai WH, Ho SL, Tse HF, Siu CW, Ho PW.

Int J Cardiol. 2016 Jan 15;203:964-71. doi: 10.1016/j.ijcard.2015.11.101. Epub 2015 Nov 17. Erratum in: Int J Cardiol. 2016 Mar 15;207:393.


Remote ischaemic pre-conditioning for the prevention of acute kidney injury.

Ho PW, Pang WF, Szeto CC.

Nephrology (Carlton). 2016 Apr;21(4):274-85. doi: 10.1111/nep.12614. Review.


PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion.

Ho PW, Pang SY, Li M, Tse ZH, Kung MH, Sham PC, Ho SL.

Brain Behav. 2015 Apr;5(4):e00321. doi: 10.1002/brb3.321. Epub 2015 Feb 16.


LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.

Liu HF, Lu S, Ho PW, Tse HM, Pang SY, Kung MH, Ho JW, Ramsden DB, Zhou ZJ, Ho SL.

Ann Clin Transl Neurol. 2014 Mar;1(3):199-208. doi: 10.1002/acn3.45. Epub 2014 Mar 4.


PTHrP, its receptor, and protein kinase A activation in osteosarcoma.

Walkley CR, Walia MK, Ho PW, Martin TJ.

Mol Cell Oncol. 2014 Dec 31;1(4):e965624. doi: 10.4161/23723548.2014.965624. eCollection 2014 Oct-Dec.


gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.

Standal T, Johnson RW, McGregor NE, Poulton IJ, Ho PW, Martin TJ, Sims NA.

J Endocrinol. 2014 Nov;223(2):181-90. doi: 10.1530/JOE-14-0424. Epub 2014 Sep 16.


Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis.

Guo Y, Chung SK, Siu CW, Kwan SC, Ho PW, Yeung PK, Chan KH.

J Neuroimmunol. 2014 Nov 15;276(1-2):64-70. doi: 10.1016/j.jneuroim.2014.08.616. Epub 2014 Aug 19.


PMCA4 (ATP2B4) mutation in familial spastic paraplegia.

Li M, Ho PW, Pang SY, Tse ZH, Kung MH, Sham PC, Ho SL.

PLoS One. 2014 Aug 13;9(8):e104790. doi: 10.1371/journal.pone.0104790. eCollection 2014.


Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo.

Ho PW, Goradia A, Russell MR, Chalk AM, Milley KM, Baker EK, Danks JA, Slavin JL, Walia M, Crimeen-Irwin B, Dickins RA, Martin TJ, Walkley CR.

Oncogene. 2015 May 28;34(22):2922-33. doi: 10.1038/onc.2014.217. Epub 2014 Jul 21.


EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.

Tonna S, Takyar FM, Vrahnas C, Crimeen-Irwin B, Ho PW, Poulton IJ, Brennan HJ, McGregor NE, Allan EH, Nguyen H, Forwood MR, Tatarczuch L, Mackie EJ, Martin TJ, Sims NA.

FASEB J. 2014 Oct;28(10):4482-96. doi: 10.1096/fj.14-254300. Epub 2014 Jun 30. Erratum in: FASEB J. 2017 Mar;31(3):1249.


Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells.

Lee YK, Ho PW, Schick R, Lau YM, Lai WH, Zhou T, Li Y, Ng KM, Ho SL, Esteban MA, Binah O, Tse HF, Siu CW.

Pflugers Arch. 2014 Sep;466(9):1831-44. doi: 10.1007/s00424-013-1414-x. Epub 2013 Dec 11.


Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system.

Ho PW, Tse ZH, Liu HF, Lu S, Ho JW, Kung MH, Ramsden DB, Ho SL.

PLoS One. 2013 Sep 6;8(9):e74065. doi: 10.1371/journal.pone.0074065. eCollection 2013.


Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese.

Chan KH, Lee R, Lee JC, Tse AC, Pang SY, Lau GK, Teo KC, Ho PW.

J Neuroimmunol. 2013 Sep 15;262(1-2):100-5. doi: 10.1016/j.jneuroim.2013.06.004. Epub 2013 Jul 6.


Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

Mutsaers AJ, Ng AJ, Baker EK, Russell MR, Chalk AM, Wall M, Liddicoat BJ, Ho PW, Slavin JL, Goradia A, Martin TJ, Purton LE, Dickins RA, Walkley CR.

Bone. 2013 Jul;55(1):166-78. doi: 10.1016/j.bone.2013.02.016. Epub 2013 Feb 26.


Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity.

Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A.

PLoS One. 2012;7(12):e52354. doi: 10.1371/journal.pone.0052354. Epub 2012 Dec 27.


Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease.

Ho PW, Ho JW, Liu HF, So DH, Tse ZH, Chan KH, Ramsden DB, Ho SL.

Transl Neurodegener. 2012 Jan 13;1(1):3. doi: 10.1186/2047-9158-1-3.


EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone.

Takyar FM, Tonna S, Ho PW, Crimeen-Irwin B, Baker EK, Martin TJ, Sims NA.

J Bone Miner Res. 2013 Apr;28(4):912-25. doi: 10.1002/jbmr.1820.


Advanced breast cancer-are we doing enough?

Pek CH, Tan EY, Chen JJ, Ho PW, Teo C, Earnest A, Chan PM.

Breast J. 2012 Nov-Dec;18(6):644-6. doi: 10.1111/tbj.12020. Epub 2012 Sep 26. No abstract available.


Plasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis.

Zhou L, Chan KH, Chu LW, Kwan JS, Song YQ, Chen LH, Ho PW, Cheng OY, Ho JW, Lam KS.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):697-702. doi: 10.1016/j.bbrc.2012.06.017. Epub 2012 Jun 12.


UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress.

Ho JW, Ho PW, Liu HF, So DH, Chan KH, Tse ZH, Kung MH, Ramsden DB, Ho SL.

Free Radic Biol Med. 2012 Jul 15;53(2):383-94. doi: 10.1016/j.freeradbiomed.2012.05.002. Epub 2012 May 8.


Detection of endocrine disruptors - from simple assays to whole genome scanning.

Sung E, Turan N, Ho PW, Ho SL, Jarratt PD, Waring RH, Ramsden DB.

Int J Androl. 2012 Jun;35(3):407-14. doi: 10.1111/j.1365-2605.2012.01254.x. Epub 2012 Mar 19. Review.


Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.

Ho PW, Ho JW, Tse HM, So DH, Yiu DC, Liu HF, Chan KH, Kung MH, Ramsden DB, Ho SL.

PLoS One. 2012;7(2):e32810. doi: 10.1371/journal.pone.0032810. Epub 2012 Feb 29.


Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse.

Chan KH, Zhang R, Kwan JS, Guo VY, Ho PW, Ho JW, Chu AC.

J Neuroimmunol. 2012 Apr;245(1-2):32-8. doi: 10.1016/j.jneuroim.2012.02.001. Epub 2012 Mar 5.


Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo.

Walker EC, Poulton IJ, McGregor NE, Ho PW, Allan EH, Quach JM, Martin TJ, Sims NA.

J Bone Miner Res. 2012 Apr;27(4):902-12. doi: 10.1002/jbmr.1506.


Predictors of nonsentinel nodal involvement to aid intraoperative decision making in breast cancer patients with positive sentinel lymph nodes.

Tan EY, Ho B, Chen JJ, Ho PW, Teo C, Earnest A, Chan PM.

ISRN Oncol. 2011;2011:539503. doi: 10.5402/2011/539503. Epub 2011 Aug 16.


Brain involvement in neuromyelitis optica spectrum disorders.

Chan KH, Tse CT, Chung CP, Lee RL, Kwan JS, Ho PW, Ho JW.

Arch Neurol. 2011 Nov;68(11):1432-9. doi: 10.1001/archneurol.2011.249.


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